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Subtype of white blood cell
A lymphocyte is a type of white blood cell (leukocyte) in the immune system of most vertebrates. Lymphocytes include T cells (for cell-mediated and cytotoxic
Lymphocyte
Type of blood and immune-system cancer
the lymph nodes. As it affects a subgroup of white blood cells called lymphocytes, it is a lymphoma. The condition was named after the English physician
Hodgkin_lymphoma
Type of white blood cell
T cells (also known as T lymphocytes) are an important part of the immune system and play a central role in the adaptive immune response. T cells can
T_cell
Lymphocytes that become large as a result of antigen stimulation
immunology, reactive lymphocytes, variant lymphocytes, atypical lymphocytes, Downey cells or Türk cells are cytotoxic (CD8+) lymphocytes that become large
Reactive_lymphocyte
Cell class
In transplantation, autologous lymphocytes refers to a person's own white blood cells. Lymphocytes have a number of roles in the immune system, including
Autologous_lymphocyte
Prognostic marker
The neutrophil to lymphocyte ratio (NLR) reflects systemic inflammation, which plays an important role in the process of treating ischemic strokes. In
Neutrophil to lymphocyte ratio
Neutrophil_to_lymphocyte_ratio
Medical condition
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a slow-growing CD20 positive form of Hodgkin lymphoma, a cancer of the immune system's B cells
Nodular lymphocyte predominant Hodgkin lymphoma
Nodular_lymphocyte_predominant_Hodgkin_lymphoma
Excess lymphocytes in the blood
number or proportion of lymphocytes in the blood. Absolute lymphocytosis is the condition where there is an increase in the lymphocyte count beyond the normal
Lymphocytosis
Lymphocyte homing receptors are cell adhesion molecules expressed on lymphocyte cell membranes that recognize addressins on target tissues. Lymphocyte
Lymphocyte_homing_receptor
Type of white blood cell
B cells, also known as B lymphocytes, are a type of lymphocyte. They function in the humoral immunity component of the adaptive immune system. B cells
B_cell
Type of cytotoxic lymphocyte
cells, are a type of cytotoxic lymphocyte critical to the innate immune system. They are a kind of large granular lymphocyte (LGL), belong to the rapidly
Natural_killer_cell
The mixed lymphocyte reaction (MLR), also called the mixed lymphocyte culture (MLC), is an in vitro immunological assay used to measure the response of
Mixed_lymphocyte_reaction
Medical condition
Lymphocyte-variant hypereosinophilia is a rare disorder in which eosinophilia or hypereosinophilia (i.e. a large or extremely large increase in the number
Lymphocyte-variant hypereosinophilia
Lymphocyte-variant_hypereosinophilia
Therapy used in the field of bone marrow transplantation
Donor lymphocyte (or leukocyte) infusion (DLI) or buffy coat infusion is a form of adoptive immunotherapy used to treat relapses after hematopoietic stem
Donor_lymphocyte_infusion
Medical condition
Bare lymphocyte syndrome (BLS) is a condition caused by mutations in certain genes of the major histocompatibility complex or involved with the processing
Bare_lymphocyte_syndrome
T cell that kills infected, damaged or cancerous cells
(also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or cd8) is a T lymphocyte (a type of white blood cell) that
Cytotoxic_T_cell
Found in the epithelial layer of mucosal linings
Intraepithelial lymphocytes (IEL) are lymphocytes found in the epithelial layer of mammalian mucosal linings, such as the gastrointestinal (GI) tract
Intraepithelial_lymphocyte
Subsystem of the immune system
response are white blood cells known as lymphocytes. B cells and T cells, two different types of lymphocytes, carry out the main activities: antibody
Adaptive_immune_system
Lack of lymphocytes in the blood
Lymphocytopenia is the condition of having an abnormally low level of lymphocytes in the blood. Lymphocytes are a white blood cell with important functions in the immune
Lymphocytopenia
Type of immune cell
hypersensitivity, are caused via the over-stimulation of immune cells, commonly lymphocytes and macrophages, resulting in chronic inflammation and cytokine release
T_helper_cell
Medical condition
exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood. It is divided into two main categories:
Large granular lymphocytic leukemia
Large_granular_lymphocytic_leukemia
Increase in lymphocytes within cerebrospinal fluid
Lymphocytic pleocytosis is an abnormal increase in the amount of lymphocytes in the cerebrospinal fluid (CSF). It is usually considered to be a sign of
Lymphocytic_pleocytosis
Organ system in vertebrates complementary to the circulatory system
mostly lymphocytes. Associated lymphoid organs are composed of lymphoid tissue, and are the sites either of lymphocyte production or of lymphocyte activation
Lymphatic_system
Protein-coding gene in the species Homo sapiens
Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. LAG3, which was discovered in 1990 and was
Lymphocyte-activation_gene_3
Type of cells of the immunological system
than red blood cells. They include three main subtypes: granulocytes, lymphocytes and monocytes. All white blood cells are produced and derived from multipotent
White_blood_cell
White blood cells that have migrated to a tumor
Tumor-infiltrating lymphocytes (TIL) are white blood cells that have left the bloodstream and migrated towards a tumor. They include T cells and B cells
Tumor-infiltrating lymphocytes
Tumor-infiltrating_lymphocytes
Genes on human chromosome 6
acids in length. Foreign antigens presented by MHC class I attract T-lymphocytes called killer T-cells (also referred to as CD8-positive or cytotoxic
Human_leukocyte_antigen
2023-08-27. Cano RL, Lopera HD (2013-07-18). "Introduction to T and B lymphocytes". In Anaya JM, Shoenfeld Y, Rojas-Villarraga A, Levy RA, Cervera R (eds
List_of_immune_cells
Medical condition
Acute beryllium poisoning is acute chemical pneumonitis resulting from the toxic effect of beryllium in its elemental form or in various chemical compounds
Acute_beryllium_poisoning
Mammalian protein found in Homo sapiens
that in humans is encoded by the TNFSF13B gene. BAFF is also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand
B-cell_activating_factor
adaptive immune system similar to that found in jawed vertebrates. The lymphocytes of the cyclostomian AIS have roles roughly equivalent to those of B-cells
Adaptive immunity in jawless fish
Adaptive_immunity_in_jawless_fish
American biopharmaceutical startup
San Carlos, California. The company works to develop tumor-infiltrating lymphocyte (TIL) therapies against cancer. The company was founded in 2007 as Genesis
Iovance_Biotherapeutics
White blood cells of the immune system
large numbers of tumor-infiltrating lymphocytes (TILs) to appear in the tumor microenvironment (TME). These lymphocytes may target cancerous cells and therefore
Regulatory_T_cell
Subset of T lymphocytes
Memory T cells are a subset of T lymphocytes that might have some of the same functions as memory B cells. Their lineage is unclear. Antigen-specific
Memory_T_cell
Splenic lymphoma with villous lymphocytes is a rare type of lymphoma that involves mature B cells. Older names include lymphoma simulating hairy cell
Splenic lymphoma with villous lymphocytes
Splenic_lymphoma_with_villous_lymphocytes
Model of the immune system response to infection
selection theory explains the functions of cells of the immune system (lymphocytes) in response to specific antigens invading the body. The concept was
Clonal_selection
Cell type
A lymphoblast is a modified naive lymphocyte with altered cell morphology. It occurs when the lymphocyte is activated by an antigen and increased in volume
Lymphoblast
Ability to produce a normal immune response to an antigen
as immuno-incompetence or being immuno-compromised). In reference to lymphocytes, immunocompetence means that a B cell or T cell is mature and can recognize
Immunocompetence
Immune organ that filters blood
The white pulp houses T lymphocytes in periarteriolar lymphoid sheaths (PALS) situated around central arterioles and B lymphocytes in follicles adjacent
Spleen
Lack of response by the immune system to foreign substances
foreign substances, and consists of a direct induction of peripheral lymphocyte tolerance. An individual in a state of anergy often indicates that the
Clonal_anergy
Genetically engineered T cell
induces T cells into an anergic state, i.e., non-functional state of lymphocytes upon stimulation with the antigen. Second- and third-generation CARs:
CAR_T_cell
Lymphocyte T-cell immunomodulator (LTCI) is an immune regulating polypeptide, which is a potent regulator of CD-4 lymphocyte production and function. It
Lymphocyte T-cell immunomodulator
Lymphocyte_T-cell_immunomodulator
Integrin found on lymphocytes
Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key role in emigration, which
Lymphocyte function-associated antigen 1
Lymphocyte_function-associated_antigen_1
Venules in some lymphatic organs
specialized ligands for lymphocytes and are able to support high levels of lymphocyte extravasation). HEVs enable naïve lymphocytes to move in and out of
High_endothelial_venules
Protein-coding gene in the species Homo sapiens
Myelin and lymphocyte protein is a protein that in humans is encoded by the MAL gene. The protein encoded by this gene is a highly hydrophobic integral
Myelin_and_lymphocyte_protein
Infectious disease
infection. In the next stage of infection, macrophages, epithelioid cells, lymphocytes and fibroblasts aggregate to form a granuloma, which surrounds and isolates
Tuberculosis
Category of antigens in immunology
B lymphocytes without T lymphocyte involvement. There are two distinct subgroups of TI antigens, different in mechanism of activating B lymphocytes: TI-1
T_independent_antigen_(TI)
Chemical compound
label lymphocytes and track their migration within animals for many months. Subsequent studies revealed that the dye can be used to monitor lymphocyte proliferation
Carboxyfluorescein succinimidyl ester
Carboxyfluorescein_succinimidyl_ester
Protein-coding gene in the species Homo sapiens
Lymphocyte-specific protein 1 is a protein that in humans is encoded by the LSP1 gene. This gene encodes an intracellular F-actin binding protein. The
LSP1
Part of a lymph node
outer ring of small lymphocytes surrounding a germinal center. It is also known as the "corona". It contains transient lymphocytes. It is the location
Mantle_zone
Medical condition
Bare lymphocyte syndrome type II (BLS II) is a rare recessive genetic condition in which a group of genes called major histocompatibility complex class
Bare lymphocyte syndrome type II
Bare_lymphocyte_syndrome_type_II
Species of virus
profile. Lymphocyte T-Cell Immunomodulator is a potent regulator of CD-4 lymphocyte production and function. It has been shown to increase lymphocyte numbers
Feline_leukemia_virus
Bone marrow cancer in which lymphocytes are overproduced
CLL, the bone marrow produces too many lymphocytes, which are a type of white blood cell. B cell lymphocytes can begin to collect in the blood, spleen
Chronic_lymphocytic_leukemia
Human lectin protein
implicated in T cell differentiation as well as lymphocyte retention in lymphoid organs. The activation of T lymphocytes and natural killer (NK) cells, both in
CD69
Genetic disorder leading to severe impairment of the immune system
antibody response due to either direct involvement with B lymphocytes or through improper B lymphocyte activation due to non-functional T-helper cells. Consequently
Severe combined immunodeficiency
Severe_combined_immunodeficiency
Topics referred to by the same term
Lymphocyte function-associated antigen (LFA) may refer to: LFA-1 CD2, LFA-2 CD58, LFA-3 This disambiguation page lists articles associated with the title
Lymphocyte function-associated antigen
Lymphocyte_function-associated_antigen
T cells with some properties of natural killer cells
talk with other immune cells, like dendritic cells, neutrophils and lymphocytes. Activation occurs by engagement with their invariant TCR. iNKT cells
Natural_killer_T_cell
Removal of autoreactive B and T cells before they become immunocompetent
In immunology, clonal deletion is the process of removing T and B lymphocytes from the immune system repertoire. The process of clonal deletion helps
Clonal_deletion
Type of white blood cell
Peripheral blood lymphocytes (PBLs) are mature lymphocytes that circulate in the blood, rather than localizing to organs (such as the spleen or lymph
Peripheral_blood_lymphocyte
Mammalian protein found in humans
B-lymphocyte antigen CD20 or CD20 is B lymphocyte cell-surface molecule. It is a 33-37 kDa non-glycosylated protein. CD20 is expressed on the surface
CD20
Mammalian protein found in humans
Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an
Cytotoxic T-lymphocyte associated protein 4
Cytotoxic_T-lymphocyte_associated_protein_4
Protein of the immune system
HLA gene complex can lead to immunodeficiency disorders such as bare lymphocyte syndrome (BLS), which is a type of MHC class II deficiency. Like MHC class
MHC_class_II
Formation of blood cellular components
immature red blood cells, gives an estimate of the rate of erythropoiesis. Lymphocytes are the cornerstone of the adaptive immune system. They are derived from
Haematopoiesis
Drug that inhibits activity of immune system
also be administered directly. By preventing the clonal expansion of lymphocytes in the induction phase of the immune response, it affects both the cell
Immunosuppressive_drug
Cell-surface glycoprotein
adhesion molecule), Pgp-1 (phagocytic glycoprotein-1), Hermes antigen, lymphocyte homing receptor, ECM-III, and HUTCH-1. CD44 is expressed in a large number
CD44
Toxic lectin
as a mitogen to trigger T-lymphocyte cell division and to activate latent HIV-1 from human peripheral lymphocytes. Lymphocytes cultured with phytohaemagglutinin
Phytohaemagglutinin
Cell type associated with Hodgkin lymphoma
from individuals with Hodgkin lymphoma. They are usually derived from B lymphocytes, classically considered crippled germinal center B cells. In the vast
Reed–Sternberg_cell
Lymphocyte protein
Tyrosin-protein kinase Lck (or lymphocyte-specific protein tyrosine kinase) is a 56 kDa protein that is found inside lymphocytes and encoded in the human by
Tyrosin-protein_kinase_Lck
Mammalian protein found in humans
Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand
CXCL13
Rare genetic medical disorder with abnormal lymphocyte survival
lymphoproliferative disorder (LPDs). It affects lymphocyte apoptosis. It is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated
Autoimmune lymphoproliferative syndrome
Autoimmune_lymphoproliferative_syndrome
Medication
mature lymphocytes, but not on the stem cells from which these lymphocytes are derived. After treatment with alemtuzumab, these CD52-bearing lymphocytes are
Alemtuzumab
Mammalian protein found in Homo sapiens
leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a pro-inflammatory cytokine protein
Interleukin_1_beta
Mammalian protein found in Homo sapiens
granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Together, these cells are known as cytotoxic lymphocytes (CLs). Perforin was initially
Perforin-1
Human retrovirus, cause of AIDS
infected cells, and killing of infected CD4+ T cells by CD8+ cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below
HIV
preferential homing of lymphocytes. While this may be the case to some extent, it is now widely held that the main driver in lymphocyte homing is the interactions
Gut-specific_homing
Hematologic cancer that affects lymphocytes
Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). The name typically refers to just the cancerous
Lymphoma
Also called Cytotoxic T-lymphocyte antigen-4 (CTLA-4). Expressed in CD4+ T Lymphocytes but also found in some B Lymphocytes. Binds to CD80 and CD86 receptors
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Protein complex
Integrin α4β7 (Lymphocyte Peyer’s patch adhesion molecule-1) is an integrin heterodimer composed of CD49d (alpha-4) subunit and beta-7 subunit noncovalently
LPAM-1
Excessive production of lymphocytes by the immune system
class of diagnoses, comprising a group of several conditions, in which lymphocytes are produced in excessive quantities. These disorders primarily present
Lymphoproliferative_disorders
Large cat native to Africa and India
Loomis, M.; Gebhard, D. G.; Tompkins, W. A. (2003). "Evaluation of T lymphocytes in captive African lions (Panthera leo) infected with feline immunodeficiency
Lion
Excess number of eosinophil cells in the blood
production of abnormal T-cell lymphocytes not eosinophils which appear phenotypically normal. The phenotypically aberrant lymphocytes function abnormally by
Eosinophilia
Medical condition
affecting circulating lymphocytes, a type of white blood cell. The lymphocytic leukemias are closely related to lymphomas of the lymphocytes, to the point that
Lymphoid_leukemia
Medication used for the treatment of gastro-intestinal diseases
ulcerative colitis and Crohn's disease. It binds to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin
Vedolizumab
is organized into nodules. In the nodules, T lymphocytes are located in the T cell zone. B lymphocytes are located in the B cell follicle. The primary
Lymph_node_stromal_cell
immunoblast is a lymphocyte that has been activated by an antigen, which will further undergo clonal expansion to increase the number of lymphocytes capable of
Immunoblast
Protein-coding gene found in humans
CD52 is present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It also is found on monocytes
CD52
Biomarker for B cell lineage
B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12
CD19
False-color scanning electron micrograph of HIV-1, in green, budding from cultured lymphocyte
History_of_HIV/AIDS
Hematological malignancy
hematological malignancy characterized by an accumulation of abnormal B lymphocytes. The incidence of hairy cell leukemia (HCL) is 0.28-0.30 cases per 100
Hairy_cell_leukemia
Spectrum of conditions caused by HIV infection
especially in the intestinal mucosa, which harbors the majority of the lymphocytes found in the body. The reason for the preferential loss of mucosal CD4+
HIV/AIDS
American physician and academic (1950–2025)
Schumann, Muhammad; Chen, Jennifer; Schulman, Howard (1991), "Regulation of Lymphocyte Chloride Channels", The Identification of the CF (Cystic Fibrosis) Gene
Phyllis Gardner (clinical pharmacologist)
Phyllis_Gardner_(clinical_pharmacologist)
Lymphocyte receptor specific for Interleukin-2
heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2. IL-2 binds to the
IL-2_receptor
Benign tumor of the salivary glands
is a benign cystic tumor of the salivary glands containing abundant lymphocytes and germinal centers (lymph node-like stroma). It is named for pathologist
Warthin's_tumor
Series of events that restore integrity to damaged tissue after an injury
formation Transforming growth factor-α TGF-α Activated macrophages T-lymphocytes Keratinocytes Hepatocyte and epithelial cell proliferation Expression
Wound_healing
Blood test
the amounts of the five normal white blood cell types – neutrophils, lymphocytes, monocytes, eosinophils and basophils – as well as abnormal cell types
White_blood_cell_differential
Seeking HIV infection through sex
A scanning electron microscope image of human immunodeficiency viria (green) in and around a cultured lymphocyte.
Bugchasing
Infectious disease caused by Borrelia bacteria, spread by ticks
almost always involves lymphocytic pleocytosis, i.e., the densities of lymphocytes (infection-fighting cells) and protein in the cerebrospinal fluid (CSF)
Lyme_disease
Contagious disease caused by SARS-CoV-2
of people who died of COVID‑19 have found diffuse alveolar damage, and lymphocyte-containing inflammatory infiltrates within the lung. From the CT scans
COVID-19
targeted migration of lymphocytes to the lymph nodes and facilitating an effective immune response. PNAd's role in lymphocyte homing is essential for
Peripheral_node_addressin
Medical condition
leukemia (PLL) that affects prolymphocytes – immature forms of B-lymphocytes and T-lymphocytes – in the peripheral blood, bone marrow, and spleen. It is an
B-cell prolymphocytic leukemia
B-cell_prolymphocytic_leukemia
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