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Search references for CD40. Phrases containing CD40
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Mammalian protein found in humans
Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding
CD40
Protein found in humans
CD40 ligand (CD40-L), also commonly called CD154, is a protein that in humans is encoded by the CD40LG gene. CD40-L is primarily expressed on activated
CD40_ligand
Monoclonal antibody
Frexalimab (SAR441344) is a second-generation monoclonal antibody that inhibits CD40 ligand. It is in development by Sanofi for the treatment of relapsing multiple
Frexalimab
Primary immune deficiency disorders
recombination (Ig-CSR) deficiencies. The most common causes are mutations in the CD40 Ligand (CD40LG) gene located at Xq26.3-27 leading to X-linked HIGM (XHIGM)
Hyper_IgM_syndrome
Lymphatic tissue structure
interaction between B and T cells in the interfollicular area of the lymph node, CD40-CD40L ligation, NF-kB signaling and expression of IRF4 and BCL6. GC B cells
Germinal_center
U.S. House district for California
Election Returns: District Definitions California Voter Foundation map – CD40 33°53′41″N 117°55′23″W / 33.894642°N 117.922955°W / 33.894642; -117.922955
California's 40th congressional district
California's_40th_congressional_district
Cell that displays antigen bound by MHC proteins on its surface
several co-stimulatory molecules required for T cell activation, including CD40 and B7. The latter can interact with CD28 on the surface of a CD4+ T cell
Antigen-presenting_cell
Type of immune cell
aid those cells through a combination of cell to cell interactions, e.g., CD40 (protein) and CD40L, and through cytokines.[citation needed] Th cells are
T_helper_cell
Type of protein
signaling pathway. Moreover, this protein is only used in cells expressing CD40 and CD40L, which are also from the tumor necrosis receptor superfamily and
Act_1_adaptor_protein
Type of white blood cell
immunohistochemical staining by their specific expression of proteins such as CD14, CD40, CD11b, CD64, F4/80 (mice)/EMR1 (human), lysozyme M, MAC-1/MAC-3 and CD68
Macrophage
Enzyme found in humans
superfamily of divalent cation-dependent phosphodiesterases. It associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors
Tyrosyl-DNA phosphodiesterase 2
Tyrosyl-DNA_phosphodiesterase_2
2000 CX39 — January 11, 2000 Socorro LINEAR · 1.4 km MPC JPL 483421 2000 CD40 — February 3, 2000 Socorro LINEAR · 2.1 km MPC JPL 483422 2000 CE59 — February
List of minor planets: 483001–484000
List_of_minor_planets:_483001–484000
American pharmacologist (born 1957)
Presbyterian Hospital). As assistant professor at Columbia, Lederman discovered the CD40-Ligand (CD154) and elucidated the molecular basis of T cell helper function
Seth_Lederman
13, 2010 Mount Lemmon Mount Lemmon Survey EOS 1.5 km MPC JPL 761582 2010 CD40 — February 13, 2010 Mount Lemmon Mount Lemmon Survey · 2.2 km MPC JPL 761583
List of minor planets: 761001–762000
List_of_minor_planets:_761001–762000
— February 2, 2017 Haleakala Pan-STARRS 1 · 1.5 km MPC JPL 755359 2017 CD40 — February 1, 2017 Mount Lemmon Mount Lemmon Survey · 1.6 km MPC JPL 755360
List of minor planets: 755001–756000
List_of_minor_planets:_755001–756000
CT39 — October 20, 2003 Kitt Peak Spacewatch · 3.1 km MPC JPL 580594 2015 CD40 — November 3, 2004 Kitt Peak Spacewatch GEF 1.5 km MPC JPL 580595 2015 CE40
List of minor planets: 580001–581000
List_of_minor_planets:_580001–581000
Excess amounts of gamma globulin in the blood
which codes for CD40 ligand. This gene is located on the long arm of the X chromosome at position 26, denoted Xq26. Normally, CD40 ligand is expressed
Hypergammaglobulinemia
Cells found in human testes which help produce sperm
T-cells on the periphery. CD40, a molecule associated with dendritic cells (DCs). SCs are able to down regulate the expression of CD40 on the surface of DCs
Sertoli_cell
Bivatuzumab mab humanized CD44 v6 squamous cell carcinoma Bleselumab mab human CD40 organ transplant rejection Blinatumomab Blincyto BiTE mouse CD19 Y pre-B
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Monoclonal antibody
Lucatumumab (CHIR 12.12 or HCD122) is a human monoclonal antibody against CD40 development of which was discontinued by Novartis in 2013 after it was investigated
Lucatumumab
Medical condition
group of primary immune deficiency disorders characterized by defective CD40 signaling; via B cells affecting class switch recombination (CSR) and somatic
Hyper-IgM_syndrome_type_4
Inflammatory arthritis triggered by infection elsewhere in the body
Lanier, L.L. (February 1995). "T-cell costimulation via CD28-CD80/CD86 and CD40-CD40 ligand interactions". Research in Immunology. 146 (3): 171–176. doi:10
Reactive_arthritis
Organ system in vertebrates complementary to the circulatory system
Olsson Bontell, T; Smits, A; Essand, M; Dimberg, A (5 July 2021). "Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint
Lymphatic_system
Type of white blood cell
co-stimulatory factor for B cell activation by binding the B cell surface receptor CD40, which promotes B cell proliferation, immunoglobulin class switching, and
B_cell
Type of autoimmune arthritis
include genes affecting co-stimulatory immune pathways—for example CD28 and CD40, cytokine signaling, lymphocyte receptor activation threshold (e.g., PTPN22)
Rheumatoid_arthritis
Topics referred to by the same term
of the mediator coactivator TNF-related activation protein, also known as CD40 ligand Tripartite ATP-independent periplasmic transporter, in prokaryotes
Trap
Retrieved May 11, 2026. Nassar, George (February 10, 2026). "Key Findings – CA CD40 Primary Survey". Public Opinion Strategies. Retrieved February 10, 2026 –
2026 United States House of Representatives elections in California (districts 27–52)
2026_United_States_House_of_Representatives_elections_in_California_(districts_27–52)
Mammalian protein found in Homo sapiens
surface receptor proteins, including the B cell antigen receptor (BCR), CD40, or CD19. The abbreviation Lyn is derived from Lck/Yes novel tyrosine kinase
LYN
Enlarged B cell in the germinal center of lymphoid follicles
centroblast development. Interaction between CD40 ligand on an activated helper T cell and the B cell CD40 receptor induces centroblasts to express activation-induced
Centroblast
Category of small signaling proteins
extracellular binding domain, and includes several other non-cytokine ligands like CD40, CD27 and CD30, besides the ligands on which the family is named. Seven transmembrane
Cytokine
Cell type
activated CD4+ T cells and monocytes are in close contact, interaction of CD40-CD40L between these two cells and subsequent IFNγ secretion by the T cells
Langhans_giant_cell
Protein-coding gene in the species Homo sapiens
different isoforms. AKNA is known to upregulate expression of the receptor CD40 and its ligand CD40L/CD154. AKNA is an essential part in the construction
AKNA
Disease typically found in young children
with Asian and non-Asian backgrounds. SNPs in FCGR2A, CASP3, BLK, ITPKC, CD40 and ORAI1 have all been linked to susceptibility, prognosis, and risk of
Kawasaki_disease
Monoclonal antibody
is a humanized monoclonal antibody being developed for the treatment of CD40-positive cancers like non-Hodgkin's lymphoma and hematological malignancies
Dacetuzumab
Activation or suppression of the immune system to treat disease
agonistic antibodies (e.g., anti-CD40) that are conjugated with antigen of interest. Multiple, next-generation anti-CD40 platforms are being actively developed
Immunotherapy
Type of immune cell involved in germinal center formation and maintenance
formation and maintenance of germinal centers through the expression of CD40 ligand (CD40L) and the secretion of IL-21 and IL-4. TFH cells also migrate
Follicular_B_helper_T_cells
Monoclonal antibody
a chimeric monoclonal antibody binding to the immune stimulatory protein CD40. As of 2009[update], it has not entered clinical trials. International Nonproprietary
Teneliximab
Signal to activate immune cells
TNF receptor super-family (TNFRSF) (such as 41-BB, OX40, CD27, GITR, HVEM, CD40, BAFFR, BAFF and others). Additionally, some co-stimulatory molecules belong
Co-stimulation
Biological system protecting an organism against disease
an upregulation of molecules expressed on the T cell's surface, such as CD40 ligand (also called CD154), which provide extra stimulatory signals typically
Immune_system
T cell that kills infected, damaged or cancerous cells
cells proceeds by signaling between CD154/CD40L on the T helper cell and the CD40 receptor on the antigen-presenting cell during immunological synapse formation
Cytotoxic_T_cell
and mediates signaling through the nuclear factor-κB pathway, mimicking CD40 receptor signaling. It is often found in the malignant Reed–Sternberg cells
Epstein–Barr virus latent membrane protein 1
Epstein–Barr_virus_latent_membrane_protein_1
Protein-coding gene in the species Homo sapiens
Zupo S, et al. (2006). "Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia
Interleukin-21_receptor
Monoclonal antibody
Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target CD40 ligand Clinical data ATC code none Identifiers CAS Number 252662-47-8 N ChemSpider
Toralizumab
Accessory cell of the mammalian immune system
co-receptors in T-cell activation such as CD80 (B7.1), CD86 (B7.2), and CD40 greatly enhancing their ability to activate T-cells. They also upregulate
Dendritic_cell
Family of viruses
(November 2009). "A genetically engineered adenovirus vector targeted to CD40 mediates transduction of canine dendritic cells and promotes antigen-specific
Adenoviridae
CD33 Causing serious injury by careless or inconsiderate driving 3 - 9 4 CD40 Causing death through careless driving when unfit through drink 3 - 11 11
List of UK driving licence endorsements
List_of_UK_driving_licence_endorsements
Genetically engineered T cell
including the use of nonconventional costimulatory molecules like MyD88/CD40, highlight the innovative approaches being taken to optimize CAR T-cell therapies
CAR_T_cell
Integral membrane protein
to continue the immune response can come from B7-CD28 and CD40–CD40L interactions. When CD40 on the APC binds CD40L(CD154) on the T cell, signals are sent
B7_(protein)
Form of immune disorder
between cells and molecules (such as T cell-B cell interaction (resulting in CD40-mediated signaling), intrinsic B-cell mechanisms (cytidine deaminase-induced
IgG_deficiency
CH34 — February 2, 2008 Kitt Peak Spacewatch · 1.7 km MPC JPL 489782 2008 CD40 — January 15, 2008 Mount Lemmon Mount Lemmon Survey · 1.2 km MPC JPL 489783
List of minor planets: 489001–490000
List_of_minor_planets:_489001–490000
Cell of the adaptive immune system
T-cell zone will bind to the MHCII ligand. The T cells will then express the CD40 ligand (CD40L) molecule and will begin to secrete cytokines which cause the
Memory_B_cell
Protein found in humans
TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)
IL2RA
CJ38 — December 14, 2006 Kitt Peak Spacewatch · 1.5 km MPC JPL 425774 2011 CD40 — January 26, 2011 Mount Lemmon Mount Lemmon Survey · 3.0 km MPC JPL 425775
List of minor planets: 425001–426000
List_of_minor_planets:_425001–426000
Mammalian protein found in humans
interleukin 2 (IL-2) as well as ɑ-chain of CD25 (which is a receptor of IL-2), CD40 ligand, tumor necrosis factor-α (TNFα), TNF-β, and interferon-γ (IFN-γ).
CD80
Protein-coding gene in the species Homo sapiens
TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)
IL2RB
Medical condition
gene is Xq26. This gene codes for the CD40 ligand, which is expressed on T cells. When the CD40 ligand binds CD40 on B cells, then the B cell switches
Hyper-IgM_syndrome_type_1
Regulators of the immune system
are members of the tumor necrosis factor (TNF) receptor superfamily—CD27, CD40, OX40, GITR and CD137. Another two stimulatory checkpoint molecules belong
Immune_checkpoint
Protein-coding gene in the species Homo sapiens
Zoog SJ, Dang TT, Kehry MR, Crute JJ (2001). "Molecular characterization of CD40 signaling intermediates". The Journal of Biological Chemistry. 276 (46):
Baculoviral IAP repeat-containing protein 2
Baculoviral_IAP_repeat-containing_protein_2
Protein that binds to a cytokine
domain, and includes several other non-cytokine ligands like receptors, CD40, CD27 and CD30, besides the ligands on which the family is named (TNF). Chemokine
Cytokine_receptor
Experimental drug
conference demonstrated that tegoprubart, a monoclonal antibody inhibiting the CD40 ligand, enabled 100% insulin independence in ten evaluable patients following
Tegoprubart
Biological mechanism
these activated B cells encounter specific signaling molecules via their CD40 and cytokine receptors (both modulated by T helper cells), they undergo antibody
Immunoglobulin class switching
Immunoglobulin_class_switching
Protein-coding gene in the species Homo sapiens
suppress NF-κB, MAP kinase and Akt signaling events stimulated by TLR and CD40 ligands. The computational analysis reported that TLR10 can interact with
Toll-like_receptor_10
Protein-coding gene in humans
Baculoviral IAP repeat-containing protein 3, CASP8AP2, CD134, CD137, CD27, CD40, CFLAR, CHUK, Caveolin 1, EDARADD, HIVEP3, IKK2, Low affinity nerve growth
TRAF2
Family of transcription factor protein complexes
Wilson CA, Lee SJ, Zhao X, Benveniste EN (November 2005). "LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages
NF-κB
Human disease
treatment for many combined primary immunodeficiencies including SCID, CD40 deficiency, CD40 ligand deficiency, and Wiskott-Aldrich syndrome, but has been extended
Hypogammaglobulinemia
Human gene
TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)
IL3RA
Enzyme found in humans
membranes mitochondrial intermembrane space endoplasmic reticulum mitochondrion CD40 receptor complex cytoplasmic side of plasma membrane chromatin cytoskeleton
Serine protease HTRA2, mitochondrial
Serine_protease_HTRA2,_mitochondrial
Excess number of eosinophil cells in the blood
Wiskott–Aldrich syndrome (defective WAS gene), IPEX syndrome (defective IPEX gene), CD40 gene defect, and autoimmune lymphoproliferative syndrome (defective Fas receptor
Eosinophilia
Mammalian protein found in Homo sapiens
TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)
Glycoprotein_130
Transmembrane protein on the surface of a B cell
lymphoid neoplasms. It has been shown that BCR signaling is synchronised with CD40 pathway activation provided by B-T cell interactions, and this seems to be
B-cell_receptor
Protein-coding gene in the species Homo sapiens
Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G (1996). "Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and
Interleukin-12_subunit_beta
Cytokine
phase), and repressing other key regulatory genes such as c-myc and ATM. CD40, a key surface molecule in the activation of the innate immune response,
Transforming growth factor beta
Transforming_growth_factor_beta
deaminase (ADA) deficiency reticular dysgenesis Omenn syndrome CD40 ligand deficiency CD40 deficiency CD3γ deficiency CD8 deficiency ICOS deficiency ZAP70
List of primary immunodeficiencies
List_of_primary_immunodeficiencies
American medical oncologist
and residency training in internal medicine. Her dissertation was titled CD40 signaling Hodgkin's disease. She came to the National Cancer Institute (NCI)
Christina_Annunziata
Protein found in humans
from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11 (TRANCE/RANKL) and IL-1 have been shown to be mediated by this protein
TRAF6
Indian cell biologist (born 1964)
he is involved in five projects viz. Leishmania-macrophage interaction, CD40 signaling, DC subset mediated priming against prostate cancer, Development
Bhaskar_Saha
Protein encoding gene in humans
TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)
CXCR2
Protein-coding gene in the species Homo sapiens
TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)
Decoy_receptor_2
Primary immune deficiency disorder
type 3 is a form of hyper IgM syndrome characterized by mutations of the CD40 gene. In this type, Immature B cells cannot receive signal 2 from helper
Hyper-IgM_syndrome_type_3
Protein-coding gene in the species Homo sapiens
responsible for phosphorylating serine 536 in monocytes and macrophages, or in CD40 receptor binding in hepatic stellate cells. IKK1 functions as the major kinase
RELA
Protein-coding gene in the species Homo sapiens
mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene
ZFP36L1
Skin cancer originating in melanocytes
antibodies (ipilimumab and tremelimumab), toll-like receptor (TLR) agonists, CD40 agonists, anti-PD-1 (pembrolizumab, pidilizumab, and nivolumab) and PD-L1
Melanoma
Protein
"Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells". The Journal of Experimental Medicine
ADAMDEC1
Immune response by adaptive immune system
Likewise, a second interaction between the CD40 ligand or CD154 (CD40L) present on T cell surface and CD40 present on B cell surface, is also necessary
Polyclonal_B_cell_response
Protein-coding gene in the species Homo sapiens
cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)". J. Immunol. 155 (2): 917–24. doi:10.4049/jimmunol
HLA-DMA
Family of regulator genes
anti-apoptotic pathways, this also includes tuning of BCR signaling and CD40 signaling in regulation of microRNAs (miR-29, miR-150, miR-17-92). c-Myc
Myc
Protein in humans
TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)
Interleukin-31_receptor
Autoimmune disease
Ohlsson M, Szodoray P, Loro LL, Johannessen AC, Jonsson R (December 2002). "CD40, CD154, Bax and Bcl-2 expression in Sjögren's syndrome salivary glands: a
Sjögren's_disease
with other signaling components such as the transmembrane TNF receptors and CD40. TRAF1 is abundant in lymphoid and myeloid cells to promote survival signaling
TNF receptor associated factor
TNF_receptor_associated_factor
Species of oncocytic human adenovirus
contains two transgenes expressing the heavy and light chains for a secreted CD40 agonist monoclonal antibody. NG-641: This vector contains four transgenes
Enadenotucirev
Type of cell
within 12 days. Additionally, a 1995 study demonstrated that obstructing the CD40-CD40L pathway using an anti-CD40L antibody could result in regulation in
Passenger_leukocyte
convention delegates Type Del. Type Del. Type Del. Type Del. CD1 5 CD14 5 CD27 5 CD40 4 CD2 5 CD15 5 CD28 4 CD41 4 CD3 5 CD16 5 CD29 6 CD42 4 CD4 5 CD17 5 CD30
2000 California Democratic presidential primary
2000_California_Democratic_presidential_primary
Vaccine against SARS-CoV-2
Retrieved 30 August 2024. "Safety and Immunogenicity of a Sub-unit Protein CD40.RBDv Bivalent COVID-19 Vaccine, Adjuvanted or Not, as a Booster in Volunteers"
COVID-19_vaccine
HGNC:1663; P16671 2500 CD37 HGNC:1666; P11049 2501 CD38 HGNC:1667; P28907 2502 CD40 HGNC:11919; P25942 2503 CD40LG HGNC:11935; P29965 2504 CD44 HGNC:1681; P16070
List of human protein-coding genes 2
List_of_human_protein-coding_genes_2
Protein-coding gene in the species Homo sapiens
(TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response
TRAF3
British biochemist
antibodies) published by the Taylor & Francis Group. The clinical trial of an anti-CD40 monoclonal antibody chiLOB7/4 developed in Glennie's laboratory was reported
Martin_Glennie
Mammalian protein found in humans
Sagurachi group that Treg cells were able to downregulate CD80 and CD86, but not CD40 or MHC class II on DC in a way that was adhesion dependent. Downregulation
CD86
Record label
Zetrospective: Dancing In The Face of Adversity 10 Tracks (File 320 kbit) CD40 Various Artists Zetrospective: Hope Springs Eternal 14 Tracks (File 320 kbit)
ZE_Records
Human cell-surface glycoprotein involved in immune regulation
B-lymphocyte activation and is regulated by signaling through the B-cell receptor, CD40 and Toll-like receptors. In B-cell-specific CD83 knockout mice, B-cell proliferation
CD83
Vertebrate receptor protein and transcription factor
8-Tetrachlorodibenzo-p-dioxin suppresses tumor necrosis factor-alpha and anti-CD40-induced activation of NF-kappaB/Rel in dendritic cells: p50 homodimer activation
Aryl_hydrocarbon_receptor
travel, tourism, insurance
CD40
CD40
CD40
CD40
CD40
CD40
CD40
CD40
CD40
travel, tourism, insurance