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PHOSPHOPEPTIDE

  • Phosphopeptide
  • Phosphopeptides are modified self antigens which may induce an immune response. Protein phosphorylation is a very important and frequent post-translational

    Phosphopeptide

    Phosphopeptide

  • Casein
  • Family of proteins found in milk

    "Increased remineralization of tooth enamel by milk containing added casein phosphopeptide-amorphous calcium phosphate". The Journal of Dairy Research. 73 (1):

    Casein

    Casein

    Casein

  • Amorphous calcium phosphate
  • Chemical substance

    incorporated into the ACP structure. A commercial preparation of ACP is casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), derived from cow milk. It is

    Amorphous calcium phosphate

    Amorphous_calcium_phosphate

  • Phosphorylation
  • Chemical process of introducing a phosphate

    "Gas-phase intermolecular phosphate transfer within a phosphohistidine phosphopeptide dimer". International Journal of Mass Spectrometry. 367: 28–34. Bibcode:2014IJMSp

    Phosphorylation

    Phosphorylation

    Phosphorylation

  • Water fluoridation
  • Addition of fluoride to a water supply to reduce tooth decay

    experimental approaches include fluoridated sugar, polyphenols, and casein phosphopeptide–amorphous calcium phosphate nanocomplexes. A 2007 Australian review

    Water fluoridation

    Water fluoridation

    Water_fluoridation

  • Lewis C. Cantley
  • American biochemist

    published a novel strategy to determine the sequence specificity of phosphopeptide binding domains (initially SH2 domains). Subsequently, the oriented

    Lewis C. Cantley

    Lewis_C._Cantley

  • Milk
  • Nutrient-rich liquid produced by mammals

    Kruif and Holt, proposes that nanoclusters of calcium phosphate and the phosphopeptide fraction of beta-casein are the centerpiece to micellar structure. Specifically

    Milk

    Milk

    Milk

  • Toothpaste
  • Substance to clean and maintain teeth

    promotes remineralization, but is limited by bioavailable calcium. Casein phosphopeptide stabilised amorphous calcium phosphate (CPP-ACP) is a toothpaste ingredient

    Toothpaste

    Toothpaste

    Toothpaste

  • Chewing gum
  • Soft substance meant to be chewed without swallowing

    polyols and carbamide. A study investigating the in situ effect of casein phosphopeptide–amorphous calcium phosphate (CPP–ACP) found that its incorporation into

    Chewing gum

    Chewing gum

    Chewing_gum

  • BRCA1
  • Gene known for its role in breast cancer

    PMID 11477095. Rodriguez M, Yu X, Chen J, Songyang Z (December 2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". The Journal

    BRCA1

    BRCA1

    BRCA1

  • Phosphotyrosine-binding domain
  • Protein domain

    Shoelson SE, Fesik SW (April 1996). "Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain". Nat. Struct. Biol. 3 (4): 388–93

    Phosphotyrosine-binding domain

    Phosphotyrosine-binding domain

    Phosphotyrosine-binding_domain

  • HDAC10
  • Protein-coding gene in the species Homo sapiens

    PMID 11861901. Rodriguez M, Yu X, Chen J, Songyang Z (December 2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". The Journal

    HDAC10

    HDAC10

    HDAC10

  • Phosphoinositide 3-kinase
  • Class of enzymes

    Pawson T, Haser WG, et al. (March 1993). "SH2 domains recognize specific phosphopeptide sequences". Cell. 72 (5): 767–78. doi:10.1016/0092-8674(93)90404-E.

    Phosphoinositide 3-kinase

    Phosphoinositide 3-kinase

    Phosphoinositide_3-kinase

  • Guard cell
  • Paired cells that control the stomatal aperture

    activation of plasma membrane H+-ATPase activity. This was done by adding phosphopeptides such as P-950, which inhibits the binding of 14-3-3 protein, to phosphorylated

    Guard cell

    Guard cell

    Guard_cell

  • Matrix-assisted laser desorption/ionization
  • Ionization technique

    proteomics; mass analysis of DNA, RNA, PNA, lipids, oligosaccharides, phosphopeptides, bacteria, small molecules and synthetic polymers, similar applications

    Matrix-assisted laser desorption/ionization

    Matrix-assisted laser desorption/ionization

    Matrix-assisted_laser_desorption/ionization

  • SH2 domain
  • Protein domain

    Honig B (2003). "Sequence, structure, and energetic determinants of phosphopeptide selectivity of SH2 domains". Journal of Molecular Biology. 334 (4):

    SH2 domain

    SH2 domain

    SH2_domain

  • Quadrupole mass analyzer
  • Type of mass spectrometer

    versus triple-quadrupole mass spectrometry for the determination of phosphopeptides by precursor ion scanning". J Mass Spectrom. 36 (7): 782–90. Bibcode:2001JMSp

    Quadrupole mass analyzer

    Quadrupole mass analyzer

    Quadrupole_mass_analyzer

  • Tandem mass tag
  • Chemical labels used to quantify biomolecules via mass spectrometry

    detection sensitivity of certain highly hydrophilic analytes, such as phosphopeptides, in RPLC-MS analyses. There are currently six varieties of TMT available:

    Tandem mass tag

    Tandem_mass_tag

  • Nuclear receptor coactivator 2
  • Protein-coding gene in the species Homo sapiens

    PMC 133867. PMID 12024042. Rodriguez M, Yu X, Chen J, Songyang Z (2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol

    Nuclear receptor coactivator 2

    Nuclear receptor coactivator 2

    Nuclear_receptor_coactivator_2

  • List of MeSH codes (D12.644)
  • The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)

    List of MeSH codes (D12.644)

    List_of_MeSH_codes_(D12.644)

  • Microfluidics
  • Interdisciplinary science

    S (November 2012). "Fully automated isotopic dimethyl labeling and phosphopeptide enrichment using a microfluidic HPLC phosphochip". Analytical and Bioanalytical

    Microfluidics

    Microfluidics

    Microfluidics

  • Epitope
  • Chemical entity which can be bound by an antibody

    Lewis ST, et al. (2006). "Identification of class I MHC-associated phosphopeptides as targets for cancer immunotherapy". Proceedings of the National Academy

    Epitope

    Epitope

  • Forkhead-associated domain
  • Protein domain

    molecular biology, the forkhead-associated domain (FHA domain) is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity

    Forkhead-associated domain

    Forkhead-associated domain

    Forkhead-associated_domain

  • Short linear motif
  • also exist, PepCyber and ScanSite focus on smaller subsets of motifs, phosphopeptide binding and important signaling domains respectively. PDZBase focuses

    Short linear motif

    Short linear motif

    Short_linear_motif

  • Colloidal gold
  • Suspension of gold nanoparticles in a liquid

    1021/la9502711. Lin HY, Chen CT, Chen YC (October 2006). "Detection of phosphopeptides by localized surface plasma resonance of titania-coated gold nanoparticles

    Colloidal gold

    Colloidal gold

    Colloidal_gold

  • BRIP1
  • Mammalian protein found in Homo sapiens

    N, Macura S, Chen J, et al. (July 2004). "Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains". Structure. 12 (7): 1137–1146

    BRIP1

    BRIP1

    BRIP1

  • Proto-oncogene tyrosine-protein kinase Src
  • Mammalian protein found in humans

    STRUCTURE OF D-AMINO ACID SUBSTITUTED PHOSPHOPEPTIDE COMPLEX 1f1w: SRC SH2 THREF1TRP MUTANT COMPLEXED WITH THE PHOSPHOPEPTIDE S(PTR)VNVQN 1f2f: SRC SH2 THREF1TRP

    Proto-oncogene tyrosine-protein kinase Src

    Proto-oncogene tyrosine-protein kinase Src

    Proto-oncogene_tyrosine-protein_kinase_Src

  • Protein phosphorylation
  • Process of introducing a phosphate group on to a protein

    structure, but much more flexible for phosphates that interact with phosphopeptide-binding domains to recruit regulatory proteins. Protein phosphorylation

    Protein phosphorylation

    Protein phosphorylation

    Protein_phosphorylation

  • Phosvitin
  • Egg yolk phosphoprotein

    Samaraweera, Himali (Sep 2011). "Egg Yolk Phosvitin and Functional Phosphopeptides—Review". Journal of Food Science. 76 (7): R143–R150. doi:10.1111/j

    Phosvitin

    Phosvitin

    Phosvitin

  • Stratifin
  • Protein found in humans

    structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide 1yz5: The crystal structure of 14-3-3-sigma at 2.8 angstrom resolution

    Stratifin

    Stratifin

    Stratifin

  • Eukaryotic DNA replication
  • DNA replication in eukaryotic organisms

    had two pairs of BRCA1 C Terminus (BRCT) domains which are known as a phosphopeptide-binding domains. The N-terminal pair of the BRCT domains binds to phosphorylated

    Eukaryotic DNA replication

    Eukaryotic DNA replication

    Eukaryotic_DNA_replication

  • Targeted protein degradation
  • Class of protein inhibiting drugs

    consisting of ovalicin (a MetAP-2 small molecule inhibitor) and IκBα phosphopeptide (a recruiter of the SCFβ-TRCP E3 ligase complex) separated by a linker

    Targeted protein degradation

    Targeted_protein_degradation

  • SHC1
  • Protein-coding gene in humans

    to tyrosine-phosphorylated proteins but they are different in their phosphopeptide-binding specificities. P66SHC is characterized by having an additional

    SHC1

    SHC1

    SHC1

  • Remineralisation of teeth
  • Natural repair process for non-cavitated tooth lesions

    Thikrayat Bani; O'Connell, Anne C.; Duane, Brett (24 June 2016). "Casein phosphopeptide-amorphous calcium phosphate products in caries prevention". Evidence-Based

    Remineralisation of teeth

    Remineralisation of teeth

    Remineralisation_of_teeth

  • Polo-like kinase
  • phosphorylate Plk1 in vitro. The polo-box domain (PBD) of Plk1 is a phosphopeptide-binding motif. This means that in the absence of a phosphorylated ligand

    Polo-like kinase

    Polo-like_kinase

  • MDC1
  • Protein-coding gene in the species Homo sapiens

    PMID 14519663. S2CID 24870579. Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol

    MDC1

    MDC1

    MDC1

  • Iodoacetamide
  • Chemical compound

    "Iodoacetamide-alkylated methionine can mimic neutral loss of phosphoric acid from phosphopeptides as exemplified by nano-electrospray ionization quadrupole time-of-flight

    Iodoacetamide

    Iodoacetamide

    Iodoacetamide

  • O-GlcNAc
  • Post-translational carbohydrate modification of proteins

    have been shown to form functional complexes with OGT. A synthetic phosphopeptide was able to be dephosphorylated and O-GlcNAcylated by an OGT immunoprecipitate

    O-GlcNAc

    O-GlcNAc

    O-GlcNAc

  • PLK1
  • Mammalian protein found in humans

    Roberts-Thomson M, et al. (August 2010). "Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular

    PLK1

    PLK1

    PLK1

  • Insulin receptor substrate 1
  • Protein found in humans

    e PDB gallery 1irs: IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE 1qqg: CRYSTAL STRUCTURE OF THE PH-PTB

    Insulin receptor substrate 1

    Insulin receptor substrate 1

    Insulin_receptor_substrate_1

  • Centromere protein C
  • Protein found in humans

    PMID 12490152. Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol

    Centromere protein C

    Centromere protein C

    Centromere_protein_C

  • Ion chromatography
  • Laboratory technique to separate ions and polar molecules

    Otto; Mechtler, Karl (5 May 2015). "Anion-Exchange Chromatography of Phosphopeptides: Weak Anion Exchange versus Strong Anion Exchange and Anion-Exchange

    Ion chromatography

    Ion chromatography

    Ion_chromatography

  • GGA3
  • Protein-coding gene in the species Homo sapiens

    6-phosphate receptor 1lf8: Complex of GGA3-VHS Domain and CI-MPR C-terminal Phosphopeptide 1p4u: CRYSTAL STRUCTURE OF GGA3 GAE DOMAIN IN COMPLEX WITH RABAPTIN-5

    GGA3

    GGA3

    GGA3

  • Topoisomerase inhibitor
  • Compounds that inhibit the activity of DNA topoisomerases

    DNA cleavage associated with hypophosphorylation of topoisomerase II phosphopeptides". Molecular Pharmacology. 50 (2): 243–248. doi:10.1016/S0026-895X(25)09213-2

    Topoisomerase inhibitor

    Topoisomerase_inhibitor

  • Hydrophilic interaction chromatography
  • Type of chromatography

    Isocratic Separation of Charged Solutes and Selective Isolation of Phosphopeptides". Anal. Chem. 80 (1): 62–76. Bibcode:2008AnaCh..80...62A. doi:10.1021/ac070997p

    Hydrophilic interaction chromatography

    Hydrophilic interaction chromatography

    Hydrophilic_interaction_chromatography

  • Index of biochemistry articles
  • phenylalanine - Philadelphia chromosome - phospholipid - phospholipid bilayer - phosphopeptide - phosphoprotein - phosphorus - phosphorylation - phosphoserine - phosphothreonine

    Index of biochemistry articles

    Index of biochemistry articles

    Index_of_biochemistry_articles

  • YWHAZ
  • Protein-coding gene in the species Homo sapiens

    N-ACETYLTRANSFERASE COMPLEX 1qja: 14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2) 1qjb: 14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1) 2c1j: MOLECULAR BASIS FOR

    YWHAZ

    YWHAZ

    YWHAZ

  • CTCFL
  • Protein-coding gene in the species Homo sapiens

    CAN-05-0823. PMID 16140944. Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol

    CTCFL

    CTCFL

    CTCFL

  • HDAC8
  • Protein-coding gene in the species Homo sapiens

    PMC 151524. PMID 12509458. Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol

    HDAC8

    HDAC8

    HDAC8

  • Hsp20
  • Protein family

    Panitch, Alyssa (2005). "Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics". The FASEB Journal. 19 (2): 261–263. doi:10

    Hsp20

    Hsp20

  • HSPB8
  • 1101/gr.180101. PMC 311163. PMID 11591653. Molloy MP, Andrews PC (2002). "Phosphopeptide derivatization signatures to identify serine and threonine phosphorylated

    HSPB8

    HSPB8

    HSPB8

  • CHEK2
  • Protein-coding gene in humans

    1gxc: FHA DOMAIN FROM HUMAN CHK2 KINASE IN COMPLEX WITH A SYNTHETIC PHOSPHOPEPTIDE 2cn5: CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH ADP 2cn8: CRYSTAL

    CHEK2

    CHEK2

    CHEK2

  • PIK3R1
  • Protein-coding gene in the species Homo sapiens

    immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775.

    PIK3R1

    PIK3R1

    PIK3R1

  • CBL (gene)
  • Mammalian gene

    Structure of the c-Cbl TKB Domain in Complex with the APS pTyr-618 Phosphopeptide 2cbl: N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE ON ZAP-70

    CBL (gene)

    CBL (gene)

    CBL_(gene)

  • RNF213
  • Protein-coding gene in the species Homo sapiens

    analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography". Proteomics. 8 (7): 1346–61

    RNF213

    RNF213

    RNF213

  • FHAD1
  • Protein found in humans

    FHAD1 has 4 aliases, Forkhead associated phosphopeptide binding domain 1, Forkhead-associated (FHA) phosphopeptide binding domain 1, FHA Domain-Containing

    FHAD1

    FHAD1

    FHAD1

  • KIF1B
  • Protein-coding gene in humans

    737. PMID 12888911. Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol

    KIF1B

    KIF1B

    KIF1B

  • 14-3-3 protein
  • Family of conserved regulatory molecules

    (July 2015). "14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides". Bioinformatics. 31 (14): 2276–83. doi:10.1093/bioinformatics/btv133

    14-3-3 protein

    14-3-3 protein

    14-3-3_protein

  • Claire E. Eyers
  • British biological mass spectrometrist

    "Gas-phase intermolecular phosphate transfer within a phosphohistidine phosphopeptide dimer". International Journal of Mass Spectrometry. 367: 28–34. Bibcode:2014IJMSp

    Claire E. Eyers

    Claire E. Eyers

    Claire_E._Eyers

  • TMEM267
  • Protein

    signaling. Motifs that were predicted are a canonical arginine-containing phosphopeptide motif, which may be involved in the transportation of the 14-3-3 proteins

    TMEM267

    TMEM267

    TMEM267

  • Molar incisor hypomineralisation
  • Medical condition

    to Treat Incisors Hypomineralization (MIH): A Combined Use of Casein Phosphopeptide-Amorphous Calcium Phosphate and Hydrogen Peroxide—A Case Report". Case

    Molar incisor hypomineralisation

    Molar incisor hypomineralisation

    Molar_incisor_hypomineralisation

  • RBBP8
  • Protein-coding gene in the species Homo sapiens

    PMID 10196224. Rodriguez M, Yu X, Chen J, Songyang Z (Dec 2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol

    RBBP8

    RBBP8

    RBBP8

  • CLSPN
  • Protein-coding gene in humans

    1158/0008-5472.CAN-05-4443. PMID 16951182. Chini CC, Chen J (2006). "Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin

    CLSPN

    CLSPN

    CLSPN

  • Zeng Rong
  • Chinese biochemist

    including multi-dimensional LC-MS/MS that can aid protein profiling, phosphopeptide enrichment, and multiplex quantitation. They applied quantitative proteomics

    Zeng Rong

    Zeng_Rong

  • DNA polymerase lambda
  • Protein-coding gene in the species Homo sapiens

    deoxyribosephosphate group from the end of a strand break. The BRCT domain is a phosphopeptide binding domain that is common among DNA repair proteins and is likely

    DNA polymerase lambda

    DNA polymerase lambda

    DNA_polymerase_lambda

  • Molecularly imprinted polymer
  • Polymer with synthetic molecular receptor

    low abundant phosphopeptides from a cell lysate, outperforming titanium dioxide (TiO2) enrichment- a gold standard to enrich phosphopeptides. Recent reviews

    Molecularly imprinted polymer

    Molecularly_imprinted_polymer

  • Carol MacKintosh
  • Cell and developmental biologist

    , bat085. 14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides Bioinformatics 2015-03-03 DOI: 10.1093/bioinformatics/btv133 GARNL1

    Carol MacKintosh

    Carol_MacKintosh

  • SH2B1
  • Protein-coding gene in the species Homo sapiens

    Homology-2 domain of the adapter protein SH2-B 2hdx: Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide

    SH2B1

    SH2B1

    SH2B1

  • Peptide microarray
  • Reimer, U; Schneider-Mergener, J (2004). "Profiling of generic anti-phosphopeptide antibodies and kinases with peptide microarrays using radioactive and

    Peptide microarray

    Peptide microarray

    Peptide_microarray

  • Protein sequencing
  • Sequencing of amino acid arrangement in a protein

    acquisition may also be used. For instance, specific enrichment of phosphopeptides may assist in identifying phosphorylation sites in a protein. Alternative

    Protein sequencing

    Protein sequencing

    Protein_sequencing

  • SOCS3
  • Protein

    v t e PDB gallery 2bbu: solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor

    SOCS3

    SOCS3

    SOCS3

  • MAP3K11
  • Protein-coding gene in humans

    "Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping". Biochemistry. 41 (17): 5613–24. doi:10.1021/bi016075c. PMID 11969422

    MAP3K11

    MAP3K11

    MAP3K11

  • Electron-capture dissociation
  • Method in mass spectrometry

    phosphorylation with a minimum number of losses of phosphates and for phosphopeptide/phosphoprotein mapping, which makes ECD a superior technique. ECD has

    Electron-capture dissociation

    Electron-capture dissociation

    Electron-capture_dissociation

  • Histidine kinase
  • Family of enzymes important in cell signaling

    "Gas-phase intermolecular phosphate transfer within a phosphohistidine phosphopeptide dimer". Int J Mass Spectrom. 367: 28–34. Bibcode:2014IJMSp.367...28G

    Histidine kinase

    Histidine kinase

    Histidine_kinase

  • Cancer epigenetics
  • Field of study in cancer research

    Histone 2A. MDC1, mediator of DNA damage checkpoint 1, binds to the phosphopeptide, and phosphorylation of H2AX may spread by a positive feedback loop

    Cancer epigenetics

    Cancer epigenetics

    Cancer_epigenetics

  • PAXIP1
  • Protein-coding gene in the species Homo sapiens

    IA, Lowery DM, Nguyen A, Yaffe MB (October 2003). "BRCT repeats as phosphopeptide-binding modules involved in protein targeting". Science. 302 (5645)

    PAXIP1

    PAXIP1

    PAXIP1

  • TOPBP1
  • Protein-coding gene in the species Homo sapiens

    IA, Lowery DM, Nguyen A, Yaffe MB (October 2003). "BRCT repeats as phosphopeptide-binding modules involved in protein targeting". Science. 302 (5645):

    TOPBP1

    TOPBP1

    TOPBP1

  • Katrin Rittinger
  • ; Cantley, Lewis C. (1997-12-26). "The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity". Cell. 91 (7): 961–971. doi:10.1016/S0092-8674(00)80487-0

    Katrin Rittinger

    Katrin Rittinger

    Katrin_Rittinger

  • Eugenia Duodu Addy
  • Canadian chemist; CEO of Visions of Science Network for Learning

    tool for the selective sequestration of ATP and PPi to aid in-solution phosphopeptide detection assays." Analyst. 2016 Feb 7;141(3):820-2. Duodu E, Kraskouskaya

    Eugenia Duodu Addy

    Eugenia Duodu Addy

    Eugenia_Duodu_Addy

  • Liang Tong
  • Chinese American biochemist

    holoenzyme of propionyl-coenzyme A carboxylase, human symplekin-Ssu72-CTD phosphopeptide complex, histone mRNA stem-loop, human stem-loop binding protein and

    Liang Tong

    Liang_Tong

  • Phosphoproteomics
  • Branch of proteomics

    digested, peptides are separated using ion exchange chromatography; phosphopeptides are enriched using phosphospecific antibodies, immobilized metal affinity

    Phosphoproteomics

    Phosphoproteomics

  • ITK (gene)
  • Protein-coding gene in the species Homo sapiens

    SH2 domain bound to a phosphopeptide 2etz: The NMR minimized average structure of the Itk SH2 domain bound to a phosphopeptide 1lun: NMR Structure of

    ITK (gene)

    ITK (gene)

    ITK_(gene)

  • MAP4K4
  • Protein-coding gene in the species Homo sapiens

    S2CID 41514608. Rodriguez M, Yu X, Chen J, Songyang Z (December 2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". The Journal

    MAP4K4

    MAP4K4

    MAP4K4

  • Enamel hypocalcification
  • Defect of tooth enamel when it is softer than normal

    fluoride uptake and reducing enamel breakdown. Additionally, casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) based products, derived from casein

    Enamel hypocalcification

    Enamel_hypocalcification

  • MEMO1
  • Protein-coding gene in Homo sapiens

    homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site". The Journal of Biological Chemistry.

    MEMO1

    MEMO1

    MEMO1

  • FCGR2A
  • Protein-coding gene in humans

    immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775.

    FCGR2A

    FCGR2A

    FCGR2A

  • Embryonal fyn-associated substrate
  • Protein-coding gene in the species Homo sapiens

    Ratnofsky S, Lechleider RJ (Mar 1993). "SH2 domains recognize specific phosphopeptide sequences". Cell. 72 (5): 767–78. doi:10.1016/0092-8674(93)90404-E.

    Embryonal fyn-associated substrate

    Embryonal_fyn-associated_substrate

  • GGA1
  • Protein-coding gene in the species Homo sapiens

    domain 1py1: Complex of GGA1-VHS domain and beta-secretase C-terminal phosphopeptide 1ujj: VHS domain of human GGA1 complexed with C-terminal peptide from

    GGA1

    GGA1

    GGA1

  • Albert J. R. Heck
  • Dutch chemist

    introduction of the material TiO2 as a method for the targeted analysis of phosphopeptides in 2004. The methods developed by Heck have been adopted by many scientists

    Albert J. R. Heck

    Albert J. R. Heck

    Albert_J._R._Heck

  • DNAJA3
  • Protein-coding gene in the species Homo sapiens

    PMID 12879007. Rodriguez M, Yu X, Chen J, Songyang Z (December 2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". The Journal

    DNAJA3

    DNAJA3

    DNAJA3

  • Pressure injection cell
  • metallic surfaces which adsorb some negatively charged molecules such as phosphopeptides. A typical pressure injection cell holds a micro-tube or a vial in

    Pressure injection cell

    Pressure_injection_cell

  • CSNK1D
  • Protein-coding gene in humans

    Perich JW, Reynolds EC, Pinna LA (June 1991). "A synthetic beta-casein phosphopeptide and analogues as model substrates for casein kinase-1, a ubiquitous

    CSNK1D

    CSNK1D

    CSNK1D

  • Hybrid mass spectrometer
  • versus triple-quadrupole mass spectrometry for the determination of phosphopeptides by precursor ion scanning". J Mass Spectrom. 36 (7): 782–90. Bibcode:2001JMSp

    Hybrid mass spectrometer

    Hybrid_mass_spectrometer

  • DNM3
  • Protein-coding gene found in humans

    Robinson PJ, Roepstorff P (2004). "Improved detection of hydrophilic phosphopeptides using graphite powder microcolumns and mass spectrometry: evidence

    DNM3

    DNM3

    DNM3

  • Natalie Ahn
  • American chemist

    uses negative precursor ion mass spectrometry to discover and count phosphopeptides. Ahn has identified numerous different proteins with this method and

    Natalie Ahn

    Natalie_Ahn

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PHOSPHOPEPTIDE

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PHOSPHOPEPTIDE

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PHOSPHOPEPTIDE

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PHOSPHOPEPTIDE

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PHOSPHOPEPTIDE

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PHOSPHOPEPTIDE

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PHOSPHOPEPTIDE