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Protein-coding gene in the species Homo sapiens
Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by EZH2 gene, that participates in histone methylation
EZH2
Rare genetic overgrowth disorder
overgrowth syndrome. Its genetic cause was identified in 2011 as mutations in the EZH2 gene. Forty-eight cases had been documented and confirmed as of December 2013[update]
Weaver_syndrome
Investigational antineoplastic drug
Tulmimetostat functions as a dual inhibitor of the histone methyltransferases EZH2 and EZH1, which are key components of the polycomb repressive complex 2 (PRC2)
Tulmimetostat
Chemical compound
a cancer drug that acts as a potent selective EZH2 inhibitor. Tazemetostat blocks activity of the EZH2 methyltransferase, which may help keep the cancer
Tazemetostat
Pharmaceutical compound
(mCRPC). It is a EZH2 histone methyltransferase inhibitor. Mevrometostat has sub nanomolar affinity for the Y641N mutant form of EZH2 (which is a proliferation
Mevrometostat
Chemical compound
enzymes enhancer of zeste homolog 1 (EZH1) and enhancer of zeste homolog 2 (EZH2), which are implicated in the etiology of some forms of cancer including
Valemetostat
Protein complex
organisms. The mouse PRC2 has four subunits: Suz12 (zinc finger), Eed, Ezh1 or Ezh2 (SET domain with histone methyltransferase activity) and Rbbp4 (histone binding
PRC2
Protein-coding gene in humans
methyltransferase activity of the enzymes EZH1 and EZH2. By extension, this inhibits the function of the PRC2-EZH1 and PRC2-EZH2 complexes, leading to a reduction in
EZH_inhibitory_protein
Cancer of plasma cells
polycomb repressive complex 2 (PRC2). Increased expression of the PRC2 subunit, EZH2 have been described to be a common feature in multiple myeloma, resulting
Multiple_myeloma
Antibiotic
inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2". Clin Epigenetics. 15 (1) 12. doi:10.1186/s13148-023-01430-y. PMC 9872437
Azithromycin
Aggressive type of brain cancer
Pasquereau S, Haidar Ahmad S, Monnien F, Abad M, Bibeau F, et al. (9 June 2023). "EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes"
Glioblastoma
Process of copying a segment of DNA into RNA
enzymes (histone/nucleosome): Histone methylation/Histone methyltransferase EZH2 Histone demethylase Histone acetylation and deacetylation Histone deacetylase
Transcription_(biology)
Medical condition
Lytle A, Chiriboga L, Ozerdem U (September 2020). "The diagnostic utility of EZH2 H-score and Ki-67 index in non-invasive breast apocrine lesions". Pathology
Pure apocrine carcinoma of the breast
Pure_apocrine_carcinoma_of_the_breast
Term for a groundbreaking pharmaceutical drug
serotonin receptor agonist Migraine 2019 2022 Tazemetostat (Tazverik) Selective EZH2 inhibitor Epithelioid sarcoma 2020 Tirzepatide (Mounjaro) GLP-1 and GIP activator
First-in-class_medication
Pharmaceutical compound
evaluated for the treatment of peripheral T-cell lymphoma. It is a EZH1/EZH2 inhibitor developed by Shanghai Haihe Pharmaceutical Research & Development
Epsametostat
Protein-coding gene in the species Homo sapiens
reduces H3K27 methylation and limits the oncogenic properties of EZH2 by phosphorylating EZH2-T311. Experiments in mouse models have indicated that UHRF1 can
UHRF1
Non-coding RNA in the species Homo sapiens
skipping. EZH2, often mutated or overexpressed in lymphomas, hyper-methylates the FAS-AS1 promoter and represses the FAS-AS1 expression. EZH2-mediated
FAS-AS1
Protein-coding gene in the species Homo sapiens
only found in about 1.5% of ovarian cancer cases. EZH2 protein is up-regulated in numerous cancers. EZH2 mRNA is up-regulated, on average, 7.5-fold in breast
RAD51C
Sub-field of genomics
deficiency occurs by either inhibition of the methyltransferase activity of EZH2, or with addition of the kinase inhibitor dasatinib. Another approach is
Oncogenomics
Chemical compound
S-adenosylhomocysteine synthesis inhibitor and also a histone methyltransferase EZH2 inhibitor. Studies have shown that it has effects in vitro against a variety
3-Deazaneplanocin_A
Field of study in cancer research
chondrosarcoma, Ewing's sarcoma, and osteosarcoma, and expression of the EZH2 component of the PRC2 complex is altered in Ewing's sarcoma and rhabdomyosarcoma
Cancer_epigenetics
Research tool in genomics
"CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2". The Journal of Clinical Investigation. 128 (1): 446–462. doi:10.1172/JCI90793
Genome-wide CRISPR-Cas9 knockout screens
Genome-wide_CRISPR-Cas9_knockout_screens
Physical effects resulting from activation of the immune system
(DNMTs), a histone deacetylase (SIRT1), and a histone methyltransferase (EZH2), and thus induce DNA methylation. DNA methylation of a CpG island in a promoter
Inflammation
Species of virus
Racha; Bibeau, Frédéric; Herbein, Georges (October 2023). "Polyploidy, EZH2 upregulation, and transformation in cytomegalovirus-infected human ovarian
Human_cytomegalovirus
Protein-coding gene in the species Homo sapiens
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. EZH1 also complements EZH2 in maintaining
EZH1
Protein family
form homo-tetramers, usually in concert with the histone methyltransferase EZH2, and act as a transcriptional repressor. In the activation pathway illustrated
STAT5
American biotechnology corporation
partnered Epizyme to conduct clinical trials exploring whether Epizyme's EZH2 inhibitor tazemetostat would be synergistic with Genentech's atezolizumab
Genentech
American neuroscientist
1038/s41598-018-37761-7 Jarome TJ, Perez GA, Hauser RM, Hatch KM, Lubin FD. 2018. EZH2 Methyltransferase Activity Controls Pten Expression and mTOR Signaling During
Farah_Lubin
Multipotent adult stem cells present in multiple tissues
their multipotency. Recent work suggests that β-catenin, via regulation of EZH2, is a central molecule in maintaining the "stemness" of MSCs. The standard
Mesenchymal_stem_cell
Protein-coding gene in the species Homo sapiens
target genes via local chromatin reorganization. EZH2 protein is up-regulated in numerous cancers. EZH2 mRNA is up-regulated, on average, 7.5-fold in breast
XRCC2
Class of protein inhibiting drugs
transcription factors (a traditionally difficult class to drug) and cancer-linked EZH2 in in vitro models. As of yet, no drug candidates have been publicly identified
Targeted_protein_degradation
Protein-coding gene in the species Homo sapiens
similar to those of Weaver syndrome. EED has been shown to interact with: EZH2, HDAC1, Histone deacetylase 2, ITGB7, PPP1R8, and TGS1. GRCh38: Ensembl release
Polycomb_protein_EED
Protein
transition (EMT) and migrate. Snail2 and EZH2 were shown to co-bind the E-cadherin promoter, and without EZH2, Snail2 could not silence the gene effectively
SNAI2
Japanese pharmaceutical company
Enhertu". PMLive. 23 December 2019. Retrieved 3 December 2020. "Dual EZH1 and EZH2 inhibitor Ezharmia launched in Japan". The Pharma Letter. 20 December 2022
Daiichi_Sankyo
Protein-coding gene in the species Homo sapiens
This is the repression of XRCC3 by over-expression of EZH2 protein. Increased expression of EZH2 leads to epigenetic repression of RAD51 paralogs, including
XRCC3
Type of blood cancer
cell proliferation and expansion to extra-nodal tissues. EZH2: This gene's product, the EZH2 protein, is a histone-lysine N-methyltransferase. It thereby
Diffuse_large_B-cell_lymphoma
Protein found in humans
E, Gómez A, Villanueva A, Esteller M (June 2012). "Intronic RNAs mediate EZH2 regulation of epigenetic targets". Nature Structural & Molecular Biology
Enhancer of polycomb homolog 2
Enhancer_of_polycomb_homolog_2
Transcription factor for converting Naive T cells to TFH
BCL6’s interaction with other mutated proteins, including CREBBP, EP300, EZH2, and KM2TD, can also lead to B-cell lymphomas. Given its role as a master
BCL6
Cell death resulting from a deficiency of or interaction between in two or more genes
expression occurs by either inhibition of the methyltransferase activity of EZH2, by inhibition of the DNA repair kinase ATR, or by exposure to the kinase
Synthetic_lethality
Protein-coding gene in humans
which is a histone H3.3 chaperone. ATRX has been also shown to interact with EZH2. Alpha-thalassemia mental retardation syndrome GRCh38: Ensembl release 89:
ATRX
Class of compounds
S-adenosyl-L-homocysteine synthesis inhibitor and histone methyltransferase EZH2 inhibitor. Directly-acting antiviral agents: Imidazo[1,2-a]pyridines: Tegobuvir
Imidazopyridine
Cancer originating in lymph nodes
ISFL B-cells. Suspect mutations include those in the following genes: 1) EZH2 (encodes polycomb repressive complex 2 family protein which is involved in
Follicular_lymphoma
American scientist
Matt F.; Elemento, Olivier; Singh, Ankur; Melnick, Ari M. (2017-10-12). "EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A
Ankur_Singh
Protein-coding gene in the species Homo sapiens
C, Ding J, Liao G, Tang B (2014). "Aberrant upregulation of 14-3-3σ and EZH2 expression serves as an inferior prognostic biomarker for hepatocellular
YWHAZ
Rare neurodegenerative disease
Hart RP, Mallimo EM, Swerdel MR, Kusnecov AW, Herrup K (December 2013). "EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia–telangiectasia"
Ataxia–telangiectasia
HGNC:3522; O95677 5206 EYS HGNC:21555; Q5T1H1 5207 EZH1 HGNC:3526; Q92800 5208 EZH2 HGNC:3527; Q15910 5209 EZHIP HGNC:33738; Q86X51 5210 EZR HGNC:12691; P15311
List of human protein-coding genes 3
List_of_human_protein-coding_genes_3
Chromatin remodeling complex
epithelioid sarcoma, causes early dependence on EZH2 activity. Similarly, inhibition of EZH2 by the EZH2 inhibitor tazemetostat has shown clinical activity
Mammalian SWI/SNF (BAF) complex
Mammalian_SWI/SNF_(BAF)_complex
French biopharmaceutical company
following gemcitabine-based therapy. Tazverik is an inhibitor of the enzyme EZH2 (enhancer of zeste homologue 2) used to treat follicular lymphoma, which
Ipsen
Medical condition
aberrations in the ISFL B-cells such as mutations in the following genes: 1) EZH2 (encodes polycomb repressive complex 2 family protein which is involved in
In_situ_lymphoid_neoplasia
Human chromosome
family domain containing 1 EGFR-AS1: encoding protein EGFR antisense RNA 1 EZH2: encoding enzyme histone-lysine N-methyltransferase for histone h3 lysine
Chromosome_7
Chinese-American biochemist
PRMT1, the H3K79 methyltransferase Dot1L, and the H3K27me3 methyltransferase EZH2/PRC2. He went on to demonstrate the function of H3K27me3 methylation in X
Yi_Zhang_(biochemist)
Non-protein coding transcripts longer than 200 nucleotides
subsequent gene expression. Components of the Polycomb complex, including Suz12, EZH2 and EED, contain RNA binding domains that may potentially bind HOTAIR and
Long_non-coding_RNA
Field of study
mediated by the PCR2 complex. PCR2 has a methyltransferase EZH2. Nerve damage stimulates EZH2 expression and increases the enrichment of H3K27me3 at the
Epigenetics_of_chronic_pain
Post-translational carbohydrate modification of proteins
found in multiple locations on EZH2, the catalytic methyltransferase subunit of PRC2, and is thought to stabilize EZH2 prior to PRC2 complex formation
O-GlcNAc
Precursor microRNA family
development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2". The Journal of Clinical Endocrinology and Metabolism. 97 (5): E710-8. doi:10
Mir-25 microRNA precursor family
Mir-25_microRNA_precursor_family
Topics referred to by the same term
related gene family (ezh) EZH1, an enzyme and gene EZH2, a histone-lysine N-methyltransferase enzyme Ezh2 gene Ezh symbols Curly-tail ezh (◌̡_) D-ezh ligature
EZH
Medical condition
have intermediate prognoses. Somatic mutations in genes such as ASXL1 and EZH2 are associated with a poor prognosis. CMML has a 20–30% chance of transformation
Chronic myelomonocytic leukemia
Chronic_myelomonocytic_leukemia
Medical condition
thereby rendering them resistant to this class of chemotherapy drugs; 4) EZH2, a histone methyltransferase that when up-regulated indirectly promotes these
Extranodal NK/T-cell lymphoma, nasal type
Extranodal_NK/T-cell_lymphoma,_nasal_type
Precursor microRNA family
and EZH2. It further induces apoptosis, inhibition of colony formation and tumorigenesis of breast cancer cells in vivo. A decrease in MTDH and EZH2 expression
Mir-26 microRNA precursor family
Mir-26_microRNA_precursor_family
American geneticist
Alfredo J.; Lee, Jeannie T. (2016-12-15). "Destabilization of B2 RNA by EZH2 Activates the Stress Response". Cell. 167 (7): 1788–1802.e13. doi:10.1016/j
Jeannie_T._Lee
Pharmaceutical compound
SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis". Acta Pharmaceutica Sinica. B. 11 (3): 708–726. doi:10.1016/j
MDL-811
Field of study
and the polycomb group of proteins such as Bmi-1, the H3K27me3 transferase Ezh2, its demethylase JMJD3, and the H3K4me3 transferase MLL were shown to be
Epigenetics of diabetes type 2
Epigenetics_of_diabetes_type_2
Protein family
an associated with SET domain (AWS) EHMT1 (FP13812), EHMT2 (BAT8), EZH1, EZH2 MLL, MLL2, MLL3, MLL5 NSD1, NSD2, NSD3 PRDM1, PRDM2, PRDM5 SETD1A, SETD2
SET_domain
Protein-coding gene in the species Homo sapiens
C.V. & Carbone, G.M. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate
EHF_(gene)
Nonprofit consortium of bioscience researchers to openly share protein structure data
include PFI-1 and JQ1 for the BET family, UNC0642 for G9a/GLP, UNC1999 for EZH2/H1, LLY-283 and GSK591 for PRMT5, and OICR-9429 for WDR5. The WDR5 chemical
Structural Genomics Consortium
Structural_Genomics_Consortium
Protein-coding gene in the species Homo sapiens
histone methyltransferase activity and the silencing function of the EED-EZH2 complex". Molecular Cell. 15 (1): 57–67. doi:10.1016/j.molcel.2004.06.020
SUZ12
immunoprecipitation procedure with RNA sequencing. Using specific antibodies (α-Ezh2) they immunoprecipitated nuclear RNA isolated from mouse ES cells, and subsequently
RNA_immunoprecipitation_chip
Protein-coding gene in the species Homo sapiens
(November 2017). "Targeting glioma stem cells through combined BMI1 and EZH2 inhibition". Nature Medicine. 23 (11): 1352–1361. doi:10.1038/nm.4415. PMC 5679732
RNF144A
Human protein and coding gene
replication. VAV1 has been shown to interact with: ARHGDIB, Abl gene, Cbl gene EZH2, Grb2, JAK2, Ku70, LAT, LCP2, MAPK1, PIK3R1, PLCG1, PRKCQ, S100B, SHB, SIAH2
VAV1
Protein-coding gene in the species Homo sapiens
Otte AP, Rubin MA, Chinnaiyan AM (Oct 2002). "The polycomb group protein EZH2 is involved in progression of prostate cancer" (PDF). Nature. 419 (6907):
Alpha-methylacyl-CoA_racemase
Protein-coding gene in the species Homo sapiens
NKX3-1 was controlled by ERG and ESE3 both directly and through induction of EZH2 (Polycomb group pcg). Using a random cDNA sequencing approach, He et al.
NKX3-1
Professor of pathology, immunology, biology, and surgery
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nature immunology, doi:10.1038/ni.3313 (2016)
Weiping_Zou
Protein-coding gene in the species Homo sapiens
(2005). "Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer". J. Biol. Chem. 280 (23):
DAB2IP
Gene found in humans
Neubert TA, Reinberg D (December 2010). "Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA". Genes & Development
HOTAIR
Medical condition
oral medication tazemetostat (trade name Tazverik), a drug that blocks the EZH2 methyltransferase, for the treatment of epithelioid sarcoma in patients aged
Epithelioid_sarcoma
Protein-coding gene in the species Homo sapiens
complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner". J. Biol. Chem. 280 (2): 1199–208. doi:10
EPC1
Epigenetic modification of HSV genetic code
infections: inhibition of Ezh1/2 and m6A addition to viral mRNA. Ezh1 and Ezh2 (Ezh1/2) are two homologous enzymes of Ezh histone methyltransferase, and
HSV_epigenetics
Biological phenomenon
mutations have been found to promote PE inclusion in the epigenetic regulator EZH2, resulting in impaired hematopoietic differentiation. The TRA2B PE is essential
Poison_exon
GA-rich chromatin sites, acting as a molecular adaptor that guides PRC2/EZH2 to target genes such as those of the TGF-β pathway. MEG3 is involved in negative
MEG3
Family of proteins that play a role in chromatin remodeling
ortolog Bmi1 RYBP RING1 SUV39H1 (histone-lysine N-methyltransferase) L3mbtl2 EZH2 (Enhancer of Zeste Homolog 2) EED SUZ12 (Suppressor of Zeste 12) Jarid2 (jumonji
Polycomb-group_proteins
American biochemist (born 1954)
the formation of diseases, Kingston's discovery of direct interactions (Ezh2 subunit) and PRC2 cofactors (Gtl2 RNA) contributed to identifying the function
Robert_E._Kingston
DNA changes that regulate human traits
trimethylating histone 3 at lysine 27 through histone methyltransferases Ezh2 and Ezh1. PRC2 is recruited by many elements, including CpG islands. PRC1
Epigenetics of human development
Epigenetics_of_human_development
RNA family
the choice between neuronal and astrocyte differentiation by fine-tuning Ezh2 expression". The Journal of Biological Chemistry. 289 (30): 20788–20801.
Mir-124 microRNA precursor family
Mir-124_microRNA_precursor_family
disruption of the PRC2 complex, which includes the histone methyltransferase Ezh2, reduces the number of upper-layer neurons (those expressing markers such
Epigenetic regulation of neurogenesis
Epigenetic_regulation_of_neurogenesis
Novel human gene
cycle regulators, including CDCA7 and EZH2. The research also uncovered that ARMH1 physically interacts with EZH2, a protein implicated in multiple cancers
ARMH1
Class of enzymes
histone methyltransferase activity include: ASH1L DOT1L EHMT1, EHMT2, EZH1, EZH2 MLL, MLL2, MLL3, MLL4, MLL5 NSD1 PRDM2 SET, SETBP1, SETD1A, SETD1B, SETD2
Histone_methyltransferase
Australian scientist
prostate cancer progression". scholar.google.com.au. Retrieved 7 October 2023. "EZH2 inhibitors in immunotherapy of melanoma". scholar.google.com.au. Retrieved
Jessamy_Tiffen
RNA family
retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2". Proceedings of the National Academy of Sciences. 117 (1): 415–425. Bibcode:2020PNAS
Hovlinc
Protein-coding gene in humans
histone methyltransferase activity and the silencing function of the EED-EZH2 complex". Molecular Cell. 15 (1): 57–67. doi:10.1016/j.molcel.2004.06.020
AEBP2
Field of study
lead to another type of cancer. Trying to modify these proteins, such as EZH2, may give rise to other types of cancer. Selectivity is another hurdle in
Pharmacoepigenetics
Medical condition
Hacioglu S, Sari I, Bagci G, Keskin A (March 2016). "Mutational status of EZH2 and CD79B hot spots in mature B-cell non-Hodgkin's lymphomas: novel CD79B
Intravascular_lymphomas
American surgeon
DS; Gudas, LJ (2005). "Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder". Clinical Cancer Research
Douglas_Scherr
American geneticist
Yi-Jang; Zhang, Haikuo; Marquez, Victor E.; Hammerman, Peter S. (2015-04-09). "EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors"
Carla_F._Kim
Enzyme found in humans
shown to interact with PPP1CA, Histone deacetylase 2, SF3B1 EED and the EZH2 domain of PRC2. GRCh38: Ensembl release 89: ENSG00000117751 – Ensembl, May
PPP1R8
Long non-coding RNA from the antisense strand in homeobox A
interaction with EZH2. Additionally, current research has found that HOXA11-AS interacts with miR-1297 and blocks its ability to repress EZH2 protein translation
HOXA11-AS1
American cancer scientist
Sebastian; Brunner, Marius; Gaedcke, Jochen; Ströbel, Philipp (2020-11-01). "EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional
Steven_A._Johnsen
South Korean molecular geneticist (born 1970)
Noh, Dong-Young; Kim, Keun Il; Kim, Kyeong Kyu; Baek, Sung Hee (2012). "EZH2 Generates a Methyl Degron that is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin
Baek_Sung-hee
RNA family
in cancer cells, has been shown to be one target of miR-138. VIM, ZEB2, EZH2 and head and neck cancers Downregulation of miR-138 has been reported in
MiR-138
Protein-coding gene in humans
CTBP1, DDX17, DDX5, DNMT3A, DNMT3L, Death-associated protein 6, EED, EVI1, EZH2, FKBP3, GATA1, HMG20B, HSPA4, HUS1, Histone deacetylase 2, Homeobox protein
HDAC1
non-coding RNA 00152 promotes tumor cell cycle progression by binding to EZH2 and repressing p15 and p21 in gastric cancer". Oncotarget. 7 (9): 9773–87
Cytoskeleton_regulator_RNA
travel, tourism, insurance
EZH2
EZH2
EZH2
EZH2
EZH2
EZH2
EZH2
EZH2
EZH2
travel, tourism, insurance