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MAPK8

  • MAPK8
  • Protein-coding gene in the species Homo sapiens

    known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene. The protein encoded by this gene is a member of the MAP kinase and

    MAPK8

    MAPK8

    MAPK8

  • ITCH
  • Protein-coding gene in the species Homo sapiens

    phosphorylated and ubiquitinated. ITCH is regulated by MAPK8. MAPK8 regulates JUNB protein turnover by MAPK8-dependent phosphorylation of ITCH and a subsequent

    ITCH

    ITCH

    ITCH

  • MAP2K4
  • Protein-coding gene in the species Homo sapiens

    kinases in response to various environmental stresses or mitogenic stimuli. MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38 are substrates for MAP2K4, but MAPK1/ERK2

    MAP2K4

    MAP2K4

    MAP2K4

  • MAPK8IP1
  • Protein-coding gene in the species Homo sapiens

    to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and

    MAPK8IP1

    MAPK8IP1

    MAPK8IP1

  • C-Jun N-terminal kinases
  • Chemical compounds

    mitogen-activated protein kinase 8 Identifiers Symbol MAPK8 Alt. symbols JNK1, PRKM8 NCBI gene 5599 HGNC 6881 OMIM 601158 RefSeq NM_002750 UniProt P45983

    C-Jun N-terminal kinases

    C-Jun N-terminal kinases

    C-Jun_N-terminal_kinases

  • Protein kinase domain
  • Protein domain

    MAPK11 ; MAPK12 ; MAPK13 ; MAPK14 ; MAPK15 ; MAPK3 ; MAPK4 ; MAPK6 ; MAPK7 ; MAPK8 ; MAPK9 ; MAPKAPK2 ; MAPKAPK3 ; MAPKAPK5 ; MARK1 ; MARK2 ; MARK3 ; MARK4 ;

    Protein kinase domain

    Protein kinase domain

    Protein_kinase_domain

  • MAP2K7
  • Protein-coding gene in the species Homo sapiens

    cytokines, and environmental stresses. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated

    MAP2K7

    MAP2K7

    MAP2K7

  • MAP3K7IP2
  • Protein-coding gene in the species Homo sapiens

    is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus

    MAP3K7IP2

    MAP3K7IP2

    MAP3K7IP2

  • Mitogen-activated protein kinase
  • P38 mitogen-activated protein kinases

    MAP kinase kinase kinase kinase MAPK1 (ERK2) MAPK3 (ERK1) MAPK7 (ERK5) MAPK8 (JNK1) MAPK9 (JNK2) MAPK10 (JNK3) MAPK11 (p38-beta) MAPK12 (p38-gamma) MAPK13

    Mitogen-activated protein kinase

    Mitogen-activated_protein_kinase

  • Cyclin-dependent kinase 1
  • Mammalian protein found in Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Cyclin-dependent kinase 1

    Cyclin-dependent kinase 1

    Cyclin-dependent_kinase_1

  • MAP kinase kinase kinase
  • Class of enzymes

    of binding. MEKK1 activates MAPK8/JNK by phosphorylation of its activator SEK1(MAP2K4). MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated

    MAP kinase kinase kinase

    MAP_kinase_kinase_kinase

  • Insulin receptor substrate 1
  • Protein found in humans

    interact (also concerted activity) with: Bcl-2, Grb2, INSR, IGF1R, JAK1, JAK2, MAPK8, PIK3R1 PIK3R3, PTK2, PTPN11, PTPN1, and YWHAE. IRS-1, as a signalling adapter

    Insulin receptor substrate 1

    Insulin receptor substrate 1

    Insulin_receptor_substrate_1

  • Cyclin-dependent kinase 8
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Cyclin-dependent kinase 8

    Cyclin-dependent kinase 8

    Cyclin-dependent_kinase_8

  • EIF2AK3
  • Human protein and coding gene

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    EIF2AK3

    EIF2AK3

    EIF2AK3

  • ZAK
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    ZAK

    ZAK

    ZAK

  • LATS1
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    LATS1

    LATS1

    LATS1

  • SGK3
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    SGK3

    SGK3

    SGK3

  • PKN2
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    PKN2

    PKN2

    PKN2

  • Protein kinase R
  • Human protein and coding gene

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Protein kinase R

    Protein kinase R

    Protein_kinase_R

  • Mitogen-activated protein kinase 9
  • Enzyme found in humans

    expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation-induced apoptosis, thought to

    Mitogen-activated protein kinase 9

    Mitogen-activated protein kinase 9

    Mitogen-activated_protein_kinase_9

  • SGK
  • Protein family

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    SGK

    SGK

  • MARK2
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    MARK2

    MARK2

    MARK2

  • DAPK1
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    DAPK1

    DAPK1

    DAPK1

  • PRKAB1
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    PRKAB1

    PRKAB1

    PRKAB1

  • MAPK4
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    MAPK4

    MAPK4

    MAPK4

  • Titin
  • Largest known protein in human muscles

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Titin

    Titin

    Titin

  • B-cell maturation antigen
  • Protein-coding gene in the species Homo sapiens

    superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members

    B-cell maturation antigen

    B-cell maturation antigen

    B-cell_maturation_antigen

  • Stress granule
  • Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress

    Like MAP4K4 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 MAPK8 JNK1 Mitogen-Activated Protein Kinase 8 MAPRE1 MAPRE1 Microtubule-associated

    Stress granule

    Stress granule

    Stress_granule

  • CDK13
  • Protein-coding gene in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    CDK13

    CDK13

    CDK13

  • ACVRL1
  • Protein-coding gene in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    ACVRL1

    ACVRL1

    ACVRL1

  • Phosphatidylinositol 3-kinase-related kinase
  • Protein family

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Phosphatidylinositol 3-kinase-related kinase

    Phosphatidylinositol_3-kinase-related_kinase

  • PLK2
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    PLK2

    PLK2

    PLK2

  • PFTK1
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    PFTK1

    PFTK1

    PFTK1

  • ACVR2B
  • Protein-coding gene in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    ACVR2B

    ACVR2B

    ACVR2B

  • Aurora kinase A
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Aurora kinase A

    Aurora kinase A

    Aurora_kinase_A

  • Cyclin-dependent kinase 4
  • Human protein

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Cyclin-dependent kinase 4

    Cyclin-dependent kinase 4

    Cyclin-dependent_kinase_4

  • CDKL2
  • Protein-coding gene in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    CDKL2

    CDKL2

    CDKL2

  • GSTP1
  • Protein-coding gene in the species Homo sapiens

    been shown to interact with Fanconi anemia, complementation group C and MAPK8. GST-Pi is expressed in many human tissues, particularly in the biliary

    GSTP1

    GSTP1

    GSTP1

  • Receptor protein serine/threonine kinase
  • Class of enzymes

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Receptor protein serine/threonine kinase

    Receptor_protein_serine/threonine_kinase

  • CDC2L1
  • Protein-coding gene in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    CDC2L1

    CDC2L1

    CDC2L1

  • BRAF (gene)
  • Protein-coding gene in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    BRAF (gene)

    BRAF (gene)

    BRAF_(gene)

  • Myc
  • Family of regulator genes

    ACTL6A BRCA1 Bcl-2 Cyclin T1 CHD8 DNMT3A EP400 GTF2I HTATIP let-7 MAPK1 MAPK8 MAX MLH1 MYCBP2 MYCBP NMI NFYB NFYC P73 PCAF PFDN5 RuvB-like 1 SAP130 SMAD2

    Myc

    Myc

  • SH3BP5
  • Protein-coding gene in the species Homo sapiens

    gene. SH3BP5 has been shown to interact with Bruton's tyrosine kinase and MAPK8. GRCh38: Ensembl release 89: ENSG00000131370 – Ensembl, May 2017 GRCm38:

    SH3BP5

    SH3BP5

    SH3BP5

  • AMP-activated protein kinase
  • Class of enzymes

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    AMP-activated protein kinase

    AMP-activated protein kinase

    AMP-activated_protein_kinase

  • Protein kinase C
  • Family of enzymes

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Protein kinase C

    Protein_kinase_C

  • CD27
  • Protein in the tumor necrosis factor receptor superfamily

    This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2, TRAF3, and TRAF5 have been shown to mediate

    CD27

    CD27

    CD27

  • MAPKAPK3
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    MAPKAPK3

    MAPKAPK3

    MAPKAPK3

  • Aurora inhibitor
  • Putative drug class for treating cancer

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Aurora inhibitor

    Aurora inhibitor

    Aurora_inhibitor

  • MAPK8IP2
  • Protein-coding gene in the species Homo sapiens

    cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function

    MAPK8IP2

    MAPK8IP2

    MAPK8IP2

  • (Pyruvate, phosphate dikinase) kinase
  • Class of enzymes

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    (Pyruvate, phosphate dikinase) kinase

    (Pyruvate,_phosphate_dikinase)_kinase

  • CHEK2
  • Protein-coding gene in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    CHEK2

    CHEK2

    CHEK2

  • MAP3K10
  • Protein-coding gene in the species Homo sapiens

    serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phosphorylated, and thus

    MAP3K10

    MAP3K10

    MAP3K10

  • ACVR1
  • Protein-coding gene

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    ACVR1

    ACVR1

    ACVR1

  • MTOR
  • Mammalian protein found in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    MTOR

    MTOR

    MTOR

  • Protein kinase B
  • Set of three serine threonine-specific protein kinases

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Protein kinase B

    Protein kinase B

    Protein_kinase_B

  • WNK3
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    WNK3

    WNK3

    WNK3

  • IL18RAP
  • Protein-coding gene in the species Homo sapiens

    of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18. Variants at IL18RAP have been linked to susceptibility

    IL18RAP

    IL18RAP

    IL18RAP

  • Cyclin-dependent kinase
  • Class of enzymes

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Cyclin-dependent kinase

    Cyclin-dependent kinase

    Cyclin-dependent_kinase

  • Serine/threonine-specific protein kinase
  • Class of protein kinase enzymes

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Serine/threonine-specific protein kinase

    Serine/threonine-specific protein kinase

    Serine/threonine-specific_protein_kinase

  • TRAF1
  • Protein-coding gene in the species Homo sapiens

    heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2

    TRAF1

    TRAF1

    TRAF1

  • Extracellular signal-regulated kinases
  • Class of enzymes

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Extracellular signal-regulated kinases

    Extracellular_signal-regulated_kinases

  • P70-S6 Kinase 1
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    P70-S6 Kinase 1

    P70-S6 Kinase 1

    P70-S6_Kinase_1

  • Transcription factor Jun
  • Mammalian protein found in Homo sapiens

    BRCA1 C-Fos CSNK2A1 COPS5 CREBBP CSNK2A2 DDX21, DDIT3 ERG ETS2, FOSL1 GTF2B MAPK8 MyoD NACA NELFB NFE2L1 NFE2L2 NCOR2 NCOA1 PIN1 RBM39 RELA RB1 RFWD2 RUNX1

    Transcription factor Jun

    Transcription factor Jun

    Transcription_factor_Jun

  • Protein kinase A
  • Family of enzymes

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Protein kinase A

    Protein kinase A

    Protein_kinase_A

  • GSK-3
  • Class of enzymes

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    GSK-3

    GSK-3

    GSK-3

  • STK11
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    STK11

    STK11

    STK11

  • Adapter molecule crk
  • Protein found in humans

    Dock180, EPS15, Epidermal growth factor receptor, Grb2, IRS4, MAP4K1, MAPK8, NEDD9, PDGFRA, PDGFRB, PTK2, Paxillin RAPGEF1, RICS, SH3KBP1, and SOS1

    Adapter molecule crk

    Adapter molecule crk

    Adapter_molecule_crk

  • Ca2+/calmodulin-dependent protein kinase II
  • Class of enzymes

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Ca2+/calmodulin-dependent protein kinase II

    Ca2+/calmodulin-dependent protein kinase II

    Ca2+/calmodulin-dependent_protein_kinase_II

  • P38 mitogen-activated protein kinases
  • Protein family

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    P38 mitogen-activated protein kinases

    P38_mitogen-activated_protein_kinases

  • AKT1
  • Protein-coding gene in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    AKT1

    AKT1

    AKT1

  • DUSP1
  • Protein-coding gene in the species Homo sapiens

    proliferation. DUSP1 has been shown to interact with MAPK14, MAPK1 and MAPK8. GRCh38: Ensembl release 89: ENSG00000120129 – Ensembl, May 2017 GRCm38:

    DUSP1

    DUSP1

    DUSP1

  • Myosin light-chain kinase
  • Class of kinase enzymes

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Myosin light-chain kinase

    Myosin light-chain kinase

    Myosin_light-chain_kinase

  • MAP3K11
  • Protein-coding gene in humans

    and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway

    MAP3K11

    MAP3K11

    MAP3K11

  • Phosphorylase kinase
  • Enzyme involved in glycogenolysis

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Phosphorylase kinase

    Phosphorylase kinase

    Phosphorylase_kinase

  • Activating transcription factor 2
  • Protein-coding gene in the species Homo sapiens

    Casein kinase 2, alpha 1, CREB binding protein, CSNK2A2, JDP2, MAPK14, MAPK8, Mothers against decapentaplegic homolog 3 NCOA6, RUVBL2, UBE2I. Activating

    Activating transcription factor 2

    Activating transcription factor 2

    Activating_transcription_factor_2

  • TANK-binding kinase 1
  • Protein found in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    TANK-binding kinase 1

    TANK-binding kinase 1

    TANK-binding_kinase_1

  • Wee1
  • Nuclear protein

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Wee1

    Wee1

    Wee1

  • SPIB
  • Protein that controls transcription of a set of genes in eukaryotes

    (5-prime-GAGGAA-3-prime).[supplied by OMIM] SPIB has been shown to interact with MAPK3 and MAPK8. GRCh38: Ensembl release 89: ENSG00000269404 – Ensembl, May 2017 GRCm38:

    SPIB

    SPIB

    SPIB

  • Mitogen-activated protein kinase kinase
  • Kinase enzyme

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Mitogen-activated protein kinase kinase

    Mitogen-activated_protein_kinase_kinase

  • CAMK
  • Enzyme type

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    CAMK

    CAMK

  • IRAK4
  • Protein-coding gene in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    IRAK4

    IRAK4

    IRAK4

  • SMG1
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    SMG1

    SMG1

    SMG1

  • Cyclin-dependent kinase 2
  • Protein found in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Cyclin-dependent kinase 2

    Cyclin-dependent kinase 2

    Cyclin-dependent_kinase_2

  • IKBKG
  • Protein-coding gene in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    IKBKG

    IKBKG

    IKBKG

  • CHUK
  • Protein-coding gene in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    CHUK

    CHUK

    CHUK

  • Acetate kinase
  • Class of enzymes

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Acetate kinase

    Acetate kinase

    Acetate_kinase

  • MAP3K7
  • Protein-coding gene in the species Homo sapiens

    the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental

    MAP3K7

    MAP3K7

    MAP3K7

  • MAP3K2
  • Protein-coding gene in the species Homo sapiens

    binds and methylates MEKK2-K260. MAP3K2 has been shown to interact with: MAPK8, MAP2K4, MAP2K5, MAP2K7, 14-3-3 protein, SMYD3, SH2D2A, and XIAP GRCh38:

    MAP3K2

    MAP3K2

    MAP3K2

  • CDK19
  • Mammalian protein found in Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    CDK19

    CDK19

    CDK19

  • MTOR inhibitors
  • Class of pharmaceutical drugs

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    MTOR inhibitors

    MTOR inhibitors

    MTOR_inhibitors

  • Cyclin-dependent kinase 9
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Cyclin-dependent kinase 9

    Cyclin-dependent kinase 9

    Cyclin-dependent_kinase_9

  • PKMYT1
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    PKMYT1

    PKMYT1

    PKMYT1

  • Cyclin-dependent kinase 7
  • Protein-coding gene in the species Homo sapiens

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    Cyclin-dependent kinase 7

    Cyclin-dependent kinase 7

    Cyclin-dependent_kinase_7

  • MAPK8IP3
  • Protein-coding gene in the species Homo sapiens

    interact with ASK1, C-Raf, PTK2, MAPK10, Mitogen-activated protein kinase 9, MAPK8, MAP2K1, KLC2, MAP2K7, KLC1, MAPK8IP2 and MAP2K4. GRCh38: Ensembl release

    MAPK8IP3

    MAPK8IP3

    MAPK8IP3

  • MAP kinase kinase kinase kinase
  • Family of proteins

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    MAP kinase kinase kinase kinase

    MAP_kinase_kinase_kinase_kinase

  • IkappaB kinase
  • Class of enzymes

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    IkappaB kinase

    IkappaB_kinase

  • Death receptor 6
  • Protein found in humans

    TNF-receptor superfamily. This receptor has been shown to activate NF-κB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor

    Death receptor 6

    Death receptor 6

    Death_receptor_6

  • MAPKAPK2
  • Protein-coding gene in humans

    signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC

    MAPKAPK2

    MAPKAPK2

    MAPKAPK2

  • DUSP10
  • Protein-coding gene in the species Homo sapiens

    found for this gene. DUSP10 has been shown to interact with MAPK14 and MAPK8. GRCm38: Ensembl release 89: ENSMUSG00000039384 – Ensembl, May 2017 "Human

    DUSP10

    DUSP10

    DUSP10

  • ELK4
  • Protein-coding gene in the species Homo sapiens

    protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. ELK4 has

    ELK4

    ELK4

    ELK4

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