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Protein-coding gene in the species Homo sapiens
Regulator of cytokinesis 1 (PRC1) is a protein that in humans is encoded by the PRC1 gene and is involved in cytokinesis. PRC1 protein is expressed at relatively
PRC1
Polycomb repressive complex 1 (PRC1) is one of the two classes of Polycomb Repressive complexes, the other being PRC2. Polycomb-group proteins play a major
Polycomb_repressive_complex_1
Family of proteins that play a role in chromatin remodeling
least three kinds of multiprotein complex Polycomb Repressive Complex 1 (PRC1), PRC2 and PhoRC. These complexes work together to carry out their repressive
Polycomb-group_proteins
Compact and highly condensed form of chromatin
There are two types of PRC proteins: PRC1 and PRC2. Among PRC1, there are variant PRC1 and canonical PRC1. vPRC1 recognizes certain binding motifs on
Heterochromatin
Protein complex
polycomb-group proteins or (PcG). The other component of this group of proteins is PRC1 (Polycomb Repressive Complex 1). This complex has histone methyltransferase
PRC2
Protein family around which DNA winds to form nucleosomes
complex, PRC1, can bind H3K27me3 and adds the histone modification H2AK119Ub which aids chromatin compaction. Based on this data it appears that PRC1 is recruited
Histone
Transformation of a stem cell to a more specialized cell
lysine 27 (H3K27me2/me3). By binding to the H3K27me2/3-tagged nucleosome, PRC1 (also a complex of PcG family proteins) catalyzes the mono-ubiquitinylation
Cellular_differentiation
Type of stable macromolecular complex
is associated with human PRC1 and PRC2 complexes. The interaction with PRC1 appears to be through the RING1B domain of PRC1 based on mutational analysis
Rixosome
Final stage of cell division
in the phosphoregulation of other central spindle components, including PRC1 (microtubule-bundling protein required for cytokinesis 1) and MKLP1 (a kinesin
Cytokinesis
Stationery item used for flat mail
sizes Format Dimensions (mm) Dimensions (in) AR Suitable content format PRC1 Chinese #1 Envelope 102 × 165 4 × 6+1⁄2 ϕ∶1 PRC2 Chinese #2 Envelope 102
Envelope
Protein-coding gene in humans
activity of the ncPRC1.1 complex at DNA lesions was necessary for the proper recruitment of the two canonical PRC1 complexes (cPRC1.2 and cPRC1.4), defined
KDM2B
Nuclear and space project of the People's Republic of China
January 20, 2014.{{cite web}}: CS1 maint: deprecated archival service (link) "PRC1: NSSDCA - Spacecraft - Details". NASA. Archived from the original on December
Two_Bombs,_One_Satellite
Epigenitic modification to the protein histone H3
lysine 27 through histone methyl transferase activity. This mark can recruit PRC1 which will bind and contribute to the compaction of the chromatin. The inflammatory
H3K27me3
Protein-coding gene in humans
binding Cellular component PcG protein complex nucleus nucleoplasm cytosol PRC1 complex Biological process regulation of transcription, DNA-templated negative
Chromobox_7
Protein-coding gene in the species Homo sapiens
canonical PRC1 complex composed of RING1A/B, CBX2/CBX4, polyhomeotic (PHC) proteins and is very similar to the PCGF4/BMI1 containing PRC1. Canonical PRC1 binds
PCGF2
Plant cell enzyme
It was first characterised from its interaction with a Procuste1 mutant (prc1-1). This Procuste1 mutant produces less cellulose because of alterations
Theseus1
Human protein
binding Cellular component cytoplasm ubiquitin ligase complex nucleoplasm PRC1 complex PcG protein complex nucleus cytosol nuclear body Biological process
BMI1
interactions with Aurora B kinase Negatively regulated by 14-3-3 RacGAP1 binds to PRC1 microtubule crosslinker, an interaction that is crucial for maintaining the
Centralspindlin
Form of dynamic modification
silenced by chromatin confirmation and polycomb repressive complexes as seen in PRC1/PCR2 silencing of p16. Specific remodeler depletion results in activation
Chromatin_remodeling
Health issue in Japan
genes of interest in Japanese populations. These genes are ADCY5, HNF1A, PRC1 that exhibited this monoallelic effect in Japanese populations and showed
Diabetes_in_Japan
Collection of microscopic DNA spots attached to a solid surface
(H3K27me3, H3K4me2, H3K9me3, etc.), Polycomb-group protein (PRC2:Suz12, PRC1:YY1) and trithorax-group protein (Ash1) to study the epigenetic landscape
DNA_microarray
Protein-coding gene in the species Homo sapiens
component defining the non-canonical polycomb repressive complex 1.1 (ncPRC1) interacting with RING1A/B, RYBP, BCOR and KDM2B. PCGF1-BCOR assembles via
PCGF1
Canadian geneticist
1042/BST20130028. PMC 3685328. PMID 23697932. Klose, Rob (2014). "Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb
Rob_Klose
Protein-coding gene in the species Homo sapiens
GR (February 2017). "Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin". Nature Genetics. 49 (2): 282–288. doi:10.1038/ng.3735. PMC 5373480
SMARCA4
Protein-coding gene in the species Homo sapiens
centrosome nucleolus nucleus nucleoplasm X chromosome PcG protein complex PRC1 complex Biological process regulation of transcription, DNA-templated transcription
PCGF5
Field of study
proteins repress genes by forming polycomb repressive complexes, such as PRC1 and PRC2. PRC2 complexes repress by trimethylating histone 3 at lysine 27
Epigenetics of human development
Epigenetics_of_human_development
Chinese-American biochemist
imprinting, and non-coding RNA regulation. He was also the first to uncover PRC1 as an E3 ligase mediating H2A ubiquitylation. By discovering two enzymatic
Yi_Zhang_(biochemist)
Mammalian protein found in humans
modification through methylation and repression of the promoter region. PRC1 and PRC2 are two protein complexes that modify the expression of p16 through
P16
GR (February 2017). "Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin". Nature Genetics. 49 (2): 282–288. doi:10.1038/ng.3735. PMC 5373480
Bivalent_chromatin
Protein-coding gene in humans
binding Cellular component heterochromatin euchromatin PcG protein complex PRC1 complex nucleus nucleoplasm chromosome Biological process cell differentiation
Chromobox_2
Protein-coding gene in the species Homo sapiens
ubiquitin ligase complex nucleoplasm chromosome heterochromatin MLL1 complex PRC1 complex PcG protein complex nucleus nuclear body Biological process germ
RNF2
Biological process where inactive X chromosomes are reactivated
Verhoeven E, et al. (May 2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin
X-chromosome_reactivation
Protein-coding gene in humans
Verhoeven E, et al. (May 2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin
CUL3
protein complexes, most of which function in chromatin modification, including PRC1, TIP60/NuA4 and INO80. Hence, it also has the names INO80J, TIP48, and TIP49B
Reptin
Protein-coding gene in the species Homo sapiens
to PRC2/EZH2-EED-mediated H3K27 methylation and subsequent recruitment of PRC1 which facilitates condensation of chromatin and formation of heterochromatin
EZH2
Protein-coding gene in the species Homo sapiens
metal ion binding Cellular component nucleus PcG protein complex nucleoplasm PRC1 complex Biological process regulation of transcription, DNA-templated negative
PCGF6
Protein-coding gene in the species Homo sapiens
cytokinesis. KIF23 is part of the centralspindlin complex that includes PRC1, Aurora B and 14-3-3 which cluster together at the spindle midzone to enable
KIF23
Mammalian protein found in Homo sapiens
Saoudi Y, Jablonski SA, Perard J, Yen TJ, et al. (March 2005). "Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires
ANLN
Sporadic biological phenomenon at the molecular scale
of mtDNA escape in yme1 strains decreases. Similarly, the disruption of PRC1, which encodes carboxypeptidase Y, lowers the rate of mtDNA escape in yme1
Nuclear mitochondrial DNA segment
Nuclear_mitochondrial_DNA_segment
American biochemist (born 1954)
eukaryotic promoters will be regulated. Because Polycomb repressive complex 1 (PRC1) contains a number of proteins that work together to repress SWI/SNF complex
Robert_E._Kingston
Protein-coding gene in the species Homo sapiens
ubiquitin ligase complex nucleoplasm PcG protein complex nucleus cytosol PRC1 complex Biological process regulation of transcription, DNA-templated histone
RING1
Protein-coding gene in the species Homo sapiens
Todokoro K (August 2004). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation". The EMBO Journal. 23 (16):
KIF4A
Protein-coding gene in humans
van Lohuizen M (May 2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin
SPOP
Protein-coding gene in the species Homo sapiens
protein binding metal ion binding Cellular component PcG protein complex PRC1 complex nucleus nucleoplasm Biological process multicellular organism development
PHC3
Protein-coding gene in humans
binding Cellular component cytoplasm ubiquitin ligase complex nucleoplasm PRC1 complex PcG protein complex nucleus cytosol nuclear body Biological process
COMMD3-BMI1
Field of study in cancer research
Expression of epigenetic modifiers such as that of the BMI1 component of the PRC1 complex is deregulated in chondrosarcoma, Ewing's sarcoma, and osteosarcoma
Cancer_epigenetics
Chemical compound
component BRG1 and RUNX1 mediated recruitment of polycomb-repressive complex 1 (PRC1) component RING1B at the three MYC enhancers. Taken together, these results
AI-10-49
Centromere- and microtubule-associated protein
Dohmae N, Todokoro K (2005). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation". EMBO J. 23 (16): 3237–48
Centromere_protein_E
Protein-coding gene in the species Homo sapiens
essential for the formation of the central spindle. RACGAP1 also interacts with PRC1 to stabilize and maintain the central spindle as anaphase proceeds. RACGAP1
RACGAP1
nucleoplasm, chromosome, cytosol Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally
ZSWIM9
Protein-coding gene in the species Homo sapiens
existing tumor will be more aggressive. TRIM37 has been shown to interact with PRC1. TRIM37 has also been shown to interact with PRC2 to alter its specificity
TRIM37
HGNC:9338; P02812 12758 PRB3 HGNC:9339; Q04118 12759 PRB4 HGNC:9340; P10163 12760 PRC1 HGNC:9341; O43663 12761 PRCC HGNC:9343; Q92733 12762 PRCD HGNC:32528; Q00LT1
List of human protein-coding genes 6
List_of_human_protein-coding_genes_6
Protein-coding gene in the species Homo sapiens
binding metal ion binding zinc ion binding Cellular component heterochromatin PRC1 complex PcG protein complex nucleus nucleoplasm Biological process spermatogenesis
PHC2
Protein-coding gene in the species Homo sapiens
resistant to replicative senescence by recruiting polycomb-repressive complexes (PRC1 and PRC2) to the promoters at the p16Ink4a locus. The increased accumulation
Jun_dimerization_protein_2
American geneticist
Jessica L.; Park, Peter J.; Kuroda, Mitzi I. (2017). "Bivalent complexes of PRC1 with orthologs of BRD4 and MOZ/MORF target developmental genes in Drosophila"
Mitzi_Kuroda
Protein-coding gene in humans
Cellular component ubiquitin ligase complex nucleoplasm heterochromatin PRC1 complex PcG protein complex nucleus Biological process positive regulation
CBX8
regulation involves epigenetic control and multiple transcription factors. PRC1, PRC2, YY1, and Id1 play a role in the suppression of p16INK4A expression
INK4
Protein-coding gene in the species Homo sapiens
van Lohuizen M (May 2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin
H2AFY
Protein-coding gene in humans
Meer J, Chalkley GE, Bezstarosti K, et al. (2022). "USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3"
USP7
Protein-coding gene in the species Homo sapiens
metal ion binding protein binding Cellular component PcG protein complex PRC1 complex nucleus nucleoplasm Biological process multicellular organism development
PHC1
PRC1
PRC1
PRC1
PRC1
Girl/Female
American, Australian, English, German, Gujarati, Hebrew, Hindu, Indian
He Sees; The Lord Beholds; Foresighted
Surname or Lastname
English
English : variant of Chaffee.
Female
Hindi/Indian
(अंकिता) Hindi name ANKITA means "marked."
Boy/Male
Tamil
Infinite God
Surname or Lastname
English
English : variant of Dole or of Doll.Dutch : nickname for a stupid person.Americanized spelling of German Dollmann (see Dollman).Hungarian Dolmán : variant of Dolmány, metonymic occupational name or nickname from dolmány ‘embroidered coat’, named after a Szekler village in Transylvania called Dolmán. In some cases this may be an Americanized spelling of Dolmáni, habitational name for someone from the village itself.
Male
Welsh
Welsh form of English Geoffrey, probably SIEFFRE means "God's peace."Â
Male
Greek
(Σόλων) Greek name SOLON means "wisdom."
Female
Greek
(Κλωθώ) Greek name KLOTHO means "spinner." In mythology, this is the name of one of the three Fates (Moirae).
Surname or Lastname
Chinese
Chinese : from the place name Pan, which existed in the state of Wei during the Zhou dynasty. Bi Gonggao, fifteenth son of the virtuous duke Wen Wang, was granted a state named Wei when the Zhou dynasty came to power in 1122 bc (see Feng 1). Bi Gonggao in turn granted the area called Pan to one of his sons, whose descendants eventually adopted Pan as their surname. This name is also Romanized as Poon, Pun, and Pon.Korean : There are two Chinese characters for this surname; only one of them, however, is common enough to warrant treatment here. There are three clans which use this character: the KisÅng (also called the KÅje), the Kwangju, and the Namp’yÅng. The founding ancestors of these clans were KoryÅ (918–1392) figures, and it is widely believed that they were related.Spanish and southern French (Occitan) : metonymic occupational name for a baker or a pantryman, from Spanish and Occitan pan ‘bread’ (Latin panis).English and Dutch : metonymic occupational name for someone who cast pans, from Middle English, Middle Dutch panne ‘pan’.Jewish (eastern Ashkenazic) : from Polish, Ukrainian, Yiddish pan ‘lord’, ‘master’, ‘landowner’, hence a nickname for a haughty person.Perhaps also an Americanized spelling or translation of German Pfann (North German Pann).
Girl/Female
Tamil
PRC1
PRC1
PRC1
PRC1
PRC1