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Immunological process
Antigen processing, or the cytosolic pathway, is an immunological process that prepares antigens for presentation to special cells of the immune system
Antigen_processing
Vital immune process that is essential for T cell immune response triggering
cells recognize only fragmented antigens displayed on cell surfaces, antigen processing must occur before the antigen fragment can be recognized by a
Antigen_presentation
Cell surface proteins, part of the acquired immune system
of MHC molecules, which is to bind an antigen derived from self-proteins, or from pathogens, and bring the antigen presentation to the cell surface for
Major histocompatibility complex
Major_histocompatibility_complex
Protein of the immune system
internalize antigens via receptor-mediated endocytosis and create MHC class II molecules plus peptide in the endosomal-lysosomal antigen processing compartment
MHC_class_II
Protein family
Transporter associated with antigen processing (TAP) protein complex belongs to the ATP-binding-cassette transporter family. It delivers cytosolic peptides
Transporter associated with antigen processing
Transporter_associated_with_antigen_processing
Immune response by adaptive immune system
of its antigens) with its subsequent engulfing by B cells or macrophages. This activates the B cell only partially. Antigen processing. Antigen presentation
Polyclonal_B_cell_response
Molecule triggering an immune response
for a single antigen. Upon exposure to an antigen, only the lymphocytes that recognize that antigen are activated and expanded, a process known as clonal
Antigen
Protein domain
preventing proteasomal breakdown, as well as impairing antigen processing and MHC class I-restricted antigen presentation. This thereby inhibits the CD8-restricted
Epstein–Barr virus nuclear antigen 1
Epstein–Barr_virus_nuclear_antigen_1
Type of protein
molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum
Tapasin
Mammalian protein found in humans
additional thyroglobulin-like region that influences proteolytic processing and MHC class II antigen presentation. Isoforms p35 and p43 also contain N-terminal
CD74
Soluble protein
transporter associated with antigen processing (TAP) complex. This association prepares the MHC class I to bind an antigen for presentation on the cell
Calreticulin
Protein-coding gene in the species Homo sapiens
Transporter associated with antigen processing 1 (TAP1) is a protein that in humans is encoded by the TAP1 gene. A member of the ATP-binding cassette transporter
TAP1
Component of MHC class I molecules
Wiley DC (May 1991). "Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution". Journal of Molecular Biology. 219 (2): 277–319
Beta-2_microglobulin
Biological system protecting an organism against disease
surface and recognizes native (unprocessed) antigen without any need for antigen processing. Such antigens may be large molecules found on the surfaces
Immune_system
Protein-coding gene in the species Homo sapiens
by the ERAP1 gene. This M1 zinc aminopeptidase is involved in the antigen processing and presentation pathway. ERAP1 is mainly located in the endoplasmic
ERAP1
Cell that displays antigen bound by MHC proteins on its surface
this process is known as antigen presentation. T cells may recognize these complexes using their T cell receptors (TCRs). APCs process antigens and present
Antigen-presenting_cell
Protein complex on the surface of T cells that recognizes antigens
recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The binding between TCR and antigen peptides is of relatively
T-cell_receptor
Protein-coding gene in the species Homo sapiens
HLA class I histocompatibility antigen, alpha chain E (HLA-E) also known as MHC class I antigen E is a protein that in humans is encoded by the HLA-E gene
HLA-E
Protein-coding gene in the species Homo sapiens
lysosomal cysteine protease that may participate in the degradation of antigenic proteins to peptides for presentation to the MHC class II. Cathepsin S
Cathepsin_S
Protein-coding gene in the species Homo sapiens
HLA-A is a group of human leukocyte antigens (HLA) that are encoded by the HLA-A locus, which is located at human chromosome 6p21.3. HLA is a major histocompatibility
HLA-A
Virus of the herpes family
more functions, such as replication, metabolism, and blockade of antigen processing. Early lytic gene products include BNLF2. Finally, late lytic gene
Epstein–Barr_virus
Protein-coding gene in the species Homo sapiens
system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the
HLA-B
Protein-coding gene in the species Homo sapiens
the endoplasmic reticulum (ER). In the ER, both enzymes help process and present antigens by trimming the ends of precursor peptides. This creates the
ERAP2
Mammalian proteins found in humans
HLA-G histocompatibility antigen, class I, G, also known as human leukocyte antigen G (HLA-G), is a protein that in humans is encoded by the HLA-G gene
HLA-G
Protein found in Homo sapiens
cytoplasmatic organelle called Birbeck granule. There, degradation and antigen processing for presentation to T-cells take place. For instance, langerin binds
Langerin
Mammalian protein found in Homo sapiens
polymorphisms in venous leg ulcer: a model in tissue injury and reparative process". Thrombosis and Haemostasis. 98 (1): 131–137. doi:10.1160/th06-11-0625
HFE_(gene)
Protein-coding gene in the species Homo sapiens
HLA-C (Human Leukocyte Antigen-C) belongs to the MHC class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene
HLA-C
Protein-coding gene in humans
CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five
CD1A
T cell subset
The antigenic molecules that activate γδ T cells are largely unknown. γδ T cells are peculiar in that they do not seem to require antigen processing and
Gamma_delta_T_cell
Protein found in humans
proteasomes which can be applied as clinical biomarkers. During the antigen processing for the major histocompatibility complex (MHC) class-I, the proteasome
PSMB8
Protein-coding gene in the species Homo sapiens
HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. DRB1 encodes the most prevalent
HLA-DRB1
Protein-coding gene in the species Homo sapiens
important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Its substrates
Cathepsin_L1
T cell that kills infected, damaged or cancerous cells
foreign proteins via antigen processing. These result in peptide fragments, some of which are presented by MHC Class I to the T cell antigen receptor (TCR)
Cytotoxic_T_cell
Protein-coding gene in the species Homo sapiens
HLA class II histocompatibility antigen, DM alpha chain is a protein that in humans is encoded by the HLA-DMA gene. HLA-DMA belongs to the HLA class II
HLA-DMA
Protein-coding gene in the species Homo sapiens
derived from extracellular proteins. Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The
HLA-DQB1
Protein-coding gene in humans
Angenieux C, et al. (2005). "Assistance of microbial glycolipid antigen processing by CD1e". Science. 310 (5752): 1321–4. Bibcode:2005Sci...310.1321D
CD1E
Protein-coding gene in the species Homo sapiens
demonstrated that PDIA3 interacts with: BACE1, ERp27, tapasin, CRT, and CNX. Antigen processing Major histocompatibility complex GRCh38: Ensembl release 89: ENSG00000167004
PDIA3
InterPro Family
molecules as well as class II MHC on antigen-presenting cells—to be specific, through induction of antigen processing genes, including subunits of the immunoproteasome
Interferon_gamma
Type of immune cell
response, professional antigen-presenting cells (APCs) endocytose antigens (typically bacteria or viruses), which undergo processing, then travel from the
T_helper_cell
Protein-coding gene in the species Homo sapiens
factors, activation of enzymatic precursors, processing of enzyme activators and inhibitors, brain antigen processing and regulation of programmed cell death
Cathepsin_D
Topics referred to by the same term
interactions Timor–Alor–Pantar languages Transporter associated with antigen processing (TAP), a protein complex 2,4,6-triaminopyrimidine (TAP), a candidate
Tap
Protein-coding gene in humans
differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are non-classical MHC proteins, related to the class
CD1D
Protein-coding gene in the species Homo sapiens
derived from extracellular proteins. Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The
Major histocompatibility complex, class II, DQ alpha 1
Major_histocompatibility_complex,_class_II,_DQ_alpha_1
Mammalian protein found in humans
transporter associated with antigen processing (TAP) complex. This association prepares the MHC class I for binding an antigen for presentation on the cell
Calnexin
Chemical compound
Tuftsin acts at the level of antigen processing. Antigen uptake by T-lymphocytes is enhanced when a given antigen is processed in the presence of tuftsin
Tuftsin
Antibody fragment receptor in humoral immunity
increasing the BCR activation threshold and suppressing B cell-mediated antigen presentation to T cells through the ITIM-dependent inhibitory mechanism
FCGR2B
Species of virus
interference with MHC class I antigen presentation on the cell surface, by blocking the transporter associated with antigen processing (TAP) induced by the secretion
Herpes_simplex_virus
Classification based on antibodies and antigens on RBC surfaces
absence of antibodies and inherited antigenic substances on the surface of red blood cells (RBCs). These antigens may be proteins, carbohydrates, glycoproteins
Blood_type
Tissue compatibility between individuals
sufficiently similar, alleles of a set of genes called human leukocyte antigens (HLA), or major histocompatibility complex (MHC). Each individual expresses
Histocompatibility
Human blood group classification
The Kell antigen system (also known as the Kell–Cellano system) is a human blood group system, that is, a group of antigens on the human red blood cell
Kell_antigen_system
Protein-coding gene in the species Homo sapiens
of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of dendritic cell antigen processing and
Thrombospondin_1
Protein-coding gene in the species Homo sapiens
HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene. HLA-DPB belongs to the HLA class
HLA-DPB1
Type of white blood cell
PMID 11367532. Blum JS, Wearsch PA, Cresswell P (2013-01-01). "Pathways of antigen processing". Annual Review of Immunology. 31 (1): 443–473. doi:10
B_cell
Protein-coding gene in humans
immune system process innate immune response negative regulation of cytokine production plasmacytoid dendritic cell antigen processing and presentation
CLEC4A
Mammalian protein found in humans
(GPIV) is a protein that in humans is encoded by the CD36 gene. The CD36 antigen is an integral membrane protein found on the surface of many cell types
CD36
British immunologist
Medicine. His lab primary focuses on the molecular mechanisms of antigen processing particularly the functions of the major histocompatibility complex
Peter Cresswell (immunologist)
Peter_Cresswell_(immunologist)
Mammalian protein found in Homo sapiens
adhesion ligand-1 (Mac-1; ITGB2 / ITGAM), leukocyte function associated antigen-1 (LFA-1), and fibrinogen. These three proteins are generally expressed
ICAM-1
Subsystem of the immune system
repertoire of immune-related genes. The immunoprotease genes involved in antigen processing and presentation as well as the class I and class II genes, are closely
Adaptive_immune_system
American immunologist (1934–2022)
macrophages did not completely catabolize antigens, foreshadowing development of the field of antigen processing and presentation. In 1970, Unanue was given
Emil_R._Unanue
Process in molecular biology
post-translational protein splicing and other lessons from the school of antigen processing". Journal of Molecular Medicine. 83 (6): 420–428. doi:10.1007/s00109-005-0652-6
RNA_splicing
consists of seven subunits, including the transporters associated with antigen processing (TAP1 and TAP2 – jointly referred to as TAP), the oxidoreductase ERp57
Peptide-loading_complex
Enzyme found in humans
interferon during the therapy of chronic hepatitis C. During the antigen processing for the major histocompatibility complex (MHC) class-I, the proteasome
PSMD3
Cellular process
of certain professional antigen-presenting cells (mostly dendritic cells) to take up, process and present extracellular antigens with MHC class I molecules
Cross-presentation
Children's Hospital, known for his contributions in understanding antigen processing and the evasion of the immune system by viruses. Ploegh, a native
Hidde_Ploegh
Protein found in humans
proteasomes which can be applied as clinical biomarkers. During the antigen processing for the major histocompatibility complex (MHC) class-I, the proteasome
PSMB9
Ability of a foreign substance to provoke an immune response
Immunogenicity is the ability of a foreign substance, such as an antigen, to provoke an immune response in the body of a human or other animal. It may
Immunogenicity
Protein-coding gene in the species Homo sapiens
HLA class I histocompatibility antigen, alpha chain F is a protein that in humans is encoded by the HLA-F gene. It is an empty intracellular molecule
HLA-F
Protein-coding gene in the species Homo sapiens
of the human MHC class II region encoding a cluster of genes for antigen processing". J. Mol. Biol. 228 (2): 433–41. doi:10.1016/0022-2836(92)90832-5
TAP2
Protein of the immune system
lumen of the ER is accomplished by the transporter associated with antigen processing (TAP). TAP is a member of the ABC transporter family and is a heterodimeric
MHC_class_I
Protein found in humans
(2002). "The role of the proteasome activator PA28 in MHC class I antigen processing". Mol. Immunol. 39 (3–4): 165–9. doi:10.1016/S0161-5890(02)00099-8
PSME1
Protein-coding gene in the species Homo sapiens
in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing
IFI30
Study of the role of the immune system in cancer
presentations. Defects are for example in transporter associated with antigen processing (TAP) or tapasin. On the other hand, a complete loss of MHC I is a
Cancer_immunology
Protein-coding gene in the species Homo sapiens
HLA class II histocompatibility antigen, DR alpha chain is a protein that in humans is encoded by the HLA-DRA gene. HLA-DRA encodes the alpha subunit
HLA-DRA
Procedure for detection and localization of an antigen
biochemical process that enables the detection and localization of an antigen to a particular site within a cell, tissue, or organ. Antigens are organic
Immunolabeling
Swiss researcher and academic
laboratory of Hidde Ploegh where he studied the role of proteolysis in antigen processing and presentation. In 2001, Kessler joined the Harvard Medical School
Benedikt_Kessler
Centromere- and microtubule-associated protein
multicellular organism development cell division antigen processing and presentation of exogenous peptide antigen via MHC class II kinetochore assembly microtubule-based
Centromere_protein_E
Protein-coding gene in the species Homo sapiens
HLA class II histocompatibility antigen, DM beta chain is a protein that in humans is encoded by the HLA-DMB gene. HLA-DMB belongs to the HLA class II
HLA-DMB
Mammalian protein found in humans
Scholzen TE (October 2006). "Monitoring neuropeptide-specific proteases: processing of the proopiomelanocortin peptides adrenocorticotropin and alpha-melanocyte-stimulating
Angiotensin-converting_enzyme
M, Kirk CJ, Groettrup M (February 2013). "The immunoproteasome in antigen processing and other immunological functions". Current Opinion in Immunology
Immunoproteasome
Genetically engineered T cell
In biology, chimeric antigen receptors (CARs)—also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors—are receptor
CAR_T_cell
Immune cells found in lymph nodes
separation from the sites of earliest antigen processing and capture provide a protected environment in which opsonized antigens can be displayed for a long time
Follicular_dendritic_cells
Method to detect an antigen using an antibody and enzyme
one antibody with specificity for a particular antigen. The sample with an unknown amount of antigen is immobilized on solid support (usually a polystyrene
ELISA
Protein-coding gene in the species Homo sapiens
HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. Also known as HLA-DXA or DAAP-381D23
HLA-DQA2
German biochemist
Biochemistry at Goethe University Frankfurt. He is known for his work on antigen processing, viral immune evasion and cellular quality control. Tampé studied
Robert_Tampé
Protein(s) forming a major part of an organism's immune system
(the antigen-binding site) that specifically binds to one particular epitope (a specific part of an antigen bound by the paratope) on an antigen, allowing
Antibody
Protein-coding gene in the species Homo sapiens
negative regulation of dendritic cell antigen processing and presentation negative regulation of macrophage antigen processing and presentation negative regulation
FGL2
Protein found in humans
Biological process ephrin receptor signaling pathway mitigation of host defenses by virus clathrin-dependent endocytosis antigen processing and presentation
Adaptor-related protein complex 2, alpha 1
Adaptor-related_protein_complex_2,_alpha_1
Species of virus
affect protein folding, post-transcriptional modifications, and antigenic processing, influencing B and T cell immunity during viral infections. This
Respiratory_syncytial_virus
Academic journal
Societies covering basic immunology research, with a primary focus on antigen processing, cellular immune response, immunity to infection, immunomodulation
European Journal of Immunology
European_Journal_of_Immunology
Corticosteroid medication
Specific immune functions affected by this process are cytokinesis, migration, phagocytosis, antigen processing and presenting, antibody synthesis, cytotoxicity
Methylprednisolone
Protein-coding gene in the species Homo sapiens
of the human MHC class II region encoding a cluster of genes for antigen processing". J. Mol. Biol. 228 (2): 433–41. doi:10.1016/0022-2836(92)90832-5
HLA-DOB
Protein-coding gene in the species Homo sapiens
Biological process mast cell activation positive regulation of phagocytosis Fc receptor mediated stimulatory signaling pathway antigen processing and presentation
FCER1G
Vaccine containing DNA
A DNA vaccine is a type of vaccine that transfects a specific antigen-coding DNA sequence into the cells of an organism as a mechanism to induce an immune
DNA_vaccine
Protein-coding gene in the species Homo sapiens
HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene. HLA-DOA belongs to the HLA class II
HLA-DOA
Protein-coding gene in the species Homo sapiens
reticulum. Cathepsin E plays a vital role in protein degradation, antigen processing via the MHC class II pathway and bioactive protein generation. The
Cathepsin_E
Protein-coding gene in the species Homo sapiens
superoxide metabolic process phagocytosis positive regulation of catalytic activity respiratory burst electron transport chain antigen processing and presentation
Neutrophil_cytosolic_factor_2
Immune system response to a substance that most people tolerate well
allergy. Impairment of the intestinal epithelial barrier, altered antigen processing, inflammation, or reduced regulatory T-cell activity may shift immune
Allergy
Protein found in humans
Sijts AJ (Oct 2002). "PI31 is a modulator of proteasome formation and antigen processing". Proceedings of the National Academy of Sciences of the United States
PSMF1
Protein-coding gene in the species Homo sapiens
EW, Morrice N, et al. (1999). "An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation". Nature. 396 (6712): 695–9. doi:10
LGMN
Mammalian protein found in Homo sapiens
Gene: ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)". Hermann P, Armant M, Brown E, Rubio M, Ishihara H, Ulrich D, et al
Integrin_alpha_V
ANTIGEN PROCESSING
ANTIGEN PROCESSING
Girl/Female
Greek Latin
Daughter of Oedipus.
Female
German
Variant spelling of Low German Anneken, ANNIKEN means "favor; grace."
Surname or Lastname
English and Scottish
English and Scottish : metonymic occupational name for a harpist (see Harper), or occasionally a habitational name for someone living at a house distinguished by the sign of a harp.English : habitational name from a minor place such as Harp House in Eastwood, Essex, or South Harp in South Petherton, Somerset, denoting a place where salt was produced, from Old English hearpe ‘harp’, an implement used in the processing of salt. Compare Harpham.German : metonymic occupational name for a harpist, from Middle High German harpfe ‘harp’.German : variant of Harpe.
Female
Swedish
Swedish form of Low German Anniken, ANNIKA means "favor; grace."
Boy/Male
Latin
Worthy of praise; of value. Saint Anthony is the patron sain of poor people. Famous Bearer:...
Girl/Female
Australian, Swedish
Grace; Favor
Male
Native American
Native American Mapuche name ANTIMAN means "condor of the sun."
Male
English
This name became popular as a boy's name after the making of the Star Wars saga by George Lucas, who named his Darth Vader character after the surname of director Ken Annakin, a variant spelling of the Low German female personal name Anniken, a form of Hannah, ANAKIN means "favor; grace."
Boy/Male
Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Tamil, Telugu
Processing
Female
German
Variant spelling of Low German Anniken, ANNIKIN means "favor; grace."
ANTIGEN PROCESSING
ANTIGEN PROCESSING
Boy/Male
Hindu, Indian, Malayalam, Marathi, Punjabi, Sikh
Celebratory Procession
Biblical
joined to the Lord
Girl/Female
Tamil
The beginning, First, Black
Surname or Lastname
English (East Anglia)
English (East Anglia) : elaborated form of Pretty, or an occupational name for a servant of someone called Pretty.
Boy/Male
American, Australian, British, Chinese, Christian, Danish, Dutch, English, Finnish, French, German, Netherlands, Swiss, Teutonic
Form of Frederick; Peace; Peaceful Ruler; Counsel from the Elves
Girl/Female
Australian, Greek, Hindu, Indian, Jain, Latin
One with Beautiful Body; Fire
Girl/Female
Indian, Tamil
Peacock; Peahen
Female
Russian
(Тома) Pet form of Russian Tamara, TOMA means "palm tree." Compare with masculine Toma.
Boy/Male
British, Celtic, English, Irish
Bishop Name
Girl/Female
Muslim
Band, Bond, Link nexus
ANTIGEN PROCESSING
ANTIGEN PROCESSING
ANTIGEN PROCESSING
ANTIGEN PROCESSING
ANTIGEN PROCESSING
n. pl.
The two projecting feathered angles of the forehead of some birds; the frontal points.
n.
A species of sand grouse (Syrrghaptes Pallasii) found in Asia and rarely in southern Europe.
a.
Full of or processing force; exerting force; mighty.
n.
Alt. of Attagen
n.
any preparation used to render an organism immune to some disease, by inducing or increasing the natural immunity mechanisms. Prior to 1995, such preparations usually contained killed organisms of the type for which immunity was desired, and sometimes used live organisms having attenuated virulence. since that date, preparations containing only specific antigenic portions of the pathogenic organism are also used, some of which are prepared by genetic engineering techniques.