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MEG3

MEG3

MEG3 (maternally expressed 3) is a maternally expressed, imprinted long non-coding RNA gene. At least 12 different isoforms of MEG3 are generated by alternative

MEG3

Alzheimer's disease

Progressive neurodegenerative disease

Thrupp N, Craessaerts K, Snellinx A, Serneels L, et al. (15 September 2023). "MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease"

Alzheimer's disease

Alzheimer's_disease

Necroptosis

Necrotic cell death regulated by intracellular signaling, exerted by activated MLKL

also been implicated in Alzheimer's disease triggered by the production of MEG3 in the brain cells. In solid-organ transplantation, ischemia-reperfusion

Necroptosis

Long non-coding RNA

Non-protein coding transcripts longer than 200 nucleotides

cases even in complexes with small molecule modulators. For instance, lncRNA MEG3 was shown to regulate transcription factor p53 thanks to its compact structured

Long non-coding RNA

Long_non-coding_RNA

Kagami–Ogata syndrome

Medical condition

which mutation can cause KOS are located on 14q32.2 and these genes are: MEG3, RTL1, MEG8. Diagnosis can be suspected by facial features and by coat-hanger

Kagami–Ogata syndrome

Kagami–Ogata_syndrome

List of taxa that use parthenogenesis

targeting, they were able to manipulate two imprinted loci H19/IGF2 and DLK1/MEG3 to produce bi-maternal mice at high frequency and subsequently show that

List of taxa that use parthenogenesis

List_of_taxa_that_use_parthenogenesis

Gestational choriocarcinoma

Malignant trophoblastic tumour arising from gestation

adenocarcinoma transcript 1 (MALAT1), H19, maternally expressed gene 3 (MEG3), prostate cancer antigen 3 (PCA3), the long intergenic non-coding RNA 00261

Gestational choriocarcinoma

Gestational_choriocarcinoma

Thomas Thum

German cardiologist and entrepreneur

T; et al. (2017), "Inhibition of the Cardiac Fibroblast-Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic Dysfunction", Circulation Research

Thomas Thum

Thomas_Thum

Polar overdominance

adipogenesis, or more simply the formation of fat cells. Imprinting (genetics) MEG3 - a gene occasionally expressed through polar overdominance Wermter, Anne-Kathrin;

Polar overdominance

Polar_overdominance

Epigenetic therapy

Use of epigenome-influencing techniques to treat medical conditions

arteries, has been associated with the hypermethylation of GNASAS, IL-10, MEG3, ABCA1, and the hypomethylation of INSIGF and IGF2. Additionally, upregulation

Epigenetic therapy

Epigenetic_therapy

Cluster of Excellence Frankfurt Macromolecular Complexes

modulate target gene expression with local and temporal precision. LncRNA Meg3 was found to control endothelial cell aging and its inhibition may serve

Cluster of Excellence Frankfurt Macromolecular Complexes

Cluster_of_Excellence_Frankfurt_Macromolecular_Complexes