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Technique used to map epigenetic methylations in cancer DNA
Methylation specific oligonucleotide microarray, also known as MSO microarray, was developed as a technique to map epigenetic methylation changes in DNA
Methylation specific oligonucleotide microarray
Methylation_specific_oligonucleotide_microarray
Collection of microscopic DNA spots attached to a solid surface
analysis of microarrays Methylation specific oligonucleotide microarray Microfluidics or lab-on-chip Pathogenomics Phenotype microarray Systems biology
DNA_microarray
Lab procedure detecting 5-methylcytosines in DNA
allow for genome-wide analysis of methylation. Oligonucleotide microarrays are designed using pairs of oligonucleotide hybridization probes targeting CpG
Bisulfite_sequencing
Biological process
methylation) GATC sites in an oligonucleotide labeled with a fluorophore and quencher. The adenine methyltransferase methylates the oligonucleotide making
DNA_methylation
DNA analysis method
heterozygosity), in the diploid human genome. Analysis of methylation data The scanned microarray images of methylation data are further analyzed by the system, which
Illumina_Methylation_Assay
English molecular biologist
"Oligonucleotide hybridisations on glass supports: A novel linker for oligonucleotide synthesis and hybridisation properties of oligonucleotides synthesised
Edwin_Southern
Set of all RNA molecules in one cell or a population of cells
were based on microarray techniques (also known as DNA chips). Microarrays consist of thin glass layers with spots on which oligonucleotides, known as "probes"
Transcriptome
Purification technique
Huang TH (January 2002). "Methylation-Specific Oligonucleotide Microarray: A New Potential for High-Throughput Methylation Analysis". Genome Res. 12 (1):
Methylated DNA immunoprecipitation
Methylated_DNA_immunoprecipitation
Single stranded RNA
method. To detect asRNA transcribed from the encoding region, oligonucleotide microarrays can be used. In this method, one or both strands of encoding
Antisense_RNA
Tiling arrays are a subtype of microarray chips. Like traditional microarrays, they function by hybridizing labeled DNA or RNA target molecules to probes
Tiling_array
Molecule that carries genetic information
other nucleic acids are the basis of aptamers, synthetic oligonucleotide ligands for specific target molecules used in a range of biotechnology and biomedical
DNA
Russian biochemist (born 1965)
USSR) is a biochemist working in bioorganic chemistry, nucleic‑acid microarray technology, and the development of isotope‑reinforced essential nutrients
Mikhail_Shchepinov
Metafemale Metamale Metamere Metaphase Metaphase plate Metastasis Methylation Microarray Microbial genetics Microinjection Micronuclei Microsatellite Microtubules
Index_of_genetics_articles
Rare genetic disorder
Genetic testing typically begins with chromosomal microarray analysis using SNP array or oligonucleotide. If that is nondiagnostic, further testing may include
O'Donnell-Luria–Rodan syndrome
O'Donnell-Luria–Rodan_syndrome
Conversion of a gene's sequence into a mature gene product or products
rRNAs. The pre-rRNA is cleaved and modified (2′-O-methylation and pseudouridine formation) at specific sites by approximately 150 different small nucleolus-restricted
Gene_expression
Biological molecules used for experiment calibration
Spike-in controls or spike-ins are known quantities of molecules—such as oligonucleotide sequences (RNA, DNA), proteins, or metabolites—added to a biological
Spike-in_controls
Examines sequence information from individual cells
amplification to provide a template for representative high-density oligonucleotide microarray analysis". Nature Protocols. 2 (3): 739–752. doi:10.1038/nprot
Single-cell_sequencing
known as methylation. MicroArray and Gene Expression (MAGE) A group that "aims to provide a standard for the representation of DNA microarray gene expression
Glossary of cellular and molecular biology (M–Z)
Glossary_of_cellular_and_molecular_biology_(M–Z)
Human gene
screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray". Cancer Science
ZNF559
Biological process of gene regulation
risk. The U.S. Food and Drug Administration has issued guidance specific to oligonucleotide therapeutics, recommending assessment of QTc interval prolongation
RNA_interference
Biomolecule
that also result in a loss of single nucleotide specificity. Because siRNA drugs are oligonucleotides rather than small molecules, they are not substrates
Small_interfering_RNA
Process that prevents the expression of a gene
DNA methylation RNA interference RNA silencing Nonsense mediated decay Transvection Meiotic silencing of unpaired DNA Antisense oligonucleotides were
Gene_silencing
Genomics centre in Toronto, Canada
Lucy Osborne.[citation needed] In 2002, SickKids built a new Affymetrix microarray facility. This core has quickly grown to become the largest such service
Centre_for_Applied_Genomics
Large-scale study of proteins
uses antibodies or other affinity reagents (such as oligonucleotide-based aptamers) as protein-specific detection probes. Currently this method can interrogate
Proteomics
either in vivo or in vitro. DNA damage DNA fingerprinting DNA methylation DNA microarray A high-throughput technology used to measure expression levels
Glossary of cellular and molecular biology (0–L)
Glossary_of_cellular_and_molecular_biology_(0–L)
SOLiD (Sequencing by Oligonucleotide Ligation and Detection) is a next-generation DNA sequencing technology developed by Life Technologies and has been
ABI_Solid_Sequencing
2’-O-Me, Ψ) Microarray modification identification through a DNA-chip, that exploits the decrease in duplex stability of cDNA oligonucleotides, due to the
Epitranscriptomic_sequencing
Sub-field of genomics
samples, which are hybridized to known probes on a microarray. Representational oligonucleotide microarray analysis: Detects copy number variation using amplified
Oncogenomics
Esposito D, Chi M, et al. (October 2003). "Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number
Molecular_cytogenetics
Protein family
post-translational modifications on the protein, which include phosphorylation, methylation, deamidation, and citrullination. These forms differ by the presence
Myelin_basic_protein
Small non-coding ribonucleic acid molecule
PMID 24608427. S2CID 20603801. Cronin JM, Yu AM (2025). "Small RNA or oligonucleotide drugs and challenges in evaluating drug-drug interactions". Frontiers
MicroRNA
Method in molecular biology
fragments are tested. A number of methods use oligonucleotide capture to enrich 3C and Hi-C libraries for specific loci of interest. These methods include Capture-C
Chromosome conformation capture
Chromosome_conformation_capture
Process of determining the nucleic acid sequence
Sequencing is then performed by addition of an oligonucleotide probe that attaches in combination to specific sites within the DNB. The probe acts as an anchor
DNA_sequencing
Inherited retrovirus encoded in an organism's genome
retrovirus transcriptional activity in human tissues with a retrovirus-specific microarray". Journal of Virology. 79 (1): 341–352. doi:10.1128/JVI.79.1.341-352
Endogenous_retrovirus
American biochemist
(1989-07-01). "Defining sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: Analysis of the yeast GCN4
Kevin_Struhl
Ionization technique
spermine can be used as a matrix for oligonucleotides analysis in MALDI mass spectrometry, for instance after oligonucleotide synthesis. Some synthetic macromolecules
Matrix-assisted laser desorption/ionization
Matrix-assisted_laser_desorption/ionization
Medicine focused on hereditary disorders
slide or microarray chip containing molecular probes (ranging from large ~200kb bacterial artificial chromosomes to small oligonucleotides) that represent
Medical_genetics
well as quality control, with some added functionality to remove biased methylation positions for RRBS sequence files (for directional, non-directional (or
List of RNA-Seq bioinformatics tools
List_of_RNA-Seq_bioinformatics_tools
Gene silencing by means of RNA
However, some plant miRNAs have been shown to act directly to promote DNA methylation. miRNAs come from hairpin precursors generated by the RNaseIII enzymes
RNA_silencing
Probe which tests for biological molecules
Utilize engineered, single-stranded oligonucleotides (DNA or RNA) that fold into unique 3D architectures to bind specific targets. Aptamers offer distinct
Biosensor
Discipline in genetics
technique. This involved two closely related methods that generated short oligonucleotides with defined 3' termini. These could be fractionated by electrophoresis
Genomics
Field of study
Nrf2-regulated Genes Induced by the Chemopreventive Agent Sulforaphane by Oligonucleotide Microarray". Cancer Research. 62 (18): 5196–5203. PMID 12234984. Lampe, Johanna
Public_health_genomics
Substrings of length k contained in a biological sequence
(KAT) uses a modified version of Jellyfish to analyze k-mer counts Oligonucleotide Genomic signature Some of the content in this article was copied from
K-mer
RNA family
miR-122 targets, including CD320, AldoA and BCKDK, have been identified by microarray analysis of changes in mRNA expression in the liver of mice treated with
MiR-122
Method used to analyse protein interactions with DNA
analyses through microarrays to determine which DNA regions were enriched with MNase-resistant nucleosomes. MNase-based microarray analyses were often
MNase-seq
Burkard ME, Freier SM, Wyatt JR, Turner DH (November 1999). "Predicting oligonucleotide affinity to nucleic acid targets". RNA. 5 (11) S1355838299991148: 1458–1469
List of RNA structure prediction software
List_of_RNA_structure_prediction_software
Family of short non-coding RNA fragments
proliferation rate of the cell line versus transfection with a control oligonucleotide. Following a similar principle to the proposed miR-92 uptake by leukaemia
Mir-92 microRNA precursor family
Mir-92_microRNA_precursor_family
METHYLATION SPECIFIC-OLIGONUCLEOTIDE-MICROARRAY
METHYLATION SPECIFIC-OLIGONUCLEOTIDE-MICROARRAY
METHYLATION SPECIFIC-OLIGONUCLEOTIDE-MICROARRAY
METHYLATION SPECIFIC-OLIGONUCLEOTIDE-MICROARRAY
METHYLATION SPECIFIC-OLIGONUCLEOTIDE-MICROARRAY
METHYLATION SPECIFIC-OLIGONUCLEOTIDE-MICROARRAY
METHYLATION SPECIFIC-OLIGONUCLEOTIDE-MICROARRAY
METHYLATION SPECIFIC-OLIGONUCLEOTIDE-MICROARRAY
METHYLATION SPECIFIC-OLIGONUCLEOTIDE-MICROARRAY