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HEPATOCYTE NUCLEAR-FACTOR-4

  • Hepatocyte nuclear factor 4 alpha
  • Protein-coding gene in the species Homo sapiens

    Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear receptor that in humans is

    Hepatocyte nuclear factor 4 alpha

    Hepatocyte nuclear factor 4 alpha

    Hepatocyte_nuclear_factor_4_alpha

  • Hepatocyte nuclear factor 4
  • Protein family

    HNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein mostly expressed in the liver, gut, kidney, and pancreatic beta cells that is critical

    Hepatocyte nuclear factor 4

    Hepatocyte_nuclear_factor_4

  • Hepatocyte nuclear factor 4 gamma
  • Protein-coding gene in the species Homo sapiens

    Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear receptor that in humans is

    Hepatocyte nuclear factor 4 gamma

    Hepatocyte nuclear factor 4 gamma

    Hepatocyte_nuclear_factor_4_gamma

  • Hepatocyte nuclear factors
  • Transcription factors

    Hepatocyte nuclear factors (HNFs) are a group of phylogenetically unrelated transcription factors that regulate the transcription of a diverse group of

    Hepatocyte nuclear factors

    Hepatocyte_nuclear_factors

  • List of MeSH codes (D12.776.660)
  • MeSH D12.776.660.352.500.500 – hepatocyte nuclear factor 1-alpha MeSH D12.776.660.352.500.750 – hepatocyte nuclear factor 1-beta MeSH D12.776.660.650.875

    List of MeSH codes (D12.776.660)

    List_of_MeSH_codes_(D12.776.660)

  • List of MeSH codes (D12.776.260)
  • MeSH D12.776.260.950.249.750 – hepatocyte nuclear factor 3-beta MeSH D12.776.260.950.249.875 – hepatocyte nuclear factor 3-gamma The list continues at

    List of MeSH codes (D12.776.260)

    List_of_MeSH_codes_(D12.776.260)

  • List of MeSH codes (D12.776.930)
  • transcription factor MeSH D12.776.930.316.750.770 – nf-e2 transcription factor, p45 subunit MeSH D12.776.930.323.500.500 – hepatocyte nuclear factor 1-alpha

    List of MeSH codes (D12.776.930)

    List_of_MeSH_codes_(D12.776.930)

  • Nuclear receptor
  • Protein

    Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription factors. The

    Nuclear receptor

    Nuclear receptor

    Nuclear_receptor

  • Hepatocyte growth factor receptor
  • Mammalian protein found in Homo sapiens

    Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity

    Hepatocyte growth factor receptor

    Hepatocyte growth factor receptor

    Hepatocyte_growth_factor_receptor

  • Sex hormone–binding globulin
  • Human glycoprotein that binds to androgens and estrogens

    mechanism of activating the promoter for SHBG in the liver involves hepatocyte nuclear factor 4 alpha (HNF4A) binding to a DR1-like cis-element which then stimulates

    Sex hormone–binding globulin

    Sex hormone–binding globulin

    Sex_hormone–binding_globulin

  • Nuclear receptor coactivator 2
  • Protein-coding gene in the species Homo sapiens

    Granner DK (1998). "SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4". J. Biol. Chem. 273 (47): 30847–50. doi:10.1074/jbc.273.47.30847

    Nuclear receptor coactivator 2

    Nuclear receptor coactivator 2

    Nuclear_receptor_coactivator_2

  • MODY 1
  • Medical condition

    chromosome 12. This gene codes for hepatocyte nuclear factor 4-alpha (HNF4-α) protein also known as transcription factor 14 (TCF14). HNF4α controls function

    MODY 1

    MODY 1

    MODY_1

  • MST1
  • Protein-coding gene in the species Homo sapiens

    Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein that in humans is encoded

    MST1

    MST1

    MST1

  • Testicular receptor 4
  • Protein-coding gene in the species Homo sapiens

    Testicular receptor 4 has been shown to interact with Androgen receptor, Estrogen receptor alpha, and Hepatocyte nuclear factor 4 alpha. Testicular receptor

    Testicular receptor 4

    Testicular receptor 4

    Testicular_receptor_4

  • Katherine A. High
  • American doctor

    (1997-01-01). "Severe factor VII deficiency due to a mutation disrupting a hepatocyte nuclear factor 4 binding site in the factor VII promoter". Blood

    Katherine A. High

    Katherine A. High

    Katherine_A._High

  • COUP-TFI
  • Protein found in humans

    aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors". Archives of Biochemistry and Biophysics

    COUP-TFI

    COUP-TFI

    COUP-TFI

  • Phospholipase A2
  • Peripheral membrane protein

    PMID 22912808. Guan M, Qu L, Tan W, Chen L, Wong CW (February 2011). "Hepatocyte nuclear factor-4 α regulates liver triglyceride metabolism in part through secreted

    Phospholipase A2

    Phospholipase A2

    Phospholipase_A2

  • MED14
  • Protein-coding gene in humans

    STAT2, Cyclin-dependent kinase 8, Glucocorticoid receptor and Hepatocyte nuclear factor 4 alpha. GRCh38: Ensembl release 89: ENSG00000180182 – Ensembl

    MED14

    MED14

    MED14

  • AMP-activated protein kinase
  • Class of enzymes

    inhibits gluconeogenesis by inhibiting transcription factors including hepatocyte nuclear factor 4 (HNF4) and CREB regulated transcription coactivator

    AMP-activated protein kinase

    AMP-activated protein kinase

    AMP-activated_protein_kinase

  • Nuclear receptor coactivator 3
  • Protein found in humans

    Granner DK (1998). "SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4". The Journal of Biological Chemistry. 273 (47): 30847–30850

    Nuclear receptor coactivator 3

    Nuclear receptor coactivator 3

    Nuclear_receptor_coactivator_3

  • USF1
  • Protein-coding gene in the species Homo sapiens

    involved in lipid metabolism, including hepatic lipase (LIPC), hepatocyte nuclear factor 4 alpha (HNF4A), Apolipoprotein AI (APOA1), Apolipoprotein L1 (APOL1)

    USF1

    USF1

    USF1

  • Small heterodimer partner
  • Protein found in humans

    Hadzopoulou-Cladaras M, Moore DD (January 2000). "The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms

    Small heterodimer partner

    Small heterodimer partner

    Small_heterodimer_partner

  • Tumor necrosis factor
  • Immune system messenger protein which induces inflammation

    cells, which then secrete fibrosis-promoting factors, such as TGF-β, as well as promoting further hepatocyte death. TNF promotes insulin resistance by inhibiting

    Tumor necrosis factor

    Tumor necrosis factor

    Tumor_necrosis_factor

  • Retinoid X receptor alpha
  • Protein-coding gene in the species Homo sapiens

    Hadzopoulou-Cladaras M, Moore DD (2000). "The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms

    Retinoid X receptor alpha

    Retinoid X receptor alpha

    Retinoid_X_receptor_alpha

  • PROX1
  • Protein-coding gene in the species Homo sapiens

    prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4 α that regulates the cholesterol 7α-hydroxylase gene". The Journal

    PROX1

    PROX1

    PROX1

  • COUP-TFII
  • Protein found in humans

    Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells". Mol. Cell. Biol. 12 (4): 1708–18.

    COUP-TFII

    COUP-TFII

    COUP-TFII

  • HNF1B
  • Mammalian protein found in Homo sapiens

    B (hepatocyte nuclear factor 1 homeobox B), also known as HNF1B or transcription factor 2 (TCF2), is a human gene. HNF1B encodes hepatocyte nuclear factor

    HNF1B

    HNF1B

    HNF1B

  • Transcription factor
  • Protein that regulates the rate of DNA transcription

    for example, hepatocyte nuclear factors). Hence, the combinatorial use of a subset of the approximately 2000 human transcription factors easily accounts

    Transcription factor

    Transcription factor

    Transcription_factor

  • George Michalopoulos
  • Greek-American pathologist

    liver regeneration, with a specific focus on the significance of hepatocyte growth factor (HGF) and its receptor (MET), as well as the role of the extracellular

    George Michalopoulos

    George_Michalopoulos

  • MED1
  • Protein-coding gene in the species Homo sapiens

    kinase 8, Estrogen receptor alpha, Glucocorticoid receptor, Hepatocyte nuclear factor 4 alpha, P53, PPARGC1A, TGS1, and Thyroid hormone receptor alpha

    MED1

    MED1

    MED1

  • List of MeSH codes (D12.776)
  • MeSH D12.776.664.962.750.374 – eukaryotic initiation factor-4f MeSH D12.776.664.962.750.750 – nuclear cap-binding protein complex MeSH D12.776.765.678.968

    List of MeSH codes (D12.776)

    List_of_MeSH_codes_(D12.776)

  • Fibroblast growth factor 2
  • Growth factor and signaling protein otherwise known as FGF2

    Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by

    Fibroblast growth factor 2

    Fibroblast growth factor 2

    Fibroblast_growth_factor_2

  • Brain-derived neurotrophic factor
  • Protein found in humans

    growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4/NT-5. Neurotrophic factors are found

    Brain-derived neurotrophic factor

    Brain-derived neurotrophic factor

    Brain-derived_neurotrophic_factor

  • C14orf119
  • Protein-coding gene in the species Homo sapiens

    member U (RHOU), deoxyhypusine hydroxylase/monooxygenase (DOHH), hepatocyte nuclear factor 4, alpha (HNF4A), leukocyte receptor cluster member 1 (LENG1),

    C14orf119

    C14orf119

    C14orf119

  • Liver regeneration
  • Natural regrowth of damaged liver tissue

    communication between β-catenin (inside the hepatocyte) and the growth factors EGFR and HGFR or c-Met (outside the hepatocyte). The presence of these two proteins

    Liver regeneration

    Liver_regeneration

  • FOXA2
  • Mammalian protein found in Homo sapiens

    Forkhead box protein A2 (FOXA2), also known as hepatocyte nuclear factor 3-beta (HNF-3B), is a transcription factor that plays an important role during development

    FOXA2

    FOXA2

    FOXA2

  • Testosterone
  • Primary male sex hormone

    dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis". PLOS Biol. 9 (4) e1001051. doi:10.1371/journal.pbio.1001051

    Testosterone

    Testosterone

    Testosterone

  • FOXA3
  • Protein-coding gene in the species Homo sapiens

    Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) is a protein that in humans

    FOXA3

    FOXA3

    FOXA3

  • PPRC1
  • Protein-coding gene in the species Homo sapiens

    25.4.1354-1366.2005. PMC 548005. PMID 15684387. Yamamoto T, Shimano H, Nakagawa Y, et al. (2004). "SREBP-1 interacts with hepatocyte nuclear factor-4 alpha

    PPRC1

    PPRC1

    PPRC1

  • C2orf72
  • Human protein encoding gene

    esterification. In a study of embryonic liver samples lacking hepatocyte nuclear factor 4 alpha (HNF4α), the expression of C2orf72 was downregulated. Both

    C2orf72

    C2orf72

    C2orf72

  • HNF1A
  • Protein-coding gene in humans

    HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene on chromosome 12. It is ubiquitously expressed in many

    HNF1A

    HNF1A

    HNF1A

  • Fibroblast growth factor
  • Family of proteins involved in anatomical development

    as FGF homologous factors 1-4 (FHF1-FHF4), have been shown to have distinct functions compared to the FGFs. Although these factors possess remarkably

    Fibroblast growth factor

    Fibroblast_growth_factor

  • Insulin-like growth factor 1
  • Protein found in humans

    Insulin-like growth factor 1 (IGF1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in

    Insulin-like growth factor 1

    Insulin-like growth factor 1

    Insulin-like_growth_factor_1

  • David Moore (biologist)
  • American molecular biologist

    Margarita; Moore, David D. (2000-01-01). "The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms

    David Moore (biologist)

    David Moore (biologist)

    David_Moore_(biologist)

  • Wound healing
  • Series of events that restore integrity to damaged tissue after an injury

    interruption or failure leading to the formation of non-healing chronic wounds. Factors that contribute to non-healing chronic wounds are diabetes, venous or arterial

    Wound healing

    Wound healing

    Wound_healing

  • AKR1C4
  • Protein-coding gene in the species Homo sapiens

    T, et al. (January 2003). "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference

    AKR1C4

    AKR1C4

    AKR1C4

  • Suresh Kumar Rayala
  • Indian biologist

    1128/MCB.01004-15. ISSN 0270-7306. PMC 4836221. PMID 26929199. PAK1 Hepatocyte nuclear factor 4 alpha India portal Biology portal Irudayaraj (16 January 2019)

    Suresh Kumar Rayala

    Suresh_Kumar_Rayala

  • Nerve growth factor
  • Mammalian protein found in humans

    necrosis factor receptor members such as TRAF6, which results in the release of nuclear factor κB (NF-κB) transcription activator. NF-κB regulates nuclear gene

    Nerve growth factor

    Nerve growth factor

    Nerve_growth_factor

  • FOXA1
  • Protein found in humans

    Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene. FOXA1

    FOXA1

    FOXA1

    FOXA1

  • FOXP1
  • Protein-coding gene in the species Homo sapiens

    "DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain". Proceedings of the National Academy of Sciences

    FOXP1

    FOXP1

    FOXP1

  • PCBD1
  • Protein-coding gene in the species Homo sapiens

    homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1). Mutations of the PCBD1 gene cause pterin-4 alpha-carbinolamine dehydratase

    PCBD1

    PCBD1

    PCBD1

  • Epidermal growth factor
  • Protein that stimulates cell division and differentiation

    Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has

    Epidermal growth factor

    Epidermal growth factor

    Epidermal_growth_factor

  • GRB2-associated-binding protein 1
  • Protein-coding gene in the species Homo sapiens

    M, Birchmeier W, Feller SM (April 2000). "Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein

    GRB2-associated-binding protein 1

    GRB2-associated-binding protein 1

    GRB2-associated-binding_protein_1

  • Fibroblast growth factor 1
  • Protein-coding gene in the species Homo sapiens

    Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1

    Fibroblast growth factor 1

    Fibroblast growth factor 1

    Fibroblast_growth_factor_1

  • IGFBP3
  • Protein-coding gene in the species Homo sapiens

    nonparenchymal cells including sinusoidal endothelium, but not in hepatocytes. In contrast, human hepatocytes do express IGFBP-3. The encoded protein includes a 27-residue

    IGFBP3

    IGFBP3

    IGFBP3

  • PCAF
  • Protein-coding gene in humans

    Katrakili N, Talianidis I (Apr 2000). "Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". J

    PCAF

    PCAF

    PCAF

  • Vascular endothelial growth factor C
  • Growth factor protein found in humans

    endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular endothelial growth factor (PDGF/VEGF) family

    Vascular endothelial growth factor C

    Vascular endothelial growth factor C

    Vascular_endothelial_growth_factor_C

  • ONECUT1
  • Protein-coding gene in the species Homo sapiens

    PMID 34663987. Rausa FM, Tan Y, Costa RH (2003). "Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional

    ONECUT1

    ONECUT1

    ONECUT1

  • Stem cell factor
  • Mammalian protein found in Homo sapiens

    Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane

    Stem cell factor

    Stem cell factor

    Stem_cell_factor

  • Betacellulin
  • Protein-coding gene in humans

    chromosome 4 at locus 4q13-q21. Betacellulin was initially identified as a mitogen. Betacellulin, is a part of an Epidermal Growth Factor (EGF) family

    Betacellulin

    Betacellulin

    Betacellulin

  • Heparin-binding EGF-like growth factor
  • Protein-coding gene in the species Homo sapiens

    EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. HB-EGF-like growth factor is synthesized

    Heparin-binding EGF-like growth factor

    Heparin-binding EGF-like growth factor

    Heparin-binding_EGF-like_growth_factor

  • NFE2L1
  • Protein-coding gene in the species Homo sapiens

    Nuclear factor erythroid 2-related factor 1 (Nrf1) also known as nuclear factor erythroid-2-like 1 (NFE2L1) is a protein that in humans is encoded by

    NFE2L1

    NFE2L1

    NFE2L1

  • Transcription factor Jun
  • Mammalian protein found in Homo sapiens

    protect hepatocytes from apoptosis, as hepatocytes lacking c-jun showed increased sensitivity to TNFα-induced apoptosis. In those hepatocytes lacking

    Transcription factor Jun

    Transcription factor Jun

    Transcription_factor_Jun

  • TGF alpha
  • Protein

    Transforming growth factor alpha (TGF-α) is a protein that in humans is encoded by the TGFA gene. As a member of the epidermal growth factor (EGF) family, TGF-α

    TGF alpha

    TGF alpha

    TGF_alpha

  • PTPN2
  • Protein-coding gene in the species Homo sapiens

    (1997). "Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97". J. Biol. Chem. 272 (34): 21548–57. doi:10.1074/jbc.272.34

    PTPN2

    PTPN2

    PTPN2

  • Maturity-onset diabetes of the young
  • Medical condition

    complex combinations of causes involving multiple genes and environmental factors, each form of MODY is caused by changes to a single gene (monogenic). HNF1A-MODY

    Maturity-onset diabetes of the young

    Maturity-onset_diabetes_of_the_young

  • Chromosome 19 open reading frame 33
  • Protein found in humans

    2001). "Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation

    Chromosome 19 open reading frame 33

    Chromosome 19 open reading frame 33

    Chromosome_19_open_reading_frame_33

  • Nuclear receptor 4A3
  • Protein-coding gene in the species Homo sapiens

    by the NR4A3 gene. NR4A3 is a member of the nuclear receptor family of intracellular transcription factors. NR4A3 plays a central regulatory role in cell

    Nuclear receptor 4A3

    Nuclear receptor 4A3

    Nuclear_receptor_4A3

  • PDGFB
  • Protein-coding gene in the species Homo sapiens

    Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene. The protein encoded by this gene is a member of the

    PDGFB

    PDGFB

    PDGFB

  • Kringle domain
  • Autonomous protein domains

    [citation needed] Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein(a). Kringles are found throughout

    Kringle domain

    Kringle domain

    Kringle_domain

  • HNRPD
  • Protein-coding gene in the species Homo sapiens

    PMID 19033365. Arao Y, Kuriyama R, Kayama F, Kato S (August 2000). "A nuclear matrix-associated factor, SAF-B, interacts with specific isoforms of AUF1/hnRNP D".

    HNRPD

    HNRPD

    HNRPD

  • EEF2
  • Protein-coding gene in the species Homo sapiens

    Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. It is the archaeal and eukaryotic counterpart of bacterial EF-G

    EEF2

    EEF2

    EEF2

  • Insulin-like growth factor 2
  • Protein hormone

    Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity with insulin. The MeSH definition reads: "A well-characterized

    Insulin-like growth factor 2

    Insulin-like growth factor 2

    Insulin-like_growth_factor_2

  • HepaRG
  • Hepatic cell line model

    injury. The HepaRG model is considered a surrogate for Primary Human Hepatocytes, which are the most pertinent model to reproduce the human liver functioning

    HepaRG

    HepaRG

    HepaRG

  • Photoaging
  • Ultraviolet light-induced biological development over time

    tissue remodeling factors (tissue inhibitor of metalloproteinase-2, hepatocyte growth factor) by dermal substitutes was not influenced by keratinocyte-fibroblast

    Photoaging

    Photoaging

    Photoaging

  • Insulin-like growth factor 2 receptor
  • Protein found in humans

    Insulin-like growth factor 2 receptor (IGF2R), also called the cation-independent mannose-6-phosphate receptor (CI-MPR) is a protein that in humans is

    Insulin-like growth factor 2 receptor

    Insulin-like growth factor 2 receptor

    Insulin-like_growth_factor_2_receptor

  • FGF3
  • Protein-coding gene in humans

    Zapatka M, Blecken V, Dickson C, Kiefer P (Aug 2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell

    FGF3

    FGF3

    FGF3

  • PAK1
  • Mammalian protein found in Homo sapiens

    epithelium-specific Ets transcription factor 1-S207, ErbB3 binding protein 1-T261, nuclear receptor-interacting factor 3-S28, SRC3-delta4-T56-S659-676, beta-catenin-S675

    PAK1

    PAK1

    PAK1

  • Cholestasis
  • Impaired flow of bile from the liver to the small intestine

    represses expression of the pregnane X receptor (PXR). PXR is a nuclear receptor in hepatocytes that senses intracellular bile acid concentrations and regulates

    Cholestasis

    Cholestasis

    Cholestasis

  • Vascular endothelial growth factor A
  • Protein involved in blood vessel growth

    Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene. The chemical formula is C3914H6252N1212O1278S52

    Vascular endothelial growth factor A

    Vascular endothelial growth factor A

    Vascular_endothelial_growth_factor_A

  • Peroxisome proliferator-activated receptor alpha
  • Nuclear receptor protein found in humans

    known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning as a transcription factor that in humans is

    Peroxisome proliferator-activated receptor alpha

    Peroxisome proliferator-activated receptor alpha

    Peroxisome_proliferator-activated_receptor_alpha

  • Liver receptor homolog-1
  • Protein-coding gene in the species Homo sapiens

    liver receptor homolog-1 (LRH-1) also known as totipotency pioneer factor NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans

    Liver receptor homolog-1

    Liver receptor homolog-1

    Liver_receptor_homolog-1

  • TNFAIP3
  • Protein-coding gene in the species Homo sapiens

    et al. (2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2". J. Biol. Chem. 276 (32): 30216–23

    TNFAIP3

    TNFAIP3

    TNFAIP3

  • Fibroblast growth factor 8
  • Protein-coding gene in the species Homo sapiens

    growth factor 8 (FGF-8) is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene belongs to the fibroblast growth factor (FGF)

    Fibroblast growth factor 8

    Fibroblast growth factor 8

    Fibroblast_growth_factor_8

  • Endoreduplication
  • Replication of the nuclear genome without mitosis

    or endocycling) is replication of the nuclear genome in the absence of mitosis, which leads to elevated nuclear gene content and polyploidy. Endoreduplication

    Endoreduplication

    Endoreduplication

  • PDGFC
  • Protein-coding gene in the species Homo sapiens

    growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. Platelet-derived growth factors are important

    PDGFC

    PDGFC

    PDGFC

  • Interleukin 6
  • Cytokine protein

    localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21". Genomics. 2 (3): 203–208

    Interleukin 6

    Interleukin 6

    Interleukin_6

  • Thyroid hormone receptor alpha
  • Protein-coding gene in the species Homo sapiens

    1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors

    Thyroid hormone receptor alpha

    Thyroid hormone receptor alpha

    Thyroid_hormone_receptor_alpha

  • Hepatoma-derived growth factor
  • Protein capable of worsening malignant diseases

    hepatoma-derived growth factor (high-mobility group protein 1-like)". Everett AD, Bushweller J (2003). "Hepatoma derived growth factor is a nuclear targeted mitogen"

    Hepatoma-derived growth factor

    Hepatoma-derived growth factor

    Hepatoma-derived_growth_factor

  • RAR-related orphan receptor gamma
  • Cellular receptor

    (RAR-related orphan receptor C) gene. RORγ is a member of the nuclear receptor family of transcription factors. It is mainly expressed in immune cells (Th17 cells)

    RAR-related orphan receptor gamma

    RAR-related orphan receptor gamma

    RAR-related_orphan_receptor_gamma

  • Transdifferentiation
  • Process in developmental biology

    fibroblasts into hepatocyte-like cells using transcription factors Gata4, Hnf1α and Foxa3, and inactivation of p19(Arf) restored hepatocyte-like liver functions

    Transdifferentiation

    Transdifferentiation

  • Chromosome 10
  • Human chromosome

    synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) PCDH15: protocadherin 15 PI4K2A: phosphatidylinositol 4-kinase 2-alpha PIP4K2A: phosphatidylinositol

    Chromosome 10

    Chromosome 10

    Chromosome_10

  • Glucokinase regulatory protein
  • protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells). GKRP binds and moves glucokinase

    Glucokinase regulatory protein

    Glucokinase regulatory protein

    Glucokinase_regulatory_protein

  • Daf-16
  • Ortholog

    DAF-16 as it encodes a member of the hepatocyte nuclear family 3 (HNF3)/ Forkhead family of transcription factors. C. elegans has long been used in aging

    Daf-16

    Daf-16

    Daf-16

  • Hepsin
  • proteolytic function. Hepsin cleaves and activates pro-hepatocyte growth factor (pro-HGF) and coagulation factor VII, suggesting roles in both signaling pathways

    Hepsin

    Hepsin

    Hepsin

  • PDX1
  • Protein involved in the pancreas and duodenum differentiation

    gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6". Mol. Cell. Biol. 22 (13): 4702–13. doi:10.1128/MCB

    PDX1

    PDX1

    PDX1

  • KIT gene
  • Mammalian protein and protein-coding gene

    which binds to stem cell factor, also known as "steel factor" or "c-kit ligand". When this receptor binds to stem cell factor (SCF) it forms a dimer that

    KIT gene

    KIT gene

    KIT_gene

  • Fas receptor
  • Protein found in humans

    (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6), is a protein that in humans is

    Fas receptor

    Fas receptor

    Fas_receptor

  • Wnt signaling pathway
  • Group of signal transduction pathways involved in embryonic development

    Wnt secretion versus disrupting the protein-protein interfaces of nuclear factors". British Journal of Pharmacology. 174 (24): 4600–4610. doi:10.1111/bph

    Wnt signaling pathway

    Wnt_signaling_pathway

  • Tyrosine kinase
  • Enzyme

    kinase function has been observed in the nuclear matrix, which comprises not the chromatin but rather the nuclear envelope and a “fibrous web” that serves

    Tyrosine kinase

    Tyrosine kinase

    Tyrosine_kinase

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  • Facer
  • Surname or Lastname

    English (chiefly Northamptonshire)

    Facer

    English (chiefly Northamptonshire) : probably from the obsolete slang term facer, denoting a braggart or bully. The earliest citation for this term in OED is c. 1515.Americanized spelling of German Feeser.

    Facer

  • ACTON
  • Male

    English

    ACTON

    English surname transferred to forename use, ACTON means "oak tree settlement." 

    ACTON

  • Acton
  • Surname or Lastname

    English

    Acton

    English : habitational name from any of several places, especially in Shropshire and adjacent counties, named Acton. Generally, these are from Old English āc ‘oak’ + tūn ‘settlement’.

    Acton

  • VICTOR
  • Male

    English

    VICTOR

    Roman Latin name VICTOR means "conqueror." 

    VICTOR

  • Clear
  • Surname or Lastname

    English

    Clear

    English : probably a habitational name from clere, a component of several place names in north Hampshire (Highclere, Burghclere, Kingsclere). This is of uncertain origin, probably from a Celtic stream name meaning ‘bright’ (cognate with Latin clarus ‘clear’, ‘bright’).English and Irish : variant of Clare.Translation of German Klar 1.

    Clear

  • VÍCTOR
  • Male

    Spanish

    VÍCTOR

    Spanish form of Roman Latin Victor, VÍCTOR means "conqueror."

    VÍCTOR

  • Actor
  • Boy/Male

    Latin

    Actor

    Son of Azeus.

    Actor

  • ASTOR
  • Male

    French

    ASTOR

     French and German name derived from Occitan astor, ASTOR means "goshawk," itself from Latin acceptor, a variant of accipiter, meaning "hawk." It was originally a derogatory term for men with hawk-like, predatory characteristics.

    ASTOR

  • Castor
  • Surname or Lastname

    English

    Castor

    English : habitational name from places called Caistor, in Lincolnshire and Norfolk, Caister in Norfolk, or Castor in Cambridgeshire, all named with Old English cæster ‘Roman fort or town’.

    Castor

  • FALKOR
  • Male

    Icelandic

    FALKOR

    Perhaps a modern form of Icelandic Fylkir, FALKOR means "people, tribe." 

    FALKOR

  • Sartor
  • Surname or Lastname

    French and Italian

    Sartor

    French and Italian : occupational name from French, northern Italian sartor ‘tailor’ (Latin sartor).English : topographic name denoting someone who lived on land which had been cleared for cultivation, Old French assart, essart ‘woodland cleared for cultivation’ + the habitational suffix -er.

    Sartor

  • Doctor
  • Boy/Male

    English American

    Doctor

    Doctor; teacher.

    Doctor

  • PASTOR
  • Male

    Spanish

    PASTOR

    Spanish name derived from Latin Pastor, PASTOR means "shepherd." St. Pastor was a 9-year-old boy who along with his 13-year-old brother, Justus, was martyred at Alcalá de Henares in the early 4th century.

    PASTOR

  • NACHOR
  • Male

    Greek

    NACHOR

    (Ναχώρ) Greek form of Hebrew Nachowr, NACHOR means "snoring" or "snorting." In the bible, this is the name of the son of Terah and brother of Abraham.

    NACHOR

  • HECTOR
  • Male

    Arthurian

    HECTOR

    , sir Hector de Maris; (defender).

    HECTOR

  • Duclea
  • Girl/Female

    Latin

    Duclea

    Sweet.

    Duclea

  • KASTOR
  • Male

    Greek

    KASTOR

    (Κάστωρ) Greek name KASTOR means "beaver." In mythology, Castor/Kastor and Pollux/Polydeukes ("very sweet") are the twin sons of Leda and are known as the Gemini twins.

    KASTOR

  • Pastor
  • Surname or Lastname

    English, Portuguese, Galician, Spanish, Catalan, and French

    Pastor

    English, Portuguese, Galician, Spanish, Catalan, and French : occupational name for a shepherd, Anglo-Norman French pastre (oblique case pastour), Portuguese, Galician, Spanish, Catalan, pastor ‘shepherd’, from Latin pastor, an agent derivative of pascere ‘to graze’. The religious sense of a spiritual leader was rare in the Middle Ages, and insofar as it occurs at all it seems always to be a conscious metaphor; it is unlikely, therefore, that this sense lies behind any examples of the surname.German and Dutch : humanistic name, a Latinized form of various vernacular names meaning ‘shepherd’, for example Hirt or Schäfer (see Schafer).Americanized spelling of Hungarian Pásztor, an occupational name from pásztor ‘shepherd’.

    Pastor

  • Hector
  • Surname or Lastname

    Scottish

    Hector

    Scottish : Anglicized form of the Gaelic personal name Eachann (earlier Eachdonn, already confused with Norse Haakon), composed of the elements each ‘horse’ + donn ‘brown’.English : found in Yorkshire and Scotland, where it may derive directly from the medieval personal name. According to medieval legend, Britain derived its name from being founded by Brutus, a Trojan exile, and Hector was occasionally chosen as a personal name, as it was the name of the Trojan king’s eldest son. The classical Greek name, Hektōr, is probably an agent derivative of Greek ekhein ‘to hold back’, ‘hold in check’, hence ‘protector of the city’.German, French, and Dutch : from the personal name (see 2 above). In medieval Germany, this was a fairly popular personal name among the nobility, derived from classical literature. It is a comparatively rare surname in France.

    Hector

  • HECTOR
  • Male

    English

    HECTOR

     Anglicized form of Scottish Gaelic Eachann, HECTOR means "brown horse." Compare with another form of Hector.

    HECTOR

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  • Factory
  • n.

    A house or place where factors, or commercial agents, reside, to transact business for their employers.

  • Nucleal
  • a.

    Alt. of Nuclear

  • Foetor
  • n.

    Same as Fetor.

  • Factor
  • v. t.

    To resolve (a quantity) into its factors.

  • Faitour
  • n.

    A doer or actor; particularly, an evil doer; a scoundrel.

  • Facta
  • pl.

    of Factum

  • Faytour
  • n.

    See Faitour.

  • Factor
  • n.

    One who transacts business for another; an agent; a substitute; especially, a mercantile agent who buys and sells goods and transacts business for others in commission; a commission merchant or consignee. He may be a home factor or a foreign factor. He may buy and sell in his own name, and he is intrusted with the possession and control of the goods; and in these respects he differs from a broker.

  • Nucleate
  • v. t.

    To gather, as about a nucleus or center.

  • Factory
  • n.

    The body of factors in any place; as, a chaplain to a British factory.

  • Nuclear
  • a.

    Of or pertaining to a nucleus; as, the nuclear spindle (see Illust. of Karyokinesis) or the nuclear fibrils of a cell; the nuclear part of a comet, etc.

  • Vector
  • n.

    Same as Radius vector.

  • Facto
  • adv.

    In fact; by the act or fact.

  • Factory
  • n.

    A building, or collection of buildings, appropriated to the manufacture of goods; the place where workmen are employed in fabricating goods, wares, or utensils; a manufactory; as, a cotton factory.

  • Factored
  • imp. & p. p.

    of Factor

  • Nuclei
  • pl.

    of Nucleus

  • Nucleate
  • a.

    Having a nucleus; nucleated.

  • Ductor
  • n.

    A contrivance for removing superfluous ink or coloring matter from a roller. See Doctor, 4.

  • Doctor
  • v. t.

    To tamper with and arrange for one's own purposes; to falsify; to adulterate; as, to doctor election returns; to doctor whisky.