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Biological phenomenon
Poison exons (PEs); also called premature termination codon (PTC) exons or nonsense-mediated decay (NMD) exons are a class of cassette exons that contain
Poison_exon
Region of a transcribed gene present in the final functional mRNA molecule
sources. DBASS3/5 Exitron Exon-intron database Exon shuffling Interrupted gene Outron Twintron Untranslated region (UTR) Poison exon Gilbert W (February 1978)
Exon
Form of RNA splicing used to cause cells to "skip" over faulty sections of genetic code
causes these exons to be skipped could be used to treat up to 50% of DMD patients. Antisense therapy Poison exon Wahl M (1 October 2011). "Exon Skipping in
Exon_skipping
into protein by selecting for poison exons during alternative splicing. SR proteins can alternatively splice poison exons into their own mRNA transcripts
SR_protein
Protein-coding gene in the species Homo sapiens
itself regulated by alternative splicing via inclusion a highly conserved poison exon. GRCh38: Ensembl release 89: ENSG00000119953 – Ensembl, May 2017 GRCm38:
Survival motor neuron domain containing 1
Survival_motor_neuron_domain_containing_1
Protein-coding gene in the species Homo sapiens
TRA2B gene. TRA2B contains a poison exon whose inclusion is autoregulated by TRA2B protein. Proper regulation of poison exon inclusion in TRA2B is important
TRA2B
Inherited neurodegenerative disorder
CRISPR/Cas9. PTC Therapeutics is evaluating small molecules that induce poison exon inclusion in HTT transcript as a therapeutic strategy to lower HTT expression
Huntington's_disease
Genetic form of epilepsy
increase the level of productive SCN1A mRNA by preventing inclusion of a poison exon and consequently increase the expression of sodium channel gene SCN1A
Dravet_syndrome
Protein-coding gene in the species Homo sapiens
encoding different isoforms, have been characterized. RBM3 contains a poison exon whose inclusion is lowered during hypothermia. This gene is a member
RBM3
Protein-coding gene in the species Homo sapiens
splicing of exon 5 gives rise to two alternate exons. SCN1A contains a poison exon within intron 20. The promoter has been identified 2.5 kilobase pairs
SCN1A
Protein-coding gene in the species Homo sapiens
transcript may be alternatively spliced to incorporate a poison exon between exons 5 and 6 or between exons 5b and 6. This gene product is a nuclear-encoded mitochondrial
Dynamin-like_120_kDa_protein
Fictional dimension in the DC Universe
the planet Exon. Years later, Erndine and Xadu, who had since married and acquired the secret of the cosmic power-grip, escaped from Exon and returned
Phantom_Zone
Small domesticated carnivorous mammal
color variety in the coat. The feline ASIP gene consists of three coding exons. Three novel microsatellite markers linked to ASIP were isolated from a
Cat
Opioid used to treat pain and opioid use disorder
receptor. Full analgesic efficacy of buprenorphine requires both exon 11- and exon 1-associated μ-opioid receptor splice variants. The active metabolites
Buprenorphine
Species of fruit fly
will have the fourth exon removed and be translated up to and including exon 6 (DSX-M[ale]), while in its presence the fourth exon which encodes a stop
Drosophila_melanogaster
Paraphyletic group of birds
and classification of the Accipitridae based on DNA sequences of the RAG-1 exon". Journal of Avian Biology. 38 (5): 587–602. doi:10.1111/j.2007.0908-8857
Bird_of_prey
existence to remain. Unlike an intron of history, I will be remembered as an exon. That will be my legacy; my mark on history. But the Patriots would deny
Characters of the Metal Gear series
Characters_of_the_Metal_Gear_series
Species of bird
(from the early 1800s to around World War II) followed by inadvertent poisoning and epidemics of nesting failure due to chemical pesticides and organic
White-tailed_eagle
Species of bear
T1R1 and T1R3), resulting from two frameshift mutations within the T1R1 exons. Umami taste corresponds to high levels of glutamate as found in meat and
Giant_panda
Japanese thoroughbred race
2000: Macky Laurel 2001: Road Bakushin 2002: Setono Ultra 2003: Meiner Exon 2004: Rugger Hitoritabi 2005: Great Stage 2006: Chance Torai 2007: Yukino Arashi
Kikusui_Sho
Most widespread New World vulture
and classification of the Accipitridae based on DNA sequences of the RAG-1 exon". Journal of Avian Biology. 38 (5): 587–602. doi:10.1111/j.2007.0908-8857
Turkey_vulture
Organism belonging to kingdom Fungi
contain DNA with noncoding regions called introns and coding regions called exons. Fungi have membrane-bound cytoplasmic organelles such as mitochondria,
Fungus
Selective breeding of plants and animals to serve humans
is derived from an ancestral rice domesticate that suffered a deletion in exon 7 which altered the coding for betaine aldehyde dehydrogenase (BADH2). Comparison
Domestication
US federal law on website liability
James Exon (D-NE). People in a grassroots effort in the tech industry reacted to try to convince the House of Representatives to challenge Exon's bill
Section_230
Protein-coding gene in the species Homo sapiens
the mutant pre-mRNA by exon skipping and/or spliceosome-mediated RNA trans-splicing (SMaRT) have been evaluated for MYBPC3. Exon skipping can be achieved
Myosin binding protein C, cardiac
Myosin_binding_protein_C,_cardiac
Medical condition
cells, by polymerase chain reaction (PCR) amplification of all 24 MAN2B1 exons, followed by DNA sequencing. There is no cure for congenital alpha-mannosidosis
Alpha-mannosidosis
Medical condition
protoporphyrinogen IX. CPOX is located at 3q11.2-q12.1, has 6 introns and 7 exons and produces an mRNA strand that is 2675 bases in length. It is inherited
Hereditary_coproporphyria
Budagov T, Fradin D, Durda P, Liu B, et al. (June 2017). "The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated
Timeline_of_aging_research
Risk factors related to schizophrenia
from seven European populations examined CNVs in neurexins, and found that exon-affecting deletions in the NRXN1 gene conferred risk of schizophrenia. An
Risk_factors_of_schizophrenia
Linguistic component of Ancient Greek
if the verb is an impersonal one, it is put in the accusative, e.g. ἔξον (éxon) "it being possible". Sometimes a participle is used with the article, in
Ancient_Greek_verbs
1979. p. 14. Hignett, Kelly (12 September 2011). "The Curious Case Of The Poisoned Umbrella: The Death Of Georgi Markov". Sofia News Agency. Archived from
List of unsolved murders in the United Kingdom (1970s)
List_of_unsolved_murders_in_the_United_Kingdom_(1970s)
Transmembrane protein family
subunits from each gene. The flip/flop sequence is one such interchangeable exon. A 38-amino acid sequence found prior to (i.e., before the N-terminus of)
AMPA_receptor
Xq22.2 on the plus strand, approximately 30,000 bases, and encodes six exons. The gene is located next to an enhancer called LOC130068517, also known
FAM199X
Subtype of serotonin receptor
events, including utilization of alternative splice acceptor sites, exon skipping, rare exon usage, and intron retention. There are a few mechanisms of regulation
5-HT2A_receptor
Human gene
NM_001145191.2, which spans approximately 4.3 kb and consists of two exons with the second exon (bases 76–4287) comprising nearly the entire coding sequence.
ZBED11
College football game
played in the last fifteen years." State governors David Hall and J. James Exon both attended, and bet a hundred pounds of Oklahoma peanuts against a hundred
1971 Nebraska vs. Oklahoma football game
1971_Nebraska_vs._Oklahoma_football_game
of peasant women consisted of free landholders. Early records such as the Exon Domesday and Little Domesday attested that, among English land-owners, 10–14%
Women_in_the_Middle_Ages
Inherited disorder of bone growth
located on chromosome 19p13.1; its precise locus is P49747. COMP contains 19 exons. The cartilage oligomeric matrix protein is 757 aa (OMIM 2008). COMP protein
Pseudoachondroplasia
Protein found in humans
Powell JF, Leigh PN, Andersen P, Shaw CE (2001). "Intron 7 retention and exon 9 skipping EAAT2 mRNA variants are not associated with amyotrophic lateral
Excitatory amino acid transporter 2
Excitatory_amino_acid_transporter_2
Human disease caused by deficiency of a muscle enzyme
recessive heterozygous alleles in the PYGM gene, where one allele is a common exon mutation and the other allele is an ultra-rare intronic mutation. It can
Glycogen storage disease type V
Glycogen_storage_disease_type_V
Protein family
erythropoietic protoporphyria: an aberrant ferrochelatase mRNA caused by exon skipping during RNA splicing". Biochimica et Biophysica Acta (BBA) - Molecular
Ferrochelatase
Medical condition
been found to mostly cluster in intron 4 and exon 4 and 5, but were also located in intron 3, and exon 2 and 3. Some mutation variants have been found
Cyclic_neutropenia
the following day, but two of the four men aboard die of carbon dioxide poisoning. June 21 – The Supreme Court of the U.S. delivers its decision in the
1973_in_the_United_States
Small raptor found in Australia
and classification of the Accipitridae based on DNA sequences of the RAG-1 exon". Journal of Avian Biology. 38 (5): 587–602. doi:10.1111/j.2007.0908-8857
Black-shouldered_kite
corresponding sequence in RNA transcripts. Contrast exon. intron-mediated recombination See exon shuffling. intronic gene A gene whose DNA sequence is
Glossary of cellular and molecular biology (0–L)
Glossary_of_cellular_and_molecular_biology_(0–L)
Investigation building under construction in Omaha, Nebraska, as the "J. James Exon Federal Bureau of Investigation Building". Pub. L. 110–335 (text) (PDF) October
List of acts of the 110th United States Congress
List_of_acts_of_the_110th_United_States_Congress
1970 American university course
Norbert Tiemann said he opposed the class and Democratic challenger J. James Exon said it was unnecessary. Senator Terry Carpenter of Scottsbluff strongly
Proseminar in Homophile Studies
Proseminar_in_Homophile_Studies
Joel Gascoyne; I. Harris sculp[sit]. London: Sold by I. Thornton [et al.]; Exon: by Chas. Ye, Bookseller; Plimouth: by Fr. Hill, Grocer; Lanceston: by Cha
Timeline_of_Cornish_history
Australian sportsman and politician (1921–2011)
appointment; on past tours, many players had fallen seriously ill, suffered food poisoning, and found the oppressive heat and third world living conditions hard
Sam_Loxton
Mitochondrial enzyme involved in amino acid metabolism
they lack a TATA box. The GOT2 gene is also located on 16q21 and has an exon count of 10. In order to produce the energy needed for everyday activities
GOT2
Protein-coding gene in the species Homo sapiens
gene spans the chromosomal locus from 62,662,817-62,665,210. There are 4 exons. It spans across 2,394 base pairs of DNA and produces an mRNA that is 646
C11orf98
Medical condition
Baylor-Hopkins Center for Mendelian Genomics, Gibbs RA, Lupski JR (2017) REST Final-Exon-Truncating Mutations Cause Hereditary Gingival Fibromatosis. Am J Hum Genet
Hereditary gingival fibromatosis
Hereditary_gingival_fibromatosis
C2orf70, is located on the positive-sense strand of locus 2p23.3. It has 9 exons, however due to overlap only 4 are distinguishable in the human genome.
CIMIP2C
Human protein
for the gene include LDOC1L, MAR6, MART6, and SIRH3. RTL6 is made up of 2 exons and is encoded by 5556 base pairs of DNA . RTL6 is a retrotransposon GAG
RTL6
Human gene
protein 7 (LEP7), XP32, Skin-Specific Protein (Xp32). This gene has only 1 exon, and no introns. It is a part of the epidermal differentiation complex (1q21)
KPLCE
spans from 31968151 to 32003387. It is 1740 base pairs long and contains 3 exons with no known isoforms. Several other genes are near the XKR7 gene along
XKR7
travel, tourism, insurance
POISON EXON
POISON EXON
Girl/Female
Biblical
Changing, extension of the mouth.
Surname or Lastname
English, Scottish, and French
English, Scottish, and French : nickname for an intelligent person, from Middle English, Old French raison ‘reasoning’, ‘intellectual faculty’ (Latin ratio, genitive rationis).
Surname or Lastname
English
English : from Middle English persone, parsoun ‘parish priest’, ‘parson’ (Old French persone, from Latin persona ‘person’, ‘character’), hence a status name for a parish priest or perhaps a nickname for a devout man. The reasons for the semantic shift from ‘person’ to ‘priest’ are not certain; the most plausible explanation is that the local priest was regarded as the representative person of the parish. The phonetic change from -er- to -ar- was a regular development in Middle English.Americanized form of one or more like-sounding Jewish names.Americanized spelling of Swedish Pärsson, Persson (see Persson).
Male
English
Variant spelling of English unisex Addison, ADISON means "son of Adam."
Female
English
 Norman French form of Old High German Adalheid, ALISON means "noble sort." In use by the English and Scottish. Compare with another form of Alison.
Surname or Lastname
English
English : variant of Hobson.
Male
English
English surname transferred to forename use, EDISON means "son of Eda."
Surname or Lastname
English
English : topographic name for someone who lived by a postern gate, from Old French posterne; in some cases it would have been a metonymic occupational name for a gatekeeper.English : habitational name from Poston in Herefordshire or Poston in Shropshire, which is named with an Old English personal name Possa + þorn ‘thorn tree’.
Surname or Lastname
English
English : unexplained.
Surname or Lastname
English (Midlands)
English (Midlands) : habitational name from Pointon in Lincolnshire, Poynton in Cheshire, or Poynton Green in Shropshire. The first is named from Old English Pohhingtūn ‘settlement (Old English tūn) associated with Pohha’, a byname apparently meaning ‘bag’; the others have as the first element the Old English personal names Pofa and Pēofa respectively.
Biblical
changing; extension of the mouth
Surname or Lastname
English
English : patronymic or metronymic from Eade.The inventor Thomas Alva Edison, born in 1847 in Milan, OH, came from a Canadian family first established in North America by John Edison, a loyalist during the American Revolution, who served under the British General Richard Howe and went into exile in Nova Scotia after the Revolutionary War.
Surname or Lastname
English
English : possibly a variant of Godson (see Goodson) or a patronymic from the personal name Gotte (see Gott).
Surname or Lastname
Scottish and northern Irish
Scottish and northern Irish : variant of Curzon.English (of Norman origin) : nickname from Old French corson, a diminutive of curt ‘short’ (see Court).
Female
Welsh
 Diminutive form of Welsh Alis, ALISON means "noble sort." Compare with another form of Alison.
Surname or Lastname
English and French
English and French : from Old French pinson ‘finch’, perhaps a nickname applied to a bright and cheerful person.English and French : metonymic occupational name for someone who made pincers or forceps or who used them in their work, from Old French pinson ‘pincers’ (a derivative of pincier ‘to pinch’).
Male
Greek
(Φίλων) Greek name derived from the word phileo, PHILON means "to love."
Surname or Lastname
English
English : patronymic from Penn 3 or Paine 1.English : habitational name from Penson in Devon.
Surname or Lastname
English
English : apparently a variant spelling of Lewison.
Female
Scottish
 Norman French form of Old High German Adalheid, ALISON means "noble sort." In use by the English and Scottish.
POISON EXON
POISON EXON
POISON EXON
POISON EXON
POISON EXON
POISON EXON
POISON EXON
n.
See Foison.
n.
To put poison upon or into; to infect with poison; as, to poison an arrow; to poison food or drink.
v. i.
To act as, or convey, a poison.
n.
A human being spoken of indefinitely; one; a man; as, any person present.
n.
That which taints or destroys moral purity or health; as, the poison of evil example; the poison of sin.
p. pr. & vb. n.
of Poise
v. t.
To remove or expel poison from.
n.
The aurochs or European bison.
n.
To taint; to corrupt; to vitiate; as, vice poisons happiness; slander poisoned his mind.
v. t.
To represent as a person; to personify; to impersonate.
n.
One who poisons.
v. t.
To poison; to imbitter; to impair.
v. t.
To imprison; to shut up in, or as in, a prison; to confine; to restrain from liberty.
n.
Any agent which, when introduced into the animal organism, is capable of producing a morbid, noxious, or deadly effect upon it; as, morphine is a deadly poison; the poison of pestilential diseases.
imp. & p. p.
of Poise
n.
To injure or kill by poison; to administer poison to.
v. t.
To poison; to impoison.
imp. & p. p.
of Poison
n.
Poison.
n.
A parson; the parish priest.
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