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Protein-coding gene in humans
dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25A (CDC25A) gene. CDC25A is a member of the CDC25 family
CDC25A
Enzyme
can be reactivated after dephosphorylation by Cdc25. The Cdc25 enzymes Cdc25A-C are known to control the transitions from G1 to S phase and G2 to M phase
Cdc25
Third subphase of interphase
phosphatase activity via activating the intermediate kinase PLK1, and stabilizes Cdc25A. Thus, CDK1 forms a positive feedback loop with Cdc25 and a double negative
G2_phase
RNA family
the cell cycle and proliferation, such as MYC, RAS, cyclin D, HMGA2, and CDC25A. Knockdown of these proteins by let-7 prevents proliferation and induces
Let-7_microRNA_family
Control mechanism in the eukaryotic cell cycle
which in turn phosphorylate the phosphatase Cdc25A, thus marking it for ubiquitination and degradation. As Cdc25A activates the previously mentioned cyclin
Cell_cycle_checkpoint
Chemical compound
viable after the CDC25B (and CDC25C) genes are "knocked out", but removal of CDC25A results in non-viable cells. Indirubin has not been shown to prevent or
Indirubin
Second subphase of interphase
active ATR and ATM stalls cell cycle progression by promoting degradation of CDC25A, a phosphatase that removes inhibitory phosphate residues from CDKs. Homologous
S_phase
Transmembrane protein
been shown to interact with: AR, ARF4, CAV1, CAV3, CBL, CBLB, CBLC, CD44, CDC25A, CRK, CTNNB1, DCN, EGF, GRB14, Grb2, JAK2, MUC1, NCK1, NCK2 PKC alpha, PLCG1
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Protein-coding gene in the species Homo sapiens
Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7):
IFNA14
Protein-coding gene in humans
PMID 7667636. Demetrick DJ, Beach DH (1994). "Chromosome mapping of human CDC25A and CDC25B phosphatases". Genomics. 18 (1): 144–7. doi:10.1006/geno.1993
CDC25B
Protein-coding gene in the species Homo sapiens
"NPAS2 promotes cell survival of hepatocellular carcinoma by transactivating CDC25A". Cell Death & Disease. 8 (3): e2704. doi:10.1038/cddis.2017.131. PMC 5386534
NPAS2
Protein family
division cycle 25A (CDC25A) is a phosphatase that removes an inhibitory phosphate group from CDK2. While ubiquitination would mark CDC25A for degradation
Deubiquitinating_enzyme
families of cell cycle kinase inhibitors. TGFb inhibits the transcription of Cdc25A, a phosphatase that activates the cell cycle kinases, and growth factor
Biochemical switches in the cell cycle
Biochemical_switches_in_the_cell_cycle
Protein-coding gene in the species Homo sapiens
βTrCP keeps CDK1 in check by promoting the degradation of the phosphatase CDC25A, whereas in G2, βTrCP contributes to CDK1 activation by targeting the kinase
BTRC_(gene)
Type of pluripotent blastocystic stem cell
transition in human embryonic stem cells through direct binding of CDK6 and CDC25A". The Journal of Cell Biology. 184 (1): 67–82. doi:10.1083/jcb.200801009
Embryonic_stem_cell
Protein-coding gene in the species Homo sapiens
βTrCP keeps CDK1 in check by promoting the degradation of the phosphatase CDC25A, whereas in G2, βTrCP contributes to CDK1 activation by targeting the kinase
FBXW11
Family of transcription factors
the placenta. Cell cycle: CCNA1,2, CCND1,2, CDK2, MYB, E2F1,2,3, TFDP1, CDC25A Negative regulators: E2F7, RB1, TP107, TP21 Checkpoints: TP53, BRCA1,2,
E2F
Mitochondrial enzyme which breaks down cyanide
related families in #Structure and mechanism): M-phase inducer phosphatase: CDC25A; CDC25B; CDC25C; Dual specificity protein phosphatase: DUSP; DUSP1; DUSP2;
Rhodanese
Mammalian protein found in Homo sapiens
and thereby activated by ATM. Activated CHK2 phosphorylates phosphatase CDC25A, which is degraded thereupon and can no longer dephosphorylate CDK1-cyclin
ATM_serine/threonine_kinase
Protein-coding gene in the species Homo sapiens
been shown to degrade Pim-1. PIM1 has been shown to interact with: CBX3, CDC25A, Heat shock protein 90kDa alpha (cytosolic), member A1, NFATC1, Nuclear
PIM1
Non-coding RNA molecule
promote cell cycle quiescence and differentiation by down-regulation of Cdc25A". Mol. Biol. Cell. 21 (13): 2138–49. doi:10.1091/mbc.E10-01-0062. PMC 2893979
MIR503
Class of enzymes
specificity. The third class of PTPs contains three cell cycle regulators, CDC25A, CDC25B and CDC25C, which dephosphorylate CDKs at their N-terminal, a reaction
Protein_phosphatase
Stage in cell cycle
into S phase and during S phase, ATM/R also activates Chk1/2 that inhibits Cdc25A, a protein responsible for activating cyclin-Cdk dimers. Without cyclin
G1/S_transition
Protein-coding gene in the species Homo sapiens
Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7):
IFNA8
Xiaodong Zhang; et al. (13 October 2009). "microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells". Cancer Research. 69 (20):
Xiaodong_Zhang
Protein-coding gene in the species Homo sapiens
Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7):
IFNA4
Protein-coding gene in the species Homo sapiens
sites is done by the Cdc25 family. In vertebrates, the Cdc25 enzymes are Cdc25A which controls the checkpoints of G1/S and G2/M as well as Cdc25B and Cdc25C
PKMYT1
Protein-coding gene in the species Homo sapiens
D, Dorrello NV, Hershko A, Pagano M, Draetta GF (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage". Nature. 426
FBXW7
Protein found in humans
well as post-transcriptional. ASK1 has been shown to interact with: C-Raf, CDC25A, DAXX, DUSP19, EIF2AK2, GADD45B, HSPA1A, MAP2K6, MAP3K7 and MAPK8IP3, PDCD6
ASK1
Protein-coding gene in humans
Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism". J. Biol. Chem. 281 (41): 30631–44. doi:10.1074/jbc
CDC45-related_protein
Q12834 2573 CDC20B HGNC:24222; Q86Y33 2574 CDC23 HGNC:1724; Q9UJX2 2575 CDC25A HGNC:1725; P30304 2576 CDC25B HGNC:1726; P30305 2577 CDC25C HGNC:1727; P30307
List of human protein-coding genes 2
List_of_human_protein-coding_genes_2
Protein-coding gene in humans
PMID 9111314. Iavarone A, Massagué J (May 1997). "Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor
CDKN2B
Protein-coding gene in the species Homo sapiens
Reed SI, Kimchi A (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7):
IFNA13
Protein-coding gene in the species Homo sapiens
information is not yet available. Cyclin E1 has been shown to interact with: CDC25A, CDKN1B, CUL3 Cdk1, Cyclin-dependent kinase 2, HERC5, P21, Retinoblastoma-like
Cyclin_E1
Protein-coding gene in the species Homo sapiens
D, Dorrello NV, Hershko A, Pagano M, Draetta GF (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage". Nature. 426
FBXW2
Protein-coding gene in the species Homo sapiens
Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7):
IFNA7
Mammalian protein found in Homo sapiens
C-Raf has been shown to interact with: AKT1, ASK1, BAG1, BRAF, Bcl-2, CDC25A, CFLAR, FYN, GRB10, HRAS, HSP90AA1, KRAS, MAP2K1, MAP3K1, MAPK7, MAPK8IP3
C-Raf
Protein-coding gene in the species Homo sapiens
SI, et al. (July 1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Molecular and Cellular Biology
Cyclin_D3
Protein-coding gene in the species Homo sapiens
Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7):
IFNA17
Protein-coding gene in humans
(2006). "ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage". Cell Cycle. 3 (7): 941–5. doi:10.4161/cc
CLSPN
Protein-coding gene in the species Homo sapiens
Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7):
IFNA21
DNA-like molecule in the human body
promote cell cycle quiescence and differentiation by down-regulation of Cdc25A". Molecular Biology of the Cell. 21 (13): 2138–49. doi:10.1091/mbc.E10-01-0062
Mir-322 microRNA precursor family
Mir-322_microRNA_precursor_family
RNA family
promote cell cycle quiescence and differentiation by down-regulation of Cdc25A". Molecular Biology of the Cell. 21 (13): 2138–49. doi:10.1091/mbc.E10-01-0062
Mir-503 microRNA precursor family
Mir-503_microRNA_precursor_family
Protein-coding gene in humans
Calvo E, et al. (2007). "Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320". Cell Cycle. 5 (24): 2894–8. doi:10.4161/cc.5.24
CDC14A
Protein-coding gene in the species Homo sapiens
Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7):
IFNA10
Chemical compound
PMC 4666830. PMID 26028036. Shen, Tao; Huang, Shile (2012). "The Role of Cdc25A in the Regulation of Cell Proliferation and Apoptosis". Anti-Cancer Agents
Cyclamin
Protein-coding gene in the species Homo sapiens
S2CID 27596435. Busino L, Donzelli M, Chiesa M, et al. (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage". Nature. 426
FBXW4
Protein-coding gene in the species Homo sapiens
Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7):
IFNA5
Protein-coding gene in the species Homo sapiens
Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7):
IFNA6
Protein-coding gene in humans
Sexl V, Diehl JA, Sherr CJ, et al. (1999). "A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of
CDKN3
Mammalian protein found in humans
Pallone F, Monteleone G (June 2008). "Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S
Ubiquitin_C
Protein-coding gene in the species Homo sapiens
for this gene. YWHAB has been shown to interact with: BRAF, C-Raf, CD29, CDC25A, CDC25B, Cbl gene, EPB41L3, HDAC4 KCNK3, MAPK7, PTPN3, PRKCZ, RPS6KA1, TESK1
YWHAB
Protein-coding gene in the species Homo sapiens
PMID 12964049. Busino L, Donzelli M, Chiesa M, et al. (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage". Nature. 426
PRPF40A
CDC25A
CDC25A
CDC25A
CDC25A
Boy/Male
Australian, British, Danish, English, Finnish, German, Norwegian, Russian, Slavic, Swedish, Teutonic
Variant of Roderick Famous Ruler; Noted Ruler; Famously Powerful
Boy/Male
Indian, Sanskrit
Coloured Like Honey
Boy/Male
Scottish American Welsh
White hawk. From the medieval name Gawain. See also Gwayne.
Boy/Male
Tamil
Name of a flower plant
Boy/Male
Hindu, Indian
Peepal Tree; Holy Tree; Buddha Got Wisdom Under it
Boy/Male
Hindu, Indian, Kannada, Marathi, Oriya, Sanskrit, Telugu
Hard Worker
Girl/Female
Arabic, Muslim
The Empowerer; The Strengthener
Surname or Lastname
English
English : variant spelling of Collingsworth, itself a variant of Collingwood.
Female
Japanese
(茜) Japanese name AKANE means "brilliant red."
Boy/Male
Indian, Telugu
Saint; Sage
CDC25A
CDC25A
CDC25A
CDC25A
CDC25A