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Protein-coding gene in the species Homo sapiens
Interferon lambda 4 (gene symbol: IFNL4) is one of the most recently discovered human genes and the newest addition to the interferon lambda protein family
Interferon_lambda_4
Protein-coding gene in the species Homo sapiens
Interferon lambda 3 encodes the IFNL3 protein. IFNL3 was formerly named IL28B, but the Human Genome Organization Gene Nomenclature Committee renamed this
Interferon_lambda_3
Type II cytokine receptor
Interferon-lambda receptor (IFNLR), formerly known as the interleukin-28 receptor (IL28R), is a type II cytokine receptor found largely in epithelial
Interferon-lambda_receptor
Signaling proteins released by host cells in response to the presence of pathogens
response. Interferon type III IFN type III signals through the interferon-lambda receptor (IFNLR) consisting of IL10R2 (also called CRF2-4) and IFNLR1
Interferon
Protein-coding gene in the species Homo sapiens
Interferon lambda receptor 1 is a subunit for the interferon lambda receptor encoded by the IFNLR1 gene. It was formerly known as interleukin 28 receptor
Interferon_lambda_receptor_1
Group of anti-viral cytokines
The type III interferon group is a group of anti-viral cytokines that in humans consists of a singular family, IFN-λ (lambda). Their function is similar
Interferon_type_III
Pharmaceutical drug
shown that genetic polymorphisms near the human IL28B gene, encoding interferon lambda 3, are associated with significant differences in response to the
Peginterferon_alfa-2a
Russian medical geneticist
Interferon Lambda 4 Is Associated with Reduced Proliferation and Increased Cell Death in Human Hepatic Cells” published in the Journal of Interferon &
Ludmila_Prokunina-Olsson
Protein-coding gene in the species Homo sapiens
Interleukin-29 (IL-29) is a cytokine and it belongs to type III interferons group, also termed interferons λ (IFN-λ). IL-29 (alternative name IFNλ1) plays an important
Interleukin_29
Protein-coding gene in the species Homo sapiens
Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon
Interferon_alpha-1
Protein-coding gene in the species Homo sapiens
one of the two chains of a receptor for type I interferons, including interferon-alpha, -beta, and -lambda. Binding and activation of the receptor stimulates
IFNAR1
Sendai virus, virus of rodents
Donnelly RP, Kotenko SV (August 2010). "Interferon-lambda: a new addition to an old family". Journal of Interferon & Cytokine Research. 30 (8): 555–64. doi:10
Murine_respirovirus
Anti-inflammatory cytokine
(Mda-7), IL-26 and interferons type-I (IFN-alpha, -beta, -epsilon, -kappa, -omega), type-II (IFN-gamma) and type-III (IFN-lambda, including IL-28A, IL-28B
Interleukin_10
Protein-coding gene in Homo sapiens
SV, Flaño E, Schindler C, et al. (November 2010). "Lambda interferon is the predominant interferon induced by influenza A virus infection in vivo". Journal
STAT2
RNA family
mount an effective antiviral interferon-lambda based innate immune response to hepatitis C virus infection". Hepatology. 60 (4): 1170–1179. doi:10.1002/hep
MiR-122
Medical condition
dangerous since they are both teratogens. Other attempted treatments include interferon-alpha, cyclosporine, PUVA photochemotherapy, electron-beam therapy, IVIg
Papular_mucinosis
Artificial stimulation of the immune system to treat cancer
S2CID 223082. Lasfar A, Abushahba W, Balan M, Cohen-Solal KA (2011). "Interferon lambda: a new sword in cancer immunotherapy". Clinical & Developmental Immunology
Cancer_immunotherapy
Protein-coding gene in the species Homo sapiens
required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFNAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor
Interleukin 10 receptor, beta subunit
Interleukin_10_receptor,_beta_subunit
Contagious disease caused by SARS-CoV-2
what is known as the cytokine storm. Levels of interleukin 1B, interferon-gamma, interferon-inducible protein 10, and monocyte chemoattractant protein 1
COVID-19
Paraneoplastic syndrome
IL-6 and stimulate T cells and NK cells to increase their production of interferon gamma and interleukin 2 (see immunomodulatory imide drug's mechanism of
POEMS_syndrome
Human infectious disease
hepatitis D which are currently under development include pegylated interferon lambda (λ), which binds to receptors on the hepatocyte surface leading to
Hepatitis_D
440.890 – interferon type i MeSH D12.776.467.374.440.890.125 – interferon type i, recombinant MeSH D12.776.467.374.440.890.125.100 – interferon alfa-2a
List_of_MeSH_codes_(D12.776)
Belgian molecular biologist and entrepreneur (1947–1992)
interactions between a prokaryote (Escherichia coli) and a virus (bacteriophage lambda). Lecocq identified new bacterial genes influencing the decision between
Jean-Pierre_Lecocq
Group of disorders
vincristine, prednisone); with Rituximab, bortezomib, thalidomide, interferon-alpha, interferon-gamma, bexarotene, gemcitabine; and with hematopoietic stem cell
Epstein–Barr virus–associated lymphoproliferative diseases
Epstein–Barr_virus–associated_lymphoproliferative_diseases
Invasion of an organism's body by pathogenic agents
shown that genetic polymorphisms near the human IL28B gene, encoding interferon lambda 3, are associated with significant differences in the treatment-induced
Infection
Study of genetic variants in different individuals
GWA study has shown that SNPs near the human IL28B gene, encoding interferon lambda 3, are associated with significant differences in response to the
Genome-wide_association_study
False or misleading virus information
March 2020. Archived from the original on 4 August 2020. Retrieved 30 December 2020. "El antiviral cubano Interferón Alfa 2B se usa en China para tratar a
COVID-19 misinformation by governments
COVID-19_misinformation_by_governments
Codon that marks the end of a protein-coding sequence
Salvatore; Zavolan, Mihaela (15 September 2020). "Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation". The
Stop_codon
American physician
Chisari, F. V. (2005). "Lambda interferon inhibits hepatitis B and C virus replication". Journal of Virology. 79 (6): 3851–4. doi:10.1128/JVI.79.6.3851-3854
Francis_V._Chisari
Variant of SARS-CoV-2, the virus that causes COVID-19
complex I (MHC-I) degradation", and that "SARS-CoV-2 ORF8 suppresses type I interferon (IFN)–mediated antiviral response". Referring to amino-acid position 501
SARS-CoV-2_Alpha_variant
Organism altered by genetic engineering
hemophilia, human growth hormone to treat various forms of dwarfism, interferon to treat some cancers, erythropoietin for anemic patients, and tissue
Genetically_modified_organism
Structural motif capable of binding DNA
several genes encoding transcription regulatory proteins from bacteriophage lambda and Escherichia coli: Cro, CAP, and λ repressor, which were found to share
Helix-turn-helix
induces the production of type I interferons, and thus may play role in defense against viruses CD284 Toll-like receptor 4 (TLR4 or TOLL). It detects lipopolysaccharide
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Drug repurposing research related to COVID-19
that may prove useful in COVID-19 treatment include type I Interferons such as Interferon-β, peginterferon alpha-2a and -2b. IFN-β 1b have been shown
COVID-19 drug repurposing research
COVID-19_drug_repurposing_research
Variant of a biopharmaceutical
of approved recombinant drugs (e.g., insulin, human growth hormone, interferons, erythropoietin, monoclonal antibodies and more) any other biotech company
Biosimilar
Accelerated multinational clinical trial program to identify therapies against COVID-19
remdesivir, lopinavir/ritonavir combined, lopinavir/ritonavir combined with interferon-beta, and hydroxychloroquine or chloroquine. Hydroxychloroquine or chloroquine
Solidarity_trial
Complete set of molecular interactions in a biological cell
of protein–protein interactions between viruses and the human type I interferon system network". Journal of Proteome Research. 9 (7): 3527–36. doi:10
Interactome
Vaccine against COVID-19
of the N protein. A robust increase of T helper cells (CD4+) secreting interferon gamma was detected 14 days after both doses in response to stimulation
CoronaVac
DNA pattern affecting anatomy development
and structural similarity to prokaryotic transcription factors, such as lambda phage proteins that alter the expression of genes in prokaryotes. The HTH
Homeobox
Protein that regulates the rate of DNA transcription
regulators 3.4 Class: Heat Shock Factors 3.4.1 Family: HSF 3.5 Class: Tryptophan clusters 3.5.1 Family: Myb 3.5.2 Family: Ets-type 3.5.3 Family: Interferon regulatory
Transcription_factor
Sequence of major events in a virus pandemic
three-drug cocktail consisting of lopinavir/ritonavir, ribavirin and interferon-beta on 127 patients with mild symptoms associated with COVID-19. The
Responses to the COVID-19 pandemic in May 2020
Responses_to_the_COVID-19_pandemic_in_May_2020
Species of virus
and lymphokines (e.g. tumor necrosis factor β, interleukin 2, and gamma-interferon). These cytokines(TNFα, TNFβ) seem to mediate the fever, shock and organ
Bacteriophage_T12
Protein-coding gene in humans
connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library". Blood. 73 (6): 1498–503. doi:10.1182/blood.V73
CXCL7
Protein family
homology, 3D structure of POUs is similar to 3D structure of bacteriophage lambda repressor and other members of HTH_3 family. Human genes encoding proteins
POU_domain
British researcher
medicines which actually have benefit for COVID-19, including metformin, interferon-lambda, and higher-dose fluvoxamine. Boulware serves as the national co-chair
David_Boulware
Aspect of viral disease pandemic
of treatment protocols which included chloroquine, hydroxychloroquine, interferon-beta, lopinavir/ritonavir and remdesivir, would be conducted in nine government
COVID-19_pandemic_in_Malaysia
COVID-19 vaccine candidate produced in a plant
Coronavirus 2019 convalescent sera. Both spike protein-specific interferon-γ and interleukin-4 cellular responses were also induced. This pre-specified interim
CoVLP
Preventative and therapeutic medications for COVID-19 infection
lopinavir–ritonavir combined, 2) lopinavir–ritonavir combined with interferon-beta, 3) remdesivir or 4) (hydroxy)chloroquine in separate trials and hospital sites
COVID-19_drug_development
Protein-coding gene in the species Homo sapiens
POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain". Cell. 73 (1): 193–205. doi:10.1016/0092-8674(93)90171-L
POU2F1
Vaccine candidate against COVID-19
Unmodified mRNA inhibits immunogenicity by triggering the production of interferons that block the generation of T helper cells, which direct B cells to
CureVac_COVID-19_vaccine
Overview of the events of 2023 in science
therapeutic candidates are reported: a phase 3 trialed pegylated interferon lambda against COVID-19 (and other viruses) (9 Feb), a monkey-tested potential
January–March_2023_in_science
Protein-coding gene in the species Homo sapiens
S2CID 18269284. Santi E, Capone S, Mennuni C, et al. (2000). "Bacteriophage lambda display of complex cDNA libraries: a new approach to functional genomics"
EMX1
INTERFERON LAMBDA-4
INTERFERON LAMBDA-4
Girl/Female
Arabic, Indian, Muslim, Pashtun, Sanskrit
Flame; Large; Spacious; Tall; Another Name for Durga and Lakshmi
Girl/Female
Indian
Soft to touch
Female
Native American
Native American Indian name ALAMEDA means "grove of cottonwood."
Girl/Female
Muslim
Dark lipped
Girl/Female
Muslim
Flame
Girl/Female
Indian
Ambitious
Boy/Male
Indian
Jaws.
Girl/Female
Indian
Flame
Boy/Male
Hindu
Lord Ganesh, The huge bellied Lord
Surname or Lastname
English
English : habitational name from Lambden in Berwickshire.
Girl/Female
Muslim
Ambitious
Female
Italian
Italian form of English Amber, AMBRA means "amber."
Female
Greek
(Λαμία) Greek myth name of an evil spirit who abducts and devours children, LAMIA means "large shark." The name means "vampire" in Latin and "fiend" in Arabic.
Surname or Lastname
English
English : from Middle English lamb, a nickname for a meek and inoffensive person, or a metonymic occupational name for a keeper of lambs. See also Lamm.English : from a short form of the personal name Lambert.Irish : reduced Anglicized form of Gaelic Ó Luain (see Lane 3). MacLysaght comments: ‘The form Lamb(e), which results from a more than usually absurd pseudo-translation (uan ‘lamb’), is now much more numerous than O’Loan itself.’Possibly also a translation of French agneau.
Female
Spanish
Feminine form of Spanish Amado, AMADA means "beloved."
Girl/Female
Muslim
Praiseworthy, Praiser of Allah
Girl/Female
Indian
Praiseworthy, Praiser of Allah
Surname or Lastname
English
English : from a pet form of Lamb 1 and 2.English : from an Old Norse personal name Lambi, from lamb ‘lamb’.
Girl/Female
Muslim
Soft to touch
Girl/Female
Indian
Dark lipped
INTERFERON LAMBDA-4
INTERFERON LAMBDA-4
Girl/Female
Hindu, Indian, Kannada, Malayalam, Marathi, Tamil, Telugu
Knowledge; Literature
Girl/Female
Anglo Saxon
Pleasant and bright.
Boy/Male
Tamil
Known lecturer
Male
German
 German form of Latin Columbanus, KOLMAN means "dove." Compare with another form of Kolman.
Boy/Male
Hindu, Indian
Lord Siva
Boy/Male
American, Anglo, Australian, British, Christian, English, German
Divinely Peaceful; Variant of Jeffrey; Peace
Boy/Male
Hindu, Indian, Punjabi, Sikh
One Full of Wisdom
Girl/Female
Australian, Irish
Bitter
Boy/Male
Tamil
Parandhama | பரநà¯à®¤à®¾à®®à®¾à®‚Â
Lord Vishnu
Girl/Female
Arabic
Exalted; Highest Social Standing
INTERFERON LAMBDA-4
INTERFERON LAMBDA-4
INTERFERON LAMBDA-4
INTERFERON LAMBDA-4
INTERFERON LAMBDA-4
v. i.
To interfere; to intermeddle.
n.
A bruise or abrasion produced on the foot or ankle of a horse that interferes. See Interfere, 3.
v. i.
To clash or interfere.
pl.
of Lamina
imp. & p. p.
of Lamb
n.
One who interferes.
v. i.
To interfere, as a horse.
n.
The point of junction of the sagittal and lambdoid sutures of the skull.
v. t.
To interfere and cut off; to debar.
n.
One of the contestants in interference before the Patent Office.
v. i.
To bring forth a lamb or lambs, as sheep.
n.
The name of the Greek letter /, /, corresponding with the English letter L, l.
v. i.
To strike one foot against the opposite foot or ankle in using the legs; -- sometimes said of a human being, but usually of a horse; as, the horse interferes.
n.
Any person who is as innocent or gentle as a lamb.
imp. & p. p.
of Interfere
v. i.
To come in collision; to be in opposition; to clash; as, interfering claims, or commands.
n.
A viola da gamba.
p. pr. & vb. n.
of Interfere
n.
The act of improperly interfering.
pl.
of Lamina