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Mammalian protein involved in blood clotting
Protein Z (PZ or PROZ), vitamin K-dependent protein Z, is a protein encoded in the human by the PROZ gene. Protein Z is a member of the coagulation cascade
Protein_Z
Process of formation of blood clots
glutamic acid residues on factors II, VII, IX and X, as well as Protein S, Protein C and Protein Z. In adding the gamma-carboxyl group to glutamate residues
Coagulation
InterPro Family
activity of cAMP-dependent protein kinase (PKA). This family is also commonly called the Gi/o (Gi /Go ) family or Gi/o/z/t family to include closely
Gi_alpha_subunit
Protein Z-dependent protease inhibitor (ZPI) is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade. It is
Protein Z-related protease inhibitor
Protein_Z-related_protease_inhibitor
Mammalian protein found in Homo sapiens
1000-fold by the presence of protein Z, while it does not require protein Z for inactivation of factor XI. Defects in protein Z lead to increased factor Xa
Factor_X
Topics referred to by the same term
Z-gene or Z gene may refer to: lacZ, a gene in the lac operon Beta-galactosidase, the type of protein encoded by lacZ Protein Z, a vitamin K-dependent
Z-gene
Small structural protein motif found mostly in transcriptional proteins
A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) which stabilize the fold.
Zinc_finger
Steady-state solution for a 2-state biological system
opposing effect. One example would be a protein Z that exists in a phosphorylated form ZP and in an unphosphorylated form Z; the corresponding kinase Y and phosphatase
Goldbeter–Koshland_kinetics
Chemical compound
required to introduce γ-carboxylation of clotting factors II, VII, IX, X and protein Z. In the biosynthesis of γ-carboxyglutamic acid, the γ-proton on glutamic
Carboxyglutamic_acid
Biomolecule consisting of chains of amino acid residues
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions
Protein
Protein encoded by the ftsZ gene
FtsZ is a protein encoded by the ftsZ gene that assembles into a ring at the future site of bacterial cell division (also called the Z ring). FtsZ is
FtsZ
Largest known protein in human muscles
muscle tissues. It connects the Z disc to the M line in the sarcomere. The protein contributes to force transmission at the Z disc and resting tension in
Titin
Protein-coding gene in the species Homo sapiens
Z-DNA-binding protein 1 (also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1) is a mammalian intracellular protein that acts
ZBP1
Repeating unit of a myofibril in a muscle cell
molecules are cross-linked in the Z-disc via the Z-line protein alpha-actinin. The M-band proteins myomesin as well as C-protein crosslink the thick filament
Sarcomere
Topics referred to by the same term
Wiktionary, the free dictionary. PROZ may refer to: Protein Z, a protein encoded by the PROZ gene. ProZ.com, an online translators' community Pröz (real
PROZ
Topics referred to by the same term
ZPI may refer to: Protein Z-related protease inhibitor, a protein circulating in the blood Zero Point Interchange, a cloverleaf interchange in Islamabad
ZPI
Protein isolate made from rice
Rice protein is a vegan protein isolate made from rice. It is often used as an alternative to the more common whey and soy protein isolates. To make it
Rice_protein
Protein family
anticoagulant proteins C and S, and the factor X-targeting protein Z. the bone Gla protein osteocalcin the calcification-inhibiting matrix Gla protein (MGP),
Gla_domain
Bacteriophage that infects Escherichia coli
head-proximal end of the tail. Protein Z is able to connect the tail to the head. Protein H is cleaved due to the actions of proteins U and Z. Lambda phage is a non-contractile
Lambda_phage
Food product and protein supplement derived from Pisum sativum
Pea protein is a food product and protein supplement derived and extracted from yellow and green split peas, Pisum sativum. It can be used as a dietary
Pea_protein
Pathogenic type of misfolded protein
A prion (/ˈpriːɒn/ ) is a misfolded protein that induces folding problems in normal variants of the same protein, leading to cellular death. Prions are
Prion
Type of viral hemorrhagic fever
code for two proteins each, one in each sense, for a total of four viral proteins. The large segment encodes a small zinc finger protein (Z) that regulates
Lassa_virus
Change of a linear protein chain to a 3D structure
Protein folding is the physical process by which a protein, after synthesis by a ribosome as a linear chain of amino acids, changes from an unstable random
Protein_folding
Fat-soluble vitamers
anticoagulant protein C and protein S, and the factor X-targeting protein Z. The bone Gla protein osteocalcin, the calcification-inhibiting matrix Gla protein (MGP)
Vitamin_K
Nutrient for the human body
Proteins are essential nutrients for the human body. They are one of the constituents of body tissue and also serve as a fuel source. As fuel, proteins
Protein_(nutrient)
Mammalian protein found in Homo sapiens
protein Z-dependent protease inhibitor (ZPI, a member of the serine protease inhibitor/serpin class of proteins), which is independent of protein Z (its
Factor_XI
Macromolecular complex formed by two, usually non-covalently bound, macromolecules
In biochemistry, a protein dimer is a macromolecular complex or multimer formed by two protein monomers, or single proteins, which are usually non-covalently
Protein_dimer
Protein-coding gene in the species Homo sapiens
receptor (RTN4R) also known as Nogo-66 Receptor (NgR) or Nogo receptor 1 is a protein which in humans is encoded by the RTN4R gene. This gene encodes the receptor
Reticulon_4_receptor
Protein-coding gene in the species Homo sapiens
LIM domain binding 3 (LDB3), also known as Z-band alternatively spliced PDZ-motif (ZASP), is a protein which in humans is encoded by the LDB3 gene. ZASP
LDB3
One of many possible double helical structures of DNA
the DNA. A Z-DNA high affinity binding protein, hZαADAR1, was used at varying concentrations to induce the transformation from B-DNA to Z-DNA. The smFRET
Z-DNA
CapZ, also known as CAPZ, CAZ1, CAPPA1 and beta-actinin, is a capping protein that caps the barbed end of actin filaments in muscle cells. CapZ is a heterodimeric
CapZ
Study of how proteins move and change shape
molecular biology, proteins are generally thought to adopt unique structures determined by their amino acid sequences. However, proteins are not strictly
Protein_dynamics
Assembly of proteins inside biological cells
Protein biosynthesis or protein synthesis (also known as proteosynthesis) is a core biological process, occurring inside cells, balancing the loss of
Protein_biosynthesis
Protein-coding gene in the species Homo sapiens
nucleotide-binding protein G(z) subunit alpha is a protein that in humans is encoded by the GNAZ gene. The protein encoded by this gene is a member of a G protein subfamily
GNAZ
Type of stable macromolecular complex
polypeptide chain. Protein complexes are a form of quaternary structure. Proteins in a protein complex are linked by non-covalent protein–protein interactions
Protein_complex
Solution of component parts of a protein
Hydrolyzed protein is a solution derived from the hydrolysis of a protein into its component amino acids and/or peptides. Hydrolyzing down to the amino
Hydrolyzed_protein
Set genes encoding proteins and enzymes for lactose metabolism
encoding proteins that affect gene expression. Current usage expands the phenotypic nomenclature to apply to proteins: thus, LacZ is the protein product
Lac_operon
Taiwanese-American biochemist and bioengineer
Yasuda, R.; Kim, D. S.; Ng, H. L.; Lin, M. Z. (2016). "A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances
Michael_Z._Lin
Family of proteins
Heat shock proteins (HSPs) are a family of proteins produced by cells in response to exposure to a stressor. They were first described in relation to the
Heat_shock_protein
malonyl-[acyl-carrier-protein] ⇌ {\displaystyle \rightleftharpoons } (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein] Thus, the two
Beta-ketoacyl-ACP_synthase_II
Macromolecular complex formed by three macromolecules
homotrimeric protein, while Type I collagen is an AAB-type heterotrimeric protein. An example of viral protein homotrimeric protein is mammarenavirus of Z matrix
Protein_trimer
Protein domain
In molecular biology, the protein domain Adenosine deaminase z-alpha domain refers to an evolutionary conserved protein domain. This family consists of
Adenosine deaminase z-alpha domain
Adenosine_deaminase_z-alpha_domain
Contractile element of muscle
very dark colored bands called Z-discs or Z-lines (from the German zwischen meaning between). These Z-discs are dense protein discs that do not easily allow
Myofibril
Three-dimensional arrangement of atoms in an amino acid-chain molecule
Protein structure is the three-dimensional arrangement of atoms in an amino acid-chain molecule. Proteins are polymers – specifically polypeptides – formed
Protein_structure
Protein without a fixed 3D structure
In molecular biology, an intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure, typically in the
Intrinsically disordered proteins
Intrinsically_disordered_proteins
Mammalian protein found in humans
Proliferation marker protein Ki-67, also known as Antigen Kiel 67 or MKI67, is a protein that in humans is encoded by the MKI67 gene (marker of proliferation
Proliferation marker protein Ki-67
Proliferation_marker_protein_Ki-67
Protein produced by Helicobacter pylori bacteria
In molecular biology, CagZ is a protein produced by Helicobacter pylori (Campylobacter pylori). It is a 23 kDa protein consisting of a single compact
CagZ
Combination of hydrogen and ionic bonding in chemistry
to the stability to the entropically unfavorable folded conformation of proteins. Although non-covalent interactions are known to be relatively weak interactions
Salt_bridge_(protein)
bacterial surface protein that binds antibodies Protein L, bacterial surface protein that binds antibodies Protein S, plasma glycoprotein Protein Z, glycoprotein
Index of protein-related articles
Index_of_protein-related_articles
Class of enzymes
molecular chaperones are proteins that assist the conformational folding or unfolding of proteins or macromolecular protein complexes. There are a number
Chaperone_(protein)
Anticoagulant medication
regulatory factors protein C, protein S, and protein Z. Other proteins not involved in blood clotting, such as osteocalcin, or matrix Gla protein, may also be
Warfarin
Physical interactions and constructions between multiple proteins
Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical
Protein–protein_interaction
Mammalian protein found in humans
C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentration rises in response to inflammation
C-reactive_protein
Abnormality of blood coagulation increasing the risk of blood clotting (thrombosis)
thrombin, factor IXa, Xa and XIa), protein C (which inhibits factors Va and VIIIa in the presence of protein S), and protein Z (which inhibits factor Xa). In
Thrombophilia
Class of enzyme complexes
Xu Y, Chen Y, Jeffrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi Y (October 2006). "Structure of protein phosphatase 2A core enzyme bound to tumor-inducing
Protein_phosphatase_2
Artificial intelligence program by DeepMind
developed by DeepMind, a subsidiary of Alphabet, which performs predictions of protein structure. It is designed using deep learning techniques. AlphaFold 1 (2018)
AlphaFold
Sequence of DNA that determines traits in an organism
types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of RNA or protein from a gene), DNA is first
Gene
Protein family
The PilZ protein family is named after the type IV pilus control protein first identified in Pseudomonas aeruginosa, expressed as part of the pil operon
PilZ_domain
Protein that exhibits bright green fluorescence when exposed to ultraviolet light
The green fluorescent protein (GFP) is a protein that exhibits green fluorescence when exposed to light in the blue to ultraviolet range. The label GFP
Green_fluorescent_protein
Family of RNA viruses
RNA-dependent RNA-polymerase (L) and a small RING-domain containing protein (Z). The Z protein forms homo oligomers and a structural component of the virions
Arenavirus
Topics referred to by the same term
Dutch basketball club ZZ method, in speedcubing ZZ scale, of model rail Z. Z. Hill (1935–1984), American blues singer ZZ Top, an American rock band ZZ
ZZ
Categories of protein tertiary structure
molecular biology, protein fold classes are broad categories of protein tertiary structure topology. They describe groups of proteins that share similar
Protein_fold_class
The Protein Information Resource (PIR), located at Georgetown University Medical Center, is an integrated public bioinformatics resource to support genomic
Protein_Information_Resource
Mechanism used by E. coli in cell division
Each component participates in generating a dynamic oscillation of FtsZ protein inhibition between the two bacterial poles to precisely specify the mid-zone
Min_System
Protein-coding gene in the species Homo sapiens
and skeletal muscles, and functions at Z-discs and in subsarcolemmal regions. Filamin-C is a 290.8 kDa protein composed of 2,725 amino acids. Filamin-C
Filamin-C
Protein family
assemblage of heterodimers and multimeric protein complexes. Mef2 family: MEF2A, MEF2B, MEF2C, MEF2D SRF Schwarz-Sommer Z, Huijser P, Nacken W, Saedler H, Sommer
MADS-box
Different products from the same gene
can consist of mRNAs or their resultant proteins. The best-studied isoforms are the protein isoforms, or "protein variants", resulting from differences
Isoform
Glycoprotein spike on a viral capsid or viral envelope
called spike protein, formerly known as E2) is the largest of the four major structural proteins found in coronaviruses. The spike protein assembles into
Coronavirus_spike_protein
Method to determine protein concentration
The Bradford protein assay (also known as the Coomassie protein assay) was developed by Marion M. Bradford in 1976. It is a quick and accurate spectroscopic
Bradford_protein_assay
Type of proteins
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved
G_protein
Superfamily of proteins with similar structures and diverse functions
Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms
Serpin
Class of peptides which help cells survive freezing conditions
Antifreeze proteins (AFPs) or ice structuring proteins refer to a class of polypeptides produced by certain animals, plants, fungi and bacteria that permit
Antifreeze_protein
lytic form. ZEBRA (BamHI Z Epstein-Barr virus replication activator, also known as Zta and BZLF1) is an early lytic protein of EBV encoded by BZLF1. ZEBRA
BZLF1
Computational modeling of molecular interaction
biological macromolecules. Protein–protein complexes are the most commonly attempted targets of such modelling, followed by protein–nucleic acid complexes
Macromolecular_docking
Biological mechanism for routing proteins
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside
Protein_targeting
Class of copper-containing proteins
Copper proteins are proteins that contain one or more copper ions as prosthetic groups. Copper proteins are found in all forms of air-breathing life. These
Copper_protein
Critical protein in embryonic development
Sonic hedgehog protein (SHH) is a major signaling molecule of embryonic development in planulozoan animals, encoded by the SHH gene. This signaling molecule
Sonic_hedgehog_protein
Protein family
SNARE proteins (soluble NSF attachment protein receptors) are a large protein family consisting of at least 24 members in yeasts and more than 60 members
SNARE_protein
Food ingredient
Hemp protein is a plant-derived protein from the cannabis plant and is isolated from hemp seeds (a type of nut). The protein content of whole hemp seeds
Hemp_protein
Group of six protein isoforms produced from the MAPT gene
The tau proteins (abbreviated from tubulin associated unit) form a group of six highly soluble protein isoforms produced by alternative splicing from the
Tau_protein
Organic compounds containing amine and carboxylic groups
codes. Bortezomib is Pyz–Phe–boroLeu, and MG132 is Z–Leu–Leu–Leu–al. To aid in the analysis of protein structure, photo-reactive amino acid analogs are
Amino_acid
Cytoskeletal structure
IF protein have been noted in an invertebrate, the cephalochordate Branchiostoma. Intermediate filaments are composed of a family of related proteins sharing
Intermediate_filament
Mammalian protein found in humans
p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription
P53
Protein in animal cells
Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (February 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins"
Survival_of_motor_neuron
Class of protein inhibiting drugs
Targeted protein degradation (TPD) is a drug design strategy that uses small molecules such as PROteolysis TArgeting Chimeras (PROTACs), molecular glues
Targeted_protein_degradation
RNA family
because of a lack of experimental investigation. Ribosomal protein leader Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal leader candidates
S10_ribosomal_protein_leader
mediating the fusion of the viral and cellular membranes. This class I fusion protein is synthesized as an inactive precursor (F0), which undergoes cleavage
Respiratory syncytial virus F protein
Respiratory_syncytial_virus_F_protein
Protein family
Major intrinsic proteins (MIPs) comprise a large superfamily of transmembrane protein channels that are grouped together on the basis of homology. The
Major_intrinsic_proteins
Protein in the human body
known as Tcap, is a protein that in humans is encoded by the TCAP gene. Telethonin is expressed in cardiac and skeletal muscle at Z-discs and functions
Telethonin
Protein-coding gene in the species Homo sapiens
a protein that in humans is encoded by the MLKL gene. This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like
Mixed lineage kinase domain like pseudokinase
Mixed_lineage_kinase_domain_like_pseudokinase
Self-stable region of a protein's chain that folds independently from the rest
In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and folds independently from the rest. Each
Protein_domain
Protein-coding gene in humans
F-actin-capping protein subunit alpha-2 also known as CapZ-alpha2 is a protein that in humans is encoded by the CAPZA2 gene. CapZ-alpha2 is a 33.0 kDa protein composed
CAPZA2
British solicitor and author
Turing, John Dermot (1985). Aspects of the regulation of larval serum protein synthesis in Drosophila. ox.ac.uk (DPhil thesis). University of Oxford
Dermot_Turing
Protein labelling technique
TimeSTAMP (Time – Specific Tag for the Age Measurement of Proteins) is a technique invented by Michael Z. Lin at the Roger Tsien lab at the University of California
TimeSTAMP_protein_labelling
RNA family
known as a previously established ribosomal protein leader ligand. Ribosomal protein leader Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal
L2_ribosomal_protein_leader
Protein-coding gene in the species Homo sapiens
Methylosome protein 50 is a protein that in humans is encoded by the WDR77 gene. WD repeat-containing protein 77 has been shown to interact with CTDP1
WD repeat-containing protein 77
WD_repeat-containing_protein_77
Molecule that carries genetic information
B form. These unusual structures can be recognized by specific Z-DNA binding proteins and may be involved in the regulation of transcription. For many
DNA
Class of enzymes
enzymology, a protein N-acetylglucosaminyltransferase (EC 2.4.1.94) is an enzyme that catalyzes the chemical reaction UDP-N-acetyl-D-glucosamine + protein ⇌ {\displaystyle
Protein N-acetylglucosaminyltransferase
Protein_N-acetylglucosaminyltransferase
Term for several kidney diseases
Farrington K, Wilkinson V, Hilson AJ, Varghese Z, Moorhead JF (November 1984). "Selective effect of low protein diets in chronic renal diseases". British Medical
Glomerulonephritis
Class of proteins
Penicillin-binding proteins (PBP) are a group of proteins that are characterized by their affinity for and binding of penicillin. They are a normal constituent
Penicillin-binding_proteins
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