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Reactions describing metabolism
In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell. The reactants, products, and intermediates of an
Metabolic_pathway
Set of chemical reactions in organisms
consumes energy. The chemical reactions of metabolism are organized into metabolic pathways, in which one chemical is transformed through a series of steps into
Metabolism
Series of interconnected biochemical reactions
The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway, is an essential metabolic pathway present in eukaryotes, archaea
Mevalonate_pathway
Collection of bioinformatics databases
in addition to regular metabolic pathway maps. The low-resolution global maps can be used, for example, to compare metabolic capacities of different
KEGG
Modifying cells' biosynthetic product output
strategies used for metabolic engineering are (1) overexpressing the gene encoding the rate-limiting enzyme of the biosynthetic pathway, (2) blocking the
Metabolic_engineering
Form of biological modelling
Metabolic network modelling, also known as metabolic network reconstruction or metabolic pathway analysis, allows for an in-depth insight into the molecular
Metabolic_network_modelling
Metabolic pathway that produces the NAD coenzyme
pathway is a metabolic pathway leading to the production of nicotinamide adenine dinucleotide (NAD+). Metabolites involved in the kynurenine pathway include
Kynurenine_pathway
Series of interconnected biochemical reactions
Glycolysis is the metabolic pathway that converts glucose (C6H12O6) into pyruvate and, in most organisms, occurs in the liquid part of cells (the cytosol)
Glycolysis
Species of multicellular bacteria
heterotrophic pathways. For autotrophic growth, it utilises the Wood–Ljungdahl pathway (also known as the reductive acetyl-coenzyme A pathway) for carbon
Candidatus Magnetoglobus multicellularis
Candidatus_Magnetoglobus_multicellularis
Metabolic pathway
4-phosphate/1-deoxy-D-xylulose 5-phosphate (MEP/DOXP) pathway—is an alternative metabolic pathway for the biosynthesis of the isoprenoid precursors isopentenyl
Non-mevalonate_pathway
Rate of turnover of molecules in a metabolic pathway
In biochemistry, metabolic flux (often referred to as flux) is the rate of turnover of molecules through a metabolic pathway. Flux is regulated by the
Flux_(metabolism)
Set of biological pathways
these networks comprise the chemical reactions of metabolism, the metabolic pathways, as well as the regulatory interactions that guide these reactions
Metabolic_network
Series of interconnected biochemical reactions
research has highlighted the metabolic role of the fructose produced. Under conditions of hyperglycemia, the activation of this pathway can lead to significant
Polyol_pathway
Biosynthetic pathway
The shikimate pathway (shikimic acid pathway) is a seven-step metabolic pathway used by bacteria, archaea, fungi, algae, some protozoans, and plants for
Shikimate_pathway
Intermediate or end product of metabolism
the metabolic pathways. Examples of primary metabolites produced by industrial microbiology include: The metabolome forms a large network of metabolic reactions
Metabolite
Metabolic pathways to build molecules
Anabolism (/əˈnæbəlɪzəm/ ə-NAB-ə-liz-əm) is the set of metabolic pathways that construct macromolecules like DNA or RNA from smaller units. These reactions
Anabolism
Metabolic pathway for the catabolism of D-galactose
The Leloir pathway is a metabolic pathway for the catabolism of D-galactose. It is named after Luis Federico Leloir, who first described it. In the first
Leloir_pathway
Metabolic pathway involving the transfer of a thiol group
The transsulfuration pathway is a metabolic pathway involving the interconversion of cysteine and homocysteine through the intermediate cystathionine.
Transsulfuration_pathway
An alternative bacterial ketosynthase-directed stilbenoids biosynthesis pathway exists in Photorhabdus bacterial symbionts of Heterorhabditis nematodes
Phenylpropanoids_metabolism
Chemical compound
Sánchez-Pérez, Raquel (November 2018). "Elucidation of the Amygdalin Pathway Reveals the Metabolic Basis of Bitter and Sweet Almonds (Prunus dulcis)1[OPEN]". Plant
Prunasin
Interconnected biochemical reactions releasing energy
Its central importance to many biochemical pathways suggests that it was one of the earliest metabolic components. Even though it is branded as a "cycle"
Citric_acid_cycle
Slowest step in a series of biochemical reactions
possible, by studying the behavior of a complicated system such as a metabolic pathway, to characterize a single factor or reaction (namely the slowest)
Rate-limiting step (biochemistry)
Rate-limiting_step_(biochemistry)
Large biological molecule that acts as a catalyst
products. Nearly all metabolic processes within a cell depend on enzyme catalysis to occur at biologically relevant rates. A metabolic pathway is typically composed
Enzyme
Compound that participates in a chemical reaction that produces another compound
refers more specifically to a chemical compound preceding another in a metabolic pathway, such as a protein precursor. In 1988, the United Nations Convention
Precursor_(chemistry)
Light-independent reactions in photosynthesis
equivalent to most enzymes used in other metabolic pathways such as gluconeogenesis and the pentose phosphate pathway, but the enzymes in the Calvin cycle
Calvin_cycle
Set of biochemical reactions used by some bacteria
Wood–Ljungdahl pathway is a set of biochemical reactions used by some bacteria. It is also known as the reductive acetyl-coenzyme A (acetyl-CoA) pathway. This
Wood–Ljungdahl_pathway
Biochemical process in living organisms
downregulate, and feedback regulate the process. Gluconeogenesis (GNG) is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate
Carbohydrate_metabolism
Biosynthesis of glucose molecules
Gluconeogenesis (GNG) is a metabolic pathway that results in the biosynthesis of glucose from certain non-carbohydrate carbon substrates. It is a ubiquitous
Gluconeogenesis
Surplus or toxic substances left over from metabolic processes that must be excreted
sulphates, etc. Animals treat these compounds as excretes. Plants have metabolic pathways which transform some of them (primarily the oxygen compounds) into
Metabolic_waste
Species of bacterium
novo and taken up from the medium, showing metabolic flexibility within A. clausii. Unique metabolic pathways of A. clausii give rise to its probiotic capabilities
Alkalihalobacillus_clausii
Series of interconnected biochemical reactions
The Entner–Doudoroff pathway (ED Pathway) is a metabolic pathway that is most notable in Gram-negative bacteria, certain Gram-positive bacteria and archaea
Entner–Doudoroff_pathway
Phenomenon in biochemistry
structural-functional complex formed between sequential enzymes of a metabolic pathway, held together both by non-covalent interactions and by structural
Metabolon
Medical condition
activity results in the accumulation of certain metabolic intermediates in the tyrosine catabolic pathway. These compounds are toxic to cells and lead to
Tyrosinemia_type_I
been identified as a metabolic pathway supporting tumorigenicity, and altering lipid availability can influence this metabolic adaptation and tumor formation
Metabolic_flexibility
Series of chemical reactions
MDH2). The proposed metabolic pathway may explain the Warburg effect – that cancer cells produce energy through a suboptimal pathway – and hypoxia in cancer
Citrate–malate_shuttle
Chemical compound
oxygen three carbons away from the first, e.g. 2,5- or 3,6-diketones). Metabolic studies confirmed the in vivo ω-oxidation of 5-nonanone to 2,5-nonanedione
5-Nonanone
basic biochemistry balances can be performed based on the established metabolic pathways of these organisms. Using glucose as substrate the natural producing
Succinic_acid_fermentation
Chemical reaction making 2,3-BPG
biochemistry, the Luebering–Rapoport pathway (also called the Luebering–Rapoport shunt) is a metabolic pathway in mature erythrocytes involving the formation
Luebering–Rapoport_pathway
Series of interconnected biochemical reactions
concentrations of H2S. The reductive acetyl CoA pathway (CoA) pathway, also known as the Wood-Ljungdahl pathway uses CO2 as electron acceptor and carbon source
Biological_carbon_fixation
The acetate pathway, also known as the polyketide pathway, is a fundamental biosynthetic route in organisms for the production of fatty acids and polyketides
Acetate_pathway
Chemical compound
catechol-O-methyltransferase (COMT). L-DOPA has the main role in the metabolic pathway as a metabolite in the biosynthesis of dopamine. This reaction happen
3-O-Methyldopa
Mathematical model of biochemical pathways
In biochemistry, metabolic control analysis (MCA) is a mathematical framework for describing metabolic, signaling, and genetic pathways. MCA quantifies
Metabolic_control_analysis
Series of interconnected biochemical reactions
C3 carbon fixation is the most common of three metabolic pathways for carbon fixation in photosynthesis, the other two being C4 and CAM. This process converts
C3_carbon_fixation
Metabolic pathway
electron transport-linked phosphorylation or terminal oxidation, is the metabolic pathway in which cells use enzymes to oxidize nutrients, thereby releasing
Oxidative_phosphorylation
Set of metabolic pathways that breaks down molecules into smaller units
Catabolism (/kəˈtæbəlɪzəm/) is the set of metabolic pathways that breaks down molecules into smaller units that are either oxidized to release energy or
Catabolism
Chemical reaction
πληρόω= 'to fill', are chemical reactions that form intermediates of a metabolic pathway. Examples of such are found in the citric acid cycle (TCA cycle).
Anaplerotic_reactions
Series of interconnected biochemical reactions
potential treatments of tuberculosis. The prospect of engineering various metabolic pathways into mammals which do not possess them is a topic of great interest
Glyoxylate_cycle
Process of releasing energy from nutrients using inorganic electron acceptors
CO2 generated annually by terrestrial ecosystems. Glycolysis is a metabolic pathway that takes place in the cytosol of cells in all living organisms.
Cellular_respiration
Metabolic pathway involving both catabolism and anabolism
1961 to emphasise the dual metabolic role of such pathways. These pathways are considered to be central metabolic pathways which provide, from catabolic
Amphibolic
Defensive mechanism of cells against glycation
The Randle cycle, also known as the glucose fatty-acid cycle, is a metabolic process involving the cross inhibition of glucose and fatty acids for substrates
Randle_cycle
KaPPA-View4 is a metabolic pathway database containing data about metabolic regulation from 'omics' data. Metabolic pathway Sakurai N, Ara T, Ogata Y,
KaPPA-View4
Chemical reactions and pathways involving lysis of purine nucleotides
Purine metabolism refers to the metabolic pathways to synthesize and break down purines that are present in many organisms. Purines are biologically synthesized
Purine_metabolism
Series of interconnected biochemical reactions
pentose phosphate pathway (also called the phosphogluconate pathway and the hexose monophosphate shunt or HMP shunt) is a metabolic pathway parallel to glycolysis
Pentose_phosphate_pathway
assortment of organism specific Pathway/Genome Databases (PGDBs) that provide reference to genome and metabolic pathway information for thousands of organisms
BioCyc_database_collection
Series of interconnected biochemical reactions
Lactic acid fermentation is a metabolic process by which glucose or other six-carbon sugars (also, disaccharides of six-carbon sugars, e.g. sucrose or
Lactic_acid_fermentation
Biochemistry; detoxification enzyme system
consume higher glycemic index diets. Although the glyoxalase pathway is the main metabolic system that reduces methylglyoxal levels in the cell, other
Glyoxalase_system
Chemical compound
start of two major metabolic pathways: glycolysis and the pentose phosphate pathway. In addition to these two metabolic pathways, glucose 6-phosphate
Glucose_6-phosphate
Theory in genetics
producing a single enzyme that in turn affects a single step in a metabolic pathway. The concept was proposed by George Beadle and Edward Tatum in an
One gene–one enzyme hypothesis
One_gene–one_enzyme_hypothesis
Compounds in biochemical reactions
Metabolic intermediates are compounds that form during these steps, and they are neither the starting substrate nor the final product of the pathway.
Metabolic_intermediate
Chemical and biochemical technique to follow reactions through using atomic isotopes
detectable variation in neutron count) through chemical reaction, metabolic pathway, or a biological cell. The reactant is 'labeled' by replacing one
Isotopic_labeling
Mechanism in enzymes
enzymes of a metabolic pathway channel substrates between themselves, this is called a metabolon. Channeling can make a metabolic pathway more rapid and
Metabolite_channeling
Metabolic pathway
happen in the endoplasmic reticulum (ER), as all components of the main pathway are found in the ER. Phytosphingosine (PHS) is phosphorylated to PHS 1-phosphate
Alpha_oxidation
Amino acid with a branched carbon chain
as determined by presence of mRNAs which encode for enzymes in the metabolic pathway. Oxidation of BCAAs may increase fatty acid oxidation and play a role
Branched-chain_amino_acid
Amino acid metabolic disorder
neurological, or developmental problems at all. PKU is an autosomal recessive metabolic genetic disorder. As such, two PKU alleles are required for an individual
Phenylketonuria
Series of interconnected biochemical reactions
named after its discoverers, Carl Ferdinand Cori and Gerty Cori, is a metabolic pathway in which lactate, produced by anaerobic glycolysis in muscles, is
Cori_cycle
Enzyme
of the amino acids tyrosine and phenylalanine. HGD appears in the metabolic pathway of tyrosine and phenylalanine degradation once the molecule homogentisate
Homogentisate_1,2-dioxygenase
Biochemical pathway that maintains glutamate supply in CNS
In biochemistry, the glutamate–glutamine cycle is a cyclic metabolic pathway which maintains an adequate supply of the neurotransmitter glutamate in the
Glutamate–glutamine_cycle
Chemical compound
biosynthesis Ron Caspi (2009-01-13). "Pathway: 5-aminoimidazole ribonucleotide biosynthesis I". MetaCyc Metabolic Pathway Database. Retrieved 2022-02-02. Zhang
Phosphoribosyl_pyrophosphate
Medical condition
also known as fish odor syndrome or fish malodor syndrome, is a rare metabolic disorder that causes a defect in the normal production of an enzyme named
Trimethylaminuria
Type of analysis in molecular biology
physiological machinery, such as a metabolic pathway describing an enzymatic process within a cell or tissue or a signaling pathway model representing a regulatory
Pathway_analysis
Experimental fluxomics technique
information for determination of pathway fluxes. Because MFA typically requires rigorous flux calculation of complex metabolic networks, publicly available
Metabolic_flux_analysis
Metabolic pathway
Glyceroneogenesis is a metabolic pathway which synthesizes glycerol 3-phosphate (used to form triglycerides) from precursors other than glucose. Usually
Glyceroneogenesis
Species of bacterium
beta-lactams. With a reduced genome and metabolic simplicity, mycoplasmas are obligate parasites with limited metabolic pathways, relying heavily on host resources
Mycoplasma_pneumoniae
Naturally produced monosaccharide
starting material for various metabolic pathways. Among them, all other monosaccharides, such as fructose (via the polyol pathway), mannose (the epimer of
Glucose
Coenzyme
different metabolic roles of NADH and NADPH. NAD+ is synthesized through two metabolic pathways. It is produced either in a de novo pathway from amino
Nicotinamide adenine dinucleotide
Nicotinamide_adenine_dinucleotide
Liquid found in cells
membranes or in the periplasmic space. In eukaryotes, while many metabolic pathways still occur in the cytosol, others take place within organelles. The
Cytosol
Flavonoids are synthesized by the phenylpropanoid metabolic pathway in which the amino acid phenylalanine is used to produce 4-coumaroyl-CoA. This can
Flavonoid_biosynthesis
Molecule that blocks enzyme activity
activity. For example, enzymes in a metabolic pathway may be inhibited by molecules produced later in the pathway, thus curtailing the production of molecules
Enzyme_inhibitor
Aspect of lactate metabolism
dehydrogenase. By this logic, lactate was traditionally considered a toxic metabolic byproduct that could give rise to fatigue and muscle pain during times
Lactate_shuttle_hypothesis
Metabolic pathway for transport of energy into and removal of ammonia from muscles
pathogenesis. A 2020 study explored the role of the glucose-alanine cycle in the metabolic reprogramming of Hepatocellular Carcinoma (HCC). HCC is the most common
Cahill_cycle
(SAFE) is a metabolic pathway. It is an intrinsic protective signaling program to limit cell death activated by the heart. This pathway allows ischaemic
Survival activating factor enhancement
Survival_activating_factor_enhancement
Metabolism of fructose
structures as those in fructolysis, the two sugars have very different metabolic fates in human metabolism. Under one percent of ingested fructose is directly
Fructolysis
discrete metabolic pathway. The genes are in physical vicinity to each other on the genome, and their expression is often coregulated. Metabolic gene clusters
Metabolic_gene_cluster
Domain of organisms
Haloquadratum walsbyi. Despite this, archaea possess genes and several metabolic pathways that are more closely related to those of eukaryotes, notably for
Archaea
Alternate ethanol oxidizing system in human metabolism
The microsomal ethanol oxidizing system (MEOS) is an alternate pathway of ethanol metabolism that occurs in the smooth endoplasmic reticulum in the oxidation
Microsomal ethanol oxidizing system
Microsomal_ethanol_oxidizing_system
Chemical compound
6-bisphosphate is a derivative of glucose 1-phosphate. In the glycogenesis metabolic pathway, glucose 1,6-bisphosphate is an intermediate in the conversion of
Glucose_1,6-bisphosphate
Muscular diseases caused by defects in metabolic processes
autosomal dominant, X-linked, or mitochondrial. Metabolic myopathies are categorized by the metabolic pathway to which the deficient enzyme or transport protein
Metabolic_myopathy
Topics referred to by the same term
a group of interacting genes Metabolic pathway, a series of cellular chemical reactions Neural pathway Signalling pathway or signal transduction, a series
Pathway
Chemical compound
formed during the conversion of lanosterol to cholesterol, a critical metabolic pathway in animals, fungi, and some protozoa. Zymostenol is produced from
Zymostenol
Entity in a chemical reaction
just mentioned) or reversible (e.g. many reactions in the glycolysis metabolic pathway). By increasing the substrate concentration, the rate of reaction
Substrate_(chemistry)
Protein metabolic pathway
The Purine Nucleotide Cycle is a metabolic pathway in protein metabolism requiring the amino acids aspartate and glutamate. The cycle is used to regulate
Purine_nucleotide_cycle
Chemical compound
intermediate in or product of several other metabolic pathways. These include its being a component of metabolic pathways that: make amino acids and in the process
Α-Ketoglutaric_acid
Iron-storage complex
hemosiderin in tissues. Hemosiderin is also generated from the abnormal metabolic pathway of ferritin. It is only found within cells (as opposed to circulating
Hemosiderin
Series of interconnected biochemical reactions
The androgen backdoor pathway (the backdoor pathway of androgen biosynthesis) is a metabolic route in which androgens are produced from 21-carbon (C21)
Androgen_backdoor_pathway
Process that produces butyric acid
allowing optimal growth for butyrate-producing bacteria. The two major metabolic pathways used for butyrate fermentation are butyryl-CoA phosphorylation and
Butyrate_fermentation
Metabolism involving breakdown of lipids
Lipolysis /lɪˈpɒlɪsɪs/ is the metabolic pathway through which lipid triglycerides are hydrolyzed into a glycerol and free fatty acids. It is used to mobilize
Lipolysis
Biochemical reaction sequence
to alter normal metabolic pathways in order to utilize waste products. These metabolic adaptations help the tumor adapt to its metabolic needs. The most
Reverse_Krebs_cycle
Aryl amine
oxidation. 4-Hydroxylation and N-acetylation of toluidine are the major metabolic pathways in rats. The primary metabolism of o-toluidine takes place in the
O-Toluidine
Metabolism of xenobiotics
xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds
Xenobiotic_metabolism
Process of fatty acid breakdown
deficiency is the most common fatty acid β-oxidation disorder and a prevalent metabolic congenital error It is often identified through newborn screening. Although
Beta_oxidation
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