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Enzyme complex
NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase) is a membrane-bound enzyme complex that faces the extracellular space. It can be found
NADPH_oxidase
Hereditary disease group
(most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens. This leads to the formation
Chronic_granulomatous_disease
Coenzyme
acid chain elongation. The NADPH system is also responsible for generating free radicals in immune cells by NADPH oxidase. These radicals are used to
Nicotinamide adenine dinucleotide phosphate
Nicotinamide_adenine_dinucleotide_phosphate
Protein-coding gene in the species Homo sapiens
NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases. Oxygen sensing is essential
NOX4
Protein-coding gene in the species Homo sapiens
types via NADPH oxidase (NOX) or dual oxidase (DUOX). This new family of proteins, termed the NOX/DUOX family or NOX family of NADPH oxidases, consists
Dual_oxidase_1
Protein-coding gene in the species Homo sapiens
NADPH oxidase 1 is an enzyme that in humans is encoded by the NOX1 gene. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH
NOX1
Protein-coding gene in the species Homo sapiens
NADPH oxidase 3 is an enzyme that in humans is encoded by the NOX3 gene. NADPH oxidases, such as NOX3, are plasma membrane-associated enzymes found in
NOX3
Protein-coding gene in the species Homo sapiens
types via NADPH oxidase (NOX) or dual oxidase (DUOX). This new family of proteins, termed the NOX/DUOX family or NOX family of NADPH oxidases, consists
Dual_oxidase_2
Chemical compound
is soluble in hot water, alcohol, benzene, chloroform, DMSO and DMF. NADPH oxidase is an enzyme that effectively reduces O2 to superoxide (O2–•), which
Apocynin
Protein-coding gene in the species Homo sapiens
NADPH oxidase 2 (Nox2), also known as cytochrome b(558) subunit beta or Cytochrome b-245 heavy chain, is a protein that in humans is encoded by the NOX2
NOX2
British physician (born 1944)
discoveries have been the NADPH oxidase and causes of Chronic Granulomatous Disease (CGD): The identity of the NADPH oxidase that generates superoxide
Anthony_Segal
Protein found in humans
cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to
Neutrophil_cytosolic_factor_2
Protein-coding gene in the species Homo sapiens
NADPH oxidase, EF-hand calcium binding domain 5, also known as NOX5, is a protein which in humans is encoded by the NOX5 gene. NOX5 is a novel NADPH oxidase
NOX5
Protein-coding gene in the species Homo sapiens
NADPH oxidase activator 1 is an enzyme that in humans is encoded by the NOXA1 gene. GRCh38: Ensembl release 89: ENSG00000188747 – Ensembl, May 2017 GRCm38:
NOXA1
Enzyme that aids in redox reactions involving O2
3.4 Glucose oxidase EC 1.4.3.4 Monoamine oxidase EC 1.6.3.1 NADPH oxidase EC 1.17.3.2 Xanthine oxidase EC 1.1.3.8 L-gulonolactone oxidase EC 1.10.3.2
Oxidase
Topics referred to by the same term
Nox (platform), a piece of the software-defined networking ecosystem NADPH oxidase, a membrane-bound enzyme complex Nox (Stargate), a race in the television
Nox
Immune system chemical weapon
NADPH oxidase (NOX2 in humans) activity. NADPH is the key substrate of NOX2, and bears reducing power. Glycogen breakdown is vital to produce NADPH.
Respiratory_burst
Protein-coding gene in the species Homo sapiens
cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein
Neutrophil_cytosolic_factor_4
Israeli immunologist
by phagocytes, known as the NADPH oxidase. With Yael Bromberg, he described a novel method of activating the NADPH oxidase derived from resting phagocytes
Edgar_Pick
Protein-coding gene in the species Homo sapiens
encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide
Neutrophil_cytosolic_factor_1
component of the membrane-associated enzyme phagocyte NADPH-oxidase This enzyme uses NADH or NADPH as the electron donor for the one electron reduction
P22phox
Kidney disease
the allele. NADPH Oxidase regulates oxidative stress by conjugating with reactive oxygen species in cells. Polymorphisms in NADPH Oxidase p22phox and
Kidney_ischemia
Networks of fibres which bind pathogens
picture of the pathway is emerging. The process is thought to begin with NADPH oxidase activation of protein-arginine deiminase 4 (PAD4) via reactive oxygen
Neutrophil extracellular traps
Neutrophil_extracellular_traps
Protein-coding gene in the species Homo sapiens
has been shown to interact with ARHGDIA and Nitric oxide synthase 2A. NADPH oxidase GRCh38: Ensembl release 89: ENSG00000128340 – Ensembl, May 2017 GRCm38:
RAC2
Protein-coding gene in the species Homo sapiens
NADPH oxidase organizer 1 is an enzyme that in humans is encoded by the NOXO1 gene. GRCh38: Ensembl release 89: ENSG00000196408 – Ensembl, May 2017 GRCm38:
NOXO1
Macrophage found in the lungs
respiratory burst is known as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which is composed of five subunits. One component is a membrane cytochrome
Alveolar_macrophage
Any chemical compound containing an O2 ion (charge –1)
enzyme NADPH oxidase for use in oxygen-dependent killing mechanisms of invading pathogens. Mutations in the gene coding for the NADPH oxidase cause an
Superoxide
Protein-coding gene in the species Homo sapiens
nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex in phagocytes. Cytb, the redox element of the NADPH oxidase complex, is a membrane heterodimer
Cytochrome b-245, alpha polypeptide
Cytochrome_b-245,_alpha_polypeptide
Thyroid hormone
peroxidase (TPO) in the presence of hydrogen peroxide generated by the NADPH oxidase DUOX2. The oxidized iodine then iodinates tyrosyl residues of thyroglobulin
Thyroxine
vertebrates is an example of the mixed-function oxidase reaction. In the process, saturated fatty acyl-CoA and NADPH are oxidized by molecular oxygen (O2) to
Mixed-function_oxidase
Class of enzymes
Ent-kaurenoic acid oxidase (EC 1.14.13.79) is an enzyme with systematic name ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating). This enzyme
Ent-kaurenoic_acid_oxidase
Protein family
important role in the activation of the oxygen superoxide-generating NADPH oxidase of phagocytes. This process requires the interaction of membrane-associated
RHO protein GDP dissociation inhibitor
RHO_protein_GDP_dissociation_inhibitor
Free radical toxicity
xanthine oxidase, NADPH oxidases and cytochromes P450. Hydrogen peroxide is produced by a wide variety of enzymes including several oxidases. Reactive
Oxidative_stress
Chemical compound
peroxide: Applications in detecting the activity of phagocyte NADPH oxidase and other oxidases". Anal Biochem. 253 (2): 162–168. doi:10.1006/abio.1997.2391
Resazurin
Enzyme decomposing hydrogen peroxide
Neutrophils and other phagocytes use peroxide to kill bacteria. The enzyme NADPH oxidase generates superoxide within the phagosome, which is converted via hydrogen
Catalase
Protein domain
anaphase-promoting complex (APC) subunits cdc16, cdc23 and cdc27, the NADPH oxidase subunit p67-phox, hsp90-binding immunophilins, transcription factors
Tetratricopeptide_repeat
Process of introducing a phosphate group on to a protein
alkylated base damage. Phosphorylation of the cytosolic components of NADPH oxidase, a large membrane-bound, multi-protein enzyme present in phagocytic
Protein_phosphorylation
Ent-kaurene oxidase (EC 1.14.14.86, Formerly EC 1.14.13.78) is an enzyme with systematic name ent-kaur-16-ene,NADPH:oxygen oxidoreductase (hydroxylating)
Ent-kaurene_oxidase
Chemical compound
Gao HM, Liu B, Hong JS (July 2003). "Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons". The Journal
Rotenone
Birth defect in which the intestine lacks certain nerves
cases.[citation needed] Another gene associated with this condition is NADPH oxidase, EF-hand calcium binding domain 5 (NOX5). This gene is located on the
Hirschsprung's_disease
Chemical compound
through inhibition of integrin β4/SOD activity and elevation of ROS/NADPH oxidase activity". Life Sciences. 80 (11): 999–1006. doi:10.1016/j.lfs.2006
Safrole
Membrane proteins that adhere temporarily to membranes with which they are associated
Wikipedia, 2023-08-16, retrieved 2023-11-29 "Pfam entry: Cholesterol oxidase". Archived from the original on 2007-09-29. Retrieved 2007-01-25. Yue,
Peripheral_membrane_protein
Class of enzymes
chemical reaction 3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } 2-(acetamidomethylene)-
5-pyridoxate_dioxygenase
Genus of fungi
fungus to the dynamic growth environment inside its host. A complex NADPH oxidase enzyme-based ROS-generating system in Epichloë species is indispensable
Epichloë
Health disease test
phagocytosing neutrophils. The NADPH oxidase enzyme is missing in CGD. From total blood, neutrophils can be purified and the NADPH oxidase activity can be measured
Neutrophil_oxidative_index
Family of antimicrobial molecules
enzymatic activity of inducible nitric oxide synthase 2 (NOS2) and NADPH oxidase respectively. NOS2 is expressed primarily in macrophages after induction
Reactive_nitrogen_species
Class of enzymes
substrate (RH), while the other oxygen atom is reduced to water: RH + O2 + NADPH + H+ → ROH + H2O + NADP+ Genes encoding P450 enzymes, and the enzymes themselves
Cytochrome_P450
Species of fungus
large for cell-mediated internalization, and thus neutrophil-mediated NADPH-oxidase-induced damage represents the dominant host defense against hyphae.
Aspergillus_fumigatus
Class of enzymes
14.21.2) is an enzyme that catalyzes the chemical reaction scoulerine + NADPH O2 2 H2O cheilanthifoline + NADP+ The three substrates of this
(S)-cheilanthifoline_synthase
Protein family
was first found in P40phox and p47phox domains of NADPH oxidase (phox stands for phagocytic oxidase). It was also identified in many other proteins involved
PX_domain
Class of enzymes
enzyme that catalyzes the chemical reaction (S)-tetrahydrocolumbamine + NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } (S)-canadine + NADP+ + 2
(S)-canadine_synthase
Type of white blood cell
needed] The respiratory burst involves the activation of the enzyme NADPH oxidase, which produces large quantities of superoxide, a reactive oxygen species
Neutrophil
Medical condition
myeloperoxidase with hydrogen peroxide (H2O2) acquired in the cells from NADPH oxidase through the respiratory bursts. This reaction generates several acidic
Myeloperoxidase_deficiency
Anion
oxygen-derived compounds, including superoxide (which is produced by NADPH oxidase). Superoxide decays to oxygen and hydrogen peroxide, which is used in
Hypochlorite
Type of programmed cell death
iron-dependent Fenton reaction, mitochondrial oxidative phosphorylation, and the NADPH oxidase (NOX) enzyme family. The NOX family, including NOX1, NOX2 (CYBB), and
Ferroptosis
Recessive genetic condition
enhances ultraviolet A-induced oxidative stress in keratinocytes: Roles of NADPH oxidase, mitochondria, and lipid rafts". Free Radical Biology and Medicine.
Smith–Lemli–Opitz_syndrome
Models used in Parkinson's disease research
(2007-06-15). "Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration
Animal models of Parkinson's disease
Animal_models_of_Parkinson's_disease
Lack of or compromised immune system
decreased production of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase by neutrophils. Hypomorphic RAG mutations are seen in patients with
Immunodeficiency
Chemical compound
(SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4". Free Radical Biology & Medicine. 54: 93–104. doi:10.1016/j.freeradbiomed
Leonurine
Mammalian protein found in humans
Cytochrome P450 reductase (also known as NADPH:ferrihemoprotein oxidoreductase, NADPH:hemoprotein oxidoreductase, NADPH:P450 oxidoreductase, P450 reductase
Cytochrome_P450_reductase
Class of enzymes
localized in the chloroplast. Human white blood cells use enzymes such as NADPH oxidase to generate superoxide and other reactive oxygen species to kill bacteria
Superoxide_dismutase
Pore-forming membrane protein
the enzyme NADPH oxidase assembles in the membrane and begins to produce reactive oxygen species (ROS) that help kill bacteria. NADPH oxidase is electrogenic
Ion_channel
nicotinamide adenine dinucleotide phosphate (quinone), dehydrogenase, NADPH oxidase, and NADPH2 dehydrogenase (quinone). It has 2 cofactors: FAD, and Flavoprotein
NADPH_dehydrogenase_(quinone)
Class of enzymes
Beta-amyrin 11-oxidase (EC 1.14.13.134, CYP88D6) is an enzyme with systematic name beta-amyrin,NADPH:oxygen oxidoreductase (hydroxylating). This enzyme
Beta-amyrin_11-oxidase
function of plastid terminal oxidase in developed chloroplasts is its role in chlororespiration. In this process, NADPH dehydrogenase (NDH) reduces the
Plastid_terminal_oxidase
Mammalian protein found in Homo sapiens
neutrophils to stimulate the production of reactive oxygen species by NADPH oxidase. HMGB1-LPS complex activates TLR4, and causes the binding of adapter
HMGB1
Highly reactive molecules formed from diatomic oxygen (O2)
PMID 30755476. Deffert C, Cachat J, Krause KH (August 2014). "Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections". Cellular
Reactive_oxygen_species
Precursor microRNA family
Wei X, Zhang B, Wen Z, Fang H, Pang Q, Yi F (2010). "Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental
Mir-25 microRNA precursor family
Mir-25_microRNA_precursor_family
Species of intracellular parasite
donovani amastigotes is Rac1 dependent and occurs in the absence of NADPH oxidase activation". European Journal of Immunology. 36 (10): 2735–2744. doi:10
Leishmania_donovani
Immune response against an organism's own healthy cells
decreased production of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase by neutrophils. Hypomorphic RAG mutations are seen in patients with
Autoimmunity
Protein kinase found in humans
pathogenesis. This activity is dependent on LRRK2-mediated phosphorylation of NADPH oxidase 2 (NOX2). Specifically, LRRK2 activity promotes activatory phosphorylation
LRRK2
Triarylmethane dye
Jürgen; Eberth, Sonja; Kube, Dieter; Wilting, Jörg (2014-04-06). "The NADPH Oxidase Inhibitor Imipramine-Blue in the Treatment of Burkitt Lymphoma". Molecular
Crystal_violet
Class of enzymes
64) is an enzyme that catalyzes the chemical reaction cheilanthifoline + NADPH O2 2 H2O (S)-stylopine + NADP+ The three substrates of this
(S)-stylopine_synthase
Regulators of the immune system
BMS-986016. NOX2: short for nicotinamide adenine dinucleotide phosphate NADPH oxidase isoform 2, is an enzyme of myeloid cells that generates immunosuppressive
Immune_checkpoint
Class of enzymes
67) is an enzyme that catalyzes the chemical reaction (R)-reticuline + NADPH O2 2 H2O salutaridine + NADP+ The three substrates of this enzyme
Salutaridine_synthase
Response of fish to environmental hypoxia
Cutz, E (2000). "NADPH oxidase is an O2 sensor in airway chemoreceptors: Evidence from K+ current modulation in wild-type and oxidase-deficient mice".
Hypoxia_in_fish
Cells that ingest harmful matter within the body
1016/S0022-1759(99)00146-5. PMID 10618505. Shatwell, KP; AW Segal (1996). "NADPH oxidase". The International Journal of Biochemistry & Cell Biology. 28 (11):
Phagocyte
Method of gene modification
in components of the nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) enzyme in phagocyte cells, which catalyzes the production of superoxide
Lentiviral vector in gene therapy
Lentiviral_vector_in_gene_therapy
Retinal-binding proteins
ligands within gp91(phox) modulate proton conduction by the phagocyte NADPH oxidase". The Journal of Biological Chemistry. 276 (32): 30277–84. doi:10.1074/jbc
Microbial_rhodopsin
Protein-coding gene in humans
(August 2001). "Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation". Biochemistry. 40 (34): 10007–10013. doi:10.1021/bi010288k
RAC1
phosphate (NADPH) oxidase. NADPH oxidase helps with the formation of ROS by generating a superoxide anion by transferring electrons from cytosolic NADPH across
Biological effects of radiation on the epigenome
Biological_effects_of_radiation_on_the_epigenome
Classification of membrane proteins including ion channels
Molybdopterin-containing Oxidoreductase (PMO) Family 5.B.1 The Phagocyte (gp91phox) NADPH Oxidase Family 5.B.2 The Eukaryotic Cytochrome b561 (Cytb561) Family 5.B.3 The
Transporter Classification Database
Transporter_Classification_Database
Class of transport proteins
from activated macrophages targets and activates TRPA1, which induces NADPH oxidase 1-dependent H2O2 release. This prolonged H2O2 release has a dual function
Transient receptor potential channel
Transient_receptor_potential_channel
Human protein and coding gene
489–94. PMID 8637704. Li G, Scull C, Ozcan L, Tabas I (December 2010). "NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation
DNA damage-inducible transcript 3
DNA_damage-inducible_transcript_3
Class of enzymes
9beta-pimara-7,15-diene oxidase (EC 1.14.13.144, CYP99A3) is an enzyme with systematic name 9beta-pimara-7,15-diene,NADPH:oxygen 19-oxidoreductase. This
9beta-pimara-7,15-diene oxidase
9beta-pimara-7,15-diene_oxidase
Chemical compound
NADPH oxidase enzyme. Secondly, the superoxide radical generated can inhibit cytokines, such as IL-4, IL-13 and IFN-γ, which usually upregulate NADPH
Pyocyanin
Medical condition
by hepatic stellate cells. The production of oxidants derived from NADPH oxidase and/or cytochrome P-450 2E1 and the formation of acetaldehyde-protein
Alcoholic_liver_disease
Protein-coding gene in the species Homo sapiens
binding platelet-derived growth factor binding superoxide-generating NADPH oxidase activator activity growth factor activity identical protein binding
PDGFB
Protein-coding gene in the species Homo sapiens
AIF-1 contribute to the pathology of kidney is upregulation of enzyme NADPH oxidase 2. This upregulation leads to oxidative stress in the cells and progression
Allograft inflammatory factor 1
Allograft_inflammatory_factor_1
Chemical compound
code GKT-831) is an experimental orally bioavailable dual inhibitor of NADPH oxidase isoforms NOX4 and NOX1. Setanaxib is a member of the pyrazolopyridine
Setanaxib
Class of enzymes
promotion, as well as vesicle exocytosis, superoxide production from NADPH oxidase, and JNK activation. Both DAG and IP3 are substrates for the synthesis
Phospholipase_C
Plant immune response to infection
ROS production include xanthine oxidase, NADPH oxidase, oxalate oxidase, peroxidases, and flavin containing amine oxidases. In some cases, the cells surrounding
Hypersensitive_response
Cell type
93650. PMID 22421663. Quinn, Mark; Schepetkin, Igor (2009). "Role of NADPH Oxidase in Formation and Function of Multinucleated Giant Cells". Journal of
Touton_giant_cell
the swarm aggregation to run more forwardly. However, below is the NADPH Oxidase 2 or NOX2 is a negative regulator of the chemoattractants that may disrupt
Neutrophil_swarming
Protein found in humans
osteoclasts from superoxide (O2−.), which forms from the action of NADPH-oxidase on oxygen (O2). They play an essential role in the function of phagocytic
Tartrate-resistant acid phosphatase
Tartrate-resistant_acid_phosphatase
Enzyme found in humans
2013). "Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function". Nature Immunology. 14 (6): 543–53
Caspase_1
Pseudogene in the species Homo sapiens
latter being responsible for encoding the 47 kDA cytosolic subunit of NADPH oxidase. In chronic granulomatous disease, the functional NCF1 gene recombines
NCF1C
Reactive oxygen species are produced by the enzyme NADPH oxidase, which transfers electrons from NADPH to oxygen, synthesizing a superoxide, which is a
Arsenic_biochemistry
Moreau, R; Groyer, A; Krause, KH; Daniel, F; Ogier-Denis, E (Jun 2010). "NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative
List of intestinal epithelial differentiation genes
List_of_intestinal_epithelial_differentiation_genes
disruption in regular functioning impacts the vascular tone regulation. NADH/NADPH oxidase: These enzymes contribute significantly to the amount of ROS present
Cardiovascular disease in women
Cardiovascular_disease_in_women
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NADPH OXIDASE
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