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Protein-coding gene in the species Homo sapiens
NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent
Sirtuin_2
Enzyme
Sirtuins are a family of signaling proteins involved in metabolic regulation. They are ancient in animal evolution and appear to possess a highly conserved
Sirtuin
Protein
Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. SIRT1 stands for sirtuin (silent
Sirtuin_1
Pharmaceutical compound
is a drug which acts as a selective allosteric inhibitor of the enzyme sirtuin 2 (SIRT2). It has moderate potency, inhibiting SIRT2 with an IC50 of 3 μM
FLS-359
Protein found in humans
(silent mating type information regulation 2 homolog) 3 (S. cerevisiae)]. SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs
Sirtuin_3
Pharmaceutical compound
AGK2 is a drug which acts as a selective sirtuin 2 (SIRT2) inhibitor. It was one of the first selective SIRT2 inhibitors developed, and inhibits SIRT2
AGK2_(SIRT2_inhibitor)
Pharmaceutical compound
SirReal2 is a drug which acts as a potent and selective sirtuin 2 (SIRT2) inhibitor. It inhibits SIRT2 with an IC50 of 140nM, and is selective over SIRT1
SirReal2
Protein-coding gene in the species Homo sapiens
Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. In laboratory
Sirtuin_6
Pharmaceutical compound
RW-93 is a drug which acts as a potent and selective sirtuin 2 (SIRT2) inhibitor. It inhibits SIRT2 with an IC50 of 15.5 nM, and is highly selective over
RW-93
Pharmaceutical compound
antiinflammatory effect. However, at higher concentrations VGVAPG upregulates Sirtuin 2 expression which has a pro-aging and neurodegenerative effect, and progressive
Hexapeptide-12
Pharmaceutical compound
2-APQC is a drug which acts as a sirtuin-3 (SIRT3) activator. In animal studies, it improved muscle and heart function in aged mice. Peng F, Liao M, Jin
2-APQC
Pharmaceutical compound
Thiomyristoyl is a drug which acts as a potent sirtuin 2 (SIRT2) inhibitor. It inhibits SIRT2 with an IC50 of 28 nM, though its activity at other SIRT
Thiomyristoyl
Protein-coding gene in the species Homo sapiens
Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), also known as SIRT5 is a protein which in humans in encoded by the SIRT5
Sirtuin_5
Pharmaceutical compound
YC8-02 is a drug which acts as a potent inhibitor of the enzymes sirtuin 2 (SIRT2) and sirtuin 3 (SIRT3). It was developed from an older SIRT2 selective inhibitor
YC8-02
Dietary regime
Preliminary research indicates that sirtuins are activated by fasting and serve as "energy sensors" during metabolism. Sirtuins, specifically Sir2 (found in
Calorie_restriction
Post-translational modification
broader pH range. Malonyl, succinyl, and glutaryl groups are removed by Sirtuin 5 (SIRT5), which shows little activity toward acetylation. Malonylation
Lysine_malonylation
Sirtuin-6 activator
United States Adopted Name; developmental code name SP-624) is a selective sirtuin-6 (SIRT6) activator which is under development for the treatment of major
Forvisirvat
Protein-coding gene in the species Homo sapiens
Sirtuin 4, also known as SIRT4, is a mitochondrial protein which in humans is encoded by the SIRT4 gene. SIRT4 is member of the mammalian sirtuin family
Sirtuin_4
Pharmaceutical compound
UBCS385 is a drug which acts as a sirtuin-4 (SIRT4) inhibitor. It also inhibits SIRT2 with around the same affinity, but has reasonable selectivity over
UBCS385
Central nervous system stimulant
several co-repressors, including HDAC1 (histone deacetylase 1) and SIRT 1 (sirtuin 1). ... The net result is c-fos gene repression. Figure 4: Epigenetic basis
Amphetamine
recombination. Accumulation of these circles has been linked to premature aging. Sirtuin 2 (SIRT2), SIR2's human analog, has also been linked to age-related disease
Silent information regulator protein
Silent_information_regulator_protein
Class of medication
Effects of Sirtuin-1 and Its Downstream Effectors: Potential Role in Mediating the Heart Failure Benefits of SGLT2 (Sodium-Glucose Cotransporter 2) Inhibitors"
SGLT2_inhibitor
Protein-coding gene in the species Homo sapiens
NAD-dependent deacetylase sirtuin 7 is an enzyme that in humans is encoded by the SIRT7 gene. SIRT7 is member of the mammalian sirtuin family of proteins, which
Sirtuin_7
American biologist
several biotech companies, most recently Evrys Bio, LLC, that is developing sirtuin 2 modulators as broad-spectrum antivirals, where he chairs the board of
Thomas_Shenk
Pharmaceutical compound
MDL-811 is a drug which acts as a sirtuin-6 (SIRT6) activator. It has antiinflammatory effects and shows neuroprotective effects in animal models of stroke
MDL-811
Mammalian protein found in humans
2016). "Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition". Cell Death & Disease. 7 (8): e2336. doi:10.1038/cddis.2016
BEX4
Chemical compound which is reduced and oxidized
(2018). "Regulatory Effects of NAD + Metabolic Pathways on Sirtuin Activity". Sirtuins in Health and Disease. Progress in Molecular Biology and Translational
Nicotinamide adenine dinucleotide
Nicotinamide_adenine_dinucleotide
Multienzyme complex
its activity and create a feedback regulatory loop. The mitochondrial sirtuin SIRT5 can remove glutaryl groups in a NAD+-dependent manner. The OADHC
2-oxoadipate dehydrogenase complex
2-oxoadipate_dehydrogenase_complex
HUVECs are cells derived from the endothelium of veins from umbilical cords
cobblestone phenotype when lining vessel walls. Inhibition of the sirtuin protein sirtuin 1 (SIRT1) in HUVECs has been shown to induce cellular senescence
Human umbilical vein endothelial cell
Human_umbilical_vein_endothelial_cell
Anthocyanidin pigment in flowering plant petals and fruits
are found in the seeds and skin. Cyanidin has been found to be a potent sirtuin 6 (SIRT6) activator. Antirrhinin (cyanidin-3-rutinoside or 3-C-R), found
Cyanidin
Pharmaceutical compound
Lu P, Cui DD, Yang B, et al. (April 2024). "Isobavachalcone, a natural sirtuin 2 inhibitor, exhibits anti-triple-negative breast cancer efficacy in vitro
Isobavachalcone
Pharmaceutical compound
UBCS039 is a drug which acts as a sirtuin-6 (SIRT6) activator. It was the first synthetic SIRT6 activator to be developed, and while it has comparatively
UBCS039
Australian geneticist (born 1969)
Sirtris was focused on developing Sinclair's research into activators of sirtuins, work that began in the Guarente lab. The company was specifically focused
David_A._Sinclair
Field of study
Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG (July 2007). "Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's
Epigenetics of neurodegenerative diseases
Epigenetics_of_neurodegenerative_diseases
Field of study
consequences. It arises through epigenetic modification (e.g., through HDAC, sirtuin, and G9a) and transcriptional regulation (primarily through ΔFosB's AP-1
Epigenetics of cocaine addiction
Epigenetics_of_cocaine_addiction
Field of study
vascular complications of diabetes exists with the SIRT1 gene, a member of Sirtuin family of genes. The SIRT1 enzyme has HDAC activity, and has been shown
Epigenetics of diabetes type 2
Epigenetics_of_diabetes_type_2
Bacterial protein
to the sirtuin family, a broadly conserved family of NAD+-dependent protein deacetylases. CobB is a bacterial protein that belongs to the sirtuin family
CobB
Pharmaceutical compound
JYQ-42 is a drug which acts as a sirtuin-6 (SIRT6) inhibitor. It has potential applications in cancer treatment, having been found to inhibit the migration
JYQ-42
Pharmaceutical compound
Thermogenic Fat and Improves the Thermogenic Capacity of Aging Mice via a Sirtuin 3-Adenosine Monophosphate-Activated Protein Kinase Pathway". Journal of
5-Heptadecylresorcinol
Pharmaceutical compound
resveratrol itself which acts as a sirtuin activator, 4-bromoresveratrol acts as a selective inhibitor of the sirtuin enzymes SIRT1 and SIRT3. In animal
4-Bromoresveratrol
Chemical compound
endproducts inhibitory effects. It is also a sirtuin-activating compound, a chemical compound having an effect on sirtuins, a group of enzymes that use NAD+ to
Butein
Biotechnology company in Massachusetts
company was focused on developing Sinclair's research into activators of sirtuins, work that began in the laboratory of Leonard P. Guarente where Sinclair
Sirtris_Pharmaceuticals
Chemical compound
deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., sirtuins). However, there are recent reports of the interactions of this molecule
Trichostatin_A
Pharmaceutical compound
MC3482 is a drug which acts as a sirtuin-5 (SIRT5) inhibitor. It has antiinflammatory effects and is used for research into the function of the SIRT5
MC3482
Central nervous system stimulant
several co-repressors, including HDAC1 (histone deacetylase 1) and SIRT 1 (sirtuin 1). ... The net result is c-fos gene repression. Figure 4: Epigenetic basis
Methamphetamine
Chemical compound
unsettled. Because NADH is a cofactor for processes inside mitochondria, for sirtuins and PARP, NMN has been studied in animal models as a potential neuroprotective
Nicotinamide_mononucleotide
List of pharmaceutical drugs under clinical development for treatment of depression
modulator, and serotonin 5-HT2 receptor agonist Forvisirvat (SP-624) – sirtuin 6 (SIRT6) stimulant Itruvone (PH-10; PH-10A; PH10-NS) – chemoreceptor cell
List of investigational antidepressants
List_of_investigational_antidepressants
Pharmaceutical compound
ADTL-SA1215 is a drug which acts as a sirtuin-3 (SIRT3) activator. It has been researched as a potential therapeutic agent for the treatment of triple
ADTL-SA1215
that contains bioactive compounds believed to modulate the activity of sirtuins, a family of NAD⁺-dependent enzymes involved in cellular stress responses
Sirtfood
Protein-coding gene in the species Homo sapiens
involves the deacetylation of residue K100 in the PGAM active site by sirtuin 2 (SIRT2) under conditions of oxidative stress. This deacetylation activates
PGAM2
Organic compound, experimental pharmaceuticum
studied by Sirtris Pharmaceuticals as a small-molecule activator of the sirtuin subtype SIRT1. The compound progressed to Phase II human trials for Type
SRT-2104
Organic compound, experimental pharmaceutical
was developed by GlaxoSmithKline as a small-molecule activator of the sirtuin subtype SIRT1, with potential applications in the treatment of diabetes
STAC-9
Process of cells digesting parts of themselves
blocks are released from the vesicle through the action of permeases. Sirtuin 1 (SIRT1) stimulates autophagy by preventing acetylation of proteins (via
Autophagy
Chemical compound
phosphate synthetase I (CPS I), interacts with a class of molecules called sirtuins, NAD dependent protein deacetylases, and ATP to form carbamoyl phosphate
Carbamoyl_phosphate
Human protein and coding gene
salvage pathway, in which NAM is recycled from enzymes that use NAD+ (sirtuins, PARPs, CD38) as these produce NAM as a waste product. Thus this reaction
Nicotinamide phosphoribosyltransferase
Nicotinamide_phosphoribosyltransferase
Medical condition
occurs and causes deplition of NAD+ which in turn decrases activity of Sirtuin 1. Sirtuin 1 normally deacetylates PGC-1α which inhibits its activity, but in
Spinocerebellar_ataxia_type_7
Pharmaceutical compound
SZC-6 is a drug from the coumarin family which acts as a sirtuin-3 (SIRT3) activator. It has been used in animal studies to study the potential role of
SZC-6
Compounds that inhibit histone deacetylases
aliphatic acid compounds such as Sodium phenylbutyrate and valproic acid. The sirtuin/Class III HDACs are dependent on NAD+ and are, therefore, inhibited by
Histone_deacetylase_inhibitor
InterPro Family
lysine molecule can be deacetylated by another class of enzyme called sirtuins. In mammals, the cytoplasmic-nuclear synthetase (AceCS1) is activated by
Acetyl-CoA_synthetase
General health article
vital for DNA repair and maintaining cellular health through proteins like sirtuins. Chronic ethanol consumption is increasingly understood to contribute to
Impact_of_alcohol_on_aging
Drug mixture used mainly to treat ADHD and narcolepsy
several co-repressors, including HDAC1 (histone deacetylase 1) and SIRT 1 (sirtuin 1). ... The net result is c-fos gene repression. Figure 4: Epigenetic basis
Adderall
Pharmaceutical compound
SIRT6 activator 12q is a drug which acts as a sirtuin-6 (SIRT6) activator. It has been researched as a potential therapeutic agent for the treatment of
SIRT6_activator_12q
Protein-coding gene in the species Homo sapiens
PMID 26443844. Klein MA, Denu JM (2020). "Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators". Journal of Biological Chemistry
PGC-1α
CNS stimulant and isomer of amphetamine
several co-repressors, including HDAC1 (histone deacetylase 1) and SIRT 1 (sirtuin 1). ... The net result is c-fos gene repression. Figure 4: Epigenetic basis
Dextroamphetamine
Class of enzymes
acids in proteins. The main ones are histone deacetylases (HDACs) and sirtuins (SIRT1,2,3,5). Because histone proteins were the first known substrate
Protein_deacetylase
Pharmaceutical compound
OSS-128167 is a drug which acts as a sirtuin-6 (SIRT6) inhibitor. It has pro-inflammatory effects and accelerates cellular aging; however, it shows anti-viral
OSS-128167
Longer than typical lifespan, especially of humans
target of rapamycin (mTOR), AMP-activating protein kinase (AMPK), and Sirtuin pathways. Emerging research suggests that vascular function and microcirculation
Longevity
Family of transcription factor protein complexes
the anti-inflammatory, pro-autophagy, anti-insulin resistance protein sirtuin 1. NF-κB increases the levels of the microRNA miR-34a, which inhibits nicotinamide
NF-κB
Disorder resulting in compulsive behaviors
several co-repressors, including HDAC1 (histone deacetylase 1) and SIRT 1 (sirtuin 1). ... The net result is c-fos gene repression. Figure 4: Epigenetic basis
Addiction
Government programme
conducted by IIST, UASD and TIFR and will include kidney stone formation and Sirtuin 1 gene marker effects in Drosophila melanogaster. IIT Patna will run experiments
Indian Human Spaceflight Programme
Indian_Human_Spaceflight_Programme
Study of DNA modifications that do not change its sequence
flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases". PLOS Genetics. 1 (6) e77. doi:10.1371/journal.pgen.0010077
Epigenetics
Mammalian protein found in humans
studies). Suppression of insulin resistance by sirtuins accounts for at least some of this effect. Impaired sirtuin 3 leads to mitochondrial dysfunction. Rapamycin
MTOR
Chemical compound
toxicity caused by decrease in PPARγ coactivator 1-α (PPARGC1A, PGC1α) and sirtuin 1 (SIRT1). Wilding JP, Gause-Nilsson I, Persson A (September 2007). "Tesaglitazar
Tesaglitazar
One of the five major groups of lipoprotein
PMID 15716581. Hwang JS, Ham SA, Yoo T, Lee WJ, Paek KS, Lee CH, Seo HG (2016). "Sirtuin 1 Mediates the Actions of Peroxisome Proliferator-Activated Receptor δ
High-density_lipoprotein
Chemical changes in proteins following their translation from mRNA
methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin". Science Translational Medicine. 14 (646) eabn4772. doi:10.1126/scitranslmed
Post-translational modification
Post-translational_modification
Phenotype of senescent cells which secrete certain substances
non-senescent cells, thereby reducing the capacity for DNA repair and sirtuin activity in non-senescent cells. SASP induction of the NAD+ degrading enzyme
Senescence-associated secretory phenotype
Senescence-associated_secretory_phenotype
Concept of extending human lifespan
as caloric restriction mimetic drugs, such as rapamycin and metformin. Sirtuin activating polyphenols, such as resveratrol and pterostilbene, and flavonoids
Life_extension
engineering an improved telomerase gene. 2012 It was discovered that protein Sirtuin 6 (SIRT6) regulates the lifespan of male mice (but not female mice). 2013
Timeline_of_aging_research
proteases to degrade proteins that fail to fold properly. UPRmt causes the sirtuin SIRT3 to activate antioxidant enzymes and mitophagy. Mitochondrial electron
Mitochondrial unfolded protein response
Mitochondrial_unfolded_protein_response
Class of enzymes
methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin". Science Translational Medicine. 14 (646) eabn4772. doi:10.1126/scitranslmed
Malonate—CoA_ligase
Biological processes used in gene regulation
and 9 while Class IIB includes HDACs 6 and 10. Class III contains the Sirtuins and Class IV contains only HDAC11. Classes of HDAC proteins are divided
Histone acetylation and deacetylation
Histone_acetylation_and_deacetylation
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
Smolka C, Baumann T, Schmidt H, Kampf J, et al. (November 2013). "The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals". Journal
Stress_granule
Chemical compound
dinucleotide (NAD+). As a coenzyme essential for energy metabolism and sirtuin activation (longevity-associated factors), the age-dependent decline of
S-1-Propenyl-L-cysteine
Types of irreversible biochemical changes
decreases and so does the ability of sirtuins to turn off unneeded genes at the right time. Decreasing the activity of sirtuins has been associated with accelerated
Hallmarks_of_aging
Organic compound, experimental pharmaceuticum
Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. It has similar activity in animal studies to another SIRT1
SRT-2183
Mammalian protein found in Homo sapiens
activation of transcription factors like NFkB, and histone deacetylases like sirtuins, which proved capable of diminishing HIV replication rates in infected
Occludin
Type of molecule that may be able to induce death of senescent cells
Senescence-associated beta-galactosidase, used as a biomarker Senotherapy Sirtuin-activating compound Unity Biotechnology Venetoclax YPEL3 § Cellular senescence
Senolytic
NOR DNA. In addition to UBF, NORs also bind to ATRX protein, treacle, sirtuin-7 and other proteins. UBF has been identified as a mitotic "bookmark" of
Nucleolus_organizer_region
Group of neural structures responsible for motivation and desire
several co-repressors, including HDAC1 (histone deacetylase 1) and SIRT 1 (sirtuin 1). ... The net result is c-fos gene repression. Figure 4: Epigenetic basis
Reward_system
Israeli professor of Biology
Sinclair. During his postdoctoral studies he studied sirtuin-1 (SIRT1) enzyme, part of the sirtuins family of enzymes involved in longevity and aging. He
Haim_Cohen
American science documentary television series
2011, Sean Carroll confirmed on his Twitter page that filming of season 2 of Through the Wormhole began. On May 17, 2011, Discovery confirmed the second
Through_the_Wormhole
Chemical compound
mononucleotide Niacin Nicotinamide Vitamin B3 Nicotinamide adenine dinucleotide Sirtuin Poly (ADP-ribose) polymerase Campbell, MT; Jones, DS; Andrews, GP; Li,
Nicotinamide_riboside
Protein
linked to changes in a number of other gene products, such as CREB and sirtuins. In the body, ΔFosB regulates the commitment of mesenchymal precursor cells
FOSB
Model of aging as a trade-off between growth, reproduction, and DNA maintenance
unlikely to survive in famine. Mechanistically, the NAD-dependent deacetylase Sirtuin 1 (SIRT-1) is upregulated during low-nutrient periods. SIRT-1 increases
Disposable soma theory of aging
Disposable_soma_theory_of_aging
Form of dynamic modification
Additionally, upregulating histone deacetylases, such as members of the sirtuin family, can delay senescence by removing acetyl groups that contribute
Chromatin_remodeling
Hypothetical anti-aging dietary supplement or drug candidate
insulin by binding to their PPAR receptors Agents that modulate sirtuins (called STAC –sirtuin-activating compounds), for example, fisetin Exanadin (exenatide)
Caloric_restriction_mimetic
Pharmaceutical compound
MC3138 is a drug which acts as a sirtuin-5 (SIRT5) activator. It has potential applications in the treatment of pancreatic cancer, as well as basic research
MC3138
Protein without a fixed 3D structure
Colonna G (March 2013). "Genealogy of an ancient protein family: the Sirtuins, a family of disordered members". BMC Evolutionary Biology. 13 (1): 60
Intrinsically disordered proteins
Intrinsically_disordered_proteins
Addition of one or more ADP-ribose moieties to a protein
addition of cyclic-ADP-ribose groups to proteins, were discovered. Finally, sirtuins, a family of enzymes that also possess NAD+-dependent deacylation activity
ADP-ribosylation
Hypothesis that aging is caused by accumulated DNA damage
Amir G, Peshti V, Zinman G, Nahum L, Bar-Joseph Z, Cohen HY (2012). "The sirtuin SIRT6 regulates lifespan in male mice". Nature. 483 (7388): 218–21. Bibcode:2012Natur
DNA_damage_theory_of_aging
SIRTUIN 2
SIRTUIN 2
Surname or Lastname
English
English : variant of Mixon 2.
Boy/Male
Tamil
Kirtin | கிரà¯à®¤à®¿à®¨
Celebrated
Kirtin | கிரà¯à®¤à®¿à®¨
Surname or Lastname
French
French : nickname from certain ‘certain’, ‘resolute’, a derivative of Old French certise ‘certitude’.English : variant spelling of Sartain, cognate with 1.
Surname or Lastname
Variant of Nicolai 2.English
Variant of Nicolai 2.English : variant of Nicholas.
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Celebrated
Boy/Male
Arabic, Muslim, Pashtun
Hazrat Imam Hassan (RA) and Hazrat Imam Hussain (RA)
Surname or Lastname
North German variant of Laas 2.Jewish (Ashkenazic)
North German variant of Laas 2.Jewish (Ashkenazic) : unexplained.English : nickname from Middle English lesse, lasse ‘smaller’ (from Old English lǣssa ‘less’), perhaps also used in the sense ‘younger’.
Surname or Lastname
English
English : patronymic meaning ‘son of the mayor’ (see Mayer 1).Jewish (Ashkenazic) : patronymic from the personal Meyer (see Meyer 2).American form of German Meyer, with excrescent -s.Irish : variant of Meyer 3.
Surname or Lastname
English
English : patronymic from a variant spelling of Mayer 1.English : variant of Myers.Spanish : variant of Mier 2.Dutch : variant of Mier 3.Dutch (van der Miers) : variant of Meers 2.
Surname or Lastname
English and Scottish
English and Scottish : variant of Mill 1.English : either a metronymic form of Mill 2, or a variant of Miles.Irish : in Ulster this is the English name, but elsewhere in Ireland it may be a translation of a Gaelic topographic byname, an Mhuilinn ‘of the mill’.
Boy/Male
Tamil
Sirthik | ஸீரà¯à®¤à®¿à®•
Lord Shiva
Sirthik | ஸீரà¯à®¤à®¿à®•
Girl/Female
Arabic, Australian, German, Indian, Muslim, Swedish, Tamil
Rich; Victory Peace; Fair
Surname or Lastname
English
English : probably a variant of Sartain.
Surname or Lastname
English
English : nickname from Old French certeyn ‘self-assured’, ‘determined’. (The phonetic change of -er- to -ar- was a normal process in Middle English).
Boy/Male
Hindu
Lord Shiva
Surname or Lastname
English
English : variant of Sartain.French : topographic name from a diminutive of sart, a reduced form of Old French essart ‘newly cleared and cultivated land’.Italian (Venetian) : variant of Sartini.
Surname or Lastname
English
English : variant spelling of Miner.German : nickname, meaning ‘small(er)’, from Latin minor ‘less’, ‘smaller’.French : nickname meaning ‘younger’, from the same word as in 2.
Surname or Lastname
Americanized spelling of Swiss German Bürki, or an altered spelling of Berke (see Berke 2).Possibly an Americanized spelling of Hungarian Berki, a habitational name from a village called Berki, in Pest county, or a topographic name from berek ‘marsh wi
Americanized spelling of Swiss German Bürki, or an altered spelling of Berke (see Berke 2).Possibly an Americanized spelling of Hungarian Berki, a habitational name from a village called Berki, in Pest county, or a topographic name from berek ‘marsh with groves’.English : unexplained.
Surname or Lastname
Americanized spelling of German Beiss(e), a variant of Beitz 2.English
Americanized spelling of German Beiss(e), a variant of Beitz 2.English : perhaps a variant of Biss. Compare Beese, Bise, Buys, Byce.Hungarian : nickname for someone with a limp or a peculiar gait, from bice ‘limp’.
Surname or Lastname
Americanized spelling of Jewish Leykin (from Belarus), a metronymic from Leyke, a pet form of the Yiddish female personal name Leye, from the Hebrew female personal name Lea, from which English Leah is derived (see Genesis 29
Americanized spelling of Jewish Leykin (from Belarus), a metronymic from Leyke, a pet form of the Yiddish female personal name Leye, from the Hebrew female personal name Lea, from which English Leah is derived (see Genesis 29 : 16) + the Slavic possessive suffix -in.English : from a medieval personal name, a diminutive of Lawrence. Compare Law 1 and Larkin.
SIRTUIN 2
SIRTUIN 2
Girl/Female
Muslim
Kind
Boy/Male
English American French
Form of Rufus: Red-haired.
Boy/Male
French, German, Latin, Swiss
In Flower
Boy/Male
Shakespearean
King Henry IV, Part 2' Ralph Mouldy, a country soldier.
Surname or Lastname
English (mainly Devon)
English (mainly Devon) : topographic name for someone who lived in a house, such as a warden’s lodge, in a park (see Park 1), from Middle English parc + hous.
Girl/Female
Indian
Beautiful woman, Distributor, Divider
Girl/Female
Muslim
Successful, Turquoise, Gem stone
Surname or Lastname
English
English : (of Norman origin): nickname from Old French beu, bel ‘fair’, ‘lovely’ + chere ‘face’, ‘countenance’. Although it originally meant ‘face’, the word chere later came to mean also ‘demeanor’, ‘disposition’ (hence English cheer), and the nickname may thus also have denoted a person of pleasant, cheerful disposition. There has been some confusion with Bowser.English : nickname for someone given to belching. See Balch.English : Andrew Belcher came before 1654 from London, England, to Cambridge, MA, where he kept a tavern. His family was originally from Wiltshire. His descendant Jonathan Belcher (1682–1757), a weathy merchant, was governor of MA and NH. Subsequently, as governor of NJ, he was one of the founders of the College of New Jersey (now Princeton).
Boy/Male
Arthurian Legend
A knight.
Boy/Male
Tamil
SIRTUIN 2
SIRTUIN 2
SIRTUIN 2
SIRTUIN 2
SIRTUIN 2
n.
The lower or under side of a sirloin of beef; the fillet.
a.
Of no legal force or effect, incapable of confirmation or ratification; null. Cf. Voidable, 2.
n.
A game in word making. See Logomachy, 2.
n.
See Viol, 2.
n.
A book composed of sheets each of which is folded into twenty-four leaves; hence, indicating more or less definitely a size of book so made; -- usually written 24mo, or 24¡.
a.
The sixth month of the calendar adopted by the first French republic. It began February 19, and ended March 20. See Vend/miaire.
n.
The first month of the French republican calendar, dating from September 22, 1792.
n.
One of the planets, the second in order from the sun, its orbit lying between that of Mercury and that of the Earth, at a mean distance from the sun of about 67,000,000 miles. Its diameter is 7,700 miles, and its sidereal period 224.7 days. As the morning star, it was called by the ancients Lucifer; as the evening star, Hesperus.
n.
A loin of beef, or a part of a loin.
n.
A loin of beef, or the upper part of the loin. See Sirloin, the more usual, but not etymologically preferable, orthography.
n.
A sign of the zodiac which the sun enters about the 21st of August, marked thus [/] in almanacs.
a.
Somewhat viscous. Cf. Mobile, a., 2.
n.
Among butchers, the piece of beef between the sirloin and the aitchbone piece. See Illust. of Beef.
n.
The quality or state of being vegetal, or exhibiting those physiological phenomena which are common to plants and animals. See Vegetal, a., 2.
n.
See Vinaigrette, n., 2.
n.
One of the vessels which carry blood, either venous or arterial, to the heart. See Artery, 2.
a.
Consisting of, or characterized by, voice, or tone produced in the larynx, which may be modified, either by resonance, as in the case of the vowels, or by obstructive action, as in certain consonants, such as v, l, etc., or by both, as in the nasals m, n, ng; sonant; intonated; voiced. See Voice, and Vowel, also Guide to Pronunciation, // 199-202.
n.
A compensation given to a hired person for services; price paid for labor; recompense; hire. See Wage, n., 2.