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Enzyme
alpha is an enzyme that in humans is encoded by the GLA gene. Pathogenic mutations in the GLA gene impair the synthesis, folding, or stability of lysosomal
GLA_(gene)
Rare human genetic lysosomal storage disorder
symptoms. Fabry disease is caused by a mutation in the DNA sequence of the GLA gene. A person who inherits this mutation does not have enough of a functioning
Fabry_disease
Topics referred to by the same term
Alpha-galactosidase, a glycoside hydrolase enzyme GLA (gene), an encoding of the enzyme alpha-galactosidase A Gla domain, a protein domain Gamma-Linolenic acid
GLA
Enzyme
α‑galactosidase B), not to human α‑galactosidase A (GLA). Human α‑galactosidases encoded by GLA and MYORG genes share a conserved modular architecture built
Α-Galactosidase
Matrix Gla protein (MGP) is member of a family of vitamin K2 dependent, Gla-containing proteins. MGP has a high affinity binding to calcium ions, similar
Matrix_Gla_protein
Protein family
carboxylation to form γ-carboxyglutamate (Gla). Proteins with this domain are known informally as Gla proteins. The Gla residues are responsible for the high-affinity
Gla_domain
Fictional comic book heroes
#48–49 and #64, and a cameo appearance in Avengers West Coast Annual #6. The GLA also make an appearance in issue #309 of Avengers and in the 1990 Avengers
Great_Lakes_Avengers
Fat-soluble vitamers
The bone Gla protein osteocalcin, the calcification-inhibiting matrix Gla protein (MGP), the cell growth regulating growth arrest specific gene 6 protein
Vitamin_K
Chemical compound
γ-carboxyglutamate residues are present in the γ-carboxyglutamic acid-rich ("GLA") domain. This GLA domain is known to be found in over a dozen known proteins, including
Carboxyglutamic_acid
Mammalian protein found in Homo sapiens
Because osteocalcin has gla domains, its synthesis is vitamin K2-dependent. In humans, osteocalcin is encoded by the BGLAP gene. Its receptors include
Osteocalcin
Group of vitamins and bacterial metabolites
2903/j.efsa.2017.4780. PMC 7010012. PMID 32625486. "Gene group: Gla domain containing". HUGO Gene Nomenclature Committee. Retrieved 9 May 2026. Institute
Vitamin_K2
Protein-coding gene in the species Homo sapiens
integrins to support adhesion and migration of epithelial cells. Periostin is a gla domain vitamin K dependent factor. Periostin is a secreted extracellular
Periostin
Enzyme involved in blood coagulation in humans
terminus of the molecule to gamma-carboxyglutamic acid (Gla). In the presence of calcium, the Gla residues promote the binding of prothrombin to phospholipid
Thrombin
Enzyme
so the function of the encoded enzyme is essential for hemostasis. Most gla domain-containing proteins depend on this carboxylation reaction for posttranslational
Gamma-glutamyl_carboxylase
Vitamin K-dependent plasma glycoprotein synthesized in the liver
"Contributions of Gla and EGF-like domains to the function of vitamin K-dependent coagulation factors". Critical Reviews in Eukaryotic Gene Expression. 9
Protein_S
Human gene coding for the GAS6 protein
It was originally found as a gene upregulated by growth arrested fibroblasts. Gas6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought
GAS6
Protein-coding gene in the species Homo sapiens
catalyzes γ‐carboxylation of specific glutamic acid residues in Gla‐factors/proteins (Gla domain) leading to their activation and participation in blood
NAD(P)H dehydrogenase (quinone 1)
NAD(P)H_dehydrogenase_(quinone_1)
Protein-coding gene in the species Homo sapiens
and neuronal), controlling nitric oxide production. Proline rich Gla, PRRG2, has a Gla domain which binds hyaluronan and is associated with proteins present
Proline-rich_12
Protein involved in coagulation
architecture. The factor IX protein is composed of four protein domains: the Gla domain, two tandem copies of the EGF domain and a C-terminal trypsin-like
Factor_IX
Mammalian protein found in Homo sapiens
that produces Factor VLeiden was noted (Bertina et al.). Two years later, Gla-domainless APC was imaged at a resolution of 2.8 Ångströms. Beginning with
Protein_C
Protein
in the cerebellum. It is a 28 kDa protein encoded in humans by the CALB1 gene. Calbindin contains 4 active calcium-binding domains, and 2 modified domains
Calbindin
A number of gene mutations have been linked to conditions of or affecting the human integumentary system. List of radiographic findings associated with
List of genes mutated in cutaneous conditions
List_of_genes_mutated_in_cutaneous_conditions
Mammalian protein involved in blood clotting
large and 396 amino acids long. The PROZ gene is located on chromosome 13 (13q34). It has four domains: a GLA-rich region, two EGF-like domains and a trypsin-like
Protein_Z
Enzyme found in humans
humans is encoded by the FADS2 gene. The protein encoded by the FADS2 gene is a member of the fatty acid desaturase (FADS) gene family. It has three catalytic
FADS2
Protein-coding gene in the species Homo sapiens
Fetuin-B is a protein that in humans is encoded by the FETUB gene. The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily
Fetuin-B
Protein-coding gene in the species Homo sapiens
Sarcalumenin is a protein that in humans is encoded by the SRL gene. Sarcalumenin is a calcium-binding protein that can be found in the sarcoplasmic reticulum
Sarcalumenin
Protein-coding gene in the species Homo sapiens
JC, Adler DA, Disteche CM (1992). "Chromosomal localization of the human gene for annexin V (placental anticoagulant protein I) to 4q26----q28". Cytogenetics
Annexin_A5
Protein found in humans
signaling. In humans, the calretinin protein is encoded by the CALB2 gene. This gene encodes an intracellular calcium-binding protein belonging to the troponin
Calretinin
Mammalian protein found in Homo sapiens
PLN or PLB, is a micropeptide protein that in humans is encoded by the PLN gene. Phospholamban is a 52-amino acid integral membrane protein that regulates
Phospholamban
Mammalian protein found in Homo sapiens
basement-membrane protein 40 (BM-40) is a protein that in humans is encoded by the SPARC gene. Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted
Osteonectin
Calcium-binding protein
integral role in cardiac regulation. Mutations in the cardiac calsequestrin gene have been associated with cardiac arrhythmia and sudden death. CASQ2 is thought
Calsequestrin
Mammalian protein found in Homo sapiens
neuronal calcium-binding protein which in humans is encoded by the NCALD gene. Neurocalcin belongs to the neuronal calcium sensor (NCS) family of proteins
Neurocalcin
R-5’ sequence. One of new enzymes GlaI recognizes and cleaves site R(5mC)GY. Due to this unique substrate specificity, GlaI is a convenient tool for identification
GLAD-PCR_assay
Protein-coding gene in the species Homo sapiens
A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. Annexin A1 belongs to the annexin family of Ca2+-dependent phospholipid-binding
Annexin_A1
Medical condition
and receding chin. It is associated with abnormalities in the gene coding for matrix gla protein, MGP. Being an autosomal recessive disorder, it may be
Keutel_syndrome
Protein family
organism used in the industry to produce γ-linolenic acid (GLA), can have a D6E(GLELO) gene overexpressed to produce dihomo-γ-linolenic acid (DGLA). Further
Fatty_acid_desaturase
Serum protein related to amyloid diseases
brains of patients with schizophrenia. Transthyretin is known to contain a Gla domain, and thus be dependent for production on post-translational modification
Transthyretin
Protein found in humans
known as annexin II is a protein that in humans is encoded by the ANXA2 gene. Annexin 2 is involved in diverse cellular processes such as cell motility
Annexin_A2
Protein-coding gene in the species Homo sapiens
Recoverin is a protein which in humans is encoded by the gene RCVRN. It is a 23 kilodalton (kDa) neuronal calcium-binding protein that is primarily detected
Recoverin
Protein found in humans
Hippocalcin is a protein that in humans is encoded by the HPCA gene. Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor
Hippocalcin
Protein complex involved in the complement system
injury. The interaction with apoptotic and necrotic cells is mediated by the Gla domain of protein S and does not affect the ability of C4BP to inhibit complement
C4b-binding_protein
Protein-coding gene in the species Homo sapiens
fyn-associated substrate is a protein that in humans is encoded by the EFS gene. It is also known as CASS3. EFS (Embryonal Fyn-associated Substrate), also
Embryonal fyn-associated substrate
Embryonal_fyn-associated_substrate
Mammalian protein found in humans
residues), acidic cytoplasmic tail. In humans, calnexin is encoded by the gene CANX. Calnexin is a chaperone, characterized by assisting protein folding
Calnexin
Protein-coding gene in the species Homo sapiens
chain H2 is a protein that in humans is encoded by the ITIH2 gene. It is known to contain a Gla domain, and thus be dependent for production on post translational
ITIH2
insertion/deletion entirely inside one gene D – Deletion of a gene or genes Dup - Duplication of a gene or genes C – Whole chromosome extra, missing, or
List_of_genetic_disorders
Cell surface receptor found in humans
transmembrane protein of approximately 95 kDa that is encoded by the TLR4 gene. TLR4 belongs to the toll-like receptor family which is representative of
Toll-like_receptor_4
Protein involved in coagulation
in the signaling function of TF. Note that one of factor VIIa's domains, GLA domain, binds in the presence of calcium to negatively charged phospholipids
Tissue_factor
Protein-coding gene in the species Homo sapiens
FBLN1 is the gene encoding fibulin-1, an extracellular matrix and plasma protein. Fibulin-1 is a secreted glycoprotein that is found in association with
FBLN1
Protein-coding gene in the species Homo sapiens
Regucalcin is a protein that in humans is encoded by the RGN gene The protein encoded by this gene is a highly conserved, calcium-binding protein, that is
Regucalcin
Protein domain
matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin SIBLINGs Bone sialoprotein Dentin matrix phosphoprotein
Fibulin
Soluble protein
resident protein 60 (ERp60), is a protein that in humans is encoded by the CALR gene. Calreticulin is a multifunctional soluble protein that binds Ca2+ ions (a
Calreticulin
Protein found in humans
(2002). "Novel insights into uremic vascular calcification: role of matrix Gla protein and alpha-2-Heremans Schmid glycoprotein/fetuin". Blood Purification
Alpha-2-HS-glycoprotein
Protein-coding gene in the species Homo sapiens
kB-like gene polymorphisms in rheumatoid arthritis". Immunology Letters. 105 (2): 193–7. doi:10.1016/j.imlet.2006.03.003. PMID 16644022. Glas J, Török
NFKBIL1
"Statistics & download files". www.genenames.org. HUGO Gene Nomenclature Committee. 3 November 2025. Retrieved 3 November 2025.
List of human protein-coding genes 3
List_of_human_protein-coding_genes_3
Mammalian protein found in Homo sapiens
Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). The murine ortholog is Spp1. Osteopontin is
Osteopontin
Protein domain
Forsen S, Drakenberg T, Trewhella J (1996). "The relative orientation of Gla and EGF domains in coagulation factor X is altered by Ca2+ binding to the
EGF-like_domain
Protein-coding gene in humans
LOC105369669 Matrix Gla protein (MGP) C12orf60 is also known as LOC144608 and MGC47869. A total of 22 exons exist within the gene.5 From these exons,
C12orf60
Marie Smith". The Norman Lear Center. Retrieved 2026-04-18. https://theses.gla.ac.uk/view/creators/Smythe=3ADavid_Kenneth=3A=3A.html https://www.davidsmythe
List of artists and entertainers with advanced degrees
List_of_artists_and_entertainers_with_advanced_degrees
Protein-coding gene in the species Homo sapiens
(EGF)-like)) is a protein that in humans is encoded by the FBLN5 gene. The protein encoded by this gene is a secreted, extracellular matrix protein containing an
FBLN5
Protein-coding gene in the species Homo sapiens
N-acetyltransferase 8 is a protein that in humans is encoded by the NAT8 gene. Mutations in the NAT8 gene have been associated with chronic kidney disease. GRCh38: Ensembl
NAT8
Late Bronze Age Greek civilization
destroyed at this time but was abandoned, while the Boeotian fortifications of Gla displays evidence for a targeted destruction as only the four gates and the
Mycenaean_Greece
Protein-coding gene in the species Homo sapiens
for binding protein C and APC. Through their gamma-carboxyglutamic acid (Gla) domain, both protein C and APC interact with EPCR. Occupied by a phospholipid
Endothelial protein C receptor
Endothelial_protein_C_receptor
President of El Salvador since 2019
Mexican embassy in Quito to arrest former Ecuadorian vice president Jorge Glas. In February 2022, Bukele accused United States president Joe Biden of "crying
Nayib_Bukele
Class of enzymes
principally for the conversions of cis-linoleic acid to gamma-linolenic acid (GLA), and palmitic acid to sapienic acid. It also converts alpha-linolenic acid
Linoleoyl-CoA_desaturase
Mohawk Valley Falcons). Nils Eklund, 99, Swedish actor (Peter-No-Tail, Doctor Glas, Amorosa). Dory Funk Jr., 85, American Hall of Fame professional wrestler
Deaths_in_August_2026
She recruits an army of local squirrels to aid the Great Lakes Avengers (GLA) in battling Maelstrom and Batroc's Brigade. All of the squirrels die, except
List of Marvel Comics characters: T
List_of_Marvel_Comics_characters:_T
Protein-coding gene in the species Homo sapiens
neuroblastoma Phox (NBPhox), is a protein that in humans is encoded by the PHOX2B gene located on chromosome 4. It codes for a homeodomain transcription factor
PHOX2B
Protein-coding gene in the species Homo sapiens
Fibulin-2 is a protein that in humans is encoded by the FBLN2 gene. This gene encodes an extracellular matrix protein, which belongs to the fibulin family
FBLN2
bayerische Legende – Vor 100 Jahren hingerichtet – ... Vor der Hinrichtung sechs Glas Bier". Der neue Tag (Weiden in der Oberpfalz) (in German). 22 February 2002
List_of_last_meals
Most common type of skin cancer
347–62. doi:10.1007/s13555-016-0123-8. PMC 4972729. PMID 27329375. From the "Glas classification" or "Sabbatsberg classification": Krynitz B, Olsson H, Lundh
Basal-cell_carcinoma
Protein
matrix proteins Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix Gla protein Osteonectin SIBLINGs Bone sialoprotein Dentin matrix phosphoprotein
Calgranulin
Captain Marvel (vol. 10) #20 Decimation: House of M - The Day After #1 G.L.A. #1 G.L.A. #3–4 Gambit #1 (December 1993) Gambit #2 (January 1994) Ronald Byrd
List of Marvel Comics characters: L
List_of_Marvel_Comics_characters:_L
Protein-coding gene in the species Homo sapiens
protein G (S100G) is a protein that in humans is encoded by the S100G gene. This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein
S100G
Family of vertebrate proteins involved in cell division and inflammation
least 21 different S100 proteins are known. They are encoded by a family of genes whose symbols use the S100 prefix, for example, S100A1, S100A2, S100A3.
S100_protein
Species of bacterium
to 23S region in the B. gladioli genome are as follows: GLA-f 5'-(CGAGCTAATACCGCGAAA)-3' and GLA-r 5'-(AGACTCGAGTCAACTGA)-3' Using these primers for PCR
Burkholderia_gladioli
Protease enzyme present in mammals and other organisms
p94) is the gene product responsible for limb-girdle muscular dystrophy type 2A, calpain 10 has been identified as a susceptibility gene for type II diabetes
Calpain
Mammalian protein found in Homo sapiens
fibronectin. Plasma gelsolin and cytoplasmic gelsolin are derived from a single gene by alternate initiation sites and differential splicing. Gelsolin has been
Gelsolin
Nigro Preminuo je András Riedlmayer, veliki prijatelj Bosne i Hercegovine i glas istine o razaranju njenog naslije?a (in Croatian) Former Lions defender Tracy
2026 deaths in the United States
2026_deaths_in_the_United_States
1999 fantasy novel by Andrzej Sapkowski
the child, she will be returned to her own time. However, Eredin Breacc Glas, the commander of a cavalry unit, tells Ciri they will never let her go.
The Lady of the Lake (Sapkowski novel)
The_Lady_of_the_Lake_(Sapkowski_novel)
Japanese video game designer (born 1963)
Christopher (December 21, 2020). "Cyberpunk 2077 cameos: How to find Kojima and GLaDOS in Night City". PC Gamer. Archived from the original on September 30,
Hideo_Kojima
Croatian pop songwriter and composer
Serbian). 25 January 2026. Retrieved 20 March 2026. "Baza autora: HDS ZAMP – Glas autora" (in Croatian). Zamp.hr. Retrieved 25 November 2022. Some quotes used
Ivan_Huljić
Chocolate sponge cake with cherries
Jamie (11 May 2012). "Feast of Fiction Tackles Portal's Black Forest Cake, GLaDOS Advises Fruit or Starvation As An Alternative". The Mary Sue. Retrieved
Black_Forest_gateau
Protein-coding gene in the species Homo sapiens
PDZ-binding motif (TAZ), is a protein that in humans is encoded by the WWTR1 gene. WWTR1 acts as a transcriptional coregulator and has no effect on transcription
WWTR1
Nomadic Iranic people of the Pontic Steppe
there to Ireland via Africa and Spain while Nel's and Scota's son, Goídel Glas, became the eponym for the Gaelic people. Drawing on the Biblical narrative
Scythians
Barnes, Mike (12 March 2023). "Pearry Reginald Teo, Writer-Director of 'The Gene Generation,' Dies at 44". The Hollywood Reporter. Retrieved 12 March 2023
2023_in_film
American cartoon series and franchise
November 16, 2012. "Kino". Gorenjski glas (in Slovenian). No. 75. September 28, 1984. p. 10. "Kino". Gorenjski glas (in Slovenian). No. 16. February 28
Tom_and_Jerry
resistance to thyroid hormone Generalized seizure Generalized torsion dystonia Genes syndrome Genetic diseases, inborn Genetic reflex epilepsy Genetic susceptibility
List_of_diseases_(G)
Type of extremely powerful computer
supercomputers in fiction include HAL 9000, Multivac, The Machine Stops, GLaDOS, SHODAN, The Evitable Conflict, Vulcan's Hammer, Colossus, WOPR, AM, and
Supercomputer
Mammalian protein found in humans
proconvertin) is a protein involved in coagulation and, in humans, is encoded by gene F7. It is an enzyme of the serine protease class. Once bound to tissue factor
Factor_VII
Protein-coding gene in the species Homo sapiens
carboxypeptidase 1 is an enzyme that in humans is encoded by the MATCAP1 gene (previously KIAA0895L). It is a protease, which removes a tyrosine from the
MATCAP1
Variety. Retrieved February 23, 2024. Unbeatable Squirrel Girl (vol. 2) #16 G.L.A. #3 The Sensational Spider-Man #11 & The Amazing Spider-Man #418 Spider-Girl
List of Marvel Comics characters: M
List_of_Marvel_Comics_characters:_M
Fictional character appearing in American comic books published by Marvel Comics
comments upon the series as well. He is later killed by Leather Boy, a rejected GLA member who was disguised as Doctor Doom. Enraged by the death of her friend
Squirrel_Girl
Two-in-One #72 (November 1980) The Mighty Avengers #247 (June 1984) G.L.A. #1 (April 2005) G.L.A. #1-4 (2005) Son of M #1 X-Men: The 198 #2 X-Men: The 198 #3
List of Marvel Comics characters: D
List_of_Marvel_Comics_characters:_D
Dick The Doctor's Dilemma Doctor Blenkinsop George Bernard Shaw Doctor Glas Dr. Glas Hjalmar Söderberg Doctor Grattan Dr. Grattan William A Hammond Doctor
List_of_fictional_doctors
American comic book writer (born 1967)
Omnibus The Unbeatable Squirrel Girl & The GLA, collects GLA:Misassembled #1–4, GLX-Mas Special, and Deadpool/GLA Summer Fun Spectacular. Guardians of the
Dan_Slott
Genus of Late Cretaceous theropod
PMID 33234083. "Trix the T. rex is ready for her big Glasgow reveal". www.gla.ac.uk. Archived from the original on May 23, 2025. Retrieved May 23, 2025
Tyrannosaurus
German multinational automotive manufacturing corporation
20 January 2022. Retrieved 20 January 2022. "Bugatti-Rimac combines the genes of strong brands". Porsche AG. Retrieved 3 September 2026. "Porsche SE –
Volkswagen_Group
Calendar year
Mexican embassy in Quito in order to arrest former vice-president Jorge Glas, who had been granted political asylum by Mexico. This action violates the
2024
Greenland (ISO 3166 digram; FIPS 10-4 territory code) (i) Grenade Launcher gla – (s) Scottish Gaelic language (ISO 639-2 code) GLAAD – (a) Gay and Lesbian
List_of_acronyms:_G
Medical classification system
DeLorenzi, Mauro; Glas, Annuska M.; Golfinopoulos, Vassilis; Goulioti, Theodora; Knox, Susan; Matos, Erika (25 August 2016). "70-Gene Signature as an Aid
Breast_cancer_classification
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GLA GENE
GLA GENE
GLA GENE
GLA GENE
GLA GENE
GLA GENE
GLA GENE
GLA GENE
GLA GENE
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