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See searches and references containing MAPK PHOSPHATASE!MAPK PHOSPHATASE
MAPK phosphatases (MKPs) are the largest class of phosphatases involved in down-regulating Mitogen-activated protein kinases (MAPK) signaling. MAPK signalling
MAPK_phosphatase
MAPK phosphatase 1 is the founding member of the family of MAPK phosphatases which is a group of 11 phosphatases. The N-terminus of MAPK phosphatase 1
Candidalysin
Protein-coding gene in humans
specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene. The activation of mitogen-activated protein kinase (MAPK) cascades
DUSP16
Cell signaling pathway
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface
MAPK/ERK_pathway
Class of enzymes
receptor tyrosine phosphatases 17 nonreceptor-type PTPs 61 VH-1-like or dual-specificity phosphatases (DSPs) 11 MAPK phosphatases (MPKs) 3 Slingshots
Protein_tyrosine_phosphatase
Protein-coding gene in the species Homo sapiens
Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular
DUSP10
Protein-coding gene in the species Homo sapiens
Gene: DUSP1 dual specificity phosphatase 1". Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on
DUSP1
Protein-coding gene in humans
Keyse SM, McDonald NQ (February 1999). "Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation".
DUSP6
Protein-coding gene in the species Homo sapiens
"New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding". J. Mol. Biol. 354 (4): 777–88. doi:10
DUSP2
P38 mitogen-activated protein kinases
Inactivation of MAPKs is performed by a number of phosphatases. A very conserved family of dedicated phosphatases is the so-called MAP kinase phosphatases (MKPs)
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
Protein-coding gene in the species Homo sapiens
tyrosine phosphatases (PTP), and dual-specificity phosphatases (DUSP). For example, ser/thr phosphatases PP2Cα/β suppress activity of p38s MAPK through
MAPK14
Mitochondrial enzyme which breaks down cyanide
Cdc25 phosphatase catalytic domain non-catalytic domains of eukaryotic dual-specificity MAPK-phosphatases non-catalytic domains of yeast PTP-type MAPK-phosphatases
Rhodanese
Protein-coding gene in the species Homo sapiens
an Overexpression of the Dual-Specificity MAPK Phosphatase PYST2 in Acute Leukemia". Protein Phosphatases. Methods in Enzymology. Vol. 366. pp. 103–13
DUSP7
Protein-coding gene in the species Homo sapiens
2002). "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise
DUSP19
Class of enzymes
A protein phosphatase is a phosphatase enzyme that removes a phosphate group from the phosphorylated amino acid residue of its substrate protein. Protein
Protein_phosphatase
concentration above the KΜ for its specific phosphatase and MAPK is at a concentration above the KΜ for MAPKK. Besides the MAPK cascade, ultrasensitivity has also
Ultrasensitivity
Pharmaceutical compound
inhibitor of the protein tyrosine phosphatase enzyme SHP2, which regulates cell growth and differentiation through the MAPK signaling pathway. It is in early
Batoprotafib
Biological signaling pathway h
then functions to allow the MAPK/ERK pathway to progress. Secondly, a protein activated by the MAPK/ERK pathway, called MAPK (mitogen-activated protein
JAK-STAT_signaling_pathway
phosphorylation (ERK 1 and ERK 2), protein phosphate 1 (PP1), and MAPK phosphatase 2 (latter two both involved in dephosphorylation) were assessed by
Sleep_and_memory
Class of corticosteroids
and Mitogen-activated protein kinase phosphatase (MAPK phosphatase) Increased gluconeogenesis – glucose 6-phosphatase and tyrosine aminotransferase The opposite
Glucocorticoid
Protein-coding gene in the species Homo sapiens
identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases". The Biochemical Journal. 395 (3): 483–491. doi:10.1042/BJ20051931
PTPN5
Protein-coding gene in humans
expressed protein tyrosine phosphatase that plays an important role in regulating cell signaling pathways, most notably the RAS/MAPK cascade, which controls
PTPN11
Medical condition
which codes for dual specificity protein phosphatase 2, a protein that regulates several components of the ERK/MAPK signaling pathway that controls cell proliferation;
T cell/histiocyte-rich large B-cell lymphoma
T_cell/histiocyte-rich_large_B-cell_lymphoma
Protein family
in intrinsically disordered substrates of MAPKs. In addition, there are several dual-specificity phosphatases lacking close relatives. Most of these atypical
Dual-specificity_phosphatase
catalyze the conversion of ATP to cAMP. ERK, a participating protein in the MAPK signaling pathway, can be activated or inhibited by cAMP. cAMP can inhibit
Crosstalk_(biology)
Protein found in humans
inhibits cell growth by inhibiting MAPK pathway. ERK phosphorylation through IRS-1/Grb-2/Sos pathway is inhibited by phosphatase activity of PTEN. PTEN does
Insulin_receptor_substrate_1
Ptc1 is a type Two C phosphatase involved in the mating decision of yeast. Ptc1 competes with Fus3 for control of the 4 phosphorylation sites on the scaffold
Ptc1
Class of experimental drugs
Newton R (May 2014). "Roles for the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, in feedback control of inflammatory gene expression and repression
Selective glucocorticoid receptor modulator
Selective_glucocorticoid_receptor_modulator
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene. The protein encoded by this
MAPK1
proteins and in close proximity to RAF to dephosphorylate “S259” to enable MAPK signaling. It has been shown that activity that results in lipidation (specifically
SHOC2
Protein-coding gene in the species Homo sapiens
AJ (2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK". J. Biol. Chem. 278 (12): 10731–6. doi:10
MAPK8IP2
Family of protein kinases
signal transduction. There are two subfamilies of rsk, p90rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70rsk, also known as S6-H1 Kinase
Ribosomal_s6_kinase
Protein-coding gene in the species Homo sapiens
Dual specificity phosphatase 8 is a protein that in humans is encoded by the DUSP8 gene. The protein encoded by this gene is a member of the dual specificity
Dual specificity phosphatase 8
Dual_specificity_phosphatase_8
Protein-coding gene in the species Homo sapiens
(March 2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK". J. Biol. Chem. 278 (12): 10731–6. doi:10
MAPK8IP1
Protein-coding gene in the species Homo sapiens
Maeda T, Saito H (August 1998). "Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways". The EMBO Journal. 17 (16):
PPM1A
Enzyme catalyzing transfer of phosphate groups onto specific substrates
the addition of inorganic phosphate groups to an acceptor, nor with phosphatases, which remove phosphate groups (dephosphorylation). The phosphorylation
Kinase
Class of enzymes
on a serine/threonine residue, they are deactivated by a phosphatase. A common phosphatase used in ASK-1 regulation is PP5. MAPKKKs contain a docking
MAP_kinase_kinase_kinase
signaling: transcription B-raf – MAPK pathway CD44 Erk1/2 – MAPK pathway, cell cycle control, proliferation Mek ½ -- MAPK pathway, cell cycle control, proliferation
IQGAP1
Enzyme grouping
the protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) families. CAPPs are a subset of intracellular serine/threonine phosphatases. Each CAPP
Ceramide-activated protein phosphatase
Ceramide-activated_protein_phosphatase
Type of protein, regulators of signalling pathways
mitogen-activated protein kinase (MAPK) pathway. Ste5 has been proposed to direct mating signaling through the Fus3 MAPK by catalytically unlocking this
Scaffold_protein
Protein-coding gene in humans
Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans
PTPN6
Pharmaceutical compound
(JAB-3312) is a drug that acts as an inhibitor of the protein tyrosine phosphatase enzyme SHP-2 (PTPN11). It has been researched for the treatment of cancer
Sitneprotafib
Protein-coding gene in the species Homo sapiens
Dual specificity protein phosphatase 5 is an enzyme that in humans is encoded by the DUSP5 gene. The protein encoded by this gene is a member of the dual
DUSP5
Rare autosomal dominant multi-system genetic condition
called Ras/MAPK pathway syndromes, is a rare autosomal dominant, multisystem disease caused by a mutation in the protein tyrosine phosphatase, non-receptor
Noonan syndrome with multiple lentigines
Noonan_syndrome_with_multiple_lentigines
Enzyme
Serine/threonine-protein phosphatase 5 is an enzyme that in humans is encoded by the PPP5C gene. PPP5C has been shown to interact with ASK1, CRY2 GNA12
PPP5C
Protein-coding gene in the species Homo sapiens
tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase (MAPK/p38) through which it reduces the phosphorylation
PPM1D
alpha-helical domain in the amino terminus. During mating, Fus3 MAPK and Ptc1 phosphatase compete to control 4 phosphorylation sites on the Ste5 scaffold
Ste5
Protein-coding gene in the species Homo sapiens
Maeda R, Nishida E (2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. 276 (28): 26629–39
MAPK11
Protein-coding gene in humans
(2000). "Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR". Oncogene. 19 (19): 2346–53. doi:10.1038/sj
FRS2
Protein-coding gene in the species Homo sapiens
S2CID 43848098. "Entrez Gene: PPP3R2 protein phosphatase 3 (formerly 2B), regulatory subunit B, beta isoform". "PathCards :: MAPK signaling pathway Pathway and related
PPP3R2
Protein-coding gene in the species Homo sapiens
Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene. The protein encoded by this gene is a member
PTPRJ
Genetic abnormality in leukemia cancer cells
transcription (STAT) pathway and the Protein Phosphatase 2A (PP2A) tumour suppressor gene –β-catenin pathway. The MAPK pathway includes several key signalling
Philadelphia_chromosome
Protein-coding gene in the species Homo sapiens
Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene. The protein encoded by this gene is a member of the dual
DUSP3
Protein-coding gene in the species Homo sapiens
Dual specificity protein phosphatase 4 is an enzyme that in humans is encoded by the DUSP4 gene. The protein encoded by this gene is a member of the dual
DUSP4
Protein-coding gene in the species Homo sapiens
(1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092
PLK2
Protein-coding gene in the species Homo sapiens
structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways". Oncogene. 14 (17): 2047–57. doi:10.1038/sj.onc.1201043. PMID 9160885
STK25
Protein-coding gene in the species Homo sapiens
Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene. The protein encoded by this gene is a member of the
DUSP12
Chemical compound
myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) at high concentrations Wortmannin has also been reported to inhibit members
Wortmannin
Fus3 is a MAPK protein involved in the mating decision of yeast. The dissociation of Fus3 from scaffold protein Ste5 results in the switch-like mating
Fus3
Protein-coding gene in the species Homo sapiens
2002). "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise
MAP2K7
In neurophysiology, a reduction of neuronal synapse efficacy
activation of calcium-dependent phosphatases that dephosphorylate the target proteins. Selective activation of these phosphatases by varying calcium levels
Long-term_depression
Protein-coding gene in the species Homo sapiens
S. National Library of Medicine. Thomas GM, Huganir RL (1 March 2004). "MAPK cascade signalling and synaptic plasticity". Nature Reviews Neuroscience
MAPK3
Protein-coding gene in the species Homo sapiens
PH domain leucine-rich repeat-containing protein phosphatase 1, also known as PHLPP1, is an enzyme which in humans is encoded by the PHLPP1 gene (previously
PHLPP1
Control mechanism in the eukaryotic cell cycle
Mos is activated. Mos then phosphorylates MEK1, which phosphorylates MAPK. MAPK serves two roles: activating the Cyclin B-Cdk1 complex to initiate entrance
Cell_cycle_checkpoint
Species of bacteria, cause of plague
an acetyltransferase that binds to a conserved α-helix of MAPK kinases. YopJ acetylates MAPK kinases at serines and threonines that are normally phosphorylated
Yersinia_pestis
Mammalian protein found in Homo sapiens
Maeda T, Saito H (August 1998). "Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways". The EMBO Journal. 17 (16):
Choline transporter-like protein 1
Choline_transporter-like_protein_1
Protein family
completely independent of calcium signalling. It is, however, controlled by MAPK during osmotic stress. When a cell encounters a hypertonic environment NFAT5
NFAT
Protein-coding gene in the species Homo sapiens
dynamics protein 3 (RMDN3), more commonly known as Protein tyrosine phosphatase interacting protein 51 (PTPIP51), is a protein that in humans is encoded
RMDN3
Protein-coding gene in the species Homo sapiens
regulation of phosphatase activity negative regulation of peptidyl-threonine phosphorylation regulation of protein deacetylation MAPK cascade multicellular
SPRED1
Protein-coding gene in the species Homo sapiens
Protein phosphatase with EF-hand domain 2 is a protein that in humans is encoded by the PPEF2 gene. This gene encodes a member of the serine/threonine
Protein phosphatase with EF-hand domain 2
Protein_phosphatase_with_EF-hand_domain_2
Protein-coding gene in the species Homo sapiens
2000). "Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR". Oncogene. 19 (19): 2346–53. doi:10.1038/sj
GRB2
Class of enzymes
an enzyme that removes phosphate groups from targets, is known as a phosphatase. Kinase enzymes that specifically phosphorylate tyrosine amino acids
Receptor_tyrosine_kinase
Lectin molecule
domain containing protein tyrosine phosphatase called SHP-1. SHP-1 inhibits mitogen-activated protein kinase (MAPK) and dephosphorylates components of
CD22
Protein-coding gene in the species Homo sapiens
identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases". Biochem. J. 395 (3): 483–91. doi:10.1042/BJ20051931
PTPRR
Family of conserved regulatory molecules
multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. More than 200 signaling proteins have been
14-3-3_protein
Protein complex on the surface of T cells that recognizes antigens
MAPK signaling pathways. These pathways use a phosphorylation cascade of three successive acting protein kinases to transmit a signal. The three MAPK
T-cell_receptor
Class of chemical compounds
cyclophilin A and calcineurin, leading to inhibition of calcineurin's phosphatase function. These cases illustrate how Type I molecular glues can modulate
Molecular_glue
protein and may play a role in modulating cellular immune response through MAPK signaling pathways. H1 dephosphorylates STAT1 to prevent nuclear transcription
Lateral_body
Animal cell cycle checkpoint
activates MEK, which phosphorylates and activates ERK (also known as MAPK, see also MAPK/ERK pathway). Active ERK then translocates into the nucleus where
Restriction_point
Genetic condition involving facial, heart, blood and skeletal features
underlying mechanism for which involves sustained activation of the RAS/MAPK cell signaling pathway. The diagnosis may be suspected based on symptoms
Noonan_syndrome
Protein-coding gene in humans
by MAPKs at its C-terminus. MAPKs are the final effectors of signal transduction pathways that begin at the plasma membrane. Phosphorylation by MAPKs results
ELK1
Human protein and coding gene
(MAPK) undergo phosphorylation via a signaling cascade where MAPKKK phosphorylates and activates MAPKK and MAPKK phosphorylates and activates MAPK which
Bone_morphogenetic_protein_4
Protein-coding gene in the species Homo sapiens
Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to
IGBP1
Mammalian protein found in Homo sapiens
differentiation response to ethanol positive regulation of stress-activated MAPK cascade positive regulation of smooth muscle cell proliferation steroid biosynthetic
HMG-CoA_reductase
Protein-coding gene in the species Homo sapiens
transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR". Mol. Endocrinol. 10 (5): 575–84. doi:10.1210/mend.10.5.8732688
Insulin_receptor_substrate_2
Family of viruses
target protein phosphatase 2A (PP2A), a key multisubunit regulator of multiple pathways including Akt, the mitogen-activated protein kinase (MAPK) pathway,
Polyomaviridae
Immune system messenger protein which induces inflammation
via NEMO. TAK1 activates the MAPK pathways, as well as IKK, which in turn activates the canonical NF-κB pathway. The MAPK pathways and the NF-κB pathway
Tumor_necrosis_factor
Protein-coding gene in the species Homo sapiens
markers CD25, CD86 and HLA-DR on cell surface via CpG-mediated NFκB and MAPK pathways activation. Expression of CD54 and CD80 was not significantly altered
FCRL3
Monoclonal antibody
protein phosphatase 2A (PP2A), as well as the phosphorylation of activating sites by p21 activated kinase (PAK) occurs. After this, Raf-1 activates MAPK/ERK
Zalutumumab
Class of protein kinase enzymes
drugs as they inhibit the MAPK cascade and reduce cell proliferation.[citation needed] Protein serine/threonine phosphatase, enzyme for reverse process
Serine/threonine-specific protein kinase
Serine/threonine-specific_protein_kinase
Decrease of collagen levels in the human body
RTKs on the cells' surface are repressed by receptor protein tyrosine phosphatases.[irrelevant citation] Exposure to ultraviolet rays damages DNA, which
Collagen_loss
Protein found in humans
containing two MAM domains (meprin, A5 protein and receptor protein tyrosine phosphatase mu), an LDLa domain (low-density lipoprotein receptor class A) and a
Anaplastic_lymphoma_kinase
Protein-coding gene in the species Homo sapiens
Receptor-type tyrosine-protein phosphatase alpha is an enzyme that in humans is encoded by the PTPRA gene. The protein encoded by this gene is a member
PTPRA
Protein-coding gene in the species Homo sapiens
activity protein binding protein heterodimerization activity protein phosphatase binding GTPase activator activity phosphatidylinositol-4,5-bisphosphate
PIK3R2
Protein-coding gene in humans
BioGPS More reference expression data Gene ontology Molecular function phosphatase binding PDZ domain binding protein domain specific binding guanylate
DLG3
Biological process of yeast
arises as a result of competition between the Fus3 protein (a MAPK protein) and the phosphatase Ptc1. These proteins both attempt to control the four phosphorylation
Mating_of_yeast
Type of plant tissue involved in cell proliferation
mitogen-activated protein kinase (MAPK), which is often involved in signalling cascades. KAPP is a kinase-associated protein phosphatase that has been shown to interact
Meristem
Protein-coding gene in the species Homo sapiens
gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into
STK24
Cartilage plate in the neck of a long bone
apoptosis through a mitochondrial pathway not involving nitric oxide or MAPKs". Endocrinology. 152 (1): 82–92. doi:10.1210/en.2010-0509. PMID 21068162
Epiphyseal_plate
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
also act as signal transducers. Most often the effector is a member of the MAPK family. In the late 1990s, evidence began accumulating to suggest that some
G_protein-coupled_receptor
MAPK PHOSPHATASE
MAPK PHOSPHATASE
MAPK PHOSPHATASE
MAPK PHOSPHATASE
MAPK PHOSPHATASE
MAPK PHOSPHATASE
MAPK PHOSPHATASE
MAPK PHOSPHATASE
MAPK PHOSPHATASE