Searches , social queries for INTRINSICALLY DISORDERED-PROTEINS
Search references for INTRINSICALLY DISORDERED-PROTEINS. Phrases containing INTRINSICALLY DISORDERED-PROTEINS
See searches and references containing INTRINSICALLY DISORDERED-PROTEINS!
Search references for INTRINSICALLY DISORDERED-PROTEINS. Phrases containing INTRINSICALLY DISORDERED-PROTEINS
See searches and references containing INTRINSICALLY DISORDERED-PROTEINS!INTRINSICALLY DISORDERED-PROTEINS
Protein without a fixed 3D structure
PMID 30430826. Oldfield CJ, Dunker AK (2014). "Intrinsically disordered proteins and intrinsically disordered protein regions". Annual Review of Biochemistry
Intrinsically disordered proteins
Intrinsically_disordered_proteins
Coping with environmental changes without adapting
including freezing and desiccation. Research has shown that intrinsically disordered proteins in these organisms may work to stabilize cell function and
Biostasis
Categories of protein tertiary structure
20–30% of all genes in most genomes encode membrane proteins. Intrinsically disordered proteins lack a fixed or ordered three-dimensional structure.
Protein_fold_class
Synchrotron Radiation Circular Dichroism
"Differential dehydration effects on globular proteins and intrinsically disordered proteins during film formation". Protein Science. 26 (4). Wiley: 718–726. Bibcode:2017ProtS
Synchrotron radiation circular dichroism spectroscopy
Synchrotron_radiation_circular_dichroism_spectroscopy
Proteins which help tardigrades survive in extreme environments
Tardigrade specific proteins are types of intrinsically disordered proteins specific to tardigrades. These proteins help tardigrades survive desiccation
Tardigrade_specific_proteins
a different fold separated by intrinsically disordered regions. These are referred to as multi-domain proteins. Proteins may also be classified based on
List_of_proteins
Computational models of intrinsically-disordered proteins
function of the flexible protein, extending the structure-function paradigm from folded proteins to intrinsically disordered proteins. The calculation of ensembles
Conformational_ensembles
Physiological process
switching whether in cancer or in normal cells is that they are Intrinsically disordered proteins (IDPs). That is, they lack a rigid 3D-structure under physiological
State_switching
understanding of protein function in health and disease". Fisher, C. K., Huang, A., & Stultz, C. M. (2010). Modeling Intrinsically Disordered Proteins with Bayesian
Collin_M._Stultz
Indian biomedical engineer
disorder, and phase separation behavior of these repetitive polypeptides make them an interesting class of minimal synthetic intrinsically disordered
Ashutosh_Chilkoti
Three-dimensional arrangement of atoms in an amino acid-chain molecule
the less stable variants are intrinsically disordered proteins. These proteins exist and function in a relatively 'disordered' state lacking a stable tertiary
Protein_structure
Database of proteins
biological database of intrinsically disordered proteins (IDPs) and regions (IDRs). DisProt annotations cover state information on the protein but also, when
DisProt
Physiology of survival in a group of animals
trehalose for this function. Instead, tardigrades produce intrinsically disordered proteins in response to desiccation. Three of these are specific to
Environmental tolerance in tardigrades
Environmental_tolerance_in_tardigrades
Canadian scientist
the dynamics, interactions, structures, and functions of intrinsically disordered proteins. Forman-Kay obtained a degree in chemistry from the Massachusetts
Julie_Forman-Kay
Category of proteins
the structure-function paradigm that proteins follow. They predominately consist of Intrinsically Disordered Proteins (IDP) that are necessary for certain
Dark_proteome
Phylum of microscopic animals
trehalose for this function. Instead, tardigrades produce intrinsically disordered proteins in response to desiccation. Three of these are specific to
Tardigrade
Openings in nuclear envelope of eukaryotic cells
unfolded" or intrinsically disordered proteins, characterized by high flexibility and a lack of ordered tertiary structure. These disordered proteins, referred
Nuclear_pore_complex
Class of membrane-less organelles within biological cells
Pappu RV (2018). "Phase Separation of Intrinsically Disordered Proteins". Intrinsically Disordered Proteins. Methods in Enzymology. Vol. 611. Elsevier
Biomolecular_condensate
American biophysicist
theoretical, computational, and experimental approaches to study intrinsically disordered proteins in the context of normal cellular function and neurodegenerative
Rohit_Pappu
System of measuring the instability of a protein under varying conditions
has its strengths and weaknesses but they all struggle with intrinsically disordered proteins without any clearly defined tertiary structure as the essence
Thermal_shift_assay
Change of a linear protein chain to a 3D structure
(un)folded proteins. Biotin 'painting' shows a bias towards predicted Intrinsically disordered proteins. Computational studies of protein folding includes
Protein_folding
Graph topology applied to electrical and communications circuits, or biomolecules
applied to quantify the conformational organisation of intrinsically disordered proteins. In protein structure prediction, coarse-grained generative approaches
Circuit_topology
Protein-coding gene in the species Homo sapiens
Major intrinsically disordered Notch2-binding receptor 1 is a protein that in humans is encoded by the MINAR1 gene (previously KIAA1024). The MINAR1 protein
MINAR1
Topics referred to by the same term
plan, a human resources term Internally displaced person Intrinsically disordered proteins International Driving Permit IPD (disambiguation) This disambiguation
IDP
Class of proteins
Proline-rich proteins (PRPs) are a class of intrinsically disordered proteins (IDPs) containing several repeats of a short proline-rich sequence. Many
Proline_rich_protein
Biomolecule consisting of chains of amino acid residues
can be classified as intrinsically disordered proteins. Predicting and analysing protein disorder is an important part of protein structure characterisation
Protein
Cognitive decline
disease. PET scans can detect amyloid beta and tau, the two intrinsically disordered proteins that are the hallmark features of Alzheimer's. Although the
Dementia
Group of six protein isoforms produced from the MAPT gene
1975 as heat-stable proteins essential for microtubule assembly, and have since been characterized as intrinsically disordered proteins. In humans, the MAPT
Tau_protein
Pathogenic type of misfolded protein
type of intrinsically disordered protein that continuously changes conformation unless bound to a specific partner, such as another protein. Once a prion
Prion
Protein in cephalopods
Reflectins are a family of intrinsically disordered proteins evolved by a certain number of cephalopods including Euprymna scolopes and Doryteuthis opalescens
Reflectin
field of LLPS are the theoretic simulations of proteins, particularly Intrinsically disordered proteins (IDPs), driving LLPS. These simulations are complementary
Liquid–liquid phase separation sequence-based predictors
Liquid–liquid_phase_separation_sequence-based_predictors
Protein fold class, typically
detection and data quality. Cysteine-rich protein Intrinsically disordered proteins Metal-binding protein Micropeptide Kihara D, Skolnick J (December
Small_protein
Protein found in humans
synucleinopathies. Alpha-synuclein in solution is considered to be an intrinsically disordered protein, i.e. it lacks a single stable 3D structure. As of 2014, an
Alpha-synuclein
Metabolic state of life
oxygen species and xenobiotics, expression of heat shock proteins and intrinsically disordered proteins as well as biosynthesis of polyunsaturated fatty acids
Cryptobiosis
Polish-Canadian academic (born 1975)
structural bioinformatics of proteins, with focus on intrinsically disordered proteins, structural genomics, and protein function prediction. His research
Lukasz_Kurgan
Kurgan L (Jan 2014). "Genome-scale prediction of proteins with long intrinsically disordered regions". Proteins. 82 (1): 145–58. doi:10.1002/prot.24348. PMID 23798504
List of disorder prediction software
List_of_disorder_prediction_software
Process of introducing a phosphate group on to a protein
bead-based detection, and cell-based formats. In the case of intrinsically disordered proteins (IDPs), one can use topological approaches to identify conformational
Protein_phosphorylation
generally formed by intrinsically disordered proteins. Structural multiplicity usually underlies functional multiplicity of protein complexes following
Fuzzy_complex
Study of the Relationship Between Protein Structure and β-Aggregation in Globular and Intrinsically Disordered Proteins". Journal of Molecular Biology.
Protein aggregation predictors
Protein_aggregation_predictors
Protein family
protein with a molecular size of about 6.9 kDa. Pup is an intrinsically disordered protein. In 2010, scientists at the Brookhaven National Laboratory
Prokaryotic ubiquitin-like protein
Prokaryotic_ubiquitin-like_protein
Protein-coding gene in the species Homo sapiens
It is also the name of a protein family, of which MARCKS is the most studied member. They are intrinsically disordered proteins, with an acidic pH, with
MARCKS
Genus of tardigrades
they can enter into a state of cryptobiosis and utilize intrinsically disordered proteins when experiencing extreme environments. Milnesium species
Milnesium
Group of evolutionarily-related proteins
Expansions are less likely, and losses more likely, for intrinsically disordered proteins and for protein domains whose hydrophobic amino acids are further
Protein_family
American chemist
cellular processes, including in vivo protein folding. In particular, She studies intrinsically disordered proteins, biomolecules which do not fold to a
Joan-Emma_Shea
Artificial peptide attached to protein for marking purpose
Els F; Tans, Sander (2013). "Designing disorder: Tales of the unexpected tails". Intrinsically Disordered Proteins. 1 (1): 5–15. doi:10.4161/idp.26790.
Protein_tag
Indian-American physicist
theory), and biological machines. He also does research in intrinsically disordered proteins (IDPs), organization and dynamics of chromosome, cell biophysics
Devarajan_Thirumalai
features (MoRFs) are small (10-70 residues) intrinsically disordered regions in proteins that undergo a disorder-to-order transition upon binding to their
Molecular_recognition_feature
Protein-coding gene in the species Homo sapiens
secondary and tertiary structures, placing it in the class of intrinsically disordered proteins (IDPs). Research is ongoing on how LBHs conformational flexibility
LBH_(gene)
Biological concepts and questions with insufficient resolutions
also Folding@home. The study of intrinsically disordered proteins is also not as advanced as the study of globular proteins: some sequences do not fold into
List of unsolved problems in biology
List_of_unsolved_problems_in_biology
Glycoprotein produced in the stomach which binds to vitamin B12
dissociation of vitamin B12 from its binding proteins in the small intestine, preventing its absorption via the intrinsic factor complex. Other risk factors contributing
Intrinsic_factor
Study of how proteins move and change shape
molecular biology, proteins are generally thought to adopt unique structures determined by their amino acid sequences. However, proteins are not strictly
Protein_dynamics
Group of signal transduction pathways involved in embryonic development
Intriguingly, the unstructured regions of several oversized intrinsically disordered proteins play crucial roles in regulating Wnt signaling. Wnt signaling
Wnt_signaling_pathway
Indian-American computational biologist
In particular, his research group studies G protein-coupled receptors and intrinsically disordered proteins using a combination of computational biology
M._Madan_Babu
Type of stable macromolecular complex
regulation and signal transduction, and proteins with intrinsically disordered regions (IDR: regions in protein that show dynamic inter-converting structures
Protein_complex
Bacterial microcompartment containing the enzyme RuBisCo
thousand protein subunits, with hexameric shell proteins populating the faces and pentameric shell proteins placed at the 12 icosahedral vertices. Proteins known
Carboxysome
American biophysicist
fluorescence correlation spectroscopy. Rhoades studies intrinsically disordered proteins and amyloidogenic proteins involved in Parkinson's disease, Alzheimer's
Elizabeth_Rhoades
American biological chemistry professor
"Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)" (2014). Francois-Xavier Theillet, Andres Binolfi,
Gary_J._Pielak
Database of protein disorder
number of proteins with prominent members known as intrinsically unstructured (or disordered) proteins. The database features three levels of annotation:
MobiDB
Protein-coding gene in the species Homo sapiens
Major intrinsically disordered NOTCH2-binding receptor 1-like is a protein that in humans is encoded by the MINAR2 gene. The MINAR2 protein binds to cholesterol
MINAR2
Glycoproteins found in plant cell walls
Characteristic of intrinsically disordered proteins, AGPs also contain repeat motifs and post-translational modifications. Proline residues in the protein backbone
Arabinogalactan_protein
New Zealand scientist
conformational sampling being of importance to enzyme catalysis and intrinsically disordered proteins, which is opposed to the theory of electrostatic preorganization
Peter_Wright_(scientist)
Protein in wheat and other cereals
percentages, 30–50% acidic acetonitrile. The gliadins are intrinsically disordered proteins meaning that they have continuously altering shapes making
Gliadin
Tardigrade protein against DNA damage
simulation of Dsup in complex with DNA shows that it is an intrinsically disordered protein. Its flexibility and electrostatic charge helps it bind to
Dsup
Japanese cell biologist (born 1945)
Yamamoto; Yuko Fujioka; Sho W Suzuki; et al. (2016). "The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation
Yoshinori_Ohsumi
Family of viruses
successfully transform the host cell and form tumors. E1A is mostly intrinsically disordered protein and contains CR3 domain which is critical for transcriptional
Adenoviridae
Radiation scattering technique
Pau; Svergun, Dmitri I. (2012). "Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering". Mol. BioSyst. 8 (1): 151–167
Small-angle_X-ray_scattering
British-born biophysicist
acid sequences of proteins and their structure and function. Dyson is well known for her work on intrinsically disordered proteins. Dyson has received
Jane_Dyson
Canadian biochemist (born 1961)
is married to biophysicist Julie Forman-Kay, who studies intrinsically disordered proteins. 1996 – Merck Frosst Award 1998 – Canada's "Top 40 under 40"
Lewis_E._Kay
Process of formation of blood clots
1987). "Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial cell attachment to adhesive proteins and the extracellular matrix". Journal of
Coagulation
Artificial intelligence program by DeepMind
regions are predicted with low confidence score, including the intrinsically disordered protein regions. Alphafold-2 was validated for predicting effects of
AlphaFold
diagrams, among others. Biomolecular condensate MobiDB database Intrinsically disordered proteins DisProt database You, Kaiqiang; Huang, Qi; Yu, Chunyu; Shen
List of liquid–liquid phase separation databases
List_of_liquid–liquid_phase_separation_databases
Process of regulating a functional proteome
nondividing cells like neurons). This risk is particularly high for intrinsically disordered proteins. The insulin-like growth factor 1 receptor (IGF-1R) pathway
Proteostasis
American chemist
"Experimental inferential structure determination of ensembles for intrinsically disordered proteins". J. Am. Chem. Soc. 138 (13): 4530–4538. Bibcode:2016JAChS
Teresa_Head-Gordon
the form of glycosylation and phosphorylation. PRR30 is an intrinsically disordered protein (IDP) and lacks any formal tertiary structure or quaternary
Proline-rich_protein_30
Protein family
cerebral cortex. Myelin basic protein has been classified as an intrinsically disordered protein that has no stable secondary structure in solution. Like most
Myelin_basic_protein
laboratory setting, ELPs share structural characteristics with intrinsically disordered proteins (IDPs) naturally found in the body, such as tropoelastin,
Elastin-like_polypeptides
British biologist
current work focuses on the physical-chemical basis by which intrinsically disordered proteins phase separate. Using this knowledge, he is studying the roles
Anthony_A._Hyman
SR proteins are a conserved family of proteins involved in RNA splicing. SR proteins are named because they contain a protein domain with long repeats
SR_protein
Protein involved in dentin formation within teeth
extensively phosphorylated protein. This belongs to a class of intrinsically disordered proteins also knows as IDPs. These proteins are not able to be synthesized
Dentin_phosphoprotein
protein. Approximately half of the tandem repeat regions have intrinsically disordered conformation being naturally unfolded. Examples of disordered repetitive
Protein_tandem_repeats
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors
G_protein-coupled_receptor
Physical interactions and constructions between multiple proteins
pre-couple with Gq proteins prior to the receptor-ligand binding. Interactions between intrinsically disordered protein regions to globular protein domains (i
Protein–protein_interaction
Protein found in humans
concentrate intrinsically disordered regions, which in turn misregulate Wnt signalling. Many other large IDPs (Intrinsically Disordered Proteins) are affected
Axin-1
Cardiac network of neurons and ganglia
from vagal NCCs and nodose placodes. Key factors like bone morphogenetic proteins (BMPs), PHOX2B, and HAND2 guide differentiation. The ICNS integrates sensory
Intrinsic cardiac nervous system
Intrinsic_cardiac_nervous_system
Halff, EF; Tans, SJ (2013). "Designing disorder: Tales of the unexpected tails". Intrinsically Disordered Proteins. 1 (1) e26790. doi:10.4161/idp.26790
Fast_parallel_proteolysis
Protein-coding gene in humans
PC2 enzyme. It is an intrinsically disordered protein that may also function as a chaperone for other aggregating secretory proteins in addition to proPC2
SCG5
Assembly of proteins inside biological cells
balancing the loss of cellular proteins (via degradation or export) through the production of fresh proteins. Proteins perform a number of critical functions
Protein_biosynthesis
Measurand in NMR spectroscopy
dynamics to remedy this. However, for many classes of proteins, including intrinsically disordered proteins, analysis of RDCs becomes more involved, as defining
Residual_dipolar_coupling
Small protein encoded from a small open reading frame (sORF)
class of protein with a single protein domain. They are related to multidomain proteins. Microproteins regulate larger multidomain proteins at the post-translational
Microprotein
Bailey RW, Griswold MD, Chiu W, Garner EC, Obradovic Z (2001). "Intrinsically disordered protein". Journal of Molecular Graphics & Modelling. 19 (1): 26–59
Turn_(biochemistry)
TMAO Chemical compound
Larini L, Levine ZA (2015-03-03). "Regulation and aggregation of intrinsically disordered peptides". Proceedings of the National Academy of Sciences of the
Trimethylamine_N-oxide
RG/RGG sequence motiff
their tendency to form intrinsically disordered regions. The RGG motif can also drive liquid-lipid phase separation of proteins inside cells as well as
RG/RGG_motif
American molecular biologist and physicist (1929–2019)
the resolution of low-field 15 N relaxation experiments on intrinsically disordered proteins with triple-resonance NMR" (PDF). Journal of Biomolecular
Alfred_G._Redfield
Mammalian protein found in Homo sapiens
phosphorylated extracellular matrix protein that lacks an extensive secondary structure as an intrinsically disordered protein. It is composed of about 300 amino
Osteopontin
Laboratory technique
Biotin-based proximity labeling studies demonstrate increased protein tagging of intrinsically disordered regions, suggesting that biotin-based proximity labeling
Proximity_labeling
suppression intrinsic membrane protein See integral membrane protein. intrinsically disordered protein (IDP) A protein (or a region or domain within a protein) that
Glossary of cellular and molecular biology (0–L)
Glossary_of_cellular_and_molecular_biology_(0–L)
Component of blood aiding in coagulation
either directly through thrombocytic PRRs and bacterial surface proteins, or via plasma proteins that bind both to platelets and bacteria. Monocytes respond
Platelet
English chemist
neurodegenerative proteins, and with several groups including Richard Kriwacki, Rohit Pappu and Gary Daughdrill to examine intrinsically disordered proteins. She works
Perdita_Barran
Protein family
this a variety of experimental data indicate that FRQ is an intrinsically disordered protein. In the absence of its partner FRH, FRQ is very unstable. The
Frequency_(gene)
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
inhibit degradation. The presence of intrinsically disordered protein segments of sufficient size, either at the protein terminus or internally, has also
Proteasome
travel, tourism, insurance
INTRINSICALLY DISORDERED-PROTEINS
INTRINSICALLY DISORDERED-PROTEINS
INTRINSICALLY DISORDERED-PROTEINS
INTRINSICALLY DISORDERED-PROTEINS
INTRINSICALLY DISORDERED-PROTEINS
INTRINSICALLY DISORDERED-PROTEINS
INTRINSICALLY DISORDERED-PROTEINS
INTRINSICALLY DISORDERED-PROTEINS
INTRINSICALLY DISORDERED-PROTEINS
travel, tourism, insurance