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Protein family
molecular biology, transcription factor DP (Dimerization Partner) is a family of proteins which function as transcription factors. DP forms a heterodimer
Transcription_factor_DP
Protein-coding gene in the species Homo sapiens
Transcription factor Dp-2 is a protein that in humans is encoded by the TFDP2 gene that dimerises with E2F, a key transcriptional activator involved in
TFDP2
Topics referred to by the same term
track from Abalando a Sua Fábrica, 2001 TFDP1 (transcription factor Dp-1) TFDP2 (transcription factor Dp-2) This disambiguation page lists articles associated
TFDP
Protein-coding gene in humans
Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene. The E2F transcription factor family (see MIM 189971) regulates the
TFDP1
General transcription initiation factor
Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase
Transcription_factor_II_F
Family of proteins
A winged-helix transcription factor is a type of transcription factor that binds to DNA using a protein domain called a winged-helix domain. In some cases
Winged-helix transcription factors
Winged-helix_transcription_factors
Protein that controls rate of transcription of GH genes
positive transcription factor 1 (PIT1), POU domain, class 1, transcription factor 1 (POU1F1) and growth hormone factor 1 (GHF1), is a transcription factor for
Pituitary-specific positive transcription factor 1
Pituitary-specific_positive_transcription_factor_1
Family of transcription factors
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six
E2F
Region of non-coding DNA that regulates the transcription of neighboring genes
regulate. CREs typically regulate gene transcription by binding to transcription factors. A single transcription factor may bind to many CREs, and hence control
Cis-regulatory_element
Family of transcription factor protein complexes
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription of
NF-κB
Transcription factor scaffold domain
trans-activating domain (TAD) is a transcription factor scaffold domain which contains binding sites for other proteins such as transcription coregulators. These binding
Transactivation_domain
Protein-coding gene in humans
Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene. This gene encodes a transcription factor that induces expression
MTF1
Protein-coding gene in the species Homo sapiens
determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids
E2F1
Protein-coding gene in the species Homo sapiens
Lillicrap DP, Mueller CR (February 1993). "Synergy between transcription factors DBP and C/EBP compensates for a haemophilia B Leyden factor IX mutation"
DBP_(gene)
Mammalian protein found in Homo sapiens
Gearing DP, Willson TA, Brown MA, King JA, Gough NM (May 1990). "Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary
Leukemia_inhibitory_factor
DNA sequence that binds activators to increase the likelihood of gene transcription
the likelihood that transcription of a particular gene will occur. These proteins are usually referred to as transcription factors. Enhancers are cis-acting
Enhancer_(genetics)
Control of gene expression at the RNA level, between transcription and translation
Post-transcriptional regulation is the control of gene expression at the RNA level. It occurs once the RNA polymerase has been attached to the gene's
Post-transcriptional regulation
Post-transcriptional_regulation
Formation of blood cellular components
show that transcription factors act as caretakers of differentiation level and not only as initiators. Mutations in transcription factors are tightly
Haematopoiesis
Protein-coding gene in the species Homo sapiens
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene. RELA, also known
RELA
Biological cell regulation mechanisms
making it more or less likely to bind to them (i.e., sigma factors used in prokaryotic transcription). Repressors bind to the Operator, coding sequences on
Regulation_of_gene_expression
Protein-coding gene in the species Homo sapiens
1998). "Characterization of ABF-1, a Novel Basic Helix-Loop-Helix Transcription Factor Expressed in Activated B Lymphocytes". Mol Cell Biol. 18 (6): 3130–9
Musculin
Protein-coding gene in the species Homo sapiens
determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids
E2F3
Cytoplasmic receptor protein found inside cells
SA, Boonyaratanakornkit V, Edwards DP (November 2003). "Progesterone receptor transcription and non-transcription signaling mechanisms". Steroids. 68
Progesterone_receptor
Protein-coding gene in the species Homo sapiens
bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the Myc family of transcription factors. The protein
MYC
Conversion of a gene's sequence into a mature gene product or products
Pribnow box with the help of the sigma factor protein (σ factor) to start transcription. In eukaryotes, transcription is performed in the nucleus by three
Gene_expression
Protein-coding gene in the species Homo sapiens
POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene. POU2F1 has been shown to interact with: EPRS, Glucocorticoid
POU2F1
Found in the epithelial layer of mucosal linings
Another transcription factor responsible for DP IELs induction is the Aryl hydrocarbon receptor (AhR). AhR is ligand-dependent transcription factor, and
Intraepithelial_lymphocyte
Protein found in humans
factor-2alpha (HIF-2α)) is a protein that is encoded by the EPAS1 gene in mammals. It is a type of hypoxia-inducible factor, a group of transcription
EPAS1
Human protein and coding gene
also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. It is a member of the CCAAT/enhancer-binding
DNA damage-inducible transcript 3
DNA_damage-inducible_transcript_3
Protein-coding gene in the species Homo sapiens
determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids
E2F4
Protein found in humans
GATA2 or GATA-binding factor 2 is a transcription factor, i.e. a nuclear protein which regulates the expression of genes. It regulates many genes that
GATA2
Protein complex
both of which are homologs of RB (p105) and bind repressive E2F transcription factors E2F4 and E2F5; DP1, DP2 and DP3, dimerization partners of E2F; and
DREAM_complex
Protein-coding gene in humans
determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids
E2F2
Protein-coding gene in the species Homo sapiens
regulatory factor (MRF) involved in the process known as myogenesis. MYF6/Mrf4 is a member of the myogenic factor (MRF) family of transcription factors that
MYF6
Protein-coding gene in the species Homo sapiens
"Entrez Gene: HLF hepatic leukemia factor". LeBrun DP (May 2003). "E2A basic helix-loop-helix transcription factors in human leukemia". Frontiers in Bioscience
HLF_(gene)
Protein-coding gene in the species Homo sapiens
helix-loop-helix transcription factors". Int. J. Cell Cloning. 10 (5): 269–76. doi:10.1002/stem.5530100504. PMID 1453013. Aplan PD, Lombardi DP, Reaman GH,
TAL1
Protein-coding gene in the species Homo sapiens
the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with TCF3 (E47). ATOH1 is required for
ATOH1
Protein-coding gene in humans
Transcription factor 7-like 2 (T-cell specific, HMG-box), also known as TCF7L2 or TCF4, is a protein acting as a transcription factor that, in humans
TCF7L2
Protein-coding gene in the species Homo sapiens
Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene. It was first purified and identified as the first mammalian gene-specific
GTF3A
Group of signal transduction pathways involved in embryonic development
eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family. Without Wnt, β-catenin
Wnt_signaling_pathway
Mammalian protein found in Homo sapiens
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages
Granulocyte-macrophage colony-stimulating factor
Granulocyte-macrophage_colony-stimulating_factor
Protein-coding gene in the species Homo sapiens
Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene. This gene product is a member of the transcriptional enhancer
TEAD3
Protein-coding gene in the species Homo sapiens
the HOXA13 gene. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D
HOXA13
Non-coding RNA
in chromatin modification at the Xist locus and another is that transcription factors of pluripotent cells play a role in Xist repression. The Tsix antisense
XIST
Protein-coding gene in the species Homo sapiens
transcriptional repression properties". The Journal of Biological Chemistry. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164. Satijn DP
RING1
Embryonic signaling pathway for proper cell differentiation
the name 'hedgehog'. Insect cells express a full size zinc-finger transcription factor Cubitus interruptus (Ci), which forms a complex with the kinesin-like
Hedgehog_signaling_pathway
Human protein and coding gene
output cycles kaput) is a gene encoding a basic helix-loop-helix-PAS transcription factor that is known to affect both the persistence and period of circadian
CLOCK
Mammalian protein found in humans
partner (E2F-DP) dimers, which are transcription factors of the E2F family that push the cell into S phase. By keeping E2F-DP inactivated, RB1 maintains
Retinoblastoma_protein
Protein-coding gene in the species Homo sapiens
Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene
TCF3
Class of proteins
cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of
CREB
Constitutive promoter
Nudler E (16 September 2014). "The translation elongation factor eEF1A1 couples transcription to translation during heat shock response". eLife. 3 e03164
Eukaryotic translation elongation factor 1 alpha 1
Eukaryotic_translation_elongation_factor_1_alpha_1
Bacterial protein
MacEachran DP, O'Toole GA, Madden DR (2010). "Purification, crystallization and preliminary X-ray diffraction analysis of Cif, a virulence factor secreted
CFTR_inhibitory_factor
Transcription factor activated by vitamin D
calcitriol receptor) is a member of the nuclear receptor family of transcription factors. Calcitriol (the active form of vitamin D, 1,25-(OH)2vitamin D3)
Vitamin_D_receptor
Protein-coding gene in the species Homo sapiens
Gutiérrez-Aguilar R, Benmezroua Y, Vaillant E, et al. (2007). "Analysis of KLF transcription factor family gene variants in type 2 diabetes". BMC Med. Genet. 8 53. doi:10
KLF15
Mammalian protein found in Homo sapiens
the HGF-induced branching morphogenesis. MET activates the STAT3 transcription factor directly, through an SH2 domain. The beta-catenin pathway, a key
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Protein-coding gene in humans
Along the gene are several transcription regulatory binding sites with common binding motifs for such transcription factors as GATA, C/EBP or NF-κB. α
Granulocyte-macrophage colony-stimulating factor receptor
Granulocyte-macrophage_colony-stimulating_factor_receptor
Protein-coding gene in the species Homo sapiens
The Jun dimerization protein is a member of the AP-1 family of transcription factors. JDP 2 was found by a Sos-recruitment system,[clarification needed]
Jun_dimerization_protein_2
Protein-coding gene in the species Homo sapiens
site-specific (consensus TNAAGGTCA) transcription regulator and has been also shown to interact with estrogen and the transcription factor TFIIB by direct protein-protein
Estrogen-related receptor alpha
Estrogen-related_receptor_alpha
Protein family
CCAAT-enhancer-binding proteins (or C/EBPs) is a family of transcription factors composed of six members, named from C/EBPα to C/EBPζ. They promote the
CCAAT-enhancer-binding proteins
CCAAT-enhancer-binding_proteins
Cytokine
"TGFBR2 transforming growth factor, beta receptor II" (Entrez gene entry). Retrieved January 11, 2007. Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL
Transforming growth factor beta
Transforming_growth_factor_beta
Protein-coding gene in the species Homo sapiens
ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative
Estrogen_receptor_alpha
Non-protein coding transcripts longer than 200 nucleotides
PMID 18185590. Pauler FM, Koerner MV, Barlow DP (June 2007). "Silencing by imprinted noncoding RNAs: is transcription the answer?". Trends in Genetics. 23 (6):
Long_non-coding_RNA
Protein-coding gene in the species Homo sapiens
doi:10.1242/dev.127.13.2933. PMID 10851137. "HES6 hes family bHLH transcription factor 6 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved
HES6
Microbial protein found in Streptococcus pyogenes M1 GAS
cleavage, CRISPR Cas9 has been modified to function as programmable transcription factors that allow activation or silencing of targeted genes. The significance
Cas9
Protein-coding gene in the species Homo sapiens
expression and promoter binding. Among them were Meis2, a homeobox transcription factor critical for development of forebrain neurons and Satb2, a protein
KMT2A
Molecular biology technique
the binding of a transcription factor onto an upstream activating sequence (UAS). For two-hybrid screening, the transcription factor is split into two
Two-hybrid_screening
Protein-coding gene in the species Homo sapiens
J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (March 1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase
GTF2F1
Protein-coding gene in the species Homo sapiens
a direct target and through downstream activation. BLIMP-1 is a transcription factor that triggers expression of many downstream signaling cascades. As
PRDM1
RNA family
transcripts encoding class III homeodomain–leucine zipper (HD-ZIP III) transcription factors. Members of the family include the closely related microRNAs miR165
MiR166 microRNA precursor family
MiR166_microRNA_precursor_family
Protein
proteins of the JUN family (e.g., c-Jun, JunD), thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators
FOSB
Protein-coding gene in the species Homo sapiens
Upstream binding transcription factor (UBTF), or upstream binding factor (UBF), is a protein that in humans is encoded by the UBTF gene. In humans, the
UBTF
Protein found in humans
architectural factors and are essential components of the enhanceosome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating
HMGA2
Nuclear receptor protein found in humans
group C, member 1), is a nuclear receptor protein functioning as a transcription factor that in humans is encoded by the PPARA gene. Together with peroxisome
Peroxisome proliferator-activated receptor alpha
Peroxisome_proliferator-activated_receptor_alpha
Protein found in humans
acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class
HDAC4
Protein-coding gene in the species Homo sapiens
E2F target genes and how P130 complex interacts with Dp, RB like, and other E2F transcription factors to help module DREAM in cell cycle arrest. The results
C16orf86
Protein-coding gene in the species Homo sapiens
Rev-Erb proteins in the nuclear receptor (NR) family of intracellular transcription factors. In humans, REV-ERBɑ is encoded by the NR1D1 gene, which is highly
Rev-ErbA_alpha
Transmembrane protein
domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation". The Journal
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Protein-coding gene in humans
determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids
E2F5
Nuclear protein that binds to CREB
acetyltransferase functions; it is able to add acetyl groups to both transcription factors as well as histone lysines, the latter of which has been shown to
CREB-binding_protein
Protein found in humans
targets of signal transducers and activators of transcription (STATs), interferon regulatory factors, and p53 protein, indicating the intricacy of its
Promyelocytic leukemia protein
Promyelocytic_leukemia_protein
Protein-coding gene in the species Homo sapiens
is predominantly localized to prostate epithelium. It acts as a transcription factor that has critical function in prostate development and tumor suppression
NKX3-1
Human chromosome
(6p21.33) SSR1: signal sequence receptor subunit 1 (6p24.3) TCF19: transcription factor 19 (6p21.33) TCP11: t-complex 11 (6p21.31) TJAP1: tight junction
Chromosome_6
Group of protein families
dimers. In the nucleus, the complex acts as a transcription factor, augmenting or suppressing transcription particular genes by its action on DNA. Type
Steroid_hormone_receptor
Protein-coding gene in the species Homo sapiens
transcription by binding to transcription factors, and the transcription machinery. On the basis of this function, p300 is called a transcriptional coactivator
EP300
Protein-coding gene in the species Homo sapiens
"Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP". Genes Dev. 13 (6): 666–74. doi:10.1101/gad.13.6.666. PMC 316551
Tetratricopeptide repeat protein 39C
Tetratricopeptide_repeat_protein_39C
Protein-coding gene in the species Homo sapiens
protein, SAP30, SIN3A, SMARCA5, SNW1, SUV39H1, Sp1 transcription factor, Sp3 transcription factor, TOP2B, and YY1. Histone deacetylase GRCh38: Ensembl
Histone_deacetylase_2
Type of specialized cells
the transcription factors (Hoxa3, Pax1/9, Eya1, Six1/4, Tbx1), most of which are in postnatal cTEC and immature TECs. The most important transcription factor
Thymic_epithelial_cell
Protein-coding gene in humans
PITX1 has been shown to interact with pituitary-specific positive transcription factor 1. GRCh38: Ensembl release 89: ENSG00000069011 – Ensembl, May 2017
PITX1
Protein-coding gene in the species Homo sapiens
gene. The transcribed EMX1 gene is a member of the EMX family of transcription factors. The EMX1 gene, along with its family members, are expressed in
EMX1
Protein-coding gene in the species Homo sapiens
receptor knockdown. The transcription factors that act on C8orf48 are presented in Table 1. The majority of the transcription factors are involved in cell
C8orf48
Organelle in eukaryotic cells
domains defined by dense localization of the transcription factor PTF, which promotes transcription of small nuclear RNA (snRNA). Promyelocytic leukemia protein
Cell_nucleus
Type of cancer
(which encodes Friend Leukemia Integration 1 transcription factor (FLI1), a member of the ETS transcription factor family) of chromosome 11. The resultant
Ewing_sarcoma
Mammalian protein found in humans
pathway if artificially fused to the DNA binding domain of LEF1 transcription factor. Plakoglobin (also called γ-catenin) has a strikingly similar architecture
Catenin_beta-1
Mammalian protein found in humans
name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers. The p53 proteins
P53
Protein-coding gene in humans
Transcription factor E2F7 is a protein that in humans is encoded by the E2F7 gene. GRCh38: Ensembl release 89: ENSG00000165891 – Ensembl, May 2017 GRCm38:
E2F7
Small non-coding ribonucleic acid molecule
the upregulation of DRD1 and delta fosB, a transcription factor that activates a series of transcription events in the nucleus accumbens that ultimately
MicroRNA
Protein-coding gene in the species Homo sapiens
nucleus. The protein functions as a transcription coactivator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction
PRRX1
Protein-coding gene in the species Homo sapiens
(August 1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nature Genetics
LHX2
Species of bacterium
across many species. RNA polymerase (RNAP) and sigma factors are necessary proteins for transcription of DNA into messenger RNA (mRNA). Eubacterial RNAP
Synechocystis_sp._PCC_6803
Protein-coding gene in the species Homo sapiens
"Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Molecular
Nuclear receptor coactivator 1
Nuclear_receptor_coactivator_1
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TRANSCRIPTION FACTOR-DP
TRANSCRIPTION FACTOR-DP
TRANSCRIPTION FACTOR-DP
TRANSCRIPTION FACTOR-DP
TRANSCRIPTION FACTOR-DP
TRANSCRIPTION FACTOR-DP
TRANSCRIPTION FACTOR-DP
TRANSCRIPTION FACTOR-DP
TRANSCRIPTION FACTOR-DP
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