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White blood cell that secretes large volumes of antibodies
Plasma cells, also called plasma B cells or effector B cells, are white blood cells that originate in the lymphoid organs as B cells and secrete large
Plasma_cell
Spectrum of blood disorders
In hematology, plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more
Plasma_cell_dyscrasias
Cancer of plasma cells
myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies
Multiple_myeloma
Type of white blood cell
secreted or inserted into the plasma membrane where they serve as a part of B-cell receptors. When a naïve or memory B cell is activated by an antigen,
B_cell
Medical condition
Plasma cell leukemia (PCL) is a plasma cell dyscrasia, i.e. a disease involving the malignant degeneration of a subtype of white blood cells called plasma
Plasma_cell_leukemia
Biological membrane that separates the interior of a cell from its outside environment
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a semipermeable biological
Cell_membrane
Medical condition
plasma cell gingivitis where the gingiva (gums) are involved, plasma cell cheilitis, where the lips are involved, and other terms such as plasma cell
Plasma_cell_gingivitis
White blood cell
Long-lived plasma cells (LLPCs) are a distinct subset of plasma cells that play a crucial role in maintaining humoral memory and long-term immunity. They
Long-lived_plasma_cell
Growth of a plasma cell tumour within soft tissue or the axial skeleton
Plasmacytoma is a plasma cell dyscrasia in which a plasma cell tumour grows within soft tissue or within the axial skeleton. The International Myeloma
Plasmacytoma
Non-neoplastic lesions of unknown etiology
Plasma cell granulomas (PCGs) are uncommon, non-neoplastic lesions of unknown etiology and are considered an entity of IgG4-related diseases. PCGs were
Plasma_cell_granuloma
Type of flat-panel display
A plasma display is a type of flat-panel display that uses small cells containing plasma (ionized gas) to produce an image. Each cell functions as a tiny
Plasma_display
Lymphatic tissue structure
long-lived plasma cells and durable memory B cells. There are several key differences between naive B cells and GC B cells. Naive B cells do not undergo
Germinal_center
Inflammation of the lips
more usually occurs on the gingiva (termed "plasma cell gingivitis") or sometimes the tongue. Plasma cell cheilitis appears as well defined, infiltrated
Cheilitis
Medical condition
or plasma cell balanitis, is a cutaneous condition characterized by a benign inflammatory skin lesion characterized histologically by a plasma cell infiltrate
Balanitis_plasmacellularis
Paraneoplastic syndrome
syndrome) is a rare paraneoplastic syndrome caused by a clone of aberrant plasma cells. The name POEMS is an acronym for some of the disease's major signs and
POEMS_syndrome
Hematologic cancer that affects lymphocytes
macroglobulinemia) Splenic marginal zone lymphoma Hairy cell leukemia Plasma cell neoplasms: Plasma cell myeloma (also known as multiple myeloma) Plasmacytoma Monoclonal
Lymphoma
Protein(s) forming a major part of an organism's immune system
of antibody that the plasma cell generates (IgG-secreting plasma cells do not, but IgM, IgA, and IgE plasma cells do). Plasma cells will secrete huge quantities
Antibody
Type of large B-cell lymphoma
The other lymphoid neoplasms within this subgroup are: plasmablastic plasma cell lymphoma (or the plasmacytoma variant of this disease); primary effusion
Plasmablastic_lymphoma
Cell of the adaptive immune system
differentiate into plasma cells, which then respond to and clear the antigen. The memory B cells that do not differentiate into plasma cells at this point
Memory_B_cell
Bulge in the plasma membrane of a cell
In cell biology, a bleb (or snout) is a bulge of the plasma membrane of a cell, characterized by a spherical, "blister-like", bulky morphology. It is
Bleb_(cell_biology)
Medical condition
disorder of plasma cells, a type of white blood cell that normally produces antibodies. It belongs to a wider family of progressive plasma cell disorders
Smouldering_myeloma
Benign lesion on the side of the tongue due to Epstein-Barr virus
with "balloon cells" (lightly staining cells) in the upper stratum spinosum and "nuclear beading" in the superficial layers (scattered cells with peripheral
Hairy_leukoplakia
Type of blood cancer
of cancer affecting two types of white blood cells: lymphoplasmacytoid cells and plasma cells (both B cells). It is characterized by having high levels
Waldenström_macroglobulinemia
Tumors that affect the blood, bone marrow, lymph, and lymphatic system
erythrocytes, thrombocytes, macrophages and mast cells; the lymphoid cell line produces B, T, NK and plasma cells. Lymphomas, lymphocytic leukemias, and myeloma
Tumors of the hematopoietic and lymphoid tissues
Tumors_of_the_hematopoietic_and_lymphoid_tissues
Autoimmune disease
triggering the infiltration of lymphocytes, specifically CD4+ T cells, B cells, and plasma cells, causing glandular dysfunction in the salivary and lacrimal
Sjögren's_disease
Medical condition
Monoclonal immunoglobulins are produced by monoclonal plasma cells, which are found in a variety of plasma cell dyscrasias. The deposition of monoclonal immunoglobulins
Monoclonal immunoglobulin deposition disease
Monoclonal_immunoglobulin_deposition_disease
Lymphocytes that become large as a result of antigen stimulation
cells with round-to-lobulated nucleus, chromatin resembling that of plasma cells, moderate amount of cytoplasm with mild basophilia. Type III cells are
Reactive_lymphocyte
Medical condition
undetermined significance (MGUS) is a plasma cell dyscrasia in which plasma cells or other types of antibody-producing cells secrete a myeloma protein, i.e.
Monoclonal gammopathy of undetermined significance
Monoclonal_gammopathy_of_undetermined_significance
Medical condition
Duct ectasia of the breast, mammary duct ectasia or plasma cell mastitis is a condition that occurs when a milk duct beneath the nipple widens, the duct
Duct_ectasia_of_breast
Inflammation of the mouth and lips
Chronic exposure to the allergen may result in a lichenoid lesion. Plasma cell gingivitis may also occur, which may be accompanied by glossitis and
Stomatitis
Immune disorder
a defect in the differentiation process of B cells into memory and plasma cells. There are also T cell abnormalities in CVID including counts, percentages
Common variable immunodeficiency
Common_variable_immunodeficiency
Metabolic disease involving abnormal deposited amyloid proteins
amyloidosis, and a diagnosis often begins with a search for plasma cell dyscrasia, memory B cells producing aberrant immunoglobulins or portions of immunoglobulins
Amyloidosis
Liquid component of blood
Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of
Blood_plasma
Protein-coding gene in humans
robust marker of normal plasma cells and malignant plasma cells in multiple myeloma. In contrast to CD138 (the traditional plasma cell marker), CD319/SLAMF7
SLAMF7
Medical condition
cell carcinoma Mucoepidermoid carcinoma Adenoid cystic carcinoma Polymorphous low-grade adenocarcinoma Epithelial-myoepithelial carcinoma clear-cell adenocarcinoma
Salivary_gland_tumour
Autoimmune disease of skin and muscle
These autoantibodies, produced by locally infiltrating plasma cells, can enter various cell types and disrupt the function of their target autoantigens
Dermatomyositis
Group of disorders
lymphoblasts, centroblasts, centrocytes, memory B cells, and ultimately plasma cells. During this maturation, the B cells rearrange their immunoglobulin genes at
Epstein–Barr virus–associated lymphoproliferative diseases
Epstein–Barr_virus–associated_lymphoproliferative_diseases
State of matter
Plasma is a state of matter that results from one of the other three classical states (often, the gaseous one) having undergone an appreciable degree of
Plasma_(physics)
Human chronic inflammatory disease
LP. Histologic findings of a deep mixed infiltrate with lymphocytes, plasma cells, and neutrophils (with or without eosinophils) and perivascular inflammation
Lichen_planus
Human disease caused by paramyxovirus
surface bond to a cell, which then causes the envelope to fuse with the host cell's cell membrane, releasing the capsid into the host cell's cytoplasm. Upon
Mumps
B cell not yet exposed to an antigen
naive B cell either becomes a memory B cell or a plasma cell that secretes antibodies specific to the antigen that was originally bound. Plasma cells do not
Naive_B_cell
Topics referred to by the same term
nucleoli Plasma cell, white blood cells that secrete large volumes of antibodies Protoplasm, the entire living substance inside the cell membrane or cell wall
Plasma
Field of medical research
cancer cells. Plasma medicine can be subdivided into five main fields: Non-thermal atmospheric-pressure direct plasma for medical therapy Plasma-assisted
Plasma_medicine
In biology, cells derived from a single clonal origin
single aberrant cell which has undergone carcinogenesis reproduces itself into a cancerous mass. Monoclonal plasma cell (also called plasma cell dyscrasia):
Monoclonality
Organ of the lymphatic system
antibody-secreting plasma cells. There are fewer cells in the medulla. The medullary cords are cords of lymphatic tissue, and include plasma cells, macrophages
Lymph_node
Abnormal immunoglobulin fragment
that is produced in excess by an abnormal monoclonal proliferation of plasma cells, typically in multiple myeloma or Monoclonal gammopathy of undetermined
Myeloma_protein
American pathologist
with plasma cell dyscrasias. Throughout his career Kyle has published more than 1,850 scientific papers and abstracts on myeloma and other plasma cell disorders
Robert_A._Kyle
Immune response by adaptive immune system
produced by plasma B cells, a type of white blood cell. This production is tightly regulated and requires the activation of B cells by activated T cells (another
Polyclonal_B_cell_response
Medical condition
characterized by tissue infiltration with lymphocytes and IgG4-secreting plasma cells, various degrees of fibrosis (scarring) and a usually prompt response
IgG4-related_disease
Aspect of immunity
become plasma cells or memory B cells. The memory B cells remain inactive here; later, upon reinfection with the same antigen, they divide to form plasma cells
Humoral_immunity
Cellular inclusion body
bodies are inclusion bodies usually found in atypical plasma cells that become known as Mott cells. Russell bodies are eosinophilic, homogeneous immunoglobulin
Russell_bodies
Immune organ that filters blood
encounter blood-borne antigens, which activate B cells to differentiate into plasma cells. Plasma cells then secrete antibodies, such as IgM antibodies
Spleen
Walter P (2002). "B Cells and Antibodies". Molecular Biology of the Cell (4th ed.). Garland Science. Retrieved 2023-08-27. "Plasma cell | Description & Antibody
List_of_immune_cells
Medical condition
population.[citation needed] A 1955 review article stated, "Interstitial plasma cell pneumonia is a type of infantile pneumonia, occurring chiefly in Europe
Pneumocystis_pneumonia
Antibodies from clones of the same blood cell
polyclonal antibodies are mixtures of antibodies derived from multiple plasma cell lineages which each bind to their particular target epitope. Artificial
Monoclonal_antibody
Medical condition
Plasmacytosis is a condition in which there is an unusually large proportion of plasma cells in tissues, exudates, or blood. Plasmacytosis may be divided into two
Plasmacytosis
Cleaning method using gas
cell confinement studies Plasma Lithography for Patterning Cell Culture Substrates Cell sorting by strength of adhesion Antibiotic removal by plasma activated
Plasma_cleaning
Inflammation of the mouth, lips, and gums, often due to herpes infection
cytoplasms of the infected cells fuse, collectively forming giant cells with many nuclei. The balloon cells and multi-nucleated giant cells can often be identified
Herpetic_gingivostomatitis
Type of immune cell involved in germinal center formation and maintenance
TFH cells play a critical role in mediating the selection and survival of B cells that go on to differentiate either into long-lived plasma cells capable
Follicular_B_helper_T_cells
Medical condition
monoclonal plasma cells, and, although AL amyloidosis can occur without diagnosis of another disorder, it is often associated with other plasma cell disorders
AL_amyloidosis
Protein-coding gene in the species Homo sapiens
which promotes plasma cell growth and of immunoglobulins in B lymphocytes. XBP1 is also essential for differentiation of plasma cells (a type of antibody
XBP1
Protein-coding gene in the species Homo sapiens
significantly when B cells prepare to leave the germinal center to form plasma cells. Long-lived plasma cells are memory B cells that secrete high-affinity
IRF4
Oxygen-delivering blood cell and the most common type of blood cell
dissolved in the blood plasma. Myoglobin, a compound related to hemoglobin, acts to store oxygen in muscle cells. The color of red blood cells is due to the heme
Red_blood_cell
Type of cells of the immunological system
Lymphoid cells (lymphocytes) include T cells (subdivided into helper T cells, memory T cells, cytotoxic T cells), B cells (subdivided into plasma cells and
White_blood_cell
Medical condition
by broad coronas of monocytoid cells, infiltration of interfollicular region by monocytoid cells or atypical plasma cells containing Dutcher bodies, monoclonality
Sialadenitis
Abnormal change in size of the lymph nodes
gives a generalized lymphadenopathy (Piringer-Kuchinka lymphadenopathy). Plasma cell variant of Castleman's disease - associated with HHV-8 infection and
Lymphadenopathy
Medical condition
abnormality in the desmosome-keratin filament complex leading to a breakdown in cell adhesion. Mutations in a single gene, ATP2A2, are the ultimate cause for
Darier's_disease
Type of mass spectrometry that uses an inductively coupled plasma to ionize the sample
Inductively coupled plasma mass spectrometry (ICP-MS) is a type of mass spectrometry that uses an inductively coupled plasma to ionize the sample. It atomizes
Inductively coupled plasma mass spectrometry
Inductively_coupled_plasma_mass_spectrometry
Blood product used in transfusion medicine
Platelet-rich plasma (PRP), also known as autologous conditioned plasma, is a concentrate of plasma protein derived from whole blood, centrifuged to remove
Platelet-rich_plasma
Type of blood cancer
neoplastic B-cells, other lymphocyte types, plasma cells, histiocytes and epithelioid cells interspersed with Reed–Sternberg-like cells infiltrate, almost
Diffuse_large_B-cell_lymphoma
Group of lymphomas
centrocyte-like B cells, centroblast-like B cells, monocyte-like B cells, plasma cell-like B cells, and/or large B cells. When the large B cells form prominent
Marginal_zone_lymphoma
Any of various disorders in medicine
medical context for an unspecified disorder of the blood, such as a plasma cell dyscrasia. To the Greeks, it meant an imbalance of the four humors: blood
Dyscrasia
Medical condition
insufficient number or function of B cells, the plasma cells they differentiate into, or the antibody secreted by the plasma cells. The most common such immunodeficiency
Humoral_immune_deficiency
The list of human cell types provides an enumeration and description of the various specialized cells found within the human body, highlighting their
List_of_human_cell_types
Mouth-lining mucous membrane
in the stratum granulosum into nonvital surface cells or squames to form the stratum corneum. The cells terminally differentiate as they migrate to the
Oral_mucosa
Medical condition
dental restorative materials, mercury, nickel and acrylic, acrylic. Plasma cell gingivitis is a rare condition thought to be a hypersensitivity reaction
List_of_periodontal_diseases
Presence of an excess of serum proteins in the urine
Pre-malignant plasma cell dyscrasias: Monoclonal gammopathy of undetermined significance Smoldering multiple myeloma Malignant plasma cell dyscrasias Multiple
Proteinuria
Medical condition
ratio greater than unity. Polyclonal plasma cells and CD21+ follicular dendritic cells are also seen. Clonal T-cell receptor gene rearrangements are detected
Angioimmunoblastic T-cell lymphoma
Angioimmunoblastic_T-cell_lymphoma
at CERN is a proof-of-principle experiment, which investigates wakefield plasma acceleration using a proton bunch as a driver, a world-wide first. It aims
AWAKE
Diagnosis classification
plasmacytoma M9732/3 Multiple myeloma (C42.1) Plasma cell myeloma Myeloma, NOS Myelomatosis M9733/3 Plasma cell leukemia (C42.1) Plasmacytic leukemia M9734/3
International Classification of Diseases for Oncology
International_Classification_of_Diseases_for_Oncology
Autoimmune disease
while T helper 2 cells stimulate the excessive production of B cells and plasma cells which generate antibodies against the thyroid antigens, leading
Hashimoto's_thyroiditis
Cell produced by hematopoiesis
volume composed of plasma, the liquid component of blood. Blood cells with differentiation potential are called hematopoietic cells; the ones with the
Blood_cell
Vascular tumor on both mucosa and skin
cause a similar kind of growth. These conditions include squamous-cell carcinoma, basal-cell carcinoma, and melanoma.[citation needed] Histopathological examination
Pyogenic_granuloma
Removal, treatment and return of blood plasma
plasma donation procedure, blood is removed from the body, blood cells and plasma are separated, and the blood cells are returned, while the plasma is
Plasmapheresis
Medical condition
gallbladder, Whipple's disease, inflammatory pseudotumor of the lung, plasma cell granuloma of the lung, malakoplakia, verruciform xanthoma, foamy histiocytosis
Xanthogranulomatous inflammation
Xanthogranulomatous_inflammation
Mathematical technique used to solve a certain class of partial differential equations
In plasma physics, the particle-in-cell (PIC) method refers to a technique used to solve a certain class of partial differential equations. In this method
Particle-in-cell
affecting the human hematologic system—the biological system that includes plasma, platelets, leukocytes, and erythrocytes, the major components of blood
List of hematologic conditions
List_of_hematologic_conditions
Semi-solid tissue in the spongy portions of bones
migratory memory T cells and a sanctuary for plasma cells. This has implications for adaptive immunity and vaccinology. Memory B and T cells persist in the
Bone_marrow
Human disease
inflammatory, lichenoid (lesions resembling oral lichen planus), or plasma cell gingivitis, which may be accompanied by glossitis and cheilitis. Apart
Burning_mouth_syndrome
Inflammation of the glans penis
balanitis, also known as Balanitis Circumscripta Plasmacellularis or plasma cell balanitis (PCB), is an idiopathic, rare, benign penile dermatosis for
Balanitis
Urinary protein
lytic (or "punched out") bone lesions, anemia, or large numbers of plasma cells in the bone marrow. Bence Jones proteins are present in 2/3 of multiple
Bence_Jones_protein
Body fluid in the circulatory system
cells of the body, and transports metabolic waste products away from those same cells. Blood is composed of blood cells suspended in plasma. Plasma,
Blood
Blistering autoimmune diseases
drugs, such as CellCept (mycophenolic acid): In recent years, adjuvant drugs, especially biologics, have shown great promise. Serum- or plasma-pooled products
Pemphigus
Type of blood and immune-system cancer
histiocytes, eosinophils, and plasma cells. The Reed–Sternberg cells are identified as large often bi-nucleated cells with prominent nucleoli and an
Hodgkin_lymphoma
Medical condition
leukoplakia and 70–100% of proliferative leukoplakia developing into squamous cell carcinoma. Leukoplakia is a descriptive term that should only be applied
Leukoplakia
Group of lymphoproliferative disorders
A cancerous cell population found in patients with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and
Castleman_disease
Medical condition
About half of people with light chain deposition disease also have a plasma cell dyscrasia, a spectrum of diseases that includes multiple myeloma, Waldenström's
Light chain deposition disease
Light_chain_deposition_disease
Inflammation of the vulva
Rarely excision for refractory lesions. Microscopic Findings: Dense plasma cell-rich band-like infiltrate in papillary and upper reticular dermis Spongiotic
Vulvitis
Study of cell activity
transported into vesicles to the plasma membrane. The cell releases secretory proteins known as exocytosis. Ions travel across cell membranes through channels
Cell_physiology
Body fluid outside the cells of a multicellular organism
having two components – plasma and lymph as a delivery system, and interstitial fluid for water and solute exchange with the cells. The extracellular fluid
Extracellular_fluid
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