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MAP2K1

  • MAP2K1

    • Protein-coding gene in the species Homo sapiens

    mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene. The protein encoded by this gene is a member of the dual-specificity

    MAP2K1

    MAP2K1

    MAP2K1

  • Mitogen-activated protein kinase kinase

    • Kinase enzyme

    kinase (MAPK). MAP2K is classified as EC 2.7.12.2. There are seven genes: MAP2K1 (a.k.a. MEK1) MAP2K2 (a.k.a. MEK2) MAP2K3 (a.k.a. MKK3) MAP2K4 (a.k.a. MKK4)

    Mitogen-activated protein kinase kinase

    Mitogen-activated_protein_kinase_kinase

  • Noonan syndrome

    • Genetic condition involving facial, heart, blood and skeletal features

    genetically undiagnosed. Heterozygous mutations in NRAS, HRAS, BRAF, SHOC2, MAP2K1, MAP2K2, and CBL have also been associated with a smaller percentage of

    Noonan syndrome

    Noonan syndrome

    Noonan_syndrome

  • Eosinophilic granuloma

    • Medical condition

    cases had mutated BRAF V600 E gene and about 21% displayed a mutation in MAP2K1. Clinically, single or multiple lesions are present mostly on the axial

    Eosinophilic granuloma

    Eosinophilic granuloma

    Eosinophilic_granuloma

  • Follicular lymphoma

    • Cancer originating in lymph nodes

    which contributes to the development and function of B cells, and the MAP2K1 gene (10–40% of cases), which regulates activation of the ERK cell signaling

    Follicular lymphoma

    Follicular lymphoma

    Follicular_lymphoma

  • Melorheostosis

    • Thickening of the bones

    appearance of dripping candle wax. A randomly occurring somatic mutation of the MAP2K1 gene during fetal development is believed to be the cause. It is not known

    Melorheostosis

    Melorheostosis

    Melorheostosis

  • List of human protein-coding genes 5

    • HGNC:13353; Q9BXW4 9187 MAP1S HGNC:15715; Q66K74 9188 MAP2 HGNC:6839; P11137 9189 MAP2K1 HGNC:6840; Q02750 9190 MAP2K2 HGNC:6842; P36507 9191 MAP2K3 HGNC:6843; P46734

    List of human protein-coding genes 5

    List_of_human_protein-coding_genes_5

  • Phosphorylase kinase

    • Enzyme involved in glycogenolysis

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Phosphorylase kinase

    Phosphorylase kinase

    Phosphorylase_kinase

  • STK11

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    STK11

    STK11

    STK11

  • RASopathy

    • Family of genetic conditions caused by mutations affecting Ras genes

    KRAS NRAS RRAS RIT1 NF1 RASA1 RASA2 SYNGAP1 SOS1 SOS2 CBL PTPN11 BRAF RAF1 MAP2K1 MAP2K2 MAP3K8 SPRED1 SPRY1 MYST4 LZTR1 A2ML1 Boxel-Woolf, Tom Van; McCarthy

    RASopathy

    RASopathy

  • Titin

    • Largest known protein in human muscles

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Titin

    Titin

    Titin

  • Cyclin-dependent kinase 2

    • Protein found in humans

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Cyclin-dependent kinase 2

    Cyclin-dependent kinase 2

    Cyclin-dependent_kinase_2

  • PRKACA

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    PRKACA

    PRKACA

    PRKACA

  • MAP kinase kinase kinase

    • Class of enzymes

    which activate the ERK1/2 (MAPK3/MAPK1) pathway, through activation of MEK1(MAP2K1) and MEK2(MAP2K2). The JNKs are regulated by the MEKK 1/4, MLK 2/3, and

    MAP kinase kinase kinase

    MAP_kinase_kinase_kinase

  • PKC alpha

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    PKC alpha

    PKC alpha

    PKC_alpha

  • BRAF (gene)

    • Protein-coding gene in humans

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    BRAF (gene)

    BRAF (gene)

    BRAF_(gene)

  • CASK

    • Protein-coding gene in humans

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    CASK

    CASK

    CASK

  • Kojo Seys John Elenitoba-Johnson

    • American pathologist

    Lim; Kojo Elenitoba-Johnson (30 June 2014). "High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis". Blood.

    Kojo Seys John Elenitoba-Johnson

    Kojo_Seys_John_Elenitoba-Johnson

  • PRKCE

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    PRKCE

    PRKCE

    PRKCE

  • Mitogen-activated protein kinase

    • P38 mitogen-activated protein kinases

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Mitogen-activated protein kinase

    Mitogen-activated_protein_kinase

  • RAF kinase

    • ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    RAF kinase

    RAF kinase

    RAF_kinase

  • MAPK1

    • Protein-coding gene in the species Homo sapiens

    shown to interact with: ADAM17, CIITA, DUSP1, DUSP3, ELK1, FHL2, HDAC4, MAP2K1, MAP3K1 MAPK14, MKNK1, MKNK2, Myc, NEK2, PEA15, PTPN7, Phosphatidylethanolamine

    MAPK1

    MAPK1

    MAPK1

  • ACVR2A

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    ACVR2A

    ACVR2A

    ACVR2A

  • EEF2K

    • Protein-coding gene in humans

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    EEF2K

    EEF2K

    EEF2K

  • MAP3K4

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    MAP3K4

    MAP3K4

    MAP3K4

  • Casein kinase 1

    • Family of protein kinases

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Casein kinase 1

    Casein_kinase_1

  • MKNK1

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    MKNK1

    MKNK1

    MKNK1

  • List of genetic disorders

    • deafness Noonan syndrome PTPN11, KRAS, SOS1, RAF1, NRAS, HRAS, BRAF, SHOC2, MAP2K1, MAP2K2, CBL dominant 1:1,000 Norman–Roberts syndrome RELN recessive Ogden

    List of genetic disorders

    List_of_genetic_disorders

  • BMPR2

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    BMPR2

    BMPR2

    BMPR2

  • G protein-coupled receptor kinase 2

    • Enzyme

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    G protein-coupled receptor kinase 2

    G protein-coupled receptor kinase 2

    G_protein-coupled_receptor_kinase_2

  • BCKDHB

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    BCKDHB

    BCKDHB

    BCKDHB

  • GAK (protein)

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    GAK (protein)

    GAK (protein)

    GAK_(protein)

  • MAP2K1IP1

    • Protein-coding gene in the species Homo sapiens

    as an interacting protein that binds specifically to MAP kinase kinase MAP2K1/MEK1 and to MAP kinase MAPK2/ERK1. This protein enhances the activation

    MAP2K1IP1

    MAP2K1IP1

    MAP2K1IP1

  • MAP3K1

    • Protein-coding gene in the species Homo sapiens

    shows cross-specificity with MAP2K1. MAP3K1 has been shown to interact with a number of proteins, including: AXIN1, C-Raf, MAP2K1, MAPK1, Grb2, MAPK8, TRAF2

    MAP3K1

    MAP3K1

    MAP3K1

  • CAMK1

    • Protein-coding gene in humans

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    CAMK1

    CAMK1

    CAMK1

  • AKT1

    • Protein-coding gene in humans

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    AKT1

    AKT1

    AKT1

  • Phosphatidylinositol 3-kinase-related kinase

    • Protein family

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Phosphatidylinositol 3-kinase-related kinase

    Phosphatidylinositol_3-kinase-related_kinase

  • KIAA0999

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    KIAA0999

    KIAA0999

    KIAA0999

  • PRKCB1

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    PRKCB1

    PRKCB1

    PRKCB1

  • AMP-activated protein kinase

    • Class of enzymes

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    AMP-activated protein kinase

    AMP-activated protein kinase

    AMP-activated_protein_kinase

  • Protein kinase C

    • Family of enzymes

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Protein kinase C

    Protein_kinase_C

  • Aurora inhibitor

    • Putative drug class for treating cancer

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Aurora inhibitor

    Aurora inhibitor

    Aurora_inhibitor

  • Extracellular signal-regulated kinases

    • Class of enzymes

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Extracellular signal-regulated kinases

    Extracellular_signal-regulated_kinases

  • Ca2+/calmodulin-dependent protein kinase II

    • Class of enzymes

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Ca2+/calmodulin-dependent protein kinase II

    Ca2+/calmodulin-dependent protein kinase II

    Ca2+/calmodulin-dependent_protein_kinase_II

  • PKMYT1

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    PKMYT1

    PKMYT1

    PKMYT1

  • SMG1

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    SMG1

    SMG1

    SMG1

  • MTORC1

    • Protein complex

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    MTORC1

    MTORC1

    MTORC1

  • MTOR

    • Mammalian protein found in humans

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    MTOR

    MTOR

    MTOR

  • MAP kinase kinase kinase kinase

    • Family of proteins

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    MAP kinase kinase kinase kinase

    MAP_kinase_kinase_kinase_kinase

  • Myosin light-chain kinase

    • Class of kinase enzymes

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Myosin light-chain kinase

    Myosin light-chain kinase

    Myosin_light-chain_kinase

  • Phototropin

    • Class of photoreceptor proteins in plants

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Phototropin

    Phototropin

  • Cyclin-dependent kinase

    • Class of enzymes

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Cyclin-dependent kinase

    Cyclin-dependent kinase

    Cyclin-dependent_kinase

  • Protein kinase B

    • Set of three serine threonine-specific protein kinases

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Protein kinase B

    Protein kinase B

    Protein_kinase_B

  • Protein kinase A

    • Family of enzymes

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Protein kinase A

    Protein kinase A

    Protein_kinase_A

  • NLK

    • Mammalian protein found in Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    NLK

    NLK

    NLK

  • Serine/threonine-specific protein kinase

    • Class of protein kinase enzymes

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Serine/threonine-specific protein kinase

    Serine/threonine-specific protein kinase

    Serine/threonine-specific_protein_kinase

  • Rho-associated protein kinase

    • Protein family

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Rho-associated protein kinase

    Rho-associated protein kinase

    Rho-associated_protein_kinase

  • Casein kinase 1, alpha 1

    • Enzyme found in humans

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Casein kinase 1, alpha 1

    Casein kinase 1, alpha 1

    Casein_kinase_1,_alpha_1

  • MTOR inhibitors

    • Class of pharmaceutical drugs

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    MTOR inhibitors

    MTOR inhibitors

    MTOR_inhibitors

  • P38 mitogen-activated protein kinases

    • Protein family

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    P38 mitogen-activated protein kinases

    P38_mitogen-activated_protein_kinases

  • ATM serine/threonine kinase

    • Mammalian protein found in Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    ATM serine/threonine kinase

    ATM serine/threonine kinase

    ATM_serine/threonine_kinase

  • C-Raf

    • Mammalian protein found in Homo sapiens

    ASK1, BAG1, BRAF, Bcl-2, CDC25A, CFLAR, FYN, GRB10, HRAS, HSP90AA1, KRAS, MAP2K1, MAP3K1, MAPK7, MAPK8IP3, PAK1, PEBP1, PHB, PRKCZ, RAP1A, RHEB, RRAS2 RB1

    C-Raf

    C-Raf

    C-Raf

  • G protein-coupled receptor kinase

    • Family of protein kinases

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    G protein-coupled receptor kinase

    G protein-coupled receptor kinase

    G_protein-coupled_receptor_kinase

  • Protein kinase domain

    • Protein domain

    LCK ; LIMK1 ; LIMK2 ; LMTK2 ; LMTK3 ; LRRK1 ; LRRK2 ; LTK ; LYN ; MAK ; MAP2K1 ; MAP2K2 ; MAP2K3 ; MAP2K4 ; MAP2K5 ; MAP2K6 ; MAP2K7 ; MAP3K1 ; MAP3K10 ;

    Protein kinase domain

    Protein kinase domain

    Protein_kinase_domain

  • Aurora kinase B

    • Protein

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Aurora kinase B

    Aurora kinase B

    Aurora_kinase_B

  • Cyclin-dependent kinase 4

    • Human protein

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Cyclin-dependent kinase 4

    Cyclin-dependent kinase 4

    Cyclin-dependent_kinase_4

  • C-Jun N-terminal kinases

    • Chemical compounds

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    C-Jun N-terminal kinases

    C-Jun N-terminal kinases

    C-Jun_N-terminal_kinases

  • IkappaB kinase

    • Class of enzymes

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    IkappaB kinase

    IkappaB_kinase

  • VRK2

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    VRK2

    VRK2

    VRK2

  • CHEK2

    • Protein-coding gene in humans

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    CHEK2

    CHEK2

    CHEK2

  • P70-S6 Kinase 1

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    P70-S6 Kinase 1

    P70-S6 Kinase 1

    P70-S6_Kinase_1

  • MAPK3

    • Protein-coding gene in the species Homo sapiens

    sclerosis. MAPK3 has been shown to interact with: DUSP3, DUSP6 GTF2I, HDAC4, MAP2K1, MAP2K2, PTPN7, RPS6KA2, and SPIB. GRCh38: Ensembl release 89: ENSG00000102882

    MAPK3

    MAPK3

    MAPK3

  • CAMK

    • Enzyme type

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    CAMK

    CAMK

  • Phosphoinositide-dependent kinase-1

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Phosphoinositide-dependent kinase-1

    Phosphoinositide-dependent kinase-1

    Phosphoinositide-dependent_kinase-1

  • Cyclin-dependent kinase 7

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Cyclin-dependent kinase 7

    Cyclin-dependent kinase 7

    Cyclin-dependent_kinase_7

  • WNK3

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    WNK3

    WNK3

    WNK3

  • MASTL

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    MASTL

    MASTL

    MASTL

  • MTORC2

    • Protein complex

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    MTORC2

    MTORC2

  • PRKCI

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    PRKCI

    PRKCI

    PRKCI

  • Protein kinase R

    • Human protein and coding gene

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Protein kinase R

    Protein kinase R

    Protein_kinase_R

  • Aurora kinase A

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Aurora kinase A

    Aurora kinase A

    Aurora_kinase_A

  • Phosphatidylethanolamine binding protein 1

    • Protein-coding gene in the species Homo sapiens

    Phosphatidylethanolamine binding protein 1 has been shown to interact with: C-Raf, MAP2K1, and MAPK1. GRCh38: Ensembl release 89: ENSG00000089220 – Ensembl, May 2017

    Phosphatidylethanolamine binding protein 1

    Phosphatidylethanolamine binding protein 1

    Phosphatidylethanolamine_binding_protein_1

  • Cyclin-dependent kinase 6

    • Protein found in humans

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Cyclin-dependent kinase 6

    Cyclin-dependent kinase 6

    Cyclin-dependent_kinase_6

  • Cyclin-dependent kinase 1

    • Mammalian protein found in Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Cyclin-dependent kinase 1

    Cyclin-dependent kinase 1

    Cyclin-dependent_kinase_1

  • Pediatric-type follicular lymphoma

    • Medical condition

    protein that contributes to the maturation and function of B-cells; 3) MAP2K1 (10-40% of cases), which encodes mitogen-activated protein kinase kinase

    Pediatric-type follicular lymphoma

    Pediatric-type_follicular_lymphoma

  • CGMP-dependent protein kinase

    • Protein kinase

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    CGMP-dependent protein kinase

    CGMP-dependent protein kinase

    CGMP-dependent_protein_kinase

  • PDK2

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    PDK2

    PDK2

    PDK2

  • VRK1

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    VRK1

    VRK1

    VRK1

  • Letterer–Siwe disease

    • Medical condition

    oncogenic mutations of BRAFV600E are identified. 10-15% of patients have MAP2K1 mutations. LSD has no clear association with hereditary or familial tendencies

    Letterer–Siwe disease

    Letterer–Siwe disease

    Letterer–Siwe_disease

  • GSK-3

    • Class of enzymes

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    GSK-3

    GSK-3

    GSK-3

  • Acetate kinase

    • Class of enzymes

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Acetate kinase

    Acetate kinase

    Acetate_kinase

  • Ataxia telangiectasia and Rad3 related

    • Protein kinase that detects DNA damage and halts cell division

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Ataxia telangiectasia and Rad3 related

    Ataxia telangiectasia and Rad3 related

    Ataxia_telangiectasia_and_Rad3_related

  • DNA-PKcs

    • Protein found in humans

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    DNA-PKcs

    DNA-PKcs

    DNA-PKcs

  • Ribosomal s6 kinase

    • Family of protein kinases

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Ribosomal s6 kinase

    Ribosomal s6 kinase

    Ribosomal_s6_kinase

  • IRAK3

    • ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    IRAK3

    IRAK3

    IRAK3

  • ACVR2B

    • Protein-coding gene in humans

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    ACVR2B

    ACVR2B

    ACVR2B

  • ACVR1

    • Protein-coding gene

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    ACVR1

    ACVR1

    ACVR1

  • TRIB1

    • Protein-coding gene in the species Homo sapiens

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    TRIB1

    TRIB1

    TRIB1

  • Wee1

    • Nuclear protein

    ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

    Wee1

    Wee1

    Wee1

  • GRB10

    • Protein-coding gene in the species Homo sapiens

    C-Raf, c-Kit, Insulin receptor, Insulin-like growth factor 1 receptor, MAP2K1, and RET proto-oncogene. GRCh38: Ensembl release 89: ENSG00000106070 – Ensembl

    GRB10

    GRB10

    GRB10

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