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Protein complex
PRC2 (polycomb repressive complex 2) is one of the two classes of polycomb-group proteins or (PcG). The other component of this group of proteins is PRC1
PRC2
Family of proteins that play a role in chromatin remodeling
three kinds of multiprotein complex Polycomb Repressive Complex 1 (PRC1), PRC2 and PhoRC. These complexes work together to carry out their repressive effect
Polycomb-group_proteins
Protein-coding gene in the species Homo sapiens
the functional enzymatic component of the Polycomb Repressive Complex 2 (PRC2), which is responsible for healthy embryonic development through the epigenetic
EZH2
Protein
vertebrate development, SLUG partners with the Polycomb repressive complex 2 (PRC2) to regulate the formation and migration of neural crest cells, a group of
SNAI2
Transformation of a stem cell to a more specialized cell
differentiate efficiently into the three germ layers, and deletion of the PRC1 and PRC2 genes leads to increased expression of lineage-affiliated genes and unscheduled
Cellular_differentiation
being PRC2. Polycomb-group proteins play a major role in transcriptional regulation during development. Polycomb Repressive Complexes PRC1 and PRC2 function
Polycomb_repressive_complex_1
Investigational antineoplastic drug
EZH1, which are key components of the polycomb repressive complex 2 (PRC2). PRC2 plays a critical role in gene silencing and is implicated in cancer progression
Tulmimetostat
DNA changes that regulate human traits
as PRC1 and PRC2. PRC2 complexes repress by trimethylating histone 3 at lysine 27 through histone methyltransferases Ezh2 and Ezh1. PRC2 is recruited
Epigenetics of human development
Epigenetics_of_human_development
Gene found in humans
Repressive Complex 2 (PRC2) and as a result regulates chromatin state. It is required for gene-silencing of the HOXD locus by PRC2. PRC2 is dispensable for
HOTAIR
Topics referred to by the same term
singer, songwriter, and internet personality Polycomb repressive complex 2 or PRC2, a protein AN/PRC, for "Army/Navy, Portable, Radio, Communication", e.g.
PRC_(disambiguation)
Induction of a plant's flowering process
act cooperatively to facilitate this loop by recruiting and retaining the PRC2 complex at the locus. This intragenic loop is gradually enhanced during prolonged
Vernalization
Protein-coding gene in humans
Repression Complex 2 (PRC2). AEBP2 is a DNA-binding transcriptional repressor. It may interact with and stimulate the activity of the PRC2 complex. AEBP2 may
AEBP2
Species of snake
Q2934219 Wikispecies: Calliophis gracilis ADW: Calliophis_gracilis CoL: PRC2 GBIF: 5227107 iNaturalist: 30424 IRMNG: 10369432 ITIS: 1057648 IUCN: 191998
Calliophis_gracilis
Cancer of plasma cells
by dysregulation of the polycomb repressive complex 2 (PRC2). Increased expression of the PRC2 subunit, EZH2 have been described to be a common feature
Multiple_myeloma
Protein family around which DNA winds to form nucleosomes
recruited through the action of PRC2, however, recent studies show that PRC1 is recruited to the same sites in the absence of PRC2. Di and tri-methylation of
Histone
Epigenitic modification to the protein histone H3
methylation and chromodomain interactions. A polycomb repressive complex (PRC); PRC2, mediates the tri-methylation of histone 3 on lysine 27 through histone methyl
H3K27me3
Compact and highly condensed form of chromatin
allosteric activation of PRC2 and long-range 3D spreading on chromatin. There are two types of PRC proteins: PRC1 and PRC2. Among PRC1, there are variant
Heterochromatin
Inactivation of copies of X chromosome
methylation mark which is placed by the PRC2 complex recruited by Xist, all of which are associated with gene silencing. PRC2 regulates chromatin compaction and
X-inactivation
Protein-coding gene in the species Homo sapiens
transcriptional repression, and recruitment of Polycomb-repressive complex 2 (PRC2). Intracellular mechanisms underlying these interactions remain largely unknown
JARID2
Stationery item used for flat mail
Suitable content format PRC1 Chinese #1 Envelope 102 × 165 4 × 6+1⁄2 ϕ∶1 PRC2 Chinese #2 Envelope 102 × 176 4 × 6+11⁄12 1.73 PRC3, ISO B6 Chinese #3 Envelope
Envelope
Single stranded RNA
inactivation. Xist, an asRNA, can recruit polycomb repressive complex 2 (PRC2) which results in heterochromatinization of the X chromosome. Antisense RNAs
Antisense_RNA
Form taken by the inactive X chromosome in a female somatic cell
histone modifications, such as histone H3 methylation (i.e. H3K27me3 by PRC2 which is recruited by Xist) and histone H2A ubiquitination, as well as direct
Barr_body
instability of imprinted genes during tumorigenesis, potential roles of AEBP2 as a PRC2 targeting protein and in neural crest cell development, as well as the DNA
Joomyeong_Kim
Non-coding RNA
a component of the PRC2 and contains a zinc finger domain. The zinc finger domain is believed to bind to the RNA molecule. The PRC2 has been observed to
XIST
Rare genetic overgrowth disorder
associated with human overgrowth. It encodes the catalytic component of the PRC2 protein complex (Polycomb Repressive Complex 2), which regulates chromatin
Weaver_syndrome
Sex chromosome present in both sexes in the XY and X0 sex-determination systems
Heterochromatin compaction is regulated by Polycomb Repressive Complex 2 (PRC2). The following are some of the gene count estimates of human X chromosome
X_chromosome
Investigational anticancer drug
that targets EZH2, the catalytic subunit of polycomb repressive complex 2 (PRC2). EZH2 plays a crucial role in epigenetic regulation by modifying gene expression
Mevrometostat
Non-protein coding transcripts longer than 200 nucleotides
the PRC2 complex to guide gene silencing in several malignancies. In MM, the long ncRNA PVT1 interacts with EZH2, the catalytic subunit of PRC2, to guide
Long_non-coding_RNA
Second subphase of interphase
accurate re-establishment of chromatin domains. Polycomb Repressive Complex 2 (PRC2) and several other histone-modifying complexes can "copy" modifications present
S_phase
Anatomical process in plants to produce flowers
post-transcriptionally. The temporal gate is set by the chromatin regulators PRC2, LHP1, and the opposing Trithorax group, keeping the program off until the
Flower_differentiation
Chromosome that differs from an ordinary autosome in form, size, and behavior
DNA and prevents expression of most genes. This compaction is regulated by PRC2 (Polycomb Repressive Complex 2). All diploid organisms with allosome-determined
Sex_chromosome
Rare disorder linked to overgrowth and is characterized by dysmorphic facial features
H3K27me3 in comparison to wild type. This decrease was linked to loss of PRC2 activity. The individuals clinical history or their past health examinations
Cohen–Gibson_syndrome
Group of genes
cluster and inhibits late HOXD genes) by binding to Polycomb-group proteins (PRC2). The chromatin structure is essential for transcription but it also requires
Hox_gene
Collection of microscopic DNA spots attached to a solid surface
modifications (H3K27me3, H3K4me2, H3K9me3, etc.), Polycomb-group protein (PRC2:Suz12, PRC1:YY1) and trithorax-group protein (Ash1) to study the epigenetic
DNA_microarray
Chinese-American biochemist
the H3K79 methyltransferase Dot1L, and the H3K27me3 methyltransferase EZH2/PRC2. He went on to demonstrate the function of H3K27me3 methylation in X chromosome
Yi_Zhang_(biochemist)
Post-translational carbohydrate modification of proteins
EZH2, the catalytic methyltransferase subunit of PRC2, and is thought to stabilize EZH2 prior to PRC2 complex formation and regulate di- and tri-methyltransferase
O-GlcNAc
Protein-coding gene in the species Homo sapiens
ubiquitination of Lys119 on histone H2A, which then leads to recruitment of PRC2 and H3K27me3 to effectively initiate a polycomb domain and mediate gene repression
PCGF1
Protein domain
as an adaptor to recruit components of the Polycomb repressive complex 2 (PRC2), a histone H3K27 methyltransferase that represses transcription. Additionally
Tudor_domain
embryogenesis. PRC2 then catalyzes the gene's methylation, inducing PCR2 recruitment and compacting the chromatin. The research found that PRC2 recruitment
Cellular_memory_modules
Non-coding RNA in the species Homo sapiens
transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of
FENDRR
Protein-coding gene in the species Homo sapiens
colon cancer. It's predicted to be a nuclear protein. It may interact with PRC2. SKIDA1 has orthologs in vertebrate species. The species least related to
SKIDA1
Mammalian protein found in humans
modification through methylation and repression of the promoter region. PRC1 and PRC2 are two protein complexes that modify the expression of p16 through the interaction
P16
dimethylation of histone 3 lysine 9, H3K9), and the Polycomb Repressive Complex 2, PRC2, (responsible for the trimethylation of H3K27). It plays an important role
KCNQ1OT1
Type of stable macromolecular complex
S. cerevisiae gene RIX1. The rixosome is associated with human PRC1 and PRC2 complexes. The interaction with PRC1 appears to be through the RING1B domain
Rixosome
Spanish-American biophysicist
transcription and translation initiation complexes, the polycomb complex PRC2, and telomerase. Nogales, Eva; Whittaker, Michael; Milligan, Ronald A.; Downing
Eva_Nogales
Blood marrow cancer originating in megakaryoblast cells
gene for microRNA MiR125B2CTCF, STAG2, RAD21, SMC3, SMC1A, NIPBL, SUZ12, PRC2, JAK1, JAK2, JAK3, MPL, KRAS, NRAS, and SH2B3. At least one but probably
Acute megakaryoblastic leukemia
Acute_megakaryoblastic_leukemia
Type of DNA sequence
the ability of hematopoietic cells to self-renew. Likewise, mutations in PRC2 genes were related to hematological conditions such as acute lymphoblastic
Silencer_(genetics)
Protein-coding gene in the species Homo sapiens
p38-MAPK, AKT3 and cyclin A/CDK2 and by protein co-factors, which include PRC2, Histone Deacetylases 1, 2, 3 and 5 and CAPERα. There is also evidence that
TBX3
Canadian geneticist
Klose, Rob (2014). "Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation". Cell. 157 (6): 1445–59. doi:10
Rob_Klose
German neuroscientist
Schaefer in 2011, they discovered that the polycomb repressive complex 2 (PRC2), which mediates repressive chromatin modifications, is actively repressing
Anne_Schaefer_(scientist)
Gene locus
transcript (Nespas: neuroendocrine secretory protein antisense) Binds to the PRC2 complex. Abolition of expression causes abnormal methylation and imprinting
GNAS_complex_locus
American biochemist (born 1954)
develop a RIP-sequence method to capture the Polycomb repressive complex 2 (PRC2) transcriptome in embryonic stem cells. Noting that Polycomb proteins factor
Robert_E._Kingston
Swiss chemist and molecular biologist
also helped elucidating key steps in gene repression via heterochromatin or PRC2. These methodologies can also be applied for the study of DNA sensors such
Beat_Fierz
Protein-coding gene in the species Homo sapiens
replicative senescence by recruiting polycomb-repressive complexes (PRC1 and PRC2) to the promoters at the p16Ink4a locus. The increased accumulation of intracellular
Jun_dimerization_protein_2
Non-coding RNA in humans
M, Xiong Y (April 2011). "Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene". Oncogene
CDKN2BAS
Physiological process in the plant
5 (VRN5) to form a complex that guides the Polycomb Repressive Complex 2 PRC2 to modify the chromatin structure surrounding the FLC gene, leaving repressive
Flower_induction
Control of DNA to RNA conversion in cells
polymerase on open DNA. For example, H3K27 trimethylation by the polycomb complex PRC2 causes chromosomal compaction and gene silencing. These histone modifications
Transcriptional_regulation
study conducted in 2020 revealed that the Polycomb repressive complex 2 (PRC2), which deposits H3K27me3, silences genes involved in differentiation, such
Epigenetic regulation of neurogenesis
Epigenetic_regulation_of_neurogenesis
Human protein-coding gene
protein histone H3 lead to inactivation of polycomb repressive complex 2 (PRC2) methyltransferase and result in global hypomethylation of H3K27me3 and transcriptional
Platelet-derived growth factor receptor A
Platelet-derived_growth_factor_receptor_A
Epigenetic modification of HSV genetic code
histone methyltransferase, and are part of the Polycomb repression complex 2 (PRC2), which functions to repress gene transcription by propagating a H3K27 trimethylation
HSV_epigenetics
Protein-coding gene in the species Homo sapiens
shown to interact with PRC1. TRIM37 has also been shown to interact with PRC2 to alter its specificity, and when TRIM37 is overexpressed, there are many
TRIM37
regulation involves epigenetic control and multiple transcription factors. PRC1, PRC2, YY1, and Id1 play a role in the suppression of p16INK4A expression and transcription
INK4
Overview article
paper that 2i ESCs gained primed-like qualities after removing a functional PRC2 complex, which rendered H3K27me3 useless. Leukemia inhibitory factor (LIF)
Epigenetics in stem-cell differentiation
Epigenetics_in_stem-cell_differentiation
Protein-coding gene in the species Homo sapiens
not yet been determined. SUZ12, as part of Polycomb Repressive Complex 2 (PRC2), may be involved with chromatin silencing in conjunction with HOTAIR ncRNA
SUZ12
Protein-coding gene in the species Homo sapiens
breast cancer. EZH2 is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2) which catalyzes methylation of histone H3 at lysine 27 (H3K27me) and mediates
XRCC3
Australian epigeneticist
Metcalf D, Alexander WS, Hilton DJ (2008). "Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity". PLOS Biol. 6 (4): e93. doi:10
Marnie_Blewitt
Long non-coding RNA from the antisense strand in homeobox A
Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1". Cancer Research. 76 (21): 6299–6310. doi:10.1158/0008-5472
HOXA11-AS1
Medical condition
gene for microRNA MiR125B2CTCF, STAG2, RAD21, SMC3, SMC1A, NIPBL, SUZ12, PRC2, JAK1, JAK2, JAK3, MPL, KRAS, NRAS, and SH2B3. The development and progression
Transient myeloproliferative disease
Transient_myeloproliferative_disease
Mammalian protein found in Homo sapiens
genes, and is associated with various transcriptional repressors, especially PRC2 complex, suggesting diverse modes of action. TET1 may play a role in memory
Tet methylcytosine dioxygenase 1
Tet_methylcytosine_dioxygenase_1
Field of study in cancer research
Ewing's sarcoma, and osteosarcoma, and expression of the EZH2 component of the PRC2 complex is altered in Ewing's sarcoma and rhabdomyosarcoma. Similarly, expression
Cancer_epigenetics
Protein-coding gene in the species Homo sapiens
chromodomain of the CBX subunit that recognizes the H3K27me3 mark deposited by PRC2. Canonical PRC1 complexes have been shown to compact chromatin and mediate
PCGF2
Protein-coding gene in humans
ERG, DYRK1A, CHAF1B, HLCS, CTCF, STAG2, RAD21, SMC3, SMC1A, NIPBL, SUZ12, PRC2, JAK1, JAK2, JAK3, MPL, KRAS, NRAS, SH2B3, and MIR125B2 which is the gene
GATA1
Protein-coding gene in the species Homo sapiens
protein. EZH2 is the catalytic subunit of polycomb repressive complex 2 (PRC2) which catalyzes methylation of histone H3 at lysine 27 (H3K27me) and mediates
RAD51C
Protein-coding gene in the species Homo sapiens
Marquez VE, Ishikawa Y, Ichinose M, Aburatani H (2013-05-29). "PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small
C16orf82
Human gene
Marquez VE, Ishikawa Y, Ichinose M, Aburatani H (2013-05-29). "PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small
C3orf67
Chromatin remodeling complex
repressive complexes, expanding the domain of H3K27me3 domains by allowing PRC2 to spread H3K27me3 at promoters where there are differentiation genes. This
Mammalian SWI/SNF (BAF) complex
Mammalian_SWI/SNF_(BAF)_complex
Protein-coding gene in the species Homo sapiens
breast cancer. EZH2 is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2) which catalyzes methylation of histone H3 at lysine 27 (H3K27me) and mediates
XRCC2
American research scientist
H3K27me was a determinant of epigenetic memory, and that PRE-associated PRC2 propagates the mark as a requirement for perpetuating the memory. In further
Gary_Struhl
Enzyme found in humans
interact with PPP1CA, Histone deacetylase 2, SF3B1 EED and the EZH2 domain of PRC2. GRCh38: Ensembl release 89: ENSG00000117751 – Ensembl, May 2017 GRCm38:
PPP1R8
PRC2
PRC2
PRC2
PRC2
Boy/Male
Indian, Telugu
Memorable Things
Boy/Male
Gujarati, Indian
Kingdom of Friends
Girl/Female
Muslim/Islamic
Lavender
Surname or Lastname
Reduced form of the Dutch surname van Galen, a habitational name, probably from Gaal in the province of North Brabant, or perhaps from the German town of Gahlen in North Rhine-Westphalia.English
Reduced form of the Dutch surname van Galen, a habitational name, probably from Gaal in the province of North Brabant, or perhaps from the German town of Gahlen in North Rhine-Westphalia.English : variant of Galyon.
Girl/Female
Latin
Of the sea.and Mary.
Girl/Female
Tamil
Lightning
Girl/Female
Hindu, Indian
People who Give
Boy/Male
Arabic, Indian, Iranian, Muslim, Parsi, Punjabi, Sikh
Famous
Boy/Male
American, Australian, British, Chinese, Christian, Danish, Dutch, English, French, German, Greek, Netherlands, Swedish
Defender of Man; Man's Defender
Girl/Female
Hindu, Indian
Daughter
PRC2
PRC2
PRC2
PRC2
PRC2