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Protein-coding gene in the species Homo sapiens
Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear receptor that in humans is
Hepatocyte nuclear factor 4 gamma
Hepatocyte_nuclear_factor_4_gamma
Protein family
HNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein mostly expressed in the liver, gut, kidney, and pancreatic beta cells that is critical
Hepatocyte_nuclear_factor_4
Transcription factors
Hepatocyte nuclear factors (HNFs) are a group of phylogenetically unrelated transcription factors that regulate the transcription of a diverse group of
Hepatocyte_nuclear_factors
Immune system messenger protein which induces inflammation
cells, which then secrete fibrosis-promoting factors, such as TGF-β, as well as promoting further hepatocyte death. TNF promotes insulin resistance by inhibiting
Tumor_necrosis_factor
Mammalian protein found in Homo sapiens
Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Protein-coding gene in the species Homo sapiens
Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein that in humans is encoded
MST1
Mammalian protein found in humans
necrosis factor receptor members such as TRAF6, which results in the release of nuclear factor κB (NF-κB) transcription activator. NF-κB regulates nuclear gene
Nerve_growth_factor
MeSH D12.776.660.352.500.500 – hepatocyte nuclear factor 1-alpha MeSH D12.776.660.352.500.750 – hepatocyte nuclear factor 1-beta MeSH D12.776.660.650.875
List of MeSH codes (D12.776.660)
List_of_MeSH_codes_(D12.776.660)
Protein-coding gene in the species Homo sapiens
25.4.1354-1366.2005. PMC 548005. PMID 15684387. Yamamoto T, Shimano H, Nakagawa Y, et al. (2004). "SREBP-1 interacts with hepatocyte nuclear factor-4 alpha
PPRC1
Protein-coding gene in the species Homo sapiens
Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) is a protein that in humans
FOXA3
Mammalian protein found in Homo sapiens
Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane
Stem_cell_factor
MeSH D12.776.260.950.249.750 – hepatocyte nuclear factor 3-beta MeSH D12.776.260.950.249.875 – hepatocyte nuclear factor 3-gamma The list continues at List
List of MeSH codes (D12.776.260)
List_of_MeSH_codes_(D12.776.260)
Structural fibrous protein
[dubious – discuss] That model is now understood to be correct. A new nuclear addition in 2006 to describe keratins takes this into account. Keratin
Keratin
Protein
Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription factors. The
Nuclear_receptor
Nuclear receptor protein found in humans
known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning as a transcription factor that in humans is
Peroxisome proliferator-activated receptor alpha
Peroxisome_proliferator-activated_receptor_alpha
Protein-coding gene in the species Homo sapiens
Hadzopoulou-Cladaras M, Moore DD (2000). "The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms
Retinoid_X_receptor_alpha
Mammalian protein found in Homo sapiens
liver nuclear extracts. The proteins were therefore originally named hepatocyte nuclear factor 3 alpha, beta and gamma. These transcription factors contain
FOXA2
Protein found in humans
alpha, Hepatocyte nuclear factor 4 alpha, Liver receptor homolog-1, Liver X receptor alpha, Peroxisome proliferator-activated receptor gamma, Retinoic
Small_heterodimer_partner
Protein-coding gene in the species Homo sapiens
"Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and
GCLC
MeSH D12.776.930.977.249.750 – hepatocyte nuclear factor 3-beta MeSH D12.776.930.977.249.875 – hepatocyte nuclear factor 3-gamma The list continues at List
List of MeSH codes (D12.776.930)
List_of_MeSH_codes_(D12.776.930)
Protein-coding gene in the species Homo sapiens
receptor (FXR), also known as NR1H4 (nuclear receptor subfamily 1, group H, member 4) or bile acid receptor (BAR), is a nuclear receptor that is encoded by the
Farnesoid_X_receptor
Protein-coding gene in the species Homo sapiens
M, Birchmeier W, Feller SM (April 2000). "Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein
GRB2-associated-binding protein 1
GRB2-associated-binding_protein_1
Cellular receptor
receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene. RORγ is a member of the nuclear receptor
RAR-related orphan receptor gamma
RAR-related_orphan_receptor_gamma
Protein found in humans
Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene. FOXA1
FOXA1
Protein-coding gene in the species Homo sapiens
and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation
Glutamic--pyruvic transaminase 2
Glutamic--pyruvic_transaminase_2
Protein-coding gene in the species Homo sapiens
Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene. The protein encoded by this gene is one subunit of
NFYC
Protein-coding gene in the species Homo sapiens
cytoplasmic RNA-interacting protein (SYNCRIP), also known as heterogeneous nuclear ribonucleoprotein (hnRNP) Q or NS1-associated protein-1 (NSAP-1), is a
SYNCRIP
Protein-coding gene in humans
transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene
CEBPA
Protein involved in blood vessel growth
Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene. The chemical formula is C3914H6252N1212O1278S52
Vascular endothelial growth factor A
Vascular_endothelial_growth_factor_A
Protein-coding gene in the species Homo sapiens
cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation". The Biochemical Journal
TNFRSF12A
Protein-coding gene in the species Homo sapiens
kinase 8, Estrogen receptor alpha, Glucocorticoid receptor, Hepatocyte nuclear factor 4 alpha, P53, PPARGC1A, TGS1, and Thyroid hormone receptor alpha
MED1
Protein-coding gene in the species Homo sapiens
(1997). "Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97". J. Biol. Chem. 272 (34): 21548–57. doi:10.1074/jbc.272.34
PTPN2
Impaired flow of bile from the liver to the small intestine
represses expression of the pregnane X receptor (PXR). PXR is a nuclear receptor in hepatocytes that senses intracellular bile acid concentrations and regulates
Cholestasis
Mammalian protein and protein-coding gene
which binds to stem cell factor, also known as "steel factor" or "c-kit ligand". When this receptor binds to stem cell factor (SCF) it forms a dimer that
KIT_gene
Protein-coding gene in humans
transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene
CEBPB
Protein-coding gene in the species Homo sapiens
T, et al. (January 2003). "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference
AKR1C4
Association between obesity and risk of cancer
Federico G (2011). "Nuclear damage in peripheral lymphocytes of obese and overweight Italian children as evaluated by the gamma-H2AX focus assay and
Obesity_and_cancer
Protein-coding gene in the species Homo sapiens
development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver activator protein
ADH1A
Protein-coding gene in the species Homo sapiens
Nuclear factor erythroid 2-related factor 1 (Nrf1) also known as nuclear factor erythroid-2-like 1 (NFE2L1) is a protein that in humans is encoded by
NFE2L1
Protein-coding gene in the species Homo sapiens
Skouteris GG (September 2000). "The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII:
GRB2
Chemical compound
phosphatase), TIL-4 (TIL = toll-like receptor), NF-KB (NF = nuclear factor), ERK, and DFF45. Cantharidin promotes TNF-α (TNF = tumor necrosis factor), FASL, ROS
Cantharidin
Protein found in humans
(APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6), is a protein that in humans is
Fas_receptor
Cytokine protein
localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21". Genomics. 2 (3): 203–208
Interleukin_6
Mammalian protein found in Homo sapiens
epithelium-specific Ets transcription factor 1-S207, ErbB3 binding protein 1-T261, nuclear receptor-interacting factor 3-S28, SRC3-delta4-T56-S659-676, beta-catenin-S675
PAK1
Biological signaling pathway h
a protein called interferon regulatory factor 9 (IRF9) to enter the nucleus. Not as much is known about nuclear entrance of other STATs, but it has been
JAK-STAT_signaling_pathway
Enzyme
a group of enzymes that possess a catalytic subunit that transfers the gamma (terminal) phosphate from nucleoside triphosphates (often ATP) to one or
Tyrosine_kinase
Protein-coding gene in the species Homo sapiens
additional functions of SIRT2 in the nucleus. During the G2/M transition, nuclear SIRT2 is responsible for global deacetylation of H4K16, facilitating H4K20
Sirtuin_2
Protein-coding gene in the species Homo sapiens
basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma". Molecular Pharmacology. 63 (5): 1180–9. doi:10.1124/mol
FOXI1
Protein-coding gene in humans
chromosome 4 at locus 4q13-q21. Betacellulin was initially identified as a mitogen. Betacellulin, is a part of an Epidermal Growth Factor (EGF) family
Betacellulin
Protein-coding gene in humans
"Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1
Constitutive androstane receptor
Constitutive_androstane_receptor
Protein-coding gene in humans
STAT2, Cyclin-dependent kinase 8, Glucocorticoid receptor and Hepatocyte nuclear factor 4 alpha. GRCh38: Ensembl release 89: ENSG00000180182 – Ensembl
MED14
Keratin protein in humans
keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431". J. Biol. Chem. 272 (11): 7556–64. doi:10
Keratin_8
Protein in Eukaryotes
National Academy of Sciences of the United States of America. 92 (8): 3100–4. Bibcode:1995PNAS...92.3100M. doi:10.1073/pnas.92.8.3100. PMC 42112. PMID 7724523
Stathmin
Gene which maintains basic cellular functions
ribonucleoprotein K (HNRPK), transcript PABPN1 poly(A) binding protein, nuclear 1 SRSF3 splicing factor, arginine/serine-rich EIF1 aka SUI1 EIF1AD EIF1B EIF2A EIF2AK1
Housekeeping_gene
Protein-coding gene in the species Homo sapiens
hepatic expression of KLF15. Forced expression of KLF15 in cultured hepatocytes increased both the expression and the promoter activity of the gene for
KLF15
Inflammation of the liver
and NASH, specifically, the presence of polymorphonuclear infiltration, hepatocyte necrosis and apoptosis in the form of ballooning degeneration, Mallory
Hepatitis
Mammalian protein found in humans
necessary DNA replication factors. Within 72–96 hours of active pRb induction in A2-4 cells, the target DNA replication factor proteins—MCMs, RPA34, DBF4
Retinoblastoma_protein
Essential nutrient
release: hepatocytes and hepatic stellate cells (HSCs). Hepatocytes take up the lipid-rich chylomicrons, bind retinol to retinol-binding protein 4 (RBP4)
Vitamin_A
Chemical compound
3.4. PMID 12869662. S2CID 8620208. Vigneri P, Wang JY (February 2001). "Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment
Imatinib
Protein family
at the N-terminus and regulatory domains. These proteins are found in hepatocytes, adipocytes, hematopoietic cells, spleen, kidney, brain, and many other
CCAAT-enhancer-binding proteins
CCAAT-enhancer-binding_proteins
veno-occlusive disease – Hepatoblastoma – Hepatocellular carcinoma – Hepatocyte – Hepatoma – Hepatomegaly – HER1 – HER2/neu – HER2/neu gene – Herba scutellaria
Index_of_oncology_articles
Protein found in humans
other is this protein and is expressed in the basolateral membranes of hepatocytes (NTCP). As a cotransporter, NTCP binds two sodium ions and one (conjugated)
Sodium/bile acid cotransporter
Sodium/bile_acid_cotransporter
Group of cytokine proteins
IL-1ra and is called anakinra. IL-18 is known as a factor that induces the production of interferon gamma (IFN-γ). It is a pro-inflammatory cytokine that
Interleukin-1_family
Protein-coding gene in the species Homo sapiens
Wilm M, Parton RG, Zerial M (February 2004). "APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment". Cell. 116 (3): 445–56
APPL1
Retinoid X receptor gamma MeSH D12.776.826.750.074.249 – coup transcription factor i MeSH D12.776.826.750.074.500 – coup transcription factor ii MeSH D12.776
List_of_MeSH_codes_(D12.776)
Protein-coding gene in the species Homo sapiens
Christoforidis S, Giner A, et al. (2004). "APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment". Cell. 116 (3): 445–56
APPL2
Family of enzymes
substrate peptide is orientated in such a way that the hydroxyl group faces the gamma phosphate group of the bound ATP molecule. Both the substrate, ATP, and
Protein_kinase_A
Protein-coding gene in the species Homo sapiens
androstane receptor, pregnane X receptor and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factors are involved in mediating induction. A
ABCC3
Class of 8 chemically related vitamins
disorders. Tocopherols and tocotrienols both occur in α (alpha), β (beta), γ (gamma), and δ (delta) forms, as determined by the number and position of methyl
Vitamin_E
Medical condition
c-Met receptor and hepatocyte growth factor/scatter factor in synovial sarcoma and epithelioid sarcoma". Virchows Archiv. 432 (4): 337–42. doi:10.1007/s004280050175
Epithelioid_sarcoma
Motor protein found in humans
Ulrich; Pfister, Eva-Doreen (January 2022). "KIF12 Variants and Disturbed Hepatocyte Polarity in Children with a Phenotypic Spectrum of Cholestatic Liver Disease"
KIF12
Protein-coding gene in humans
S2CID 13941716. Esufali S, Charames GS, Bapat B (October 2007). "Suppression of nuclear Wnt signaling leads to stabilization of Rac1 isoforms". FEBS Letters. 581
RAC1
Keratin protein in humans
Momoi T, Inagaki M (October 2001). "Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD". J. Cell Biol. 155
Keratin_18
Protein-coding gene in humans
can act as either tumor promoter or suppressor. In aged mouse model, hepatocyte-specific deletion of PTPN11/Shp2 promotes inflammatory signaling through
PTPN11
L.; Doyen, A.; Garbay, S.; Robine, S.; Pontoglio, M. (2010). "Hepatocyte nuclear factor 1 and control terminal differentiation and cell fate commitment
List of intestinal epithelial differentiation genes
List_of_intestinal_epithelial_differentiation_genes
Chemical compound
human hepatocyte-derived cancer cells were treated with buffer or 4-octyl itaconate for 2 days and then infected with Zika virus for 4 days. 4-Octyl itaconate
Itaconic_acid
Protein-coding gene in the species Homo sapiens
Y, Nakayama K (July 2001). "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine
Sortilin
Keratin protein
of such structure. This association between the plasma membrane and the nuclear surface provides important implications for the organization of the cytoplasm
Cytokeratin
Class of enzymes
inhibits gluconeogenesis by inhibiting transcription factors including hepatocyte nuclear factor 4 (HNF4) and CREB regulated transcription coactivator
AMP-activated_protein_kinase
Protein-coding gene in the species Homo sapiens
the epidermal growth factor receptor (EGFR), hepatocyte growth factor (HGF)/Met receptor (c-Met), leptin and tumor necrosis factor (TNF) receptors. While
KHDRBS1
Chemical compound
binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells). Few effects are reported within 10 hours; it is not unusual
Α-Amanitin
receptor for interferon gamma - two receptors bind one interferon gamma dimer. CD120* a receptor for Tumour Necrosis Factor, an inflammatory cytokine
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
contain about 30 to 40 trillion (4×1013) human cells, with the number varying between 20 and 100 trillion depending on factors such as sex, age, and weight
List_of_human_cell_types
Protein-coding gene in the species Homo sapiens
Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3". Cell. 116 (4): 527–40. doi:10.1016/S0092-8674(04)00162-X. PMID 14980220
Bcl-2-like_protein_1
644.276.174.400.800 – transforming growth factor beta MeSH D12.644.276.174.420 – hepatocyte growth factor MeSH D12.644.276.174.440 – interferons MeSH D12
List_of_MeSH_codes_(D12.644)
Mammalian protein found in Homo sapiens
Fernandez-Sauze S, Reuzeau E, et al. (May 2006). "Transforming growth factor beta induces rosettes of podosomes in primary aortic endothelial cells"
Gelsolin
Sterol biosynthesized by all animal cells
synthesizing it, the majority of cholesterol is ingested or synthesized by hepatocytes and transported in the blood to peripheral cells. The levels of cholesterol
Cholesterol
Chemical compound
interaction of both substances might also influence apoptosis and necrosis in hepatocytes. The existing information on occurrence of citrinin in food suggests
Citrinin
Group of innate immune cells that are derived from common lymphoid progenitors
present in the liver. Their production of IFN–γ promotes the survival of hepatocytes. The production of IFN-γ by ILC1s is dependent on the expression of the
Innate_lymphoid_cell
Hypothesis that aging is caused by accumulated DNA damage
both mitochondrial and nuclear DNA damage can contribute to aging, nuclear DNA is the main subject of this analysis. Nuclear DNA damage can contribute
DNA_damage_theory_of_aging
Laboratory technique in biochemistry
& Chuck, S. L. (2002). A Proteomic Approach Identifies Proteins in Hepatocytes That Bind Nascent Apolipoprotein B. The Journal of Biological Chemistry
Immunoprecipitation
Mammalian protein found in humans
(July 2008). "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells". Proteomics. 8 (14): 2885–96. doi:10.1002/pmic
Ubiquitin_C
Protein-coding gene in the species Homo sapiens
N-cadherin (CDH2). PTPmu has also been shown to interact with the c-Met hepatocyte growth factor receptor, a protein that is also localized to adherens junctions
PTPRM
Sendai virus, virus of rodents
2002). "The roles of IFN gamma in protection against tumor development and cancer immunoediting". Cytokine & Growth Factor Reviews. 13 (2): 95–109. doi:10
Murine_respirovirus
Mechanisms of action
production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis". Clinical
Pharmacodynamics of spironolactone
Pharmacodynamics_of_spironolactone
Protein-coding gene in the species Homo sapiens
travel to these various regions. Primary bile acids are synthesized by hepatocytes in the liver and get conjugated with taurine or glycine before they are
G protein-coupled bile acid receptor
G_protein-coupled_bile_acid_receptor
Scientific research area
intravenous infusion of siRNA-GalNAc conjugates that gain entry into liver hepatocytes to silence the expression of pathogenic aminolevulinate synthase 1 (ALAS1)
Intracellular_delivery
Barbiturate medication used to treat seizures and tremors
P450 expression in cultured human hepatocytes". Drug Metabolism and Disposition. 31 (4): 421–431. doi:10.1124/dmd.31.4.421. PMID 12642468. Li CC, Lii CK
Primidone
Protein-coding gene in the species Homo sapiens
sequence. In related studies further testing the effects of CDCA on hepatocytes, CDCA was shown to have induced PKC translocation to the plasma membrane
PKC_alpha
Form of cancer
driven by the 3'UTRs of integrin alpha 3 (ITGA3) or transcription factor AP-2 gamma (TFAP2C), was repressed significantly. The team then tried to assess
Epigenetics_and_melanoma
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HEPATOCYTE NUCLEAR-FACTOR-4-GAMMA
HEPATOCYTE NUCLEAR-FACTOR-4-GAMMA
HEPATOCYTE NUCLEAR-FACTOR-4-GAMMA
HEPATOCYTE NUCLEAR-FACTOR-4-GAMMA
HEPATOCYTE NUCLEAR-FACTOR-4-GAMMA
HEPATOCYTE NUCLEAR-FACTOR-4-GAMMA
HEPATOCYTE NUCLEAR-FACTOR-4-GAMMA
HEPATOCYTE NUCLEAR-FACTOR-4-GAMMA
HEPATOCYTE NUCLEAR-FACTOR-4-GAMMA
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