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Ratio of concentrations in a mixture at equilibrium
In the physical sciences, a partition coefficient (P) or distribution coefficient (D) is the ratio of concentrations of a compound in a mixture of two
Partition_coefficient
Measure of solubility of general anaesthetics in blood
Blood–gas partition coefficient, also known as Ostwald coefficient for blood–gas, is a term used in pharmacology to describe the solubility of inhaled
Blood–gas partition coefficient
Blood–gas_partition_coefficient
Measure of lipophilicity and hydrophilicity
The n-octanol-water partition coefficient, Kow is a partition coefficient for the two-phase system consisting of n-octanol and water. Kow is also frequently
Octanol-water partition coefficient
Octanol-water_partition_coefficient
Gas law regarding proportionality of dissolved gas
solutes. Pervaporation – Industrial liquid purification method Partition coefficient – Ratio of concentrations in a mixture at equilibrium Scientific
Henry's_law
Electrochemical interface that is either polarisable or polarised
tetra-pentafluorophenyl borate. Contrary to a neutral solute, the partition coefficient of an ion depends on the Galvani potential difference between the
ITIES
Type of chemical equilibrium
distributes or partitions itself between two immiscible solvents. It is called the partition coefficient or distribution coefficient. See: Partition chromatography
Partition_equilibrium
Chemical compound
the stratum corneum/water partition coefficient, and K w / o {\displaystyle K_{w/o}} is the water/octanol partition coefficient. The values of a and b vary
1-Octanol
Partitioning of elements in a mineral
interior. In addition, numerous studies have focused on looking at the partition coefficients of certain elements in the basaltic magma to characterize the composition
Compatibility_(geochemistry)
Topics referred to by the same term
LogP may refer to: the logarithm of the partition coefficient, in the physical sciences LogP machine, a model for parallel computation p-adic logarithm
LogP
chemistry. The fluorous character of a molecule can be assessed by its partition coefficient between a perfluorocarbon and a hydrocarbon. In the following table
Fluorous_chemistry
Chemical compound
polar rather than non-polar environments. In two-phase systems, bronopol partitions preferentially into the polar (usually aqueous) phase. In aqueous solutions
Bronopol
Specialized form of column chromatography
method in 1941. The article contains both the theory in terms of the partition coefficient of a compound, and application to the separation of amino acids
Partition_chromatography
Rule of thumb to predict if a chemical compound is likely to be an orally active drug
molecular mass less than 500 daltons A calculated octanol-water partition coefficient (Clog P) that does not exceed 5 Note that all numbers are multiples
Lipinski's_rule_of_five
Topics referred to by the same term
Look up partition in Wiktionary, the free dictionary. Partition may refer to: Partition (1987 film), directed by Ken McMullen Partition (2007 film), directed
Partition
Distribution of a solute between two immiscible solvents
solvents. C1/C2 = Kd Where Kd is called the distribution coefficient or the partition coefficient. Concentration of X in solvent A/concentration of X in
Distribution_law
Drug that causes anesthesia
comparison. Most important of those properties is known as the blood/gas partition coefficient. This concept refers to the relative solubility of a given agent
Anesthetic
Set of laboratory techniques for separation of mixtures
the differential partitioning between the mobile and the stationary phases. Subtle differences in a compound's partition coefficient result in differential
Chromatography
Compound that induces a loss of consciousness
anesthesia onset, as will the extent of pulmonary blood flow. The partition coefficient of a gaseous drug is indicative of its relative solubility in various
General_anaesthetic
Level of water-borne toxins in an organism
bioaccumulation and bioconcentration. These include: octanol-water partition coefficients (KOW), bioconcentration factors (BCF), bioaccumulation factors (BAF)
Bioconcentration
solvent in each phase. The term is often confused with partition coefficient or distribution coefficient. The ratio of activities of a solute, A in an aqueous/organic
Distribution_constant
Chemical compound
hydrogen bond is about 50 kJ/mol, but it also has high experimental partition coefficient in non-polar medium, as characterized by experimental logP 5.284
Lauryldimethylamine_oxide
Parameter used in drug design
logarithm of the ratio of potency (measured as binding energy) and the partition coefficient to compute a lipophilic ligand efficiency index (LE) with a different
Lipophilic_efficiency
Number of partitions of an integer
In number theory, the partition function p(n) represents the number of possible partitions of a non-negative integer n. For instance, p(4) = 5 because
Partition function (number theory)
Partition_function_(number_theory)
Decomposition of an integer as a sum of positive integers
In number theory and combinatorics, a partition of a non-negative integer n, also called an integer partition, is a way of writing n as a sum of positive
Integer_partition
Predictive chemical model
all similar molecules have similar activities. Analogously, the "partition coefficient"—a measurement of differential solubility and itself a component
Quantitative structure–activity relationship
Quantitative_structure–activity_relationship
Technique in analytical chemistry
analytes may do the opposite. That is, the analytes may have different partition coefficients, leading to the separation of the analytes. The interaction between
High-performance liquid chromatography
High-performance_liquid_chromatography
change in temperature to the change in a material's dimensions. Partition coefficient (KD) (chemistry) - The ratio of concentrations of a compound in
Physical_coefficient
Element not easily hosted in a crystal lattice
sites of the minerals in which it is included. It is defined by a partition coefficient between rock-forming minerals and melt being much smaller than 1
Incompatible_element
How drugs induce reversible suppression of consciousness
their olive oil/water partition coefficient. He found a nearly linear relationship between potency and the partition coefficient for many types of anaesthetic
Theories of general anaesthetic action
Theories_of_general_anaesthetic_action
Measure of linear correlation
statistics, the Pearson correlation coefficient (PCC), also known as Pearson's r, the Pearson product-moment correlation coefficient (PPMCC), or simply the unqualified
Pearson correlation coefficient
Pearson_correlation_coefficient
Concept in drug design
the octanol-water partition coefficient, known as LogP, is used to predict the solubility of a potential oral drug. This coefficient can be experimentally
Druglikeness
phases according to its partition coefficient which is also called the distribution coefficient, distribution constant, or partition ratio and is represented
Countercurrent_chromatography
Solvent interface of a solute
electrolyte can be linked to the statistical component of the activity coefficient of the electrolyte and to the ratio between the apparent molar volume
Solvation_shell
System to differentiate drugs on the basis of their solubility and permeability
mass-balance determination or in comparison to an intravenous dose. ADME Partition coefficient Bioavailability Drug metabolism First pass effect Polar surface
Biopharmaceutics Classification System
Biopharmaceutics_Classification_System
Indicator for how well data points fit a line or curve
In statistics, the coefficient of determination, denoted R2 or r2 and pronounced "R squared", is the proportion of the variation in the dependent variable
Coefficient_of_determination
Form of chromatography
in 1981. In MLC, there are three partition coefficients which must be taken into account. The solute will partition between the water and the stationary
Micellar liquid chromatography
Micellar_liquid_chromatography
buffer biphasic solvent system. The distribution coefficient (Kc which coincides with partition coefficient) of atabrine varied by the composition of the
Countercurrent_distribution
Expansion coefficients in statistical mechanics
obtaining a closed expression for virial coefficients is a cluster expansion of the grand canonical partition function Ξ = ∑ n λ n Q n = e ( p V ) / (
Virial_coefficient
Subdiscipline of chemistry concerned with chemical equilibrium
partitioned between the two solvents. The ratio of concentrations in the two solvents is known as a partition coefficient or distribution coefficient
Equilibrium_chemistry
coefficients are measures of interactions that involve “solutes that participate in a reaction in solution.” Binding constant Partition coefficient Binding
Binding_coefficient
Device to estimate blood alcohol concentration
January 2013. Gullberg RG (2005-01-01). "Determining the Air/Water Partition Coefficient to Employ when Calibrating Forensic Breath Alcohol Test Instruments"
Breathalyzer
Substance added to improve solubility
an Environmental Toxicology and Chemistry paper, among them the partition coefficient, surface tension, dielectric constant, interfacial tension, and
Cosolvent
Volatile anaesthesia medication
pressure (mmHg at 20 °C) 22.5 Partition coefficient (Blood:Gas) 12 Partition coefficient (Oil:Gas) 950 Partition coefficient (Oil:Water) 400 Specific gravity
Methoxyflurane
Inhalational anesthesia medication
30 age group. Desflurane has a blood-to-gas partition coefficient of 0.42, with a blood-to-gas coefficient of 0.47. Emergence from desflurane after an
Desflurane
Medical diagnostic method
substances like acetone (partition coefficient λ b:air = 340 {\displaystyle \lambda _{\text{b:air}}=340} ) or isoprene (partition coefficient λ b:air = 0.75 {\displaystyle
Breath_gas_analysis
Topics referred to by the same term
Kowloon station (MTR), Hong Kong, MTR station code KOW Octanol-water partition coefficient, Kow Kou language Kow Nkensen Arkaah (1927–2001), Ghanaian politician
Kow
Equilibrium partitioning (EqP) predicts the bioavailable concentration of a chemical under given sediment conditions by using partition coefficients. The bioavailable
Equilibrium partitioning sediment benchmark
Equilibrium_partitioning_sediment_benchmark
Benzodiazepine sedative
donors. Diazepam is moderately lipophilic with LogP (Octanol-Water Partition Coefficient) value of 2,82 and hydrophilic with a TPSA (Topological Polar Surface
Diazepam
Number of subsets of a given size
the binomial coefficients are the positive integers that occur as coefficients in the binomial theorem. Commonly, a binomial coefficient is indexed by
Binomial_coefficient
Chemical process
12)}} The value of constant KN depends on temperature and is called partition coefficient. This equation is valid if concentrations are not too large and
Absorption_(chemistry)
Set of accepted specifications
106 Adsorption – Desorption Using a Batch Equilibrium Method 107 Partition coefficient (n-octanol/water): Shake Flask Method 108 Complex formation ability
OECD Guidelines for the Testing of Chemicals
OECD_Guidelines_for_the_Testing_of_Chemicals
Respiration of oxygen-rich liquid by a normally air-breathing organism
Potential Respiratory Media: Application to Oxygen Solubility, Partition Coefficient, Viscosity, Vapor Pressure, and Density". ASAIO Journal. 42 (6):
Liquid_breathing
biological membranes. ITIES Lipophilicity Partition coefficient Reymond, Frédéric; et al. (1999). "Ionic partition diagrams of ionisable drugs: pH-lipophilicity
Ionic_partition_diagram
Ability of two substances to form a homogeneous solution when mixed
Oxford. ISBN 9780199655304. Sangster, J. (1997-05-28). Octanol-Water Partition Coefficients: Fundamentals and Physical Chemistry. John Wiley & Sons. ISBN 9780471973973
Miscibility
Modeling the body's responses to drugs
incoming arterial blood concentration, Pi the tissue over blood partition coefficient and Vi the volume of compartment i. A complete set of differential
Physiologically based pharmacokinetic modelling
Physiologically_based_pharmacokinetic_modelling
Class of antidepressant medication
Bioavailability (%) VdTooltip Volume of distribution (L/kg) logPTooltip Partition coefficient PPBTooltip Plasma protein binding (%) Major metabolic enzymes (additional)
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Topics referred to by the same term
player ISO 639-3 code for Kpati language Soil Organic Carbon-Water Partitioning Coefficient, the ratio of the adsorbed organic analyte to the dissolved King
KOC
Lowering the temperature of a liquid below its freezing point without it becoming a solid
composition, C S L = C 0 {\displaystyle C^{SL}=C_{0}} , and the partition coefficient, k = C S L / C L S {\displaystyle k=C^{SL}/C^{LS}} , can be assumed
Supercooling
{\displaystyle BP_{2}} : The "specific to nonspecific equilibrium partition coefficient", in the literature also denoted as V 3 ″ {\displaystyle V_{3}''}
Binding_potential
Chemical compound
an experimentally determined equilibrium constant at 25 °C. The partition coefficient log POW is measured to −0.85. Since the density of DMF (0.95 g·cm−3
Dimethylformamide
Method to separate compounds or metal complexes
is important. The partition coefficient is a thermodynamic equilibrium constant and has a fixed value for the solute’s partitioning between the two phases
Liquid–liquid_extraction
Phenomenon of drug metabolism
excretion Biopharmaceutics Classification System Enteral administration Partition coefficient Rowland, Malcolm (January 1972). "Influence of route of administration
First_pass_effect
Flowering plant in the St John's wort family
state plasma concentration in mM log P {\displaystyle \log {P}} Partition coefficient. PSA Polar surface area of the molecule in question in square angstroms
Hypericum_perforatum
Extracting agent Partition coefficient Distribution of catalyst Dibutyl ether 0.59 Aqueous phase Methylisobutylketone 0.88 Aqueous+Organic phase Ethyl
OxFA_process
Chemical compound
compound is extremely lipophilic, with a very high octanol-water partition coefficient, and therefore has limited water solubility. These properties are
Zotarolimus
Aggregation of non-polar molecules in aqueous solutions
quantified by measuring the partition coefficients of non-polar molecules between water and non-polar solvents. The partition coefficients can be transformed to
Hydrophobic_effect
Relative measure of dispersion expressed as the ratio of standard deviation to the mean
In probability theory and statistics, the coefficient of variation (CV), also known as normalized root-mean-square deviation (NRMSD), and relative standard
Coefficient_of_variation
Chemical compound
pharmaceutical formulations. PEG 400 is strongly hydrophilic. The partition coefficient of PEG 400 between hexane and water is 0.000015 (log P = − 4.8 {\displaystyle
PEG_400
Lowest perceivable odor concentration
in air. Concentration in the food. Solubility in oil and water. Partition coefficient between the air and the food. The pH of the food. Some aroma compounds
Odor_detection_threshold
Substance dissolving a solute resulting in a solution
of water-miscible solvents Lyoluminescence Occupational health Partition coefficient (log P) is a measure of differential solubility of a compound in
Solvent
Trichloro-nitro-methane
mole. The octanol-water partition coefficient (Kow) of chloropicrin is estimated to be 269. Its soil adsorption coefficient (Koc; normalized to soil
Chloropicrin
Chemical equilibrium of a reversible reaction
constants for dynamic equilibrium involving phase changes include partition coefficient and solubility product. Raoult's law defines the equilibrium vapor
Dynamic_equilibrium
arithmetical coefficient similar to, but more recondite than, the rank of a partition; I shall call this hypothetical coefficient the "crank" of the partition and
Crank_of_a_partition
Antihistamine medication
cetirizine enantiomers: comparison of three different tissue-to-plasma partition coefficients: K(p), K(p,u), and K(p,uu)". Drug Metabolism and Disposition. 34
Cetirizine
Approximate quantum chemistry model
thermodynamic equilibrium properties such as activity coefficients, solubility, partition coefficients, vapor pressure and free energy of solvation. The method
COSMO-RS
Anesthesia resulting from effects on the lipid membrane
based on the oil partition coefficient. In the 70s this concept was extended to the disruption of lipid partitioning. Partitioning itself is an integral
Membrane-mediated_anesthesia
Chemical compound
significant solubility in both water and lipids (octanol-water partition coefficient = 0.41). Gallium maltolate delivers gallium with higher oral bioavailability
Gallium_maltolate
Chemical compound
DBP is leached from landfills. As reflected by its octanol-water partition coefficient of around 4, it is lipophilic, which means that it is not readily
Dibutyl_phthalate
General anaesthetic
a minimum alveolar concentration (MAC) of 0.74%. Its blood/gas partition coefficient of 2.4 makes it an agent with moderate induction and recovery time
Halothane
Medically induced loss of consciousness
intubation Rapid sequence induction Scientific principles Blood–gas partition coefficient Concentration effect Fink effect Minimum alveolar concentration
General_anaesthesia
Aquifer contamination by medical drugs
Lipophilicity, often measured through the so-called octanol-water partition coefficient (typically addressed as K O W {\displaystyle K_{OW}} ) Large K O
Groundwater contamination by pharmaceuticals
Groundwater_contamination_by_pharmaceuticals
Values of chemical properties
descriptor for microenvironment was derived from the octanol-water partition coefficient, (known as Rekker's Fragmental Constants) widely used for pharmacophores
Hydrophobicity_scales
compounds can partition from the gas phase to the particle phase. This process can be described by the gas particle partitioning coefficient, K i {\displaystyle
Secondary_organic_aerosol
Numerical measure of a statistical relationship between variables
A correlation coefficient is a numerical measure of some type of linear correlation, meaning a linear function between two variables. The variables may
Correlation_coefficient
Pumping fluids or gas through pipes
volatilize before equilibrating with water. Using the octanol-water partition coefficient and a 100-year precipitation event for the area, a worst-case estimate
Pipeline
Method of administering medication
physicochemical properties of the drug, for example, its oil/water partition coefficient, molecular weight, structural conformation, determines whether the
Buccal_administration
Alpha-adrenergic agonist
version. Clonidine is fairly lipid soluble with the logarithm of its partition coefficient (log P) equal to 1.6; to compare, the optimal log P to allow a drug
Clonidine
Software application for cheminformatics
and more. Molecular properties: including LogP (octanol-water partition coefficient), molar refractivity, polar surface area (PSA), solvent-accessible
AlvaDesc
Of a Kronecker product (combinatorics)
Murnaghan in 1938. Given a partition λ of n, write Vλ for the Specht module associated to λ. Then the Kronecker coefficients gλμν are given by the rule
Kronecker_coefficient
Capacity of a substance to dissolve in a homogeneous way
physical constants such as the enthalpy of fusion. The octanol-water partition coefficient, usually expressed as its logarithm (Log P), is a measure of differential
Solubility
Region from 660 to 2900 km below Earth's surface
This spin transition of the iron cation results in the increase in partition coefficient between ferropericlase and bridgmanite to 10–14 depleting bridgmanite
Lower_mantle
Nonparametric measure of rank correlation
In statistics, Spearman's rank correlation coefficient or Spearman's ρ is a number ranging from -1 to 1 that indicates how strongly two sets of ranks
Spearman's rank correlation coefficient
Spearman's_rank_correlation_coefficient
Medication applied to body surfaces
concentration when being applied on skin. Despite CYP450 enzyme action, the partition coefficient (K) determines the activity of topical drugs. The ability of drug
Topical_medication
Laboratory glassware
funnels. They have standard taper ground glass joints at the stem. Partition coefficient is a measure of the distribution of an analyte between the two phases
Separatory_funnel
Barbiturate general anesthetic
into muscle and fatty tissue, due to its very high lipid–water partition coefficient (approximately 10), leading to sequestration in fatty tissue. Once
Sodium_thiopental
Chemical compound
has a bio concentration factor (BCF) of 156 and an octanol-water partition coefficient (Log Kow) of 4.2, which makes that this material not a very persistent
Cashmeran
Large area of molten rock on the surface of a planet
Yaxley, G. (1997). "Prediction of siderophile element metal-silicate partition coefficients to 20 GPa and 2800°C: the effects of pressure, temperature, oxygen
Magma_ocean
Any of the fifteen lanthanides plus scandium and yttrium
Fractionation is in turn a function of the partition coefficients of each element. Partition coefficients are responsible for the fractionation of trace
Rare-earth_element
Mathematical rule
tableaux and symmetric polynomials. Littlewood–Richardson coefficients depend on three partitions, say λ , μ , ν {\displaystyle \lambda ,\mu ,\nu } , of
Littlewood–Richardson_rule
Pharmaceutical drug class
oral pharmacokinetics in both mice and rats, it also retained high partition coefficient at 6.69. So, in attempts to reduce the molecule's lipophilicity
Bcr-Abl tyrosine-kinase inhibitor
Bcr-Abl_tyrosine-kinase_inhibitor
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PARTITION COEFFICIENT
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PARTITION COEFFICIENT
PARTITION COEFFICIENT
PARTITION COEFFICIENT
PARTITION COEFFICIENT
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