AI & ChatGPT searches , social queriess for TRAF6
Search references for TRAF6. Phrases containing TRAF6
See searches and references containing TRAF6!
Search references for TRAF6. Phrases containing TRAF6
See searches and references containing TRAF6!TRAF6
Protein found in humans
TRAF6 is a TRAF human protein. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins
TRAF6
characterized in mammals: TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, and TRAF7. TRAF3, TRAF5, and TRAF6 share identical domains- the ring domain at the N-terminus
TNF receptor associated factor
TNF_receptor_associated_factor
Protein complex on the surface of T cells that recognizes antigens
MALT1. This multi-subunit complex binds the ubiquitin ligase TRAF6. Ubiquitination of TRAF6 serves as scaffold to recruit NEMO, IκB kinase (IKK) and TAK1
T-cell_receptor
Protein-coding gene in the species Homo sapiens
This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate
MAP3K7IP2
Protein-coding gene in humans
Sequestosome 1 has been shown to interact with: MAP1LC3A, PRKCI, RAD23A, RIPK1, TRAF6 TrkA, and TrkB. Nrf2 The SQSTM1 gene, which is actively transcribed as part
Sequestosome_1
Protein-coding gene in humans
its receptor complex. IRAK-1 dissociates from the receptor alongside of TRAF6 - a ubiquitin E3 ligase that intermediates between various types of receptors
IRAK1
Mammalian protein found in humans
signal transduction through tumor necrosis factor receptor members such as TRAF6, which results in the release of nuclear factor κB (NF-κB) transcription
Nerve_growth_factor
Mammalian protein found in Homo sapiens
continuous. TRAF6 has been shown to be imperative to the RANK-related osteoclastogenesis pathway. RANKL binds to RANK, which then binds to TRAF6. TRAF6 stimulates
RANK
Protein-coding gene in the species Homo sapiens
demonstrated that ligand-occupied TGF-β receptors can directly trigger the TRAF6-TAK1 signalling module, resulting in MAP kinase activation. Here we report
TTRAP
Protein-coding gene in the species Homo sapiens
is encoded by the MAST2 gene. The protein encoded by this gene controls TRAF6 and NF-kappaB activity. MAST2 has been shown to interact with PCLKC. GRCh38:
MAST2
important for the interaction with the signaling molecule TRAF6. IRAK-1 contains three TRAF6 interaction motifs, IRAK-2 contains two and IRAK-M contains
Interleukin-1 receptor associated kinase
Interleukin-1_receptor_associated_kinase
Protein family
IKKgamma and TRAF6. The interact of Znf216 with IKK-gamma and RIP is mediated by the A20 zinc-finger domain, while its interaction with TRAF6 is mediated
AN1_zinc_finger
Antibodies rarely making an infection worse instead of better
cell to detect viral proteins. On the other hand, many proteins (TRIF, TRAF6, TRAM, TIRAP, IKKα, TAB1, TAB2, NF-κB complex) involved in the Toll-like
Antibody-dependent enhancement
Antibody-dependent_enhancement
Type of protein
family proteins, in particular, TRAF6 in order to activate the NF-κB pathway. Indeed, Act1 polyubiquitinates TRAF6. TRAF6 will then be activated and recruit
Act_1_adaptor_protein
White blood cells of the immune system
CARD (Caspase activation and recruitment domains) domains; that then binds TRAF6, which is ubiquitinated at K63. This form of ubiquitination does not lead
T_cell
Protein-coding gene in the species Homo sapiens
pathway. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation
MAP3K7
Protein-coding gene in the species Homo sapiens
TGF-β, and BMP. ECSIT plays a regulatory role as part of the TAK1-ECSIT-TRAF6 complex that is involved in the activation of NF-κB by the TLR4 signal and
ECSIT
Protein-coding gene in the species Homo sapiens
shown to interact with TNIP1, TRAF1, TRAF2, IKBKG, TAX1BP1, YWHAB, YWHAZ, TRAF6 and YWHAH. The TNFAIP3 locus is implicated as a positively associated factor
TNFAIP3
Class of immune system proteins
IRAK1 and IRAK2. IRAK kinases then phosphorylate and activate the protein TRAF6, which in turn polyubiquinates the protein TAK1, as well as itself to facilitate
Toll-like_receptor
Protein-coding gene in the species Homo sapiens
20.15336. PMID 10809768. Naito A, Yoshida H, Nishioka E, et al. (2002). "TRAF6-deficient mice display hypohidrotic ectodermal dysplasia". Proc. Natl. Acad
TNFRSF19
Protein-coding gene in the species Homo sapiens
gene. TAX1BP1 has been shown to interact with TNFAIP3 and TRAF6. TAX1BP1 binds to TNFAIP3 or TRAF6 and suppresses NF-kappaB transcriptional activation. GRCh38:
TAX1BP1
Type of protein, regulators of signalling pathways
Kinase 4 (IRAK4)-IRAK-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Complex". Journal of Biological Chemistry. 278 (13): 10952–6. doi:10.1074/jbc
Scaffold_protein
Group of proteins
when compared to other cytokine receptors. Transcription factors such as TRAF6, JNK, Erk1/2, p38, AP-1 and NF-κB have been implicated in IL-17 mediated
Interleukin_17
InterPro Family
suppresses osteoclast formation by rapidly degrading the RANK adaptor protein TRAF6 in the RANK-RANKL signaling pathway, which otherwise stimulates the production
Interferon_gamma
Interaction motifs found in a wide array of proteins
components in virus-induced activation of NF-κB and/or IRF3, including TRAF3, TRAF6, TANK, NEMO (IKKg), TRADD, FADD, and RIP (Kawai et al., 2005; Michallet
CARD_(domain)
Medical condition
service (link) Noels H, van Loo G, Hagens S, et al. (April 2007). "A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation
MALT_lymphoma
Dutch physician, molecular biologist and professor
interactions between TRAF6 and CD40L were key drivers of atherosclerosis. She has developed lipid lowering compounds that can target the TRAF6 binding pocket
Esther_Lutgens
Chemical compound
and mitigates estrogen deficiency-induced bone mass loss by modulating TRAF6-mediated signaling". FASEB Journal. 33 (2): 2574–2586. doi:10.1096/fj.201800920R
Tomatidine
Protein-coding gene in humans
CDC37, CHUK and IKK2, IRAK1, NCOA3, PPM1B, TANK, TNFAIP3, TRAF3IP2, and TRAF6. GRCh38: Ensembl release 89: ENSG00000269335 – Ensembl, May 2017 GRCm38:
IKBKG
Protein-coding gene in humans
activation of TRAF6. This signal transduction is not crucial. Activation of cell effector mechanisms trough IL-33/ST2 is present also in TRAF6 deficient mice
IL1RL1
Protein family
SH3RF1, SH3RF2, SYVN1, TIF1, TMEM118, TOPORS, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, TRAF7, TRAIP, TRIM2, TRIM3, TRIM4, TRIM5, TRIM6, TRIM7, TRIM8, TRIM9, TRIM10
RING_finger_domain
Species of bacterium
bacterial invasion by suppressing the TNF-α-receptor-associated factor 6 (TRAF6)-mediated signalling pathway. OspI has glutamine deamidase activity, and
Shigella_flexneri
Protein-coding gene in the species Homo sapiens
postreplication repair. UBE2N has been shown to interact with: AURKA, HLTF, TRAF2, TRAF6, and UBE2V1. GRCh38: Ensembl release 89: ENSG00000177889 – Ensembl, May
UBE2N
Chinese American biochemist
G.; Choi, Yongwon (2002). "Distinct molecular mechanism for initiating TRAF6 signalling". Nature. 418 (6896): 443–447. doi:10.1038/nature00888. ISSN 0028-0836
Hao_Wu_(biochemist)
Protein found in humans
GRIK1, GRIK2, Interleukin 5 receptor alpha subunit, Merlin, RAB5A, SOX4, TRAF6, ULK1. and ERICH2 GRCh38: Ensembl release 89: ENSG00000137575 – Ensembl
Syntenin-1
Protein-coding gene in humans
lymphomas or autoimmune disorders. MALT1 has been shown to interact with BCL10, TRAF6 and SQSTM1/p62. MALT1 (PCASP1) is part of the paracaspase family and shows
MALT1
Protein-coding gene in humans
IL1-induced upregulation of NF-kappaB. IRAK2 has been shown to interact with TRAF6 and Myd88. GRCh38: Ensembl release 89: ENSG00000134070 – Ensembl, May 2017
IRAK2
complex. This signaling complex in turn triggers downstream recruitment of TRAF6 and NF-κB activation. A wide range of ligands promote signalling through
Mincle_receptor
Protein-coding gene in humans
"Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an
TRAF2
Group of cytokine proteins
IRAK1, IRAK2 and tumor necrosis factor receptor-associated factor (TRAF) 6. TRAF6 is a ubiquitin E3 ligase, that in association with ubiquitin-conjugating
Interleukin-1_family
Cell surface receptor found in humans
(IRAKs) and the adaptor molecules TNF Receptor-Associated Factor 6 (TRAF6). TRAF6 induces the activation of TAK1 (Transforming growth factor-β-Activated
Toll-like_receptor_4
Protein-coding gene in the species Homo sapiens
co-complex interactions. HADHA appears to interact with GABARAP, MAP1LC3B, TRAF6, GABARAPL2, GABARAPL1, GAST, BCAR3, EPB41, TNFRSF1A, HLA-B, NFKB2, MAP3K1
HADHA
Mammalian protein found in Homo sapiens
involving SRC kinase and tumor necrosis factor receptor-associated factor 6 (TRAF6), indicating that RANKL may have a role in the regulation of apoptosis.
RANKL
Protein found in humans
Jiang J, Wooten MW (July 2008). "Identification of a consensus site for TRAF6/p62 polyubiquitination". Biochemical and Biophysical Research Communications
Tropomyosin_receptor_kinase_A
Protein-coding gene in humans
recruit and activate TNF receptor-associated factor 6 (TRAF6), a ubiquitin protein ligase. TRAF6 can polyubiquitinate IKK-γ as well as itself, which recruits
IRAK4
Protein-coding gene in the species Homo sapiens
MAP3K7IP3, MAP3K7, MAP3K1, MAPK14, Mothers against decapentaplegic homolog 7, TRAF6, XIAP, and ZMYND11. GRCh38: Ensembl release 89: ENSG00000100324 – Ensembl
TAB1
Protein-coding gene in humans
CCT5, CCT6A, CCT7, IGBP1, PPP2R1A, PPP4R1, REL, SMEK2, T-complex 1, and TRAF6. GRCh38: Ensembl release 89: ENSG00000149923 – Ensembl, May 2017 GRCm38:
PPP4C
Protein-coding gene in the species Homo sapiens
APRIL. TNFRSF13B has been shown to interact with B-cell activating factor, TRAF6, TRAF5, TNFSF13, TRAF2 and CAMLG. GRCh38: Ensembl release 89: ENSG00000240505
Transmembrane activator and CAML interactor
Transmembrane_activator_and_CAML_interactor
Protein-coding gene in the species Homo sapiens
original on 20 February 2020. Retrieved 2 August 2020. "ELM - Detail for LIG_TRAF6". elm.eu.org. Archived from the original on 22 February 2020. Retrieved
ISLR
Protein found in humans
TNF-α receptor-associated factor 2 (TRAF2), an ASK1 activator. TRAF2 and TRAF6 are then recruited to ASK1 to form a larger molecular mass complex. Subsequently
ASK1
Family of cell surface receptors
and IRAK2 to form a signaling complex. The signaling complex reacts with TRAF6 which leads to TAK1 activation and consequently the induction of inflammatory
Pattern_recognition_receptor
Protein-coding gene in humans
complex. This signaling complex in turn triggers downstream recruitment of TRAF6 and NF-κB activation. This transcription factor is responsible for the production
CLEC7A
Protein-coding gene in humans
M207923200. PMID 12270937. Naito A, Yoshida H, Nishioka E, et al. (2002). "TRAF6-deficient mice display hypohidrotic ectodermal dysplasia". Proc. Natl. Acad
Ectodysplasin_A2_receptor
Chinese immunologist
Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2". Journal of Immunology. 183 (3): 2150–2158. doi:10.4049/jimmunol
Cao_Xuetao
Mammalian protein found in humans
haematopoiesis. CD40 (protein) has been shown to interact with TRAF2, TRAF3, TRAF6, TRAF5 and TTRAP. The remaining member of TRAF4 family, namely TRAF4, positively
CD40
Overview article
Downregulaton of miR-146a is predicted to influence the expression of TRAF6, which has a number of downstream effects, including regulation of inflammatory
Epigenetic_effects_of_smoking
Glycolipid found in mycobacterial cell walls
ManLAM is thought to inhibit the IL-1 receptor-associated kinase (IRAK)-TRAF6 interaction, IκB-α phosphorylation, and nuclear translocation of c-Rel and
Lipoarabinomannan
Protein-coding gene in the species Homo sapiens
regulator of IL-1β-induced signaling by interfering with ubiquitin ligase TRAF6 and Ubc13. This suppresses the activation of NF-kB and reduces the transcription
FAM177A1
Chinese immunologist
VISA (virus-induced signaling adaptor). It can also interact with TRIF and TRAF6, and plays an essential role in virus-triggered TLR3-independent and TLR3-mediated
Shu_Hongbing
Protein found in humans
The recruitment of MyD88 leads to subsequent activation of IRAK4, IRAK1, TRAF6, and eventually IκB kinases. Activation of IκB kinases contributes to the
Toll-like_receptor_5
Protein found in humans
the amino terminal region of TICAM1 are necessary for association with TRAF6. Destruction of these motifs reduced the activation of NF-κB, a transcription
TICAM1
Post-translational carbohydrate modification of proteins
its interaction with TNF receptor-associated factor 6 (TRAF6) in cellular and mouse models. TRAF6 mediates K63-linked ubiquitination of IRF5 which is necessary
O-GlcNAc
Protein-coding gene in the species Homo sapiens
protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Letters. 442 (2–3): 147–50. doi:10.1016/S0014-5793(98)01645-7. PMID 9928991
OTUD7B
Q9Y228 17305 TRAF4 HGNC:12034; Q9BUZ4 17306 TRAF5 HGNC:12035; O00463 17307 TRAF6 HGNC:12036; Q9Y4K3 17308 TRAF7 HGNC:20456; Q6Q0C0 17309 TRAFD1 HGNC:24808;
List of human protein-coding genes 8
List_of_human_protein-coding_genes_8
Protein-coding gene in the species Homo sapiens
kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex". J. Biol. Chem. 278 (13): 10952–10956. doi:10.1074/jbc.M212112200
PELI1
Mammalian protein found in Homo sapiens
specific TRAIL receptors on osteoclast precursor cell surfaces, inducing TRAF6 signalling, activating NF-κB signalling and upregulating NFATc1 expression
Osteoprotegerin
Mammalian protein found in humans
PARK2, RIPK1, RPS6KB1, S100A10, SCNN1A, SCNN1G, SFPQ, SMAD3, SMURF2, SP1, TRAF6, and THRA. GRCh38: Ensembl release 89: ENSG00000150991 – Ensembl, May 2017
Ubiquitin_C
Protein-coding gene in the species Homo sapiens
such as IRAK1/4 and tumor necrosis factor receptor-associated factor 6 (TRAF6). These molecules are linked to at least three major downstream pathways:
Interferon_alpha-1
Type of protein
adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway". Molecular Cell. 5 (4): 649–58
Signal transducing adaptor protein
Signal_transducing_adaptor_protein
Protein-coding gene in humans
M103824200. PMID 11387339. Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ (2004). "The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1
CARD10
Immunoglobulin superfamily
(such as IRAKs) and by other adaptors, such as tumor necrosis factor 6 (TRAF6). The final step of signalization is phosphorilation of the inhibitory molecule
Interleukin-1_receptor_family
Enzyme
acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF". European Journal of Immunology. 35 (8): 2477–85. doi:10.1002/eji
Maltase-glucoamylase
Protein-coding gene in the species Homo sapiens
ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1
MAP3K7IP3
Protein-coding gene in the species Homo sapiens
"Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an
MAP3K1
Protein-coding gene in the species Homo sapiens
C, Chen ZJ (October 2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin
UBE2V1
Protein family
and CBM-3 (CARD10/CARMA3). CBM complex assembly results in recruitment of TRAF6 to MALT1 and downstream activation of NF-κB transcriptional activity and
CARD-CC_family
Protein-coding gene in humans
C, Chen ZJ (October 2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin
CHUK
Protein-coding gene in the species Homo sapiens
it translocates to mitochondria to interact with MAVS. NLRP11 degrades TRAF6 using MAVS to attenuate the production of type I IFNs and virus-induced
NLRP11
Catalytically deficient enzymes
A, Peggie M, Marchesi F, Arthur JS, Cohen P (April 2017). "Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling". Proceedings of the
Pseudoenzyme
Ziwei; Ding, Fei; Sun, Hualin (September 2019). "miR-125b-5p targeting TRAF6 relieves skeletal muscle atrophy induced by fasting or denervation". Annals
MiR-125
Protein-coding gene in the species Homo sapiens
protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Letters. 442 (2–3): 147–150. doi:10.1016/s0014-5793(98)01645-7. PMID 9928991
TRAF1
Protein-coding gene in the species Homo sapiens
PMID 37287005. Xiao X, Xu Y, Chen H (May 2020). "Sodium butyrate-activated TRAF6-TXNIP pathway affects A549 cells proliferation and migration". Cancer Medicine
Free_fatty_acid_receptor_2
the pathogenesis of asthma. IL-17F employs Act1[clarification needed] and TRAF6 as its signal transducers to induce the expression of the pro-inflammatory
Interleukin_17F
Protein-coding gene in the species Homo sapiens
"Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6". Cell. Signal. 19 (7): 1514–20. doi:10.1016/j.cellsig.2007.01.025. PMID 17346928
IL17RA
Protein-coding gene in the species Homo sapiens
J, et al. (October 2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin
Kua-UEV
upstream molecules of INFs are unchanged in infected cells, such as MAVS, TRAF6 and TRAF3. This suggests that INFs are still being produced, but they have
Bunyaviridae nonstructural S proteins
Bunyaviridae_nonstructural_S_proteins
Protein-coding gene in the species Homo sapiens
shown to interact with: CRYAB, HSPB8, Myotonic dystrophy protein kinase and TRAF6. GRCh38: Ensembl release 89: ENSG00000170276 – Ensembl, May 2017 GRCm38:
HSPB2
Protein-coding gene in the species Homo sapiens
J, et al. (October 2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin
IKK2
Protein-coding gene in the species Homo sapiens
factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif". The Journal of Biological Chemistry. 274 (12): 7724–31
TRAF5
Overview of and topical guide to immunology
TLR9 TLR10 TLR11 TLR12 TLR13 Other receptors CD14 LBP MD2 Downstream signalling IRAK1 IRAK2 IRAK3 IRAK4 IRF3 MAP3K7 MYD88 TAB1 TICAM1 TIRAP TOLLIP TRAF6
Outline_of_immunology
Protein-coding gene in the species Homo sapiens
CD18, CD29, CD49c, CREB1, EIF6, FHL3, IGFBP5, ITGA7, ITGB6, MAPK1, PSEN2, TRAF6, TTN, ZNF638, and ZBTB16. GRCh38: Ensembl release 89: ENSG00000115641 –
FHL2
Protein-coding gene in humans
ARIH1, ARIH2, CBL, CHEK1, NEDD4, PARK2, SMURF2, TNFAIP3, TNFSF4, TNIP1, TRAF6, UBE3A, UBE3A, and UBOX5. GRCh38: Ensembl release 89: ENSG00000185651 –
UBE2L3
Protein-coding gene in the species Homo sapiens
"NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6". FEBS Letters. 532 (1–2): 241–246. Bibcode:2002FEBSL.532..241K. doi:10
TRAF3IP2
Protein-coding gene in the species Homo sapiens
acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF". Eur. J. Immunol. 35 (8): 2477–85. doi:10.1002/eji.200526151.
TRAF4
Protein-coding gene in the species Homo sapiens
by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex". Mol. Cell. Biol. 25 (10): 4010–22. doi:10.1128/MCB.25
LIMD1
and co-localize with IL-17RA, mediate IL-17 signaling, and interact with TRAF6 (an IL-17 downstream molecule). Moreover, deletion of IL-17RD intracellular
IL17RD
Protein-coding gene in the species Homo sapiens
Activation by Affecting the Assembly and Activity of the Protein Kinase Cζ/p62/TRAF6 Signaling Complex". Mol. Cell. Biol. 25 (10): 4010–22. doi:10.1128/MCB.25
JUB_(gene)
TRAF6
TRAF6
TRAF6
TRAF6
Boy/Male
Indian, Marathi
Courage and Patience
Boy/Male
Tamil
Poornachandra | பூரà¯à®¨à®¾à®šà®‚தà¯à®°à®¾Â
Full Moon
Girl/Female
Indian
Pure gold
Boy/Male
Biblical
Noble; rulers.
Girl/Female
Tamil
Radha, Long beautiful hair
Girl/Female
Slavic Russian
Glorious ruler.
Boy/Male
Spanish
follower of Christ; the annointed.
Girl/Female
Hindu, Indian, Sanskrit, Traditional
With Divine Beauty
Boy/Male
Gujarati, Hindu, Indian, Kannada, Punjabi, Sikh, Telugu
Good Love
Girl/Female
Tamil
Honey
TRAF6
TRAF6
TRAF6
TRAF6
TRAF6