Searches , social queries for FIBRONECTIN TYPE-I-DOMAIN
Search references for FIBRONECTIN TYPE-I-DOMAIN. Phrases containing FIBRONECTIN TYPE-I-DOMAIN
See searches and references containing FIBRONECTIN TYPE-I-DOMAIN!
Search references for FIBRONECTIN TYPE-I-DOMAIN. Phrases containing FIBRONECTIN TYPE-I-DOMAIN
See searches and references containing FIBRONECTIN TYPE-I-DOMAIN!FIBRONECTIN TYPE-I-DOMAIN
Protein family
Fibronectin, type I repeats are one of the three repeats found in the fibronectin protein. Fibronectin is a plasma protein that binds cell surfaces and
Fibronectin_type_I_domain
Protein involved in cell adhesion, cell growth, cell migration and differentiation
IGFBP3, TNC, and TRIB3. Fetal fibronectin Fibronectin type I domain Fibronectin type II domain Fibronectin type III domain Monobody, an engineered antibody
Fibronectin
Protein domain
Fibronectin type II domain is a collagen-binding protein domain. Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in
Fibronectin_type_II_domain
Gene on human chromosome 5
Fibronectin type III domain–containing protein 9 (FNDC9) is a protein which in humans is encoded by the FNDC9 gene. FNDC9 is a single-pass membrane-associated
FNDC9
Receptors on the surface of cells
signal transduction. The common cytokine-binding domain is related to the Fibronectin type III domain. The signal transducing chains are often shared between
Type_I_cytokine_receptor
Two opposing antiparallel beta sheets that commonly occur in proteins
binding domain of Staphylococcus aureus Adhesin and in modules that bind fibronectin as found in Tenascin (Third Fibronectin Type III Repeat). The L-type lectin
Beta-sandwich
Protein in the extracellular matrix
form independent networks and are associated with type IV collagen networks via entactin, fibronectin, and perlecan. The proteins also bind to cell membranes
Laminin
Largest known protein in human muscles
of two types of modules, also referred to as protein domains (244 copies in total): type I fibronectin type III domain (132 copies) and type II immunoglobulin
Titin
Protein family
which this domain is functional. The fibronectin type II repeat domain is conserved amongst all members of the mannose receptor family. Collagens I-IV bind
Mannose_receptor
Protein-coding gene in the species Homo sapiens
propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain. Proteins of the matrix
MMP9
Neurotoxin produced by Clostridium botulinum
The seven main types of botulinum toxin are named types A to G (A, B, C1, C2, D, E, F and G). New types are occasionally found. Types A and B are capable
Botulinum_toxin
Protein-coding gene in the species Homo sapiens
Macrophage-activating factor Macrophage polarization Cluster of differentiation Fibronectin type III domain GRCh38: Ensembl release 89: ENSG00000077238 – Ensembl, May 2017
Interleukin-4_receptor
Protein-coding gene in humans
Fibronectin type III domain-containing protein 5, the precursor of irisin, is a type I transmembrane glycoprotein that is encoded by the FNDC5 gene. Irisin
FNDC5
Family of zinc-dependent metalloendopeptidases
incorporate Fibronectin type II modules inserted immediately before in the zinc-binding motif in the catalytic domain. The catalytic domain is connected
Matrix_metalloproteinase
Transmembrane proteins
ligand-binding fibronectin type III domains (FN3; each pair is called a cytokine homology region, CHR), then extends intracellularly. Unlike class I CRs, all
Type_II_cytokine_receptor
Self-stable region of a protein's chain that folds independently from the rest
120 fibronectin-III-type and Ig-type domains. In the serine proteases, a gene duplication event has led to the formation of a two β-barrel domain enzyme
Protein_domain
Proteins found on the outer membrane of Gram-negative bacteria
this protein domain is to bind to the extracellular matrix of the host, most notably fibronectin, collagen, and laminin. The head domain is very important
Trimeric autotransporter adhesin
Trimeric_autotransporter_adhesin
Enterotoxin produced by the bacteria Staphylococcus aureus
In the field of molecular biology, enterotoxin type B, also known as Staphylococcal enterotoxin B (SEB), is an enterotoxin produced by the gram-positive
Enterotoxin_type_B
Group of anti-viral cytokines
restricted by type III interferons. This group of cytokines share a heterodimeric receptor. The receptors have two type III fibronectin domains in their extracellular
Interferon_type_III
Species of endospore forming bacterium
an unjustified change of the type strain under the Prokaryotic Code. (The current type strain ATCC 25763 falls into group I.) Dobritsa et al. (2018) argues
Clostridium_botulinum
Protein domain
Cricetidae sp. (Hamster) serine protease Casp, which degrades type I and IV collagen and fibronectin in the presence of calcium. Mammalian complement-activating
CUB_domain
Protein found in humans
(1985). "Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II". Histochemistry. 82 (2): 149–58
Collagen,_type_IV,_alpha_3
Process of formation of blood clots
forms additional links between the platelets' glycoprotein Ib/IX/V and A1 domain. This localization of platelets to the extracellular matrix promotes collagen
Coagulation
(2007). "Monobodies: antibody mimics based on the scaffold of the fibronectin type III domain". Protein Engineering Protocols. Methods Mol. Biol. Vol. 352
Antibody_mimetic
Extracellular matrix glycoprotein family
1TEN; Leahy DJ, Hendrickson WA, Aukhil I, Erickson HP (November 1992). "Structure of a fibronectin type III domain from tenascin phased by MAD analysis
Tenascin
Most abundant structural protein in animals
Collagen may be attached to cell membranes via several types of protein, including fibronectin, laminin, fibulin, and integrin. A single collagen molecule
Collagen
Human protein-coding gene
in the number and identity of fibronectin type III domain repeats. Tenascin-C has been shown to interact with fibronectin. This interaction is shown to
Tenascin_C
Protein domain
growth factor-like domains. They have overlapping binding sites for several basement-membrane proteins, tropoelastin, fibrillin, fibronectin and proteoglycans
Fibulin
Heterodimeric receptor
ligand binding domain (with two or four fibronectin type II-like subdomains, for IFNAR2 and IFNAR1, respectively), a transmembrane (TM) domain, and a cytoplasmic
Interferon-alpha/beta receptor
Interferon-alpha/beta_receptor
Synthetic binding proteins
Monobodies are synthetic binding proteins constructed using a fibronectin type III domain (FN3) as a molecular scaffold. Specifically, this class of binding
Monobody
Type of lectin
type 2 ribosome-inactivating protein (RIP)[N.B]. Whereas type 1 RIPs are composed of a single protein chain that possesses catalytic activity, type 2
Ricin
Mammalian protein found in Homo sapiens
of five immunoglobulin-like (Ig) domains followed by two fibronectin type III (FNIII) domains. The different domains of NCAM have been shown to have different
Neural_cell_adhesion_molecule
Structural support for biological cells
binding to transmembrane integrins. The attachment of fibronectin to the extracellular domain initiates intracellular signalling pathways as well as
Extracellular_matrix
Protein family
growth factor, transforming growth factor-beta, fibronectin and antithrombin-1. Interactions between fibronectin and some syndecans can be modulated by the
Syndecan
domains including a unique N-terminal followed by two immunoglobulin-like (Ig) domains, five fibronectin type III (Fn) domains, five more Ig domains.
Myomesin
Protein-coding gene in the species Homo sapiens
fibronectin partially reverses this phenomenon. However this domain is not without a two-faced nature of its own. Bound protein fragments of the type
Thrombospondin_1
Protein found in humans
that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the
Collagen,_type_V,_alpha_1
Structures connecting keratinocyte cells to the extracellular matrix
composed to two α and β subunit dimers. The larger β4 subunit has domains that bind to fibronectin III and calcium. The α6 subunit binds to extracellular BP180
Hemidesmosome
Species of bacterium
signal peptide. NanH contains only a catalytic domain, whereas NanI and NanJ contain a catalytic domain and additional carbohydrate-binding modules (CBMs)
Clostridium_perfringens
Mammalian protein found in Homo sapiens
gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion
Glycoprotein_130
Peptide that consists of four amino acids
to a variety of extracellular matrix component including; fibronectin, type I collagen, type II collagen, laminin, and lens capsule basement membrane.
Tetrapeptide
(1985). "Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II". Histochemistry. 82 (2): 149–58
Collagen,_type_IV,_alpha_2
Subset of cell adhesion proteins
characterized by their extracellular domains containing Ig-like domains. The Ig domains are then followed by fibronectin type III domain repeats and IgSFs are anchored
Cell_adhesion_molecule
Cytotoxin produced by Clostridioides difficile
structural domains: catalytic, cysteine protease, translocation, and receptor binding. The N-terminal glucosyltransferase catalytic domain includes amino
Clostridioides difficile toxin B
Clostridioides_difficile_toxin_B
Protein-coding gene in humans
in humans is encoded by the BSPH1 gene. It contains two fibronectin type II domains (Fn2 domains) linked in tandem by disulfide bonds. BSPH1 is a member
BSPH1
Insecticide
structural domains: an N-terminal helical bundle domain (InterPro: IPR005639) involved in membrane insertion and pore formation; a beta-sheet central domain involved
Delta_endotoxins
Fibronectin binding protein A (FnBPA) is a Staphylococcus aureus MSCRAMM cell surface-bound protein that binds to both fibronectin and fibrinogen. It is
Fibronectin_binding_protein_A
Extracellular matrix protein
domain also known as complement control protein (CCP) domain, and three type III fibronectin (FN3) domains in the carboxy-terminal region. SNED1 is located
SNED1
Protein-coding gene in humans
(December 2000). "Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase
MMP2
Mammalian protein found in Homo sapiens
1989). "Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2". Annals of Human Genetics
Integrin_beta_1
Exotoxin
three domains. Fragment A contains the catalytic C domain, and fragment B consists of the T and R domains: The amino-terminal catalytic domain, known
Diphtheria_toxin
Protein
cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to
Integrin_alpha_5
Protein found in humans
COL4A1 belongs to the type IV collagen family and contains three domains: a short N-terminal domain, a long triple-helical 7S domain at its center, and a
Collagen,_type_IV,_alpha_1
Protein-coding gene in humans
typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors
EPHA7
Enzyme in human blood that degrades clots and other proteins
Plasmin is also integrally involved in inflammation. It cleaves fibrin, fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin, like trypsin
Plasmin
American immunologist
an RGD motif in fibronectin is sufficient for recognition by its receptor and common to other extracellular proteins, the fibronectin and vitronectin
Timothy_A._Springer
Toxin from bacteria that destroys or disrupts cells
exotoxin may have different names, depending on the field of research. Type I toxins bind to a receptor on the cell surface and stimulate intracellular
Exotoxin
Protein-coding gene in the species Homo sapiens
found in association with extracellular matrix structures including fibronectin-containing fibers, elastin-containing fibers and basement membranes.
FBLN1
Surface glycoproteins involved in hemostasis
collagen type I and IV. It consists of two subunits (α2 and β1). The α2 subunit includes a domain homologous to von Willebrand factor domain binding to
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Protein-coding gene in the species Homo sapiens
adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron
NRCAM
Protein-coding gene in the species Homo sapiens
Tenascin assembly domain (TAD), a series of 18.5 repeats of epidermal growth factor (EGF)-like motif, a high number of Fibronectin type III (FNIII) module
Tenascin_X
Protein-coding gene in humans
matrix by degrading macromolecules including casein, type I, II, IV, and V gelatins, fibronectin, and proteoglycan. The human MMP7 is located on chromosome
MMP7
Mammalian protein found in humans
cells, microglia). Human CD68 is a Type I transmembrane glycoprotein, heavily glycosylated in its extracellular domain, with a molecular weight of 110 kD
CD68
Protein-coding gene in the species Homo sapiens
surface of fibroblasts and epithelial cells. Syndecans interact with fibronectin on the cell surface, cytoskeletal and signaling proteins inside the cell
Syndecan-4
Exotoxin produced by Pseudomonas aeruginosa
"Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa". The Biochemical Journal. 385
Pseudomonas_exotoxin
Long projection on a neuron that conducts signals to other neurons
categories: Type I, Type II, Type III, and Type IV. An axon is one of two types of cytoplasmic protrusions from the cell body of a neuron; the other type is a
Axon
Protein found in humans
Snellman A, et al. (2002). "The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin"
Collagen,_type_XIII,_alpha_1
Protein found in humans
629 amino acids; it is a type I penetrating protein and includes a signal peptide, an N-terminal fibronectin III-like domain and an intracellular part
Interleukin-23_receptor
Pore-forming toxin produced by the bacteria Staphylococcus
A leukocidin is a type of cytotoxin created by some types of bacteria (Staphylococcus). It is a type of pore-forming toxin. Leukocidins fall into the category
Leukocidin
Protein found in humans
of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin". Diabetes. 53
ABCC11
Serine protease enzyme
can degrade many proteins in the extracellular matrix (ECM) including fibronectin, vitronectin and aggrecan. Cleavage can cause cell death by anoikis and
Granzyme_B
Class of enzymes
antiparallel beta stranded beta sheets. Furthermore, there is the fibronectin type II (FNII), important for recognition, folding, and mediation of gelatin
Gelatinase
Transmembrane receptors involved in cellular adhesion and signalling
cell–cell and cell–matrix interaction. Ligands for integrins include fibronectin, vitronectin, collagen and laminin. Integrins are obligate heterodimers
Integrin
Protein-coding gene in the species Homo sapiens
protein Usherin that contains laminin EGF motifs, a pentraxin domain, and many fibronectin type III motifs. The encoded basement membrane-associated protein
USH2A
Mammalian protein found in Homo sapiens
of six immunoglobulin domains followed by five fibronectin type III domains which are connected to a small intracellular domain by a transmembrane helix
Neural cell adhesion molecule L1
Neural_cell_adhesion_molecule_L1
Mammalian protein found in Homo sapiens
1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa"
Integrin_alpha_V
Protein-coding gene in humans
single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain
PTPRZ1
Protein found in humans
with aggrecan, the TSR domain interacts with VEGF and, the CT domain interacts with members of the TGF-β superfamily, fibronectin, perlecan, fibulin-1,
CCN_family_member_2
Protein-coding gene in humans
catalytic domains, thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like
PTPRD
Monoclonal antibody
it as a conjugate of Iodine-131 to an antibody which binds to fibronectin extra domain-B for treatment of Hodgkin lymphoma. "Radretumab (L19-131I)". Philogen
Radretumab
Protein-coding gene in the species Homo sapiens
aggregation, similar to other type R2B subfamily members. The MAM domain, Ig domain and all four fibronectin III domain of PTPrho are necessary for cell-cell
PTPRT
thuringiensis toxins Cry6Aa Cry34Ab1 Virulence factor Clumping factor A Fibronectin binding protein A Mycotoxins Aflatoxin Amatoxin (alpha-amanitin, beta-amanitin
Staphylococcus aureus alpha toxin
Staphylococcus_aureus_alpha_toxin
Bacterial toxins
thuringiensis toxins Cry6Aa Cry34Ab1 Virulence factor Clumping factor A Fibronectin binding protein A Mycotoxins Aflatoxin Amatoxin (alpha-amanitin, beta-amanitin
Cry34Ab1
Crystal protein
a three domain structure that are connected by singular links. Domain I, is composed of hydrophobic and amphipathic alpha helices. The domain is located
Cry1Ac
Species of bacterium
(1994-08-01). "A fibronectin-binding protein from Streptococcus equisimilis: characterization of the gene and identification of the binding domain". Veterinary
Streptococcus_dysgalactiae
Myosin Binding Protein H (MYBPH)
and Rad23 domain of the strand to be a stretched out, while the fibronectin type III (FN3) domains and immunoglobulin (Ig and I-set) domains of the strand
MYBPH
Protein family
pore-forming AB toxin found in the eggs of a snail. They can be classified as Type III toxins because they interfere with internal cell function. They are named
AB_toxin
Protein-coding gene in the species Homo sapiens
typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors
EPH_receptor_A3
Protein-coding gene in the species Homo sapiens
typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors
EPH_receptor_A5
Human chromosome
repeat and fibronectin type III domain containing 4 MADD: MAP kinase-activating death domain protein MEN1: Multiple endocrine neoplasia type 1 MIR210:
Chromosome_11
Protein found in humans
network. The structure of the IGF2R is a type I transmembrane protein (that is, it has a single transmembrane domain with its C-terminus on the cytoplasmic
Insulin-like growth factor 2 receptor
Insulin-like_growth_factor_2_receptor
Protein-coding gene in the species Homo sapiens
typically have a single kinase domain and an extracellular region containing a Cysteine-rich domain and 2 fibronectin type III repeats. The ephrin ligands
Ephrin_B3
Cytotoxin forming pores in cell membranes
thuringiensis toxins Cry6Aa Cry34Ab1 Virulence factor Clumping factor A Fibronectin binding protein A Mycotoxins Aflatoxin Amatoxin (alpha-amanitin, beta-amanitin
Panton–Valentine_leukocidin
Protein
three different domains: the folded E domain, which contains fibrinopeptides A and B that thrombin cleaves during blood clotting, the D domain, where the γ-chain
Clumping_factor_A
Category of small signaling proteins
family include: an extracellular fibronectin III-like domain, a transmembrane domain and a cytoplasmic SERIF domain. The known members of this family
Cytokine
Low-density lipoprotein containing apolipoprotein(a)
of the Lp(a) particle, binds to immobilized fibronectin and endows Lp(a) with the serine-proteinase-type proteolytic activity. Nonetheless, individuals
Lipoprotein(a)
Class of molecules found in the outer membrane of Gram-negative bacteria
the core oligosaccharide (also hydrophilic), and lipid A, the hydrophobic domain. The repetitive glycan polymer contained within an LPS is referred to as
Lipopolysaccharide
Overview of and topical guide to immunology
Fibrinogen receptor Macrophage-1 antigen (CR3) - Heterodimer: CD11b / CD18 Fibronectin receptor: Integrin alpha2beta1 Integrin alpha4beta1 Integrin alpha5beta1
Outline_of_immunology
Protein-produced toxins that create pores in cell membrane
head domain in Etx/Mtx2 toxins. In addition, the head domains of the Toxin_10 proteins show lectin-like features of carbohydrate binding domains. The
Pore-forming_toxin
Tripartite protein complex secreted by virulent strains of Bacillus anthracis
recognition and binding. This specificity of PA and the receptor CMG2 (similar to type I integrins) is due to interactions through a metal ion dependent adhesion
Anthrax_toxin
travel, tourism, insurance
FIBRONECTIN TYPE-I-DOMAIN
FIBRONECTIN TYPE-I-DOMAIN
FIBRONECTIN TYPE-I-DOMAIN
FIBRONECTIN TYPE-I-DOMAIN
FIBRONECTIN TYPE-I-DOMAIN
FIBRONECTIN TYPE-I-DOMAIN
FIBRONECTIN TYPE-I-DOMAIN
FIBRONECTIN TYPE-I-DOMAIN
FIBRONECTIN TYPE-I-DOMAIN
travel, tourism, insurance