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Search references for ULK1. Phrases containing ULK1
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Enzyme found in humans
Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene. Unc-51-like autophagy-activating kinases 1 and 2 (ULK1/2) are two similar
ULK1
Mammalian protein found in humans
TRIM16 to guide selective autophagy of damaged lysosomes. TRIM16 gathers ULK1 and principal components (Beclin 1 and ATG16L1) of other complexes (Beclin
MTOR
Process of cells digesting parts of themselves
although all ATG proteins and genes do not follow this pattern (such as ULK1). To give specific examples, the UKL1 enzyme (kinase complex) induces autophagosome
Autophagy
Protein-coding gene in the species Homo sapiens
with essential autophagy protein ATG13 in mammals, which is an ULK1-interacting protein. ULK1 (unc-51-like kinase 1) is thought to be important in the activation
Autophagy-related_protein_101
Protein-coding gene in humans
extracellular space guanyl-nucleotide exchange factor complex cytoplasm Atg1/ULK1 kinase complex axonal growth cone main axon P-body membrane axon dendrite
C9orf72
Protein-coding gene in the species Homo sapiens
regulates autophagy through phosphorylation of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. GRCh38: Ensembl release 89: ENSG00000175224
Autophagy-related_protein_13
Resilient and smooth elastic tissue present in animals
Haqqi, Tariq M. (2018-09-05). "Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes"
Cartilage
Cancer biologist
Tiffany, et al. "Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma." Nature Cell Biology 22.4 (2020): 412–424
Donita_Brady
Cytokine protein
Ahmad N, Haqqi TM (2018). "Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes"
Interleukin_6
Death of a cell mediated by intracellular program, often as part of development
kinase -1, -2, and -3 (ULK1, ULK2, UKL3), which play a similar role as the yeast Atg1, act downstream of the mTOR complex. ULK1 and ULK2 form a large complex
Programmed_cell_death
Autophagic process in which mitochondria are delivered to the vacuole and degraded
Laurie J.; Kundu, Mondira; Yan, Zhen (2017-09-15). "Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced
Mitophagy
Class of enzymes
the cell. AMPK activates autophagy by directly and indirectly activating ULK1. AMPK also appears to stimulate mitochondrial biogenesis by regulating PGC-1α
AMP-activated_protein_kinase
Topics referred to by the same term
Lensk Airport, IATA code Enzymes of the Unc-51-like kinase (ULK) family ULK1 ULK2 ULK3 ULK4 ulk Meriam language, ISO 639-3 code Ulk Ulk, a German satirical
ULK
Medical condition
mATXN7 aggregates which causes reduction of FIP200 levels which destabilize ULK1 which in turn impairs autophagy. Also, mATXN7 can interact with CRX directly
Spinocerebellar_ataxia_type_7
British-American biochemist (born 1973)
Mollapour, Mehdi (2023-07-25). "Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery"
Mehdi_Mollapour
Protein-coding gene in the species Homo sapiens
D, Keegan S, Melville D, Adler NS, Saraf A, et al. (December 2018). "The ULK1-FBXW5-SEC23B nexus controls autophagy". eLife. 7. doi:10.7554/eLife.42253
FBXW5
Increase of the total mass of a cell
normally directly inhibits the function of the autophagy inducing kinase Atg1/ULK1. Thus, reducing TOR activity both reduces the global rate of translation
Cell_growth
model. There are until now five potential Atg1 orthologues in vertebrates. ULK1 and ULK2 (unc-51-like kinase) have been reported to have an additional function
Atg1
Protein-coding gene in the species Homo sapiens
activated, it can phosphorylate downstream targets such as p70S6K, 4EBP, and ULK1 which are important for regulating protein anabolic/catabolic balance. Physical
P70-S6_Kinase_1
Protein family binding to β-galactoside sugars
and AMPK (galectin-9), and as a factor (galectin-3) in the assembly of the ULK1-Beclin 1-ATG16L1 initiator complex on TRIM16 during endomembrane damage.
Galectin
Protein-coding gene in the species Homo sapiens
cytoplasm GATOR2 complex nucleotide-activated protein kinase complex Atg1/ULK1 kinase complex TORC2 complex Biological process mitochondrial DNA metabolic
SESN2
Types of irreversible biochemical changes
Loffler, A. S.; Wesselborg, S.; Stork, B. (2012-01-01). "Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks".
Hallmarks_of_aging
Protein-coding gene in humans
important for mTOR to be able to catalyze phosphorylation. RPTOR interacts with ULK1. This interaction depends on nutrients and is reduced in the case of starvation
RPTOR
Protein-coding gene in humans
and recruit specific cargo. GABARAP has been shown to interact with TFRC, ULK1 and GABRG2. A bound structure for GABARAP to GABRG2 consistent with experimental
GABARAP
Cell biology structure
process is tightly regulated by multiple autophagy-related (ATG) proteins. The ULK1/ATG1 complex is the initial activator of autophagy in response to nutrient
Autophagosome
Protein-coding gene
AMBRA1 interacts with Beclin1 and ULK1 to initiate autophagy and form autophagosomes. The interaction with ULK1 also regulates cell proliferation. AMBRA1
AMBRA1
Protein in Homo sapiens
Ras at the post-synapse. SYNGAP1 has been shown to interact with DLG3 and ULK1. ENSG00000197283 GRCh38: Ensembl release 89: ENSG00000227460, ENSG00000197283
SYNGAP1
Non-profit medical research institute
Retrieved 2025-10-09. "The Salk Institute and Sanford Burnham Prebys license ULK1/2 inhibitors to Endeavor BioMedicines for treatment of cancer". Salk Institute
Sanford_Burnham_Prebys
Autophagy-related structure in cell biology
to the activation of the UNC51-like kinase (ULK1) complex, and the activity of ULK1 promotes autophagy. ULK1 and PI3KC complexes are recruited to the ER
Omegasome
Protein complex
phosphorylates autophagy-related protein 13 (Atg 13), preventing it from entering the ULK1 kinase complex, which consists of Atg1, Atg17, and Atg101. This prevents
MTORC1
Protein domain
TSSK4 ; TSSK6 ; TTBK1 ; TTBK2 ; TTK ; TTN ; TXK ; TYK2 ; TYRO3 ; UHMK1 ; ULK1 ; ULK2 ; ULK3 ; ULK4 ; VRK1 ; VRK2 ; VRK3 ; WEE1 ; WEE2 ; WNK1 ; WNK2 ; WNK3 ;
Protein_kinase_domain
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
B, Maxwell BA, Joo JH, Gwon Y, Messing J, Mishra A, et al. (May 2019). "ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and
Stress_granule
Protein-coding gene in the species Homo sapiens
encoded by the GABARAPL2 gene. GABARAPL2 has been shown to interact with ULK1, ATG4B, and FAM134B. GRCh38: Ensembl release 89: ENSG00000034713 – Ensembl
GABARAPL2
Chinese medical researcher
Junghyun; Lachance, Véronik; Deng, Zhiqiang; Yue, Zhenyu (2016-12-09). "ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's
Zhenyu_Yue
Protein-coding gene in the species Homo sapiens
"Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9". Molecular
YWHAZ
Q9BZM6 17877 ULBP2 HGNC:14894; Q9BZM5 17878 ULBP3 HGNC:14895; Q9BZM4 17879 ULK1 HGNC:12558; O75385 17880 ULK2 HGNC:13480; Q8IYT8 17881 ULK3 HGNC:19703; Q6PHR2
List of human protein-coding genes 8
List_of_human_protein-coding_genes_8
Protein found in humans
GRIK2, Interleukin 5 receptor alpha subunit, Merlin, RAB5A, SOX4, TRAF6, ULK1. and ERICH2 GRCh38: Ensembl release 89: ENSG00000137575 – Ensembl, May 2017
Syntenin-1
Chemical compound
by the integrated stress response (ISR) and does not require the protein ULK1, indicating that mycolactone behaves as an alternative route of autophagy
Mycolactone
Protein-coding gene in the species Homo sapiens
Cellular component phagophore assembly site membrane nuclear membrane Atg1/ULK1 kinase complex phagophore assembly site nucleus cytoplasm endoplasmic reticulum
RB1CC1
Gene of the species Homo sapiens
also acts as a platform for other autophagy-related proteins, including ULK1, ATG16L1, and LC3B, thereby facilitating the formation of autophagosomes
TRIM16
American cell biologist
Giunti, Paola; Hardy, John (26 April 2018). "mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition". Bioscience
Sharon_Tooze
Protein-coding gene
a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation". Autophagy. 10 (10): 1749–60. doi:10.4161/auto.29640. PMC 4198360
Folliculin
ULK1
ULK1
ULK1
ULK1
Girl/Female
Tamil
Girl/Female
Indian
Delighted, Satisfied
Boy/Male
Arabic, Muslim
Blessing for the Creation
Boy/Male
Arabic, Muslim
Prince; Saint; King; Friend of the City
Boy/Male
Tamil
Luminous
Boy/Male
Hindu
Lord Murugan
Surname or Lastname
English
English : nickname for a new arrival in a place, from Middle English newe-come(n) ‘recently come’, ‘just arrived’. The intrusive -b- is the result of the influence of place names ending in -combe (see Coombe).Americanized form of German Neukamm, possibly arising from a misinterpretation of its etymology as neu ‘new’ + Kamm ‘comb’ (see Neukam).According to family tradition, Capt. Andrew Newcomb was born in England in 1618 and died in Boston, MA, in 1686, leaving family who settled both in MA and in Kittery, ME. Among his descendants was the internationally renowned astronomer Simon Newcomb (1835–1909).
Boy/Male
Muslim/Islamic
Honest and caring
Girl/Female
French American Teutonic German
Feminine of Bernard, meaning strong as a bear, or bear hard.
Male
Japanese
Variant spelling of Japanese Jurou, JURO means "tenth son."
ULK1
ULK1
ULK1
ULK1
ULK1