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American Company
Insert Therapeutics, Inc., now Calando Pharmaceuticals, Inc., is a medical research company that uses nanobiotechnology specializing in therapeutic agents
Insert_Therapeutics
Ongoing cancer chemotherapy experiment
Engineering at the California Institute of Technology, and associates at Insert Therapeutics, Inc., now Calando Pharmaceuticals, Inc., hence the original name
CRLX101
Medical technology
Medicine, Intellia Therapeutics, CRISPR Therapeutics, Casebia, Cellectis, Precision Biosciences, bluebird bio, Excision BioTherapeutics, and Sangamo have
Gene_therapy
Rare autosomal-recessive human disease
fibroblasts. PPL-001 (Papillon Therapeutics) is an ex vivo gene-edited cell therapy in preclinical development. CRISPR Therapeutics received a grant from FARA
Friedreich's_ataxia
Chemical Engineer
2011, the National Academy of Medicine. He is also the founder of Insert Therapeutics and Calando Pharmaceuticals. Mark was born in Ellwood City, Pennsylvania
Mark_E._Davis
Chinese material scientist
Santa Barbara. Following his PhD, Cheng became a senior scientist at Insert Therapeutics from 2001 to 2004 before accepting a postdoctoral fellowship at the
Jianjun_Cheng
DNA structure
to degradation by nucleases. Gapmers are currently being developed as therapeutics for a variety of cancers, viruses, and other chronic genetic disorders
Gapmer
American bioengineer
Mark E. Davis. After working in industry as a senior scientist at Insert Therapeutics from 2000 to 2003, she returned to academia in 2003 as an assistant
Suzie_Pun
Medication to treat gastroesophageal reflux disease and other conditions
October 2018. "[99] Comparative effectiveness of proton pump inhibitors | Therapeutics Initiative". 28 June 2016. Archived from the original on 30 October 2020
Omeprazole
Drug interactions with grapefruit juice
on the container, and the interaction is elaborated upon in the package insert. People are advised to ask their physician or pharmacist about drug interactions
Grapefruit–drug_interactions
Bodily function of expelling intestinal gas from the anus
functional abdominal bloating and distension". Alimentary Pharmacology & Therapeutics. 33 (10): 1071–86. doi:10.1111/j.1365-2036.2011.04637.x. PMID 21488913
Flatulence
American pharmaceutical company
2021) Akouos Inc (acq. 2022) Dice Therapeutics (acq. 2023) Emergence Therapeutics (acq. 2023) Sigilon Therapeutics (acq. 2023) Versanis Bio (acq. 2023)
Eli_Lilly_and_Company
Type of mutation in a DNA sequence
mutation-induced disease. Other RNA therapeutics under investigation include synthetic suppressor tRNAs that enable ribosomes to insert an amino acid, instead of
Nonsense_mutation
Pharmaceutical drug
failure in children and adolescents with severe primary IGF-1 deficiency". Therapeutics and Clinical Risk Management. 5 (3): 553–9. doi:10.2147/tcrm.s6178. PMC 2724186
Mecasermin
Opioid analgesic
(January–February 2002). "Meperidine: a critical review". American Journal of Therapeutics. 9 (1): 53–68. doi:10.1097/00045391-200201000-00010. PMID 11782820. S2CID 23410891
Pethidine
Chemical compound and gastrointestinal medication
Therapeutic Guidelines on Stress Ulcer Prophylaxis. ASHP Commission on Therapeutics and approved by the ASHP Board of Directors on November 14, 1998". American
Sucralfate
Medical condition
relatively pure tauopathy, and it is often selected for trials of anti-tau therapeutics. Corticobasal degeneration (CBD) is characterized by both motor and cognitive
Tauopathy
British molecular biologist
the merits of a non-reductionist approach, and the possibility of mRNA therapeutics. Lane is the son of biologist and nature conservationist Miriam Rothschild
Charles_Daniel_Lane
Nonsteroidal anti-inflammatory drug (NSAID)
subcutaneous and oral administration". Journal of Veterinary Pharmacology and Therapeutics. 36 (5): 486–493. doi:10.1111/jvp.12038. PMID 23406022. "NADA 141-213:
Meloxicam
Brand of eye drops
Ocular Pharmacology and Therapeutics. 28 (6): 598–603. doi:10.1089/jop.2012.0066. PMID 22813209. "Visine L.R.: Package Insert / Prescribing Information"
Visine
Chemical compound
Texas against four defendants: Macoven Pharmaceuticals (owned by Pernix Therapeutics), Gnosis SpA of Italy, Gnosis U.S.A and Gnosis Bioresearch Switzerland
Levomefolic_acid
Citrus fruit
incompatible with grapefruit are marked as such on the container or package insert. In 2023, world production of grapefruits (combined with pomelos) was 9
Grapefruit
Opioid medication used for pain relief
management: Availability and implications of different treatment options". Therapeutics and Clinical Risk Management. 3 (3): 381–400. PMC 2386360. PMID 18488078
Hydromorphone
Opioid drug used in pain relief
single-entity, once-daily, extended-release hydrocodone tablet". Clinical Therapeutics. 37 (10): 2286–2296. doi:10.1016/j.clinthera.2015.08.007. PMID 26350273
Hydrocodone
more rapid metabolism. Exubera, developed by Inhale Therapeutics (later named Nektar Therapeutics), became the first inhaled insulin product to be marketed
List of commercially available insulins
List_of_commercially_available_insulins
Intravenous medication used in anesthesia
anesthetic agent with neuroprotective properties". CNS Neuroscience & Therapeutics. 14 (2): 95–106. doi:10.1111/j.1527-3458.2008.00043.x. PMC 6494023. PMID 18482023
Propofol
Collection of the total genomic DNA from a single organism
stored in a population of identical vectors, each containing a different insert of DNA. In order to construct a genomic library, the organism's DNA is extracted
Genomic_library
Medical condition
release). Orchard Therapeutics. 21 December 2020. Retrieved 12 January 2021 – via GlobeNewswire. Orchard, Therapeutics. "Orchard Therapeutics Receives Positive
Metachromatic_leukodystrophy
Medication used to treat diabetes
metformin (N,N-dimethylbiguanide) in man". Clinical Pharmacology and Therapeutics. 24 (6): 683–93. doi:10.1002/cpt1978246683. PMID 710026. S2CID 24531910
Metformin
Line of continuous glucose monitors
Dangers of Reuse Beyond Approved Duration of Wear". Diabetes Technology & Therapeutics. 21 (4): 222–229. doi:10.1089/dia.2018.0401. ISSN 1557-8593. PMC 6477582
Dexcom_CGM
Chemical compound
mid-1990s. It is a derivative of metopon in which a methoxy group has been inserted at the 14-position. It is a highly potent analgesic drug that is around
14-Methoxymetopon
Antihistamine drug
three-period crossover study in healthy, nonatopic adults". Clinical Therapeutics. 29 (5): 814–822. doi:10.1016/j.clinthera.2007.05.001. PMID 17697901
Ebastine
Atypical antipsychotic medication
PMID 1860915. "ADASUVE Package Insert" (PDF). Galen US Inc. "Clozapine and loxapine for schizophrenia". Drug and Therapeutics Bulletin. 29 (11): 41–42. May
Loxapine
Muscle relaxant
carisoprodol, cyclobenzaprine hydrochloride, and metaxalone". Clinical Therapeutics. 26 (9): 1355–1367. doi:10.1016/j.clinthera.2004.09.008. PMID 15530999
Metaxalone
Medication used to treat overdose of paracetamol
The emerging role of H2S and sulfane sulfur species". Pharmacology & Therapeutics. 228 107916. doi:10.1016/j.pharmthera.2021.107916. PMID 34171332. Raghu
Acetylcysteine
Introduction of foreign genetic material into a host
us has resulted in the vast majority of current personalized cellular therapeutics involving multipotent stem cells (typically mesenchymal stem cells from
Transgenesis
Eye muscle which is used for focussing
Schachar. Contraction and relaxation of the longitudinal fibers, which insert into the trabecular meshwork in the anterior chamber of the eye, cause an
Ciliary_muscle
Condition of impaired digestion
endoscopy (a procedure whereby a camera attached to a flexible tube is inserted down the throat and into the stomach) is recommended to further assess
Indigestion
Chemical compound
Laboratories and is now marketed in two formulations by Cornerstone Therapeutics Inc. under the brand names Zyflo and Zyflo CR. The original immediate-release
Zileuton
Cholesterol-lowering medication
with atorvastatin-induced myopathy" (PDF). Clinical Pharmacology and Therapeutics. 79 (6): 532–9. doi:10.1016/j.clpt.2006.02.014. PMID 16765141. S2CID 12838555
Atorvastatin
Drug delivery technique
rather than conventional diffusion. This is done by utilizing catheters inserted into the target region of the brain and utilizing pressure to deliver the
Convection_enhanced_delivery
Genetic form of macular degeneration
number of research groups working with stem cells one of which is Ocata Therapeutics. Alkeus Pharma is evaluating the potential of deuterated vitamin A as
Stargardt_disease
Diabetes medication
placebo-controlled studies with single oral doses". Clinical Pharmacology and Therapeutics. 78 (6): 675–688. doi:10.1016/j.clpt.2005.09.002. PMID 16338283. S2CID 20935646
Sitagliptin
Drug mixture used mainly to treat ADHD and narcolepsy
"The vascular effects of trace amines and amphetamines". Pharmacology & Therapeutics. 125 (3): 363–375. doi:10.1016/j.pharmthera.2009.11.005. PMID 19948186
Adderall
Opioid medication
(September 2006). "Oxycodone controlled release in cancer pain management". Therapeutics and Clinical Risk Management. 2 (3): 229–234. doi:10.2147/tcrm.2006.2
Oxycodone
Medication for treatment of obesity
which led to the development of the combination medication. Orexigen Therapeutics submitted a New Drug Application (NDA) for the combination to the FDA
Naltrexone/bupropion
Regional economic development and geographic location
Sciences Vigilant Bioservices Vita Therapeutics VLP Therapeutics Wellstat Group Westat WindMIL Therapeutics X-Cor Therapeutics Xcision Medical Systems xMD Diagnostics
DNA_Valley
Central nervous system stimulant
Disorder Compared with Obesity: Implications for Differential Therapeutics". Clinical Therapeutics. 43 (1): 50–69. doi:10.1016/j.clinthera.2020.10.014. PMC 7902428
Amphetamine
Chemical compound
B". Therapeutics and Clinical Risk Management. 5: 789–798. doi:10.2147/tcrm.s5318. PMC 2762437. PMID 19851526. Drugs.com. "Tyzeka: Package Insert / Prescribing
Telbivudine
Calcium channel blocker medication
involvement of several mechanisms". Journal of Clinical Pharmacy and Therapeutics. 30 (2): 153–158. doi:10.1111/j.1365-2710.2004.00618.x. PMID 15811168
Nifedipine
Genetic engineering to produce pharmaceuticals
farming and pharmaceutical, refers to the use of genetic engineering to insert genes that code for useful pharmaceuticals into host animals or plants that
Pharming_(genetics)
Combination hormonal birth control
Population Council, an international non-profit organization, and licensed to TherapeuticsMD. It was approved for medical use in the United States in August 2018
Segesterone acetate/ethinylestradiol
Segesterone_acetate/ethinylestradiol
Study of the role of the genome in drug response
involve drug targets are within the field of oncology and include targeted therapeutics designed to address somatic mutations (see also Cancer Pharmacogenomics)
Pharmacogenomics
Type of medication
delta Generic follitropin delta injection Brands Rekovelle The package insert for Gonal-f states that based on physio-chemical tests and bioassays that
Gonadotropin_preparations
Hypothetical organism
animal models in biological and medical research for developing human therapeutics. Human–animal hybrids are the subject of legal, moral and technological
Human–animal_hybrid
Species of flowering plant in the family Phytolaccaceae
Ellingwood, Finley. "Phytolacca americana". The American Materia Medica, Therapeutics and Pharmacognosy. Felter. "Pokeweed" (PDF). Materia Medica. Lloyd, John
Phytolacca_americana
Antipsychotic medication
actually had a mean weight loss overall. According to the manufacturer insert, ziprasidone caused an average weight gain of 2.2 kg (4.8 lbs), which is
Ziprasidone
SSRI antidepressant
Knollman B (2010). Goodman and Gilman's The Pharmacological Basis of Therapeutics (12th ed.). New York: McGraw-Hill Professional. ISBN 978-0-07-162442-8
Fluvoxamine
Temporary surgical incision to create an airway into the trachea
an airway or as a site for a tracheal tube (or tracheostomy tube) to be inserted; this tube allows a person to breathe without the use of the nose or mouth
Tracheotomy
Protein found in humans
diagnostic biomarkers and, eventually, potential development of new therapeutics. XRCC4 polymorphisms have been linked to a risk of susceptibility for
DNA_repair_protein_XRCC4
American molecular biologist, biochemist, and organic chemist (born 1973)
human therapeutics), Pairwise Plants (genome editing for agriculture), Beam Therapeutics (base editing for human therapeutics), Exo Therapeutics (novel
David_R._Liu
Medication for pain and fever
2000). "Paracetamol: past, present, and future". American Journal of Therapeutics. 7 (2): 143–147. doi:10.1097/00045391-200007020-00011. PMID 11319582
Paracetamol
Type of α-amino acid
Matthaei and Marshall W. Nirenberg in 1961. They showed that by using mRNA to insert multiple uracil repeats into the genome of the bacterium E. coli, they could
Phenylalanine
vector, and improves the yield of the vector containing the appropriate insert. Calf-intestinal alkaline phosphatase can serve as an effective tool for
Calf-intestinal alkaline phosphatase
Calf-intestinal_alkaline_phosphatase
Benzodiazepine sedative
medical procedures. It can be taken orally (by mouth), as a suppository (inserted into the rectum), intramuscularly (injected into muscle), intravenously
Diazepam
DNA construct contains a DNA insert, called a transgene, delivered via a transformation vector which allows the insert sequence to be replicated and/or
DNA_construct
Autoimmune disease
called lab on a chip, the diagnosis can be more convenient. Concerning therapeutics, multiple monoclonal antibodies were under investigation in 2007. The
Sjögren's_disease
Cervical barrier type of birth control
on the World Health Organization's List of Essential Medicines. Before inserting or removing a diaphragm, one's hands should be washed to avoid introducing
Diaphragm_(birth_control)
Class of broad-spectrum antibiotics
2024. "Ceftriaxone: Package Insert". Archived from the original on April 2, 2023. "ROCEPHIN for Injection Package Insert" (PDF). accessdata.fda.gov. Roche
Β-Lactam_antibiotic
Antifungal medication
Hilal-Dandan R (eds.). Goodman & Gilman's the Pharmacological Basis of Therapeutics (Thirteenth ed.). New York: McGraw Hill / Medical. ISBN 978-1-259-58473-2
Nystatin
Family of proteins
During heat stress, outer membrane proteins (OMPs) do not fold and cannot insert correctly into the outer membrane. They accumulate in the periplasmic space
Heat_shock_protein
Injection into the cerebrospinal fluid
surgeon. Intracerebroventricular injection has also been used to test therapeutics and other drugs in animals. Examples of these studies include injection
Intracerebroventricular injection
Intracerebroventricular_injection
Pharmaceutical compound
vaginosis, and trichomoniasis. It is administered as a capsule or suppository inserted into the vagina. The compound is not a pharmaceutical drug and is instead
Boric_acid_(vaginal)
Benzodiazepine drug
electroencephalographic effects of diazepam and bromazepam". Clinical Pharmacology and Therapeutics. 20 (2): 184–191. doi:10.1002/cpt1976202184. PMID 7375. S2CID 38155674
Bromazepam
US non-profit biotechnology company
technologies. To systemically deliver a subset of therapeutics, including CRISPR, the therapeutic is inserted into the adeno-associated virus (AAV). The drug
Cure_Rare_Disease
Protein created by joining other proteins into a single polypeptide
artificially by recombinant DNA technology for use in biological research or therapeutics. Chimeric or chimera usually designate hybrid proteins made of polypeptides
Fusion_protein
Autosomal recessive metabolic disorder
minocycline may have a neuro-protective role in MSUD. Exploring targeted therapeutics for the various states contributing to neurotoxicity may play a role
Maple_syrup_urine_disease
protein or small molecule. "Roles of RNA in Cells - RNAi Biology - RNA Therapeutics Institute at UMass Medical School - Worcester". www.umassmed.edu. Archived
Spinach_aptamer
Rare neurodegenerative disease
Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics". Marine Drugs. 14 (5): 102. doi:10.3390/md14050102. PMC 4882576. PMID 27213408
ALS
Central nervous system stimulant
genetic polymorphisms and role in drug metabolism". Pharmacology & Therapeutics. 106 (3): 357–387. doi:10.1016/j.pharmthera.2005.01.001. PMC 1828602
Methamphetamine
Gabapentinoid and Skeletal Muscle Relaxant
double-blind randomized controlled trial". Journal of Clinical Pharmacy and Therapeutics. 26 (1): 67–71. doi:10.1111/j.1365-2710.2001.00325.x. PMID 11286609.
Baclofen
Chemical compound
after administration of the insert is complete. The manufacturer also recommends waiting 30 minutes after removal of insert before starting oxytocin. The
Prostaglandin_E2
Tail region of an antibody
other processes). In a new development in the field of antibody-based therapeutics, the Fc region of immunoglobulins has been engineered to contain an antigen-binding
Fragment crystallizable region
Fragment_crystallizable_region
Organism altered by genetic engineering
multi-step process. Genetic engineers must isolate the gene they wish to insert into the host organism and combine it with other genetic elements, including
Genetically_modified_organism
Type of protein
kidney. Affimers can be conjugated to form multimers for the design of therapeutics. Examples include the production of multi-specific Affimer molecules
Affimer
Biomolecules capable of binding to DNA by unwinding the Double Helix
compounds that unwind the DNA double helix and insert themselves between DNA base pairs. Metallo-intercalators insert themselves between two intact base pairs
DNA-binding metallo-intercalators
DNA-binding_metallo-intercalators
Medication and metabolite of cholesterol
acid--adverse effects and drug interactions". Alimentary Pharmacology & Therapeutics. 18 (10): 963–972. doi:10.1046/j.1365-2036.2003.01792.x. PMID 14616161
Ursodeoxycholic_acid
Bioscience liquid handler manufacturer
March 2021, Neo creates genome-scale cell engineering solutions for therapeutics Zenith AI – acquired in June 2021, Zenith AI brings no-code AI and modern
Opentrons
Medication
headache, and feeling jittery. Drug interactions listed on the package insert include delayed or reduced concentrations of lovastatin, paracetamol (acetaminophen)
Exenatide
Pharmaceutical drug
1722101. ISSN 1747-4124. PMID 31985305. S2CID 210922857. "TRULANCE package insert" (PDF). Trulance website. Synergy Pharmaceuticals Inc. 420 Lexington Avenue
Plecanatide
Tincture of opium
ISBN 978-1-4055-1364-7. Potter S (1902). "Opium". A Compend of materia medica, therapeutics, and prescription writing... P. Blakiston, Son & Company. Retrieved 2007-10-13
Laudanum
Use of oxygen as a medical treatment
preference. A nasal cannula (NC) is a thin tube with two small nozzles inserted into a person's nostrils. It can provide oxygen at low flow rates, 1–6
Oxygen_therapy
Stomach acid suppressing medication
ISBN 9780857113382. "[99] Comparative effectiveness of proton pump inhibitors". Therapeutics Initiative. 28 June 2016. Retrieved 14 July 2016. Fischer J, Ganellin
Rabeprazole
Pharmaceutical compound
structure-affinity relationships". The Journal of Pharmacology and Experimental Therapeutics. 337 (3): 860–867. doi:10.1124/jpet.111.179606. PMC 3101003. PMID 21422162
Dimethylhomotryptamine
Weak acid with formula H3BO3
Gilman, A. (eds.). Goodman & Gillman's The Pharmacological Basis of Therapeutics (6th ed.). Macmillan. p. 971. ISBN 978-0-02-344720-4. "Borates in Pesticides
Boric_acid
Medication
Dowd FJ, Johnson B, Mariotti A (3 September 2016). Pharmacology and Therapeutics for Dentistry - E-Book. Elsevier Health Sciences. pp. 406–. ISBN 978-0-323-44595-5
Cimetidine
Chemical compound
excitotoxicity and assess the neuroprotective capabilities of potential therapeutics. Kainic acid is a potent central nervous system excitant that is used
Kainic_acid
Combination medication
Insert. Concordia Pharmaceuticals. http://www.donnatal.com/wp-content/uploads/2015/03/Donnatal-Tablets-PI-0315-v3.pdf Donnatal Elixir Package Insert.
Donnatal
Chemotherapy medication
frequency): Hyper- or hypopigmentation Scarring The United States package insert warns that acute cerebellar syndrome has been observed following injection
Fluorouracil
Protein family
undesirable side effects. Major challenges to the use of cecropins as cancer therapeutics are delivery of the peptides to tumor cells. Repeated administration
Cecropin
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