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ALK inhibitor for treatment of non-small-cell lung cancer
Alectinib (INN), sold under the brand name Alecensa, is an anticancer medication that is used to treat non-small-cell lung cancer (NSCLC). It blocks the
Alectinib
Class of pharmaceutical drugs
alectinib in efficacy, while being active against some resistant mutations such as the common G1202R mutation that provides resistance to alectinib.
ALK_inhibitor
Malignant tumor characterized by uncontrolled cell growth in lung tissue
which can be treated with ALK inhibitors crizotinib, or its successors alectinib, brigatinib, and ceritinib. Those treated with ALK inhibitors who relapse
Lung_cancer
American biotechnology corporation
to treat metastatic melanoma caused by BRAF mutation. 2015: Alecensa (alectinib): Treatment for non-small cell lung cancer (NSCLC). 2016: Venclexta (venetoclax):
Genentech
ALK inhibitor for treatment of non-small-cell lung cancer
chemotherapy. In February 2016, the J-ALEX phase III study comparing alectinib with crizotinib ALK-positive metastatic NSCLC was terminated early because
Crizotinib
Medication
Regorafenib Semaxanib Sorafenib Sunitinib Tivozanib Toceranib Vandetanib ALK Alectinib Brigatinib Ceritinib Crizotinib Ensartinib Lorlatinib RET inhibitors:
Elranatamab
2035 MA 2006 Linagliptin 2011 2031 SM 2007 Apixaban 2012 2032 SM 2007 Alectinib 2014 2014 SM 2007 Sofosbuvir 2007, Raymond F. Schinazi. N/A N/A N/A SM
List of drugs by year of discovery
List_of_drugs_by_year_of_discovery
Pharmaceutical drug classification
Encorafenib L01EC04 Tovorafenib L01ED01 Crizotinib L01ED02 Ceritinib L01ED03 Alectinib L01ED04 Brigatinib L01ED05 Lorlatinib L01EE01 Trametinib L01EE02 Cobimetinib
ATC_code_L01
Kinase inhibitor for treatment of non-small-cell lung cancer
kinase inhibitor for metastatic disease or whose disease has progressed on alectinib or ceritinib as the first anaplastic lymphoma kinase inhibitor therapy
Lorlatinib
Medical condition
superior anti-tumor response in patients with metastatic disease to the CNS. Alectinib another second generation targeted therapy and was approved (for this)
ALK_positive_lung_cancer
Use of math in the study of cancer
Basanta, David; Marusyk, Andriy; Scott, Jacob G. (2019). "Fibroblasts and alectinib switch the evolutionary games played by non-small cell lung cancer". Nature
Mathematical_oncology
Monoclonal antibody
Regorafenib Semaxanib Sorafenib Sunitinib Tivozanib Toceranib Vandetanib ALK Alectinib Brigatinib Ceritinib Crizotinib Ensartinib Lorlatinib RET inhibitors:
Mosunetuzumab
Cancer that has metastasized (spread) to the brain from another location in the body
and various genes. In 2015, the United States FDA approved Alecensa (alectinib) for use in patients with a specific type of non-small cell lung cancer
Brain_metastasis
Lung cancer of glandular origin or characteristics
benefited from second-generation ALK inhibitors including ceritinib, alectinib and brigatinib. Resistance to ALK inhibitors can occur with novel acquired
Adenocarcinoma_of_the_lung
Vemurafenib Hoffmann-La Roche Erdheim-Chester disease with BRAF V600 mutation Alectinib Hoffmann-La Roche ALK-positive, metastatic non-small cell lung cancer
List of drugs granted breakthrough therapy designation
List_of_drugs_granted_breakthrough_therapy_designation
Mammalian protein found in humans
inhibitor) for MPNSTs, or lovastatin (HMG-CoA reductase inhibitor), and alectinib (ALK inhibitor) for NF1 cognitive and learning disabilities. In 2013,
Neurofibromin
along with RET. These included cabozantinib, lenvatinib, sunitinib and alectinib. Since they were not designed to bind RET specifically, these inhibitors
RET_inhibitor
Medical condition
DHAP, and ICE. Drugs that inhibit ALK activity such as crizotinib and alectinib have been successful in establishing complete and partial remissions in
Anaplastic large-cell lymphoma
Anaplastic_large-cell_lymphoma
ALECTINIB
ALECTINIB
ALECTINIB
ALECTINIB
Girl/Female
Hindu, Indian, Marathi, Traditional
Goddes of the Woods
Girl/Female
Tamil
Virendri | விரேநà¯à®¤à¯à®°à¯€
Goddess of beauty
Boy/Male
Tamil
Virtuous
Male
Arthurian
, (Sir) knight of the Round Table (the servant).
Boy/Male
Indian
Ploughman, Cultivator, Friend
Boy/Male
Bengali, Celebrity, Gujarati, Hindu, Indian, Kannada, Sanskrit, Tamil, Telugu, Traditional
Anything; God of the Universe; Son of Emperor Ashok; Popularity; Numerology; The Person who can See the Beauty; Lotus
Boy/Male
Hindu
The one who never gets destroyed
Surname or Lastname
English (of Norman origin)
English (of Norman origin) : from an Old French personal name, Rainbaut, composed of the Germanic elements ragin ‘counsel’ + bald ‘bold’, ‘brave’. Compare Rainbow, Rammel.
Girl/Female
Tamil
Poorvabhadra | பூரà¯à®µà®¾à®ªà®¤à¯à®°à®¾
Name of a star
Boy/Male
Irish
Son of Owen.
ALECTINIB
ALECTINIB
ALECTINIB
ALECTINIB
ALECTINIB