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Enzyme that metabolizes substances by oxidation
(abbreviated CYP3A4) (EC 1.14.14.56) is an important enzyme in the body, mainly found in the liver and the intestine. In humans is encoded by CYP3A4 gene. It
CYP3A4
Antibiotic
pancytopenia, and organ failure. CYP3A4 is an enzyme that metabolizes many drugs in the liver. Some drugs can inhibit CYP3A4, which means they reduce its
Azithromycin
Drug interactions with grapefruit juice
inhibit key drug metabolizing enzymes, such as cytochrome P450 3A4 (CYP3A4). CYP3A4 is a metabolizing enzyme for almost 50% of drugs, and is found in the
Grapefruit–drug_interactions
Chemical compound
dehydrogenase (CYP3A4). 6β-hydroxycortisol is used as a biomarker of 6β-hydroxysteroid dehydrogenase (CYP3A4) activity. Drugs that induce CYP3A4 may accelerate
6β-Hydroxycortisol
Medication used to treat insomnia
impairment. Concomitant use of daridorexant with strong CYP3A4 inhibitors and moderate to strong CYP3A4 inducers is not recommended and should be avoided due
Daridorexant
Antidepressant medication
enzymes, including CYP3A4, CYP2D6, and CYP1A2. Its active metabolite meta-chlorophenylpiperazine (mCPP) is known to be formed by CYP3A4 and metabolized by
Trazodone
Medication to treat gastroesophageal reflux disease and other conditions
possible because omeprazole is an inhibitor of the enzymes CYP2C19 and CYP3A4. Clopidogrel is an inactive prodrug that partially depends on CYP2C19 for
Omeprazole
Cholesterol-lowering medication
rarely with other CYP3A4 inhibitors, such as amiodarone and aprepitant. Often, bosentan, fosphenytoin, and phenytoin, which are CYP3A4 inducers, can decrease
Atorvastatin
Antiretroviral medication
metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4). The drug binds to and inhibits CYP3A4, so a low dose can be used to enhance other protease
Ritonavir
Combination drug
serious drug interactions due to strong CYP3A4 inhibition by ergotamine. Ergotamine is a vasoconstrictive CYP3A4 substrate. Bellergal was widely used during
Bellergal
Citrus fruit
inhibit the CYP3A4 enzyme (among others from the cytochrome P450 enzyme family responsible for metabolizing 90% of drugs). The action of the CYP3A4 enzyme
Grapefruit
Opioid medication
to inhibition of CYP3A4 and CYP2D6. Rifampicin greatly reduces plasma concentrations of oxycodone due to strong induction of CYP3A4. There is also a case
Oxycodone
Class of natural products
results. US FDA-approved: Azithromycin – unique; does not extensively inhibit CYP3A4 Clarithromycin Dirithromycin – discontinued but was US FDA approved Erythromycin
Macrolide
Cough suppressant and dissociative drug
metabolizers. Dextromethorphan is also metabolized by CYP3A4. N-demethylation is primarily accomplished by CYP3A4, contributing to at least 90% of the MEM formed
Dextromethorphan
Antihypertensive drug of the calcium channel blocker class
cells. The substance is metabolised by the liver enzyme CYP3A4. In a study, the strong CYP3A4 inhibitor ketoconazole increased the maximal blood plasma
Lercanidipine
cocaine. Buspirone has been shown in vitro to be metabolized by the enzyme CYP3A4. This finding is consistent with the in vivo interactions observed between
Buspirone
Anxiolytic medication
schizophrenia. Tofisopam has been shown to act as an inhibitor of the liver enzyme CYP3A4, and some researches suspect that this could cause dangerous drug interactions
Tofisopam
Anticoagulant drug
recommend administering rivaroxaban with drugs known to be strong combined CYP3A4/P-glycoprotein inhibitors because this results in significantly higher plasma
Rivaroxaban
Chemical compound
P-glycoprotein (P-gp) and CYP3A4. Hence P-gp and CYP3A4 inhibitors may increase plasma levels of bosutinib. Likewise CYP3A4 inducers may reduce plasma
Bosutinib
Major active metabolite of ketamine
is the major active metabolite of ketamine, which is formed mainly by CYP3A4. Similarly to ketamine, norketamine acts as a noncompetitive NMDA receptor
Norketamine
Chemical compound
the liver by the cytochrome P450 enzyme CYP3A4. When administered concomitantly with drugs that inhibit CYP3A4, such as ketoconazole, the metabolism of
Solifenacin
Medication against high blood pressure
inhibitors, by nature of inhibiting the enzyme that metabolizes amlodipine, CYP3A4, are one such class of drugs. Others include the calcium-channel blocker
Amlodipine
Enzyme involved in drug metabolism
expressed as a 52.5-kD protein, whereas CYP3A4 migrates as a 52.0-kD protein. The human CYP3A subfamily, CYP3A4, CYP3A5, CYP3A7 and CYP3A43, is one of
CYP3A5
the oxidative metabolism of the statins, with CYP3A4 and CYP2C9 isoenzymes being the most dominant. CYP3A4 isoenzyme is the most predominant isoform involved
Discovery and development of statins
Discovery_and_development_of_statins
Toxic plant alkaloid
metabolism. The results indicate that aconitine was mainly metabolized by CYP3A4, 3A5 and 2D6. CYP2C8 and 2C9 had a minor role to the aconitine metabolism
Aconitine
Human gene
cytochrome P450 superfamily of genes. The CYP3A cluster consists of four genes: CYP3A4, CYP3A5, CYP3A7, and CYP3A43. The region also contains four pseudogenes:
CYP3A
Medication for chronic obstructive pulmonary disease
Fluticasone furoate is metabolized by cytochrome P450 3A4 (CYP3A4). Medications that are inhibitors of CYP3A4 (e.g. ketoconazole) may decrease fluticasone's metabolism
Fluticasone furoate/umeclidinium bromide/vilanterol
Fluticasone_furoate/umeclidinium_bromide/vilanterol
Class of pharmaceutical drugs
the liver by CYP3A4 enzyme. Strong CYP3A4 inhibitors, other than pazopanib, can increase the plasma concentration of pazopanib, and CYP3A4 inducers will
VEGFR-2_inhibitor
Non-opioid analgesic drug
studies comparing suzetrigine with high-dose opioids. Suzetrigine exhibits CYP3A4-mediated drug interactions and there is limited long-term data regarding
Suzetrigine
Investigational selective androgen receptor modulator
CYP3A4 and the UDP-glucuronosyltransferase (UGT) enzymes UGT1A1 and UGT2B7. It shows very minimal metabolism by cytochrome P50 enzymes, with CYP3A4 merely
Enobosarm
Medication used to treat insomnia
strong CYP3A4 inhibitors is not recommended due to potential for increased suvorexant exposure while concomitant use of suvorexant with strong CYP3A4 inducers
Suvorexant
Chemical compound
Cilostazol is metabolized by CYP3A4 and CYP2C19, two isoenzymes of the cytochrome P450 system. Drugs that inhibit CYP3A4, such as itraconazole, erythromycin
Cilostazol
Type of corticosteroid medication
Budesonide is mainly metabolized in the liver by the enzyme CYP3A4. Drugs that are CYP3A4 inhibitors such as ketoconazole, clarithromycin, ritonavir,
Budesonide
Chemical compound
N-phenethylnormorphine. with its formation from morphine catalyzed by the liver enzymes CYP3A4 and CYP2C8. Normorphine is a controlled substance listed under the Single
Normorphine
Calcium channel blocker medication
infarction, and hepatotoxicity. Because of its inhibition of hepatic cytochromes CYP3A4, CYP2C9 and CYP2D6, there are a number of drug interactions. Some of the
Diltiazem
Beta-1 selective adrenenergic blocker medication used to treat cardiovascular diseases
Bioavailability >90% Protein binding 30% Metabolism 50% liver, CYP2D6, CYP3A4 Elimination half-life 10–12 hours Excretion Kidney, fecal (<2%) Identifiers
Bisoprolol
Species of plant
metabolites excreted in urine. In in vitro experiments, kratom extracts inhibited CYP3A4, CYP2D6, and CYP1A2 enzymes, which results in significant potential for
Mitragyna_speciosa
Benzodiazepam
alleviating anxiety at one week follow-up. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin
Mexazolam
Coronary medication
other adverse effects. Ticagrelor is a weak CYP3A4 inhibitor and can increase the plasma concentration of CYP3A4 substrates Current evidence suggests that
Ticagrelor
Medication for migraine headache acute treatment
mouth. Ubrogepant is contraindicated for co-administration with strong CYP3A4 inhibitors. Ubrogepant, also known as MK-1602, was discovered by scientists
Ubrogepant
Chemical compound
limited use because they are metabolized by CYP3A4 may become viable medications when taken with a CYP3A4 inhibitor because the dose required to achieve
Bergamottin
Class of compounds
CYP3A4 enzyme, so concurrent use is not recommended as it may increase the plasma levels of the Alpha-1 blockers which are metabolised by the CYP3A4 enzyme
Alpha-1_blocker
Glucocorticoid medication
Fluticasone propionate is broken down by CYP3A4 (cytochrome P450 3A4), and has been shown to interact with strong CYP3A4 inhibitors such as ritonavir and ketoconazole
Fluticasone_propionate
Antihypertensive drug of the calcium channel blocker class
enzyme CYP3A4. Consequently, CYP3A4 inducers such as rifampicin or carbamazepine could reduce the effectiveness of nisoldipine, while CYP3A4 inhibitors
Nisoldipine
Chemical compound
Naringin inhibits some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions. Ingestion of naringin
Naringin
Allergy medication
cytochrome P450 system. It was found to weakly inhibit CYP2B6, CYP2D6, and CYP3A4/CYP3A5, and not to inhibit CYP1A2, CYP2C8, CYP2C9, or CYP2C19. Desloratadine
Desloratadine
Opioid drug used in pain relief
oxycodone. Hydrocodone is metabolized by the cytochrome P450 enzymes CYP2D6 and CYP3A4, and inhibitors and inducers of these enzymes can modify hydrocodone exposure
Hydrocodone
Chemical compound
Rufinamide is an anticonvulsant medication. It is used in combination with other medication and therapy to treat Lennox–Gastaut syndrome and various other
Rufinamide
Antibiotic medication
clarithromycin is excreted in human milk. Clarithromycin inhibits a liver enzyme, CYP3A4, involved in the metabolism of many other commonly prescribed drugs. Taking
Clarithromycin
Chemical compound
levomethorphan, and has been shown to produce local anesthetic effects. It is the CYP3A4 metabolite of the aforementioned drugs, and is itself metabolized by the
3-Methoxymorphinan
Class of medications
faeces (15%) Oral, IM, IV CYP3A4 None Iloperidone 96% ? 95% 2–4 h ? 1340–2800 L Urine (45–58%), faeces (20–22%) Oral CYP3A4, CYP2D6 None notable. Levomepromazine
Antipsychotic
Compound that activates dopamine receptors
metabolized by CYP3A4 enzyme concentration rises with the use of CYP3A4 inhibitors. For example, in one study bromocriptine was given with a CYP3A4 inhibitor
Dopamine_agonist
Class of drugs to lower cholesterol
bergamottin and dihydroxybergamottin) inhibit the cytochrome P450 enzyme CYP3A4, which is involved in the metabolism of most statins (however, it is a major
Statin
Active metabolite of Δ9-THC
metabolized inside the body by cytochrome P450 enzymes such as CYP2C9 and CYP3A4 into 11-hydroxy-THC and then further metabolized by dehydrogenase[which
11-Hydroxy-THC
Lipid-lowering medication
the active β-hydroxyacid form. Simvastatin is primarily metabolized by CYP3A4 yielding products which are also active HMG-CoA reductase inhibitors. The
Simvastatin
Chemical compound
cytochrome P450 enzyme CYP3A4. Thus the potential exists for adverse drug interactions with other drugs that induce or inhibit CYP3A4. Specifically, the concomitant
Eplerenone
Chemical compound
increased concentrations of drugs that are metabolized by the liver enzymes CYP3A4 and CYP2C9, because miconazole inhibits these enzymes. Such interactions
Miconazole
Steroid medication
of the liver enzyme CYP3A4 speed up metabolization of triamcinolone and can therefore reduce its effectiveness. Conversely, CYP3A4 inhibitors, such as
Triamcinolone
Chemical compound
7-trimethyluric acid in humans include CYP1A2, CYP2E1, CYP2C8, CYP2C9, and CYP3A4. "1,3,7-trimethyluric acid". PubChem Compound. National Center for Biotechnology
1,3,7-Trimethyluric_acid
Atypical antipsychotic medication
contraindicated in individuals who are taking strong inhibitors of the liver enzyme CYP3A4 (ketoconazole, clarithromycin, ritonavir, levodropropizine, etc.) or inducers
Lurasidone
Chemical compound, antibiotic
Norfloxacin, sold under the brand name Noroxin among others, is an antibiotic that belongs to the class of fluoroquinolone antibiotics. It is used to treat
Norfloxacin
Pharmaceutical drug
Kishimoto W, Sakai K, Funae Y, Igarashi T (January 2000). "Identification of CYP3A4 as the predominant isoform responsible for the metabolism of ambroxol in
Ambroxol
Hypnotic medication
depression with other medications that inhibit the metabolic activities of the CYP3A4 enzyme system of the liver. Substances that inhibit this enzyme system include
Eszopiclone
Antibiotic
Chloramphenicol is a potent inhibitor of the cytochrome P450 isoforms CYP2C19 and CYP3A4 in the liver. Inhibition of CYP2C19 causes decreased metabolism and therefore
Chloramphenicol
Antihistamine medication
retention, dry mouth, blurred vision). Substances that act as inhibitors of the CYP3A4 enzyme such as ketoconazole, erythromycin, cimetidine, and furanocoumarin
Loratadine
ISOZYMES". "The Life Raft Group: Long List of Inhibitors and Inducers of CYP3A4 and CYP2D6". "DRUGBANK Online: Cytochrome P-450 Enzyme Inhibitors". "MEDICATIONS
List of cytochrome P450 modulators
List_of_cytochrome_P450_modulators
Chemical compound
agonist of the human pregnane X receptor ligand-binding domain and to induce CYP3A4 expression in vitro. Shukla SJ, Sakamuru S, Huang R, Moeller TA, Shinn P
Metacycline
Chemical compound
selectivity. Sildenafil is mainly metabolized by the microsomal isozymes CYP3A4 with secondary metabolism by CYP2C9. The major active metabolite is N-desmethylsildenafil
Homosildenafil
Chemical compound
CYP3A4 inhibitors may increase levels of apalutamide or its major active metabolite N-desmethylapalutamide, while mild to moderate CYP2C8 or CYP3A4 inhibitors
Apalutamide
Anticonvulsant medication
juice raises the bioavailability of carbamazepine by inhibiting the enzyme CYP3A4 in the gut wall and in the liver. Lower levels of carbamazepine are seen
Carbamazepine
Breast cancer medication
enzyme CYP3A4. While the CYP3A4 inhibitor ketoconazole had no significant effect on exemestane levels in a clinical trial, the strong CYP3A4 inductor
Exemestane
Benzodiazepine sedative
lipophilic and is metabolised by the liver via oxidative pathways. The enzyme CYP3A4 is the main enzyme in its phase 1 metabolism in human liver microsomes.
Flunitrazepam
Anticonvulsant medication
oxcarbazepine and licarbazepine are CYP3A4 and CYP3A5 inducers and thus have the potential to decrease the plasma concentration of CYP3A4 and CYP3A5 substrates, including
Oxcarbazepine
Chemical compound
minimally metabolized by the CYP450 enzymes CYP2C9 and CYP2C8, but not by CYP3A4 (which is a common source of interactions in other statins). As a result
Pitavastatin
Chemical compound
and is partially metabolized by CYP3A4 and CYP1A2. Dose adjustments may be necessary if people are treated with CYP3A4 and CYP1A2 inhibitors and medications
Cinacalcet
Blood pressure medication
about 33%. Metabolism is primarily by cytochrome P450 isoenzymes CYP2C9 and CYP3A4. Peak plasma concentrations of losartan and EXP3174 occur about one hour
Losartan
Triazolobenzodiazepine
by CYP2B6, CYP2C19, and CYP3A4. 4-hydroxy bromazolam, as well as α-hydroxy bromazolam, were formed by CYP2B6, CYP2C19, CYP3A4, and CYP3A5. Additionally
Bromazolam
Antibiotic medication
simvastatin levels and the potential for rhabdomyolysis. Another group of CYP3A4 substrates are drugs used for migraine such as ergotamine and dihydroergotamine;
Erythromycin
Antiarrhythmic medication
predominantly by CYP3A4 enzymes predominantly in the liver and GI tract. This means that it is likely to interact with drugs that inhibit CYP3A4, such as erythromycin
Dofetilide
Medication for parasite infestations
potentiation of inhibitory chloride channels. Since drugs that inhibit the enzyme CYP3A4 often also inhibit P-glycoprotein transport, the risk of increased absorption
Ivermectin
Atypical antipsychotic medicine
cytochrome P450 3A4 isoenzyme (CYP3A4), with some minor metabolism by CYP2D6. Cariprazine does not induce the production of CYP3A4 or CYP1A2 in the liver, and
Cariprazine
Drug
eliminated from the body after inactivation by the liver enzymes CYP2C9 and CYP3A4, and its high plasma protein binding (see below), phenprocoumon has significant
Phenprocoumon
Psychoactive drug, often called ecstasy
metabolism may be primarily by cytochrome P450 (CYP450) enzymes CYP2D6 and CYP3A4 and COMT. Complex, nonlinear pharmacokinetics arise via autoinhibition of
MDMA
Mammalian protein found in Homo sapiens
transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic
Pregnane_X_receptor
Atypical antidepressant drug
is a potent inhibitor of CYP3A4, and may interact adversely with many commonly used medications that are metabolized by CYP3A4. Nefazodone acts primarily
Nefazodone
Medication used for major depressive disorder
history of congenital long QT syndrome, use medications that strongly inhibit CYP3A4 (an enzyme involved in gepirone's metabolism), severe liver problems, or
Gepirone
Antibacterial drug
gepotidacin levels. Strong inhibitors of CYP3A4 can increase gepotidacin exposure, whereas strong inducers of CYP3A4 can decrease it. Additionally, gepotidacin
Gepotidacin
Medication
CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4. The drug appears to primarily inhibit CYP1A2, CYP2D6, and CYP3A4, of which it is described as a moderate
Cimetidine
Chemical compound
never marketed. It is formed from mifepristone in the liver by the enzyme CYP3A4 via monodemethylation, and circulates at concentrations higher than those
Metapristone
Medication of the calcium channel blocker type
3A4, so substances that inhibit or activate CYP3A4 can strongly effect how much felodipine is present. CYP3A4 inhibitors, which increase the amount of felodipine
Felodipine
Antiarrhythmic medication
warfarin depend on metabolism of warfarin by both cytochromes CYP2C9 and CYP3A4, coadministation leads to rise in international normalized ratio (INR)—the
Amiodarone
Hormone replacement medication
CYP3A4. It has three major metabolites: 6'-hydroxydutasteride, 4'-hydroxydutasteride, and 1,2-dihydrodutasteride. The former two are formed by CYP3A4
Dutasteride
Chemical compound
metabolized mainly by the cytochrome P450 enzyme CYP3A4, and for this reason, inhibitors and inducers of CYP3A4 can alter the amount of exposure to dienogest
Dienogest
Quaternary ammonium cation
diarrhea as common issues. Berberine is known to inhibit the activity of CYP3A4, an enzyme important to drug metabolism and clearance of endogenous substances
Berberine
Medication used to treat insomnia
or Z-drugs. The CYP3A4 liver enzyme is a minor metabolic pathway for zaleplon, normally metabolizing about 9% of the drug. CYP3A4 inducers such as rifampicin
Zaleplon
Benzodiazepine medication
method of discontinuation. Alprazolam is primarily metabolized via CYP3A4. Combining CYP3A4 inhibitors such as cimetidine, erythromycin, norfluoxetine, fluvoxamine
Alprazolam
Chemical compound
showing significant benefit, and tabimorelin was also found to act as a CYP3A4 inhibitor which could cause it to have undesirable interactions with other
Tabimorelin
Chemical compound
inhibit nor induce the liver enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. They also do not induce UGT enzymes. This means that racecadotril has a
Racecadotril
Chemical compound
proteins, mainly albumin. Lenvatinib is metabolized by the liver enzyme CYP3A4 to desmethyl-lenvatinib (M2). M2 and lenvatinib itself are oxidized by aldehyde
Lenvatinib
Chemical compound
interactions. In studies, inhibitors of the liver enzymes CYP3A4, CYP2C19, and CYP2C9, as well as the CYP3A4 inducer rifampicin, had no relevant influence on baricitinib
Baricitinib
CYP3A4
CYP3A4
CYP3A4
CYP3A4
Boy/Male
Hindu, Indian, Marathi
Faith
Boy/Male
Indian
He who cures
Girl/Female
Italian Polish
Stammers.
Girl/Female
Hindu, Indian
Slim Girl
Boy/Male
Indian
Prince, The honest and kind peace and truth
Female
Egyptian
, the Sun; or, the self-existent.
Boy/Male
Tamil
Religious
Boy/Male
Indian, Telugu
Devotion
Girl/Female
Arabic, Hindu, Indian, Muslim
Lucky Number; Stone; Metal; Colour
Male
Native American
Native American Sioux name MAHPEE means "sky."
CYP3A4
CYP3A4
CYP3A4
CYP3A4
CYP3A4