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MARAVIROC

  • Maraviroc
  • Antiretroviral drug

    Maraviroc, sold under the brand names Selzentry (US) and Celsentri (EU), is an antiretroviral medication used to treat HIV infection. It is taken by mouth

    Maraviroc

    Maraviroc

    Maraviroc

  • CCR5 receptor antagonist
  • Cell entry inhibitor

    and Pfizer with maraviroc.[citation needed] All of the compounds reached clinical trials in humans;[citation needed] only maraviroc has been approved[vague]

    CCR5 receptor antagonist

    CCR5_receptor_antagonist

  • CCR5
  • Immune system protein

    accommodating both endogenous chemokines and small molecule inhibitors like maraviroc, with key residues such as Glu283 and Tyr251 mediating ligand interactions

    CCR5

    CCR5

    CCR5

  • High throughput biology
  • creating new blood vessels in the body. Another discovery made using HTS is Maraviroc. It is an HIV entry inhibitor, and slows the process and prevents HIV

    High throughput biology

    High_throughput_biology

  • Management of HIV/AIDS
  • blocking one of several targets. Maraviroc, enfuvirtide and Ibalizumab are available agents in this class. Maraviroc works by targeting CCR5, a co-receptor

    Management of HIV/AIDS

    Management of HIV/AIDS

    Management_of_HIV/AIDS

  • Entry inhibitor
  • Antiviral drug

    Vicriviroc, similar to maraviroc, is currently undergoing clinical trials for FDA approval. Aplaviroc, an agent similar to maraviroc and vicriroc. Clinical

    Entry inhibitor

    Entry_inhibitor

  • Brazilian Controlled Drugs and Substances Act
  • Brazil's federal drug control statute

    Stavudine (d4T) Etravirine Fosamprenavir Indinavir Lamivudine (3TC) Lopinavir Maraviroc Nelfinavir Nevirapine Raltegravir Ritonavir Saquinavir Tenofovir Tipranavir

    Brazilian Controlled Drugs and Substances Act

    Brazilian_Controlled_Drugs_and_Substances_Act

  • Peptide T
  • HIV entry inhibitor discovered in 1986

    Roy, A.; Dasarathy, S.; Kordower, J. H.; Pahan, K. (2019). "Low-Dose Maraviroc, an Antiretroviral Drug, Attenuates the Infiltration of T Cells into the

    Peptide T

    Peptide_T

  • Innate resistance to HIV
  • course of the infection. Alternatively to gene therapy, medication such as maraviroc (MVC) is being used to bind with CCR5 particles, blocking the entry of

    Innate resistance to HIV

    Innate_resistance_to_HIV

  • Antiviral drug
  • Medication used to treat a viral infection

    develop to HTAs. Commonly used FDA-approved HTAs include maraviroc, and interferon. Maraviroc binds to the CCR5 receptor on the surface of host cells.

    Antiviral drug

    Antiviral drug

    Antiviral_drug

  • Allosteric regulation
  • Regulation of enzyme activity

    targets include the calcium-mimicking cinacalcet and the HIV treatment maraviroc.[citation needed] Allosteric proteins are involved in, and are central

    Allosteric regulation

    Allosteric regulation

    Allosteric_regulation

  • Sandwich, Kent
  • Town in Kent, England

    drugs including Viagra, Pfizer's treatment for erectile dysfunction, Maraviroc, a drug used for treatment of HIV and the horse wormer Strongid P were

    Sandwich, Kent

    Sandwich, Kent

    Sandwich,_Kent

  • ViiV Healthcare
  • Pharmaceutical company

    Lexiva and Telzir) nelfinavir (brand name Viracept) Entry inhibitors: maraviroc (brand names Selzentry and Celsentri) Antiretroviral fixed-dose combinations

    ViiV Healthcare

    ViiV_Healthcare

  • List of antiviral drugs
  • Letermovir (Prevymis) Cytomegalovirus (CMV) Lopinavir HIV Loviride HIV Maraviroc HIV entry inhibitor Methisazone Smallpox Molnupiravir COVID-19 Merck &

    List of antiviral drugs

    List_of_antiviral_drugs

  • Allosteric modulator
  • Substance that binds to a receptor to change its response to stimuli

    negative allosteric modulators (NAM) lower agonist affinity and/or efficacy. Maraviroc is a medicine that modulates CCR5. Fenobam, raseglurant and dipraglurant

    Allosteric modulator

    Allosteric_modulator

  • Monogram Biosciences
  • International biotechnology laboratory located in United States

    Monogram Biosciences Launches New "Trofile" HIV Co-receptor Tropism Test to Select Patients Eligible to User CCR5 Antagonist Maraviroc (Selzentry) [6] v t e

    Monogram Biosciences

    Monogram_Biosciences

  • Namandjé Bumpus
  • American pharmacologist (born 1981)

    than reverse transcriptase inhibition such as the HIV entry inhibitor maraviroc; she found that genetic variants of CYP3A genes could impact its clearance

    Namandjé Bumpus

    Namandjé Bumpus

    Namandjé_Bumpus

  • Interleukin 8
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Interleukin 8

    Interleukin 8

    Interleukin_8

  • Timeline of HIV/AIDS
  • donor. Other similar cases are being studied to confirm similar results. Maraviroc, the first available CCR5 receptor antagonist, is approved by the FDA

    Timeline of HIV/AIDS

    Timeline_of_HIV/AIDS

  • ATC code J05
  • Pharmaceutical drug classification

    J05AX05 Inosine pranobex J05AX06 Pleconaril J05AX07 Enfuvirtide J05AX09 Maraviroc J05AX10 Maribavir J05AX12 Dolutegravir J05AX13 Umifenovir J05AX17 Enisamium

    ATC code J05

    ATC_code_J05

  • David Roblin (physician)
  • Welsh physician and scientist (born 1966)

    12 important medicines including Zithromax (azithromycin), Selzentry (maraviroc), ciprofloxacin and moxifloxacin. Roblin has chaired the research director’s

    David Roblin (physician)

    David Roblin (physician)

    David_Roblin_(physician)

  • C-C motif chemokine receptor 8
  • Protein-coding gene in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    C-C motif chemokine receptor 8

    C-C motif chemokine receptor 8

    C-C_motif_chemokine_receptor_8

  • Leronlimab
  • Monoclonal antibody

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Leronlimab

    Leronlimab

  • CXCL10
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCL10

    CXCL10

    CXCL10

  • List of investigational long COVID drugs
  • Investigational long COVID drugs

    against CD3 [16] LTI-2355 – phagocyte modulator [17] Maraviroc/atorvastatin – combination of maraviroc (antiviral/CCR5 receptor antagonist) and atorvastatin

    List of investigational long COVID drugs

    List_of_investigational_long_COVID_drugs

  • Cenicriviroc
  • Chemical compound

    cenicriviroc arms. Discovery and development of CCR5-receptor antagonists Maraviroc Vicriviroc "International Nonproprietary Names for Pharmaceutical Substances

    Cenicriviroc

    Cenicriviroc

    Cenicriviroc

  • CXCL6
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCL6

    CXCL6

    CXCL6

  • Conolidine
  • Chemical compound

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Conolidine

    Conolidine

    Conolidine

  • Chemokine receptor
  • Cytokine receptor

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Chemokine receptor

    Chemokine receptor

    Chemokine_receptor

  • CXCL16
  • Protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCL16

    CXCL16

    CXCL16

  • Platelet factor 4
  • Protein involved in blood clotting, wound healing and inflammation

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Platelet factor 4

    Platelet factor 4

    Platelet_factor_4

  • XCL1
  • Protein-coding gene in the species Homo sapiens

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    XCL1

    XCL1

    XCL1

  • CCL21
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL21

    CCL21

    CCL21

  • Dapivirine Ring
  • Antiretroviral vaginal ring

    inhibitors (Discovery and development) gp41 (Enfuvirtide (ENF, T-20))◊ CCR5 (Maraviroc (MVC) Vicriviroc†, Cenicriviroc†, Leronlimab†) CD4 (Ibalizumab (IBA),

    Dapivirine Ring

    Dapivirine Ring

    Dapivirine_Ring

  • Pre-exposure prophylaxis for HIV prevention
  • HIV prevention strategy using preventative medication for HIV-negative individuals

    evidence that other regimens, like ones based on the antiretroviral agent Maraviroc, could potentially prevent HIV infection. Similarly, researchers are investigating

    Pre-exposure prophylaxis for HIV prevention

    Pre-exposure prophylaxis for HIV prevention

    Pre-exposure_prophylaxis_for_HIV_prevention

  • Protein–protein interaction
  • Physical interactions and constructions between multiple proteins

    inhibitor of the glycoprotein IIb/IIIa, used as a cardiovascular drug Maraviroc, inhibitor of the CCR5-gp120 interaction, used as anti-HIV drug. Venetoclax

    Protein–protein interaction

    Protein–protein interaction

    Protein–protein_interaction

  • CXCL9
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCL9

    CXCL9

    CXCL9

  • Aplaviroc
  • Chemical compound

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Aplaviroc

    Aplaviroc

    Aplaviroc

  • Ubiquitin
  • Regulatory protein found in most eukaryotic tissues

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Ubiquitin

    Ubiquitin

    Ubiquitin

  • Envelope glycoprotein GP120
  • Glycoprotein exposed on the surface of the HIV virus

    can physically block gp120 from binding to a cell. Only one such agent, Maraviroc, which binds the co-receptor CCR5 is currently licensed and in clinical

    Envelope glycoprotein GP120

    Envelope glycoprotein GP120

    Envelope_glycoprotein_GP120

  • Chemerin
  • Protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Chemerin

    Chemerin

    Chemerin

  • Endothelial cell tropism
  • Group of cells allowing a pathogen to infect nearby endothelium

    Cycle Group Drug(s) Mechanism of Action References Viral Entry Inhibitors Maraviroc Inmazeb Blocks receptor engagement, endocytosis/macropinocytosis, attachment

    Endothelial cell tropism

    Endothelial_cell_tropism

  • Cabotegravir/rilpivirine
  • Co-packaged antiretroviral medication

    inhibitors (Discovery and development) gp41 (Enfuvirtide (ENF, T-20))◊ CCR5 (Maraviroc (MVC) Vicriviroc†, Cenicriviroc†, Leronlimab†) CD4 (Ibalizumab (IBA),

    Cabotegravir/rilpivirine

    Cabotegravir/rilpivirine

    Cabotegravir/rilpivirine

  • Mogamulizumab
  • Monoclonal antibody

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Mogamulizumab

    Mogamulizumab

  • CXCL14
  • Protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCL14

    CXCL14

    CXCL14

  • CXCR3
  • Protein-coding gene in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCR3

    CXCR3

    CXCR3

  • CX3CL1
  • Protein-coding gene in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CX3CL1

    CX3CL1

    CX3CL1

  • C-C motif chemokine ligand 24
  • Protein-coding gene in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    C-C motif chemokine ligand 24

    C-C motif chemokine ligand 24

    C-C_motif_chemokine_ligand_24

  • Laura Waters
  • British physician

    antiviral that is regularly used for antiviral therapy, to etravirine or maraviroc. After completing her doctorate Walters worked in clinical trials at Chelsea

    Laura Waters

    Laura_Waters

  • Raymond C. Stevens
  • American chemist and structural biologist

    Wu (2013) Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex Science 341: 1387-90 H. Wu, C. Wang, K. J. Gregory, G. W. Han

    Raymond C. Stevens

    Raymond_C._Stevens

  • C-C chemokine receptor type 6
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    C-C chemokine receptor type 6

    C-C chemokine receptor type 6

    C-C_chemokine_receptor_type_6

  • CXC chemokine receptors
  • Protein family

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXC chemokine receptors

    CXC_chemokine_receptors

  • Alcino J. Silva
  • American neuroscientist (born 1961)

    in memory linking that the Silva lab had discovered in 2016. Indeed, Maraviroc, an FDA approved CCR5 inhibitor, as well as a CCR5 genetic mutation, can

    Alcino J. Silva

    Alcino J. Silva

    Alcino_J._Silva

  • NIBR2130
  • Pharmaceutical compound

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    NIBR2130

    NIBR2130

    NIBR2130

  • CXCL2
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCL2

    CXCL2

    CXCL2

  • Vicriviroc
  • Chemical compound

    antagonists. Studies into vicriviroc are ongoing, and another CCR5 antagonist, maraviroc, is currently on the market. However, concerns have arisen regarding the

    Vicriviroc

    Vicriviroc

    Vicriviroc

  • CCL2
  • Protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL2

    CCL2

    CCL2

  • Plerixafor
  • Chemical compound

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Plerixafor

    Plerixafor

    Plerixafor

  • CCL7
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL7

    CCL7

    CCL7

  • CXCL1
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCL1

    CXCL1

    CXCL1

  • CXCL13
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCL13

    CXCL13

    CXCL13

  • CCR3
  • Protein-coding gene in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCR3

    CCR3

    CCR3

  • CCL14
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL14

    CCL14

    CCL14

  • Interleukin 8 receptor, beta
  • Mammalian protein found in Homo sapiens

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Interleukin 8 receptor, beta

    Interleukin 8 receptor, beta

    Interleukin_8_receptor,_beta

  • Β-Thromboglobulin
  • Protein

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Β-Thromboglobulin

    Β-Thromboglobulin

  • Chemokine
  • Small cytokines or signaling proteins secreted by cells

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Chemokine

    Chemokine

    Chemokine

  • Atypical chemokine receptor 3
  • Protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Atypical chemokine receptor 3

    Atypical chemokine receptor 3

    Atypical_chemokine_receptor_3

  • Jeffrey P. Nadler
  • American physician

    Felstead S, Dunne MW, van der Ryst E, Mayer H; MOTIVATE Study Teams. Maraviroc for previously treated patients with R5 HIV-1 infection. N Engl J Med

    Jeffrey P. Nadler

    Jeffrey P. Nadler

    Jeffrey_P._Nadler

  • Ulocuplumab
  • Monoclonal antibody

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Ulocuplumab

    Ulocuplumab

  • VIR-576
  • Pharmaceutical compound

    needed] Compared with other antiretroviral drugs such as Enfuvirtide and Maraviroc, VIR-576's mechanism has allowed it to being effective against resistant

    VIR-576

    VIR-576

    VIR-576

  • C-C chemokine receptor type 7
  • Protein-coding gene in the species Homo sapiens

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    C-C chemokine receptor type 7

    C-C chemokine receptor type 7

    C-C_chemokine_receptor_type_7

  • CCR4
  • Protein-coding gene in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCR4

    CCR4

    CCR4

  • CC chemokine receptors
  • Protein family

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CC chemokine receptors

    CC_chemokine_receptors

  • HIV Prevention Trials Network
  • study designed to learn more about the safety and acceptability of oral maraviroc in at-risk HIV uninfected men who have sex with men (MSM) and in at-risk

    HIV Prevention Trials Network

    HIV Prevention Trials Network

    HIV_Prevention_Trials_Network

  • CXCR4
  • Protein

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCR4

    CXCR4

    CXCR4

  • Macrophage migration inhibitory factor
  • Protein-coding gene in the species Homo sapiens

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Macrophage migration inhibitory factor

    Macrophage migration inhibitory factor

    Macrophage_migration_inhibitory_factor

  • LIH383
  • Opioid receptor modulator

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    LIH383

    LIH383

    LIH383

  • CCL5
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL5

    CCL5

    CCL5

  • CXCR5
  • Protein-coding gene in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCR5

    CXCR5

    CXCR5

  • CX3C motif chemokine receptor 1
  • Protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CX3C motif chemokine receptor 1

    CX3C motif chemokine receptor 1

    CX3C_motif_chemokine_receptor_1

  • CCL25
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL25

    CCL25

    CCL25

  • Stromal cell-derived factor 1
  • Mammalian protein found in Homo sapiens

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Stromal cell-derived factor 1

    Stromal cell-derived factor 1

    Stromal_cell-derived_factor_1

  • CCL4
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL4

    CCL4

  • CCL9
  • Mammalian protein found in mice

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL9

    CCL9

    CCL9

  • CCL3
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL3

    CCL3

    CCL3

  • Atypical chemokine receptor 2
  • Protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Atypical chemokine receptor 2

    Atypical chemokine receptor 2

    Atypical_chemokine_receptor_2

  • CCL22
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL22

    CCL22

    CCL22

  • CCL20
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL20

    CCL20

    CCL20

  • CCR2
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCR2

    CCR2

    CCR2

  • CCL11
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL11

    CCL11

    CCL11

  • CXCL5
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCL5

    CXCL5

    CXCL5

  • RTI-5152-12
  • Synthetic opioid modulator

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    RTI-5152-12

    RTI-5152-12

    RTI-5152-12

  • CCR9
  • Protein-coding gene in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCR9

    CCR9

    CCR9

  • CXCL17
  • Cytokine

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCL17

    CXCL17

    CXCL17

  • CXCL3
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CXCL3

    CXCL3

    CXCL3

  • CCL8
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL8

    CCL8

    CCL8

  • CCL13
  • Mammalian protein found in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CCL13

    CCL13

    CCL13

  • Bertilimumab
  • Chemical compound

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Bertilimumab

    Bertilimumab

  • Interleukin-8 receptor
  • 7-transmembrane protein

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    Interleukin-8 receptor

    Interleukin-8_receptor

  • CMKLR1
  • Protein-coding gene in humans

    CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140 CCR6 Agonists: CCL20 CCR7 Agonists: CCL19

    CMKLR1

    CMKLR1

    CMKLR1

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