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Cyclic oligosaccharide with 6 to 8 glucose units
Cyclodextrins are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits joined by α-1,4 glycosidic bonds. Cyclodextrins
Cyclodextrin
Chemical compound
β-Cyclodextrin sometimes abbreviated as β-CD, is a heptasaccharide derived from glucose. The α- (alpha), β- (beta), and γ- (gamma) cyclodextrins correspond
Β-Cyclodextrin
Chemical compound
α-Cyclodextrin (alpha-cyclodextrin), sometimes abbreviated as α-CD, is a hexasaccharide derived from glucose. It is related to the β- (beta) and γ- (gamma)
Α-Cyclodextrin
Chemical compound
γ-Cyclodextrin sometimes abbreviated as γ-CD, is an octasaccharide derived from glucose. The α- (alpha), β- (beta), and γ- (gamma) cyclodextrins correspond
Γ-Cyclodextrin
Brand of household odor eliminators manufactured by Procter & Gamble
active ingredient in several Febreze products is hydroxypropyl beta-cyclodextrin (HPβCD). The molecule traps and binds volatilized hydrocarbons within
Febreze
Class of enzymes
In enzymology, a cyclomaltodextrin glucanotransferase (also cyclodextrin glycosyl transferase or CGTase for short) (EC 2.4.1.19) is an enzyme that catalyzes
Cyclomaltodextrin glucanotransferase
Cyclomaltodextrin_glucanotransferase
Molecular entity that is attracted to water
atoms, is the only one among its isomers to be miscible with water. Cyclodextrins are used to make pharmaceutical solutions by capturing hydrophobic molecules
Hydrophile
Supramolecular structures held together other than by covalent bonds
host–guest interaction. There are several typical host molecules, such as cyclodextrin and crown ether. Host molecules usually have a pore-like structure that
Host–guest_chemistry
Class of chemical compounds
which contain cyclodextrin towards hydrolytic degradations. The stability differs between size and characterization of the cyclodextrins that are used
Curcuminoid
Chemical compound
nucleophilic functional groups, for example hydroxy groups (as in the case of β-cyclodextrin) or amino groups (as in the case of polymethine dyes). In such, the sulfobutyl
1,4-Butane_sultone
Dissociative anesthetic and anti-depressant
opposite migration order of the enantiomers of ketamine with α- and β-cyclodextrin in capillary electrophoresis". Journal of Separation Science. 25 (15–17):
Ketamine
American Company
owned by Arrowhead Research Corporation. The conjugates consist of a cyclodextrin-containing polymer (Cyclosert) that acts as a drug delivery system, and
Insert_Therapeutics
Scientific publications term
commercially based on various chiral selectors including polysaccharides, cyclodextrins, glycopeptide antibiotics, proteins, Pirkle, crown ethers, etc. to achieve
Chiral_analysis
Medical condition
2010, the FDA granted hydroxypropyl-beta-cyclodextrin orphan drug status and designated HPbCD cyclodextrin as a potential treatment for Niemann–Pick
Niemann–Pick_disease_type_C
Medical condition
the University of Arizona first proposed the use of 2-hydroxypropyl-β-cyclodextrins for the treatment of Niemann–Pick Type C1 in 2001. Researchers noted
Niemann–Pick_disease
Porous nanoparticle, often a synthesised carbon-containing polymer
referred to as "cyclodextrin nanosponges" by DeQuan Li and Min Ma in 1998. This term was used because there is a cross-linked β-cyclodextrin with organic
Nanosponges
Chemical separation technique
on oligosaccharides such as amylose, cellulose, or cyclodextrin (in particular with β-cyclodextrin, a seven sugar ring molecule) immobilized on silica
Chiral_column_chromatography
prepare a synthetic ion channel was made in 1982 using a substituted β-cyclodextrin. Inspired by gramicidin, this molecule was designed to be a barrel-shaped
Synthetic_ion_channels
American chemist
university spin-off that seeks to bring to market water filtration with cyclodextrin polymers. Dichtel is an accomplished marathon open water swimmer. In
William_Dichtel
Low-molecular-weight carbohydrates
hydrolyse the alpha-1,6 bonds at branch points. Cyclodextrin The cyclical dextrins are known as cyclodextrins. They are formed by enzymatic degradation of
Dextrin
Class of artificial materials
Metal-organic frameworks (MOFs) (with a range of sub-classes for example Cyclodextrin-metal–organic framework (CD-MOF), Zeolitic Imidazolate Frameworks (ZIFs)
Reticular_materials
Process in which disordered components form an organized structure or pattern
and (c) SDS-cyclodextrin complexes. SDS is a surfactant with a hydrocarbon tail (yellow) and a SO4 head (blue and red), while cyclodextrin is a saccharide
Self-assembly
Inflammatory disease involving a buildup of lesions in the walls of arteries
cells in atherosclerosis to identify new therapeutic targets. The sugar cyclodextrin (CD) removed cholesterol that had built up in the arteries of mice fed
Atherosclerosis
Biochemical cofactor and antioxidant
hydrogenated lecithin, and complexation with cyclodextrins; among the latter, the complex with β-cyclodextrin has been found to have highly increased bioavailability
Coenzyme_Q10
Medication used to treat fungal infections
manufactured in Beerse, Belgium. The oral solution is better absorbed. The cyclodextrin contained in the oral solution can cause an osmotic diarrhea, and if
Itraconazole
Enzyme that hydrolyses α bonds of large α-linked polysaccharides
GH13 catalytic domain Cyclodextrin glucanotransferase (e.c.2.4.1.19) (cgtase) Identifiers Symbol Alpha-amylase Pfam PF00128 Pfam clan CL0058 InterPro IPR006047
Α-Amylase
Protein family
structure of a complex of soybean beta-amylase with an inhibitor (alpha-cyclodextrin) has been determined to 3.0 Å resolution by X-ray diffraction. The enzyme
Glycoside_hydrolase_family_14
Selective relaxant binding agent
vecuronium. Sugammadex is a modified γ-cyclodextrin, with a lipophilic core and a hydrophilic periphery. This gamma cyclodextrin has been modified from its natural
Sugammadex
Ring molecule able to store other molecules within itself
capsules that share a similar molecular shape with cucurbiturils include cyclodextrins, calixarenes, and pillararenes. Cucurbiturils are amidals (less precisely
Cucurbituril
Chemical compound
solubility (hence bio-availability) can be increased by encapsulation in cyclodextrin cavities. The Algar-Flynn-Oyamada reaction is a chemical reaction whereby
3-Hydroxyflavone
Molecule with a large ring structure
Classical examples include the crown ethers, calixarenes, porphyrins, and cyclodextrins. Macrocycles describe a large, mature area of chemistry. IUPAC definition
Macrocycle
Set of laboratory techniques for separation of mixtures
Immunoglobulin G (IgG) from serum with satisfactory yield and used β-cyclodextrin as a competitor to displace IgG from the matrix. This largely opens up
Chromatography
Accumulation of degenerative material in the inner layer of artery walls
or healthy, blood pressure levels; oligosaccharide 2-hydroxypropyl-β-cyclodextrin (2HPβCD) "is ineffective in inducing atherosclerosis regression". When
Atheroma
Subfield of condensed matter physics
(2017-07-10). "Dynamic Macromolecular Material Design-The Versatility of Cyclodextrin-Based Host-Guest Chemistry". Angewandte Chemie International Edition
Soft_matter
Chemical compound
via GABAA receptors and reversible photoisomerization in water using cyclodextrin. Solutions of sodium barbital have also been used as pH buffers for biological
Barbital
Veterinary medication
formulated with beta-cyclodextrin to increase solubility; at cooler temperatures, more of the maropitant remains bound to the cyclodextrin, leaving less maropitant
Maropitant
British chemist
Crystal structure of a rotaxane with an α-cyclodextrin macrocycle.
Harry_Anderson_(chemist)
Chemical compound
other countries. Alfaxalone is dissolved in 2-hydroxypropyl-β cyclodextrin. The cyclodextrin is a large, starch-derived molecule with a hydrophobic core
Alfaxalone
Cyclodextrins have been extensively studied as host molecules (ring) in polyrotaxanes. The poly(ethylene glycol)s can assemble with α-cyclodextrins to
Polyrotaxane
UV-A protectant used in sunscreens
avobenzone with cyclodextrins may also increase its photostability. Formulations of avobenzone with hydroxypropyl-beta-cyclodextrin have shown significant
Avobenzone
Biological process of gene regulation
amyloidosis II Recruiting Alnylam Pharmaceuticals NCT01617967 CALAA-01 RRM2 Cyclodextrin NP Solid tumours I Active Calando Pharmaceuticals NCT00689065 TD101 K6a
RNA_interference
Process of determining the nucleic acid sequence
nucleotides passed by alpha(α)-hemolysin pores covalently bound with cyclodextrin. However the subsequent commercial method, 'strand sequencing', sequenced
DNA_sequencing
Artificial sweetener
"Determination of Neotame by High-Performance Capillary Electrophoresis Using β-cyclodextrin as a Chiral Selector". Analytical Letters. 47 (17): 2795–2812. doi:10
Neotame
Interlocked molecular structure resembling a dumbbell
"macrocycle" by non-covalent interactions, for example rotaxinations with cyclodextrin macrocycles involve exploitation of the hydrophobic effect. This dynamic
Rotaxane
Class of chemical substance
consists of repeating base units of 6 γ-cyclodextrin rings bound together by potassium ions. γ-cyclodextrin (γ-CD) is a symmetrical cyclic oligosaccharide
Metal–organic_framework
Capacity of a substance to dissolve in a homogeneous way
solubilities in hot and cold solvent. A few exceptions exist, such as certain cyclodextrins. For condensed phases (solids and liquids), the pressure dependence
Solubility
receptors. Examples of SRBAs include: 1. Sugammadex is a modified gamma cyclodextrin that specifically encapsulates and binds the aminosteroid NMBAs: affinity
Selective relaxant binding agents
Selective_relaxant_binding_agents
Polycyclic organic compound having sterane as a core structure
steroid side chain cleavage by Mycobacterium sp. in the presence of cyclodextrins". Enzyme and Microbial Technology. 11 (7): 398–404. Bibcode:1989EnzMT
Steroid
Skin product helping to prevent sunburn
ingredients can also assist in photostabilizing unstable UV filters. Cyclodextrins have demonstrated the ability to reduce photodecomposition, protect
Sunscreen
Muscle relaxant
vecuronium can be accomplished by administration of sugammadex which is a γ-cyclodextrin which encapsulates vecuronium preventing it from binding to receptors
Vecuronium_bromide
Antiviral drug
proprietary excipient Captisol (based on University of Kansas research into cyclodextrin) with remdesivir at a 30:1 ratio. Since that implies an enormous amount
Remdesivir
Cannabis sativa L. (marijuana; hemp) used medicinally
2006). "Sublingual administration of Delta9-tetrahydrocannabinol/beta-cyclodextrin complex increases the bioavailability of Delta9-tetrahydrocannabinol
Medical_cannabis
Protein domain
hydrolyses pullulan to panose, and cyclomaltodextrinase, which hydrolyses cyclodextrins. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G (July
Glycoside_hydrolase_family_13
Tranquilizer drug
88 mg Inactive ingredients: lactose monohydrate, magnesium stearate, β-cyclodextrin, acesulfame potassium. Phenobarbital, one of the principal ingredients
Corvalol
Chemical compound
fluorescence of these sulfonamide adducts can be enhanced by adding alpha-cyclodextrin. Dansyl chloride is unstable in dimethyl sulfoxide, which should never
Dansyl_chloride
2'-bipyridine)ruthenium(II) Complexes and Their Supramolecular Assemblies with β-Cyclodextrin". Inorg Chem. 43 (11): 3521–3527. doi:10.1021/ic0352250. PMID 15154817
List of chemical compounds with unusual names
List_of_chemical_compounds_with_unusual_names
Non-depolarizing neuromuscular blocker
same drug class (non-depolarizing neuromuscular blocking drugs). The γ-cyclodextrin derivative sugammadex (trade name Bridion) is an agent to reverse the
Rocuronium_bromide
Secondary metabolite
(July 2003). "Investigation of the complexation of (+)-catechin by beta-cyclodextrin by a combination of NMR, microcalorimetry and molecular modeling techniques"
Catechin
Method to determine protein concentration
detergents, although this problem can be alleviated by the addition of cyclodextrins to the assay mixture. Much of the non-linearity stems from the equilibrium
Bradford_protein_assay
Chemical compound
serotonin in liver regeneration. The molecular recognition of ureido-cyclodextrin with busulfan was investigated. The formation of complexes was observed
Busulfan
Pharmaceutical compound
2025. Fronza G, Bovis G, Ventura P, Redenti E (1992). "Application of γ-cyclodextrin to enantiomeric purity determination of a new 2-amino-tetralin derivative
Nolomirole
Field of chemistry
acid and α-cyclodextrin, Breslow et al. developed a catalyst based on a β-cyclodextrin carrying two imidazole groups. This cyclodextrin catalytic system
Supramolecular_catalysis
Chemical compound
and stabilization of lipoic acid trisulfide by creation of various β-cyclodextrin clathrates. Biosci Biotechnol Biochem. 2024 May 22;88(6):601-607. doi:10
Lipoic_acid_trisulfide
Thickening agent
breaking down viscosity enzyme-treated starch (INS 1405), maltodextrin, cyclodextrin monostarch phosphate (INS 1410, E1410) with phosphorous acid or the salts
Modified_starch
Inclusion compound
supramolecular chemistry, hosts such as hydroquinone, urea, thiourea, cyclodextrins, calixarenes, and Dianin's compound can form inclusion compounds with
Clathrate_compound
Chemical compound
which is a mixture of edaravone and hydroxypropyl-sulfobutyl ether β-cyclodextrin (SBE-HP-βCD), has been under development by Ferrer (called FAB122) and
Edaravone
Topics referred to by the same term
creator of Sherlock Holmes ACD (gene), protein encoded by the ACD gene α-Cyclodextrin, a glucose polymer Alveolar capillary dysplasia, disorder of the lung
ACD
American biochemist
hydrolysis and intramolecular catalysis in water. He also showed that cyclodextrin can be used to investigate catalysis of organic reactions within the
Myron_L._Bender
Naming system for food additives
emulsifier 452 A E U polyphosphates mineral salt, emulsifier 459 E U beta-cyclodextrin emulsifier 460 A E U powdered cellulose, microcrystalline cellulose anti-caking
International Numbering System for Food Additives
International_Numbering_System_for_Food_Additives
Process of introducing nucleic acids into eukaryotic cells
procedure. Chemical-based transfection can be divided into several kinds: cyclodextrin, polymers, liposomes, or nanoparticles (with or without chemical or viral
Transfection
Chromatography technique
extended by several techniques including the use of organic modifiers, cyclodextrins, and mixed micelle systems. Short-chain alcohols or acetonitrile can
Micellar electrokinetic chromatography
Micellar_electrokinetic_chromatography
Species of bacterium
Sheng; Wang, Ning; Chan, Jian; Wu, Jing (2012). "Gamma-Cyclodextrin Production Using Cyclodextrin Glycosyltransferase from Bacillus clarkii 7364". Applied
Evansella_clarkii
Cyclic, multidentate ligands adept at encapsulating cations
Cryptophane, a family of organic compounds that encapsulates other molecules Cyclodextrin, a family of organic compounds consists of ring of glucose subunits,
Cryptand
Protein found in humans
well as the delivery of resiquimod via nanoparticles formed from beta-cyclodextrin. Loss-of-function variants in TLR7 diminish the innate immune response
Toll-like_receptor_7
Biomolecule
cancers may require different non-lipid based organic nanovectors such as cyclodextrin based nanoparticles. siRNAs delivered via lipid based nanoparticles have
Small_interfering_RNA
Badria FA, ElNaggar MH, El-Masry SM, Helmy SA (May 2022). "Development of Cyclodextrin-Functionalized Transethoniosomes of 6-Gingerol: Statistical Optimization
List_of_capsaicinoids
Chemical compound
needed] It has been also reported that silymarin inclusion complex with β-cyclodextrin is much more soluble than silymarin itself. There have also been prepared
Silibinin
Chemical compound
having any effect on Alzheimer symptoms. A formulation of imatinib with a cyclodextrin (Captisol) as a carrier to overcome the blood–brain barrier has shown
Imatinib
Codes for food additives
products. Approved in the UK. Approved in the US for i and ii. E459 Beta-cyclodextrin emulsifier Approved in the EU for flavoured powdered instant drinks and
E_number
Molecular-scale artificial or biological device
(1992). "The molecular necklace: a rotaxane containing many threaded α-cyclodextrins". Nature. 356 (6367): 325–327. Bibcode:1992Natur.356..325H. doi:10.1038/356325a0
Molecular_machine
Benzodiazepine analog drug
G, Denora N, Laquintana V, et al. (May 2007). "Effects of different cyclodextrins on the morphology, loading and release properties of poly
Etizolam
Procedure to preserve sperm cells
Incorporation of cholesterol into sperm cell membranes with the use of cyclodextrins prior to freezing also increases sperm viability. The packaging method
Semen_cryopreservation
Derivative of cholesterol obtained by oxidation
cholesterol turnover and homeostasis" of rodents. In addition, the sugar cyclodextrin (CD) reverses atherosclerosis in mice fed a high-fat diet. CD is absorbed
Oxysterol
Creatine kinase Crystallin Cyclic adenosine monophosphate (cAMP) α-Cyclodextrin Cyclodextrin glycosyltransferase Cyclooxygenase Cyclopamine Cyclopiazonic acid
List_of_biomolecules
German biochemist (1939–2026)
of 86. Water Molecule in Hydrophobic Surroundings: Structure of alpha-Cyclodextrin-Hexahydrate (C6H10O5)6·6H2O, Nature, 1972 Circular hydrogen bonds, Nature
Wolfram_Saenger
Complexes: Surface Tension, Calorimetry, and Molecular Dynamics of Cyclodextrins with a Non-ionic Surfactant". Journal of Physical Chemistry B. 111 (17):
Determination of equilibrium constants
Determination_of_equilibrium_constants
2-Hydroxypropyl-β-Cyclodextrin Formulations of E2-CDS — Phase I Clinical Trials". Proceedings of the Eighth International Symposium on Cyclodextrins. pp. 507–510
Pharmacokinetics_of_estradiol
Vaccine against COVID-19
monohydrate, trisodium citrate dihydrate, ethanol (alcohol), 2-hydroxypropyl-β-cyclodextrin (HBCD) (hydroxypropyl betadex), polysorbate 80, sodium chloride, sodium
Janssen_COVID-19_vaccine
Chemical compound
to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin. The chemical is currently used by researchers interested in studying
CGS-21680
Structures containing lipids
(October 2019). "Evaluation of novel cationic gene based liposomes with cyclodextrin prepared by thin film hydration and microfluidic systems". Scientific
Cationic_liposome
Branch of chemistry
chemistry. The macrocyclic effect enhances otherwise weak interactions. Cyclodextrins, calixarenes, cucurbiturils, and crown ethers allow the incorporation
Supramolecular_chemistry
Type of chemical reaction
forming a stable inclusion complex with β-cyclodextrin in aqueous media. This complex, formed with the β-cyclodextrin, can then be stored as a lyophilized
Copper-free_click_chemistry
Chemical compound
Aniceto, N.; Gibaud, S. (2013). "The antitumor effects of an arsthinol-cyclodextrin complex in an heterotopic mouse model of glioma" (PDF). Eur J Pharm Biopharm
Arsthinol
Species of plant
active ingredient in the root was synthesized and encapsulated with beta-cyclodextrins. The roots were also subjected to supercritical carbon-dioxide based
Decalepis_hamiltonii
Variety of osmometers
Masahiko; ITO, Kiyoko; FUSHIMI, Chigusa; KONDO, Tamotsu (1993). "A Study of Cyclodextrin Complex Formation by a Freezing Point Depression Method". Chemical &
Freezing point depression osmometer
Freezing_point_depression_osmometer
Chemical compound
(2021). "Supramolecular Gold Stripping from Activated Carbon Using α-Cyclodextrin". Journal of the American Chemical Society. 143 (4): 1984–1992. doi:10
Potassium_dicyanoargentate
Chemistry of carbon's allotrope fullerene
compound with cyclodextrin (CD). A separation method for both fullerenes based on this principle is made possible by anchoring cyclodextrin to colloidal
Fullerene_chemistry
All ligands directly bound to the central metal atom of a chemical complex
nitrogen centres of cyanometallates. Macrocyclic molecules such as cyclodextrins act often as the second coordination sphere for metal complexes. Coordination
Coordination_sphere
Species of bacterium
include gamma-D-Glutamyl-meso-diaminopimelate peptidase, sonorensin, gamma-cyclodextrin, 2,5-Diketopiperazines, laccases, bacteriocin, paenicidin A, tridecaptin
Bacillus_isolates
Combination in the membranes of cells
abolition of IgE signaling by surface cholesterol depletion with methyl-β-cyclodextrin and so on. This signaling pathway can be described as follows: IgE first
Lipid_raft
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