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Search references for CD40. Phrases containing CD40
See searches and references containing CD40!CD40
Mammalian protein found in humans
Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding
CD40
Protein found in humans
CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules
CD154
Type of white blood cell
immunohistochemical staining by their specific expression of proteins such as CD14, CD40, CD11b, CD64, F4/80 (mice)/EMR1 (human), lysozyme M, MAC-1/MAC-3 and CD68
Macrophage
Monoclonal antibody
Frexalimab (SAR441344) is a second-generation monoclonal antibody that inhibits CD40 ligand. It is in development by Sanofi for the treatment of relapsing multiple
Frexalimab
Type of protein
signaling pathway. Moreover, this protein is only used in cells expressing CD40 and CD40L, which are also from the tumor necrosis receptor superfamily and
Act_1_adaptor_protein
Primary immune deficiency disorders
recombination (Ig-CSR) deficiencies. The most common causes are mutations in the CD40 Ligand (CD40LG) gene located at Xq26.3-27 leading to X-linked HIGM (XHIGM)
Hyper_IgM_syndrome
Type of immune cell
aid those cells through a combination of cell to cell interactions (e.g. CD40 (protein) and CD40L) and through cytokines.[citation needed] Th cells are
T_helper_cell
Monoclonal antibody
is a humanized monoclonal antibody being developed for the treatment of CD40-positive cancers like non-Hodgkin's lymphoma and hematological malignancies
Dacetuzumab
Type of white blood cell
co-stimulatory factor for B cell activation by binding the B cell surface receptor CD40, which promotes B cell proliferation, immunoglobulin class switching, and
B_cell
Cell that displays antigen bound by MHC proteins on its surface
several co-stimulatory molecules required for T cell activation, including CD40 and B7. The latter can interact with CD28 on the surface of a CD4+ T cell
Antigen-presenting_cell
Monoclonal antibody
a chimeric monoclonal antibody binding to the immune stimulatory protein CD40. As of 2009[update], it has not entered clinical trials. International Nonproprietary
Teneliximab
Excess amounts of gamma globulin in the blood
which codes for CD40 ligand. This gene is located on the long arm of the X chromosome at position 26, denoted Xq26. Normally, CD40 ligand is expressed
Hypergammaglobulinemia
Lymphatic tissue structure
interaction between B and T cells in the interfollicular area of the lymph node, CD40-CD40L ligation, NF-kB signaling and expression of IRF4 and BCL6. GC B cells
Germinal_center
Monoclonal antibody
Lucatumumab (CHIR 12.12 or HCD122) is a human monoclonal antibody against CD40 development of which was discontinued by Novartis in 2013 after it was investigated
Lucatumumab
T cell that kills infected, damaged or cancerous cells
cells proceeds by signaling between CD154/CD40L on the T helper cell and the CD40 receptor on the antigen-presenting cell during immunological synapse formation
Cytotoxic_T_cell
American pharmacologist (born 1957)
Presbyterian Hospital). As assistant professor at Columbia, Lederman discovered the CD40-Ligand (CD154) and elucidated the molecular basis of T cell helper function
Seth_Lederman
Cells found in human testes which help produce sperm
T-cells on the periphery. CD40, a molecule associated with dendritic cells (DCs). SCs are able to down regulate the expression of CD40 on the surface of DCs
Sertoli_cell
Type of immune cell involved in germinal center formation and maintenance
formation and maintenance of germinal centers through the expression of CD40 ligand (CD40L) and the secretion of IL-21 and IL-4. TFH cells also migrate
Follicular_B_helper_T_cells
Accessory cell of the mammalian immune system
co-receptors in T-cell activation such as CD80 (B7.1), CD86 (B7.2), and CD40 greatly enhancing their ability to activate T-cells. They also upregulate
Dendritic_cell
Cell type
activated CD4+ T cells and monocytes are in close contact, interaction of CD40-CD40L between these two cells and subsequent IFNγ secretion by the T cells
Langhans_giant_cell
Cell of the adaptive immune system
T-cell zone will bind to the MHCII ligand. The T cells will then express the CD40 ligand (CD40L) molecule and will begin to secrete cytokines which cause the
Memory_B_cell
Inflammatory arthritis triggered by infection elsewhere in the body
Lanier, L.L. (February 1995). "T-cell costimulation via CD28-CD80/CD86 and CD40-CD40 ligand interactions". Research in Immunology. 146 (3): 171–176. doi:10
Reactive_arthritis
Activation or suppression of the immune system to treat disease
agonistic antibodies (e.g., anti-CD40) that are conjugated with antigen of interest. Multiple, next-generation anti-CD40 platforms are being actively developed
Immunotherapy
Integral membrane protein
to continue the immune response can come from B7-CD28 and CD40–CD40L interactions. When CD40 on the APC binds CD40L(CD154) on the T cell, signals are sent
B7_(protein)
Experimental drug
conference demonstrated that tegoprubart, a monoclonal antibody inhibiting the CD40 ligand, enabled 100% insulin independence in ten evaluable patients following
Tegoprubart
Protein-coding gene in the species Homo sapiens
(TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response
TRAF3
Type of autoimmune arthritis
include genes affecting co-stimulatory immune pathways—for example CD28 and CD40, cytokine signaling, lymphocyte receptor activation threshold (e.g., PTPN22)
Rheumatoid_arthritis
Biological mechanism
these activated B cells encounter specific signaling molecules via their CD40 and cytokine receptors (both modulated by T helper cells), they undergo antibody
Immunoglobulin class switching
Immunoglobulin_class_switching
Frequently fatal immune reaction
showed over-stimulation of the immune system, including ADA, BTC, CA12, CAPG, CD40, CDCP1, CXCL9, ENTPD2, Flt3L, IL-6, IL-8, LRP1, OSM, PD-L1, PTN, STX8, and
Cytokine_storm
Mammalian protein found in humans
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
CD37
Protein-coding gene in the species Homo sapiens
and CD40. This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor
TTRAP
Category of small signaling proteins
extracellular binding domain, and includes several other non-cytokine ligands like CD40, CD27 and CD30, besides the ligands on which the family is named. Seven transmembrane
Cytokine
Enlarged B cell in the germinal center of lymphoid follicles
centroblast development. Interaction between CD40 ligand on an activated helper T cell and the B cell CD40 receptor induces centroblasts to express activation-induced
Centroblast
Topics referred to by the same term
receptor-associated proteins TNF-related activation protein, also known as CD40 ligand Tripartite ATP-independent periplasmic transporter, in prokaryotes
Trap
Regulators of the immune system
are members of the tumor necrosis factor (TNF) receptor superfamily—CD27, CD40, OX40, GITR and CD137. Another two stimulatory checkpoint molecules belong
Immune_checkpoint
Indian cell biologist (born 1964)
he is involved in five projects viz. Leishmania-macrophage interaction, CD40 signaling, DC subset mediated priming against prostate cancer, Development
Bhaskar_Saha
Bivatuzumab mab humanized CD44 v6 squamous cell carcinoma Bleselumab mab human CD40 organ transplant rejection Blinatumomab Blincyto BiTE mouse CD19 Y pre-B
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Cell signaling pathway
aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival". Blood. 102 (3):
MAPK/ERK_pathway
Genetically engineered T cell
including the use of nonconventional costimulatory molecules like MyD88/CD40, highlight the innovative approaches being taken to optimize CAR T-cell therapies
CAR_T_cell
Biological system protecting an organism against disease
an upregulation of molecules expressed on the T cell's surface, such as CD40 ligand (also called CD154), which provide extra stimulatory signals typically
Immune_system
Organ system in vertebrates complementary to the circulatory system
Olsson Bontell, T; Smits, A; Essand, M; Dimberg, A (5 July 2021). "Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint
Lymphatic_system
Pharmaceutical drug
antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice". Transplantation
Odulimomab
Disease found in young children
with Asian and non-Asian backgrounds. SNPs in FCGR2A, CASP3, BLK, ITPKC, CD40 and ORAI1 have all been linked to susceptibility, prognosis, and risk of
Kawasaki_disease
Human disease
treatment for many combined primary immunodeficiencies including SCID, CD40 deficiency, CD40 ligand deficiency, and Wiskott-Aldrich syndrome, but has been extended
Hypogammaglobulinemia
Mammalian protein found in humans
interleukin 2 (IL-2) as well as ɑ-chain of CD25 (which is a receptor of IL-2), CD40 ligand, tumor necrosis factor-α (TNFα), TNF-β, and interferon-γ (IFN-γ).
CD80
U.S. House district for California
Election Returns: District Definitions California Voter Foundation map – CD40 33°53′41″N 117°55′23″W / 33.894642°N 117.922955°W / 33.894642; -117.922955
California's 40th congressional district
California's_40th_congressional_district
Family of transcription factor protein complexes
Wilson CA, Lee SJ, Zhao X, Benveniste EN (November 2005). "LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages
NF-κB
Family of microRNA precursors found in mammals, including humans
linked with pancreatic ductal carcinoma, where it is thought to repress CD40 expression in cancer cells. Ambros V (December 2001). "microRNAs: tiny regulators
MiR-224
Family of viruses
(November 2009). "A genetically engineered adenovirus vector targeted to CD40 mediates transduction of canine dendritic cells and promotes antigen-specific
Adenoviridae
Signal to activate immune cells
TNF receptor super-family (TNFRSF) (such as 41-BB, OX40, CD27, GITR, HVEM, CD40, BAFFR, BAFF and others). Additionally, some co-stimulatory molecules belong
Co-stimulation
2010 Mount Lemmon Mount Lemmon Survey EOS 1.5 km MPC · JPL 761582 2010 CD40 — February 13, 2010 Mount Lemmon Mount Lemmon Survey · 2.2 km MPC · JPL
List of minor planets: 761001–762000
List_of_minor_planets:_761001–762000
Type of blood cancer
overexpressed. The following signalling pathways have been implicated: CD154/CD40 Akt ubiquitination, p53 activation, and cytochrome c release NF-κB Wnt/beta-catenin
Waldenström_macroglobulinemia
Melanin-producing cells of the skin
Importantly, melanocytes stimulated by cytokines express surface proteins such as CD40 and ICAM1 in addition to MHC class II, allowing for co-stimulation of T cells
Melanocyte
February 2, 2017 Haleakala Pan-STARRS 1 · 1.5 km MPC · JPL 755359 2017 CD40 — February 1, 2017 Mount Lemmon Mount Lemmon Survey · 1.6 km MPC · JPL 755360
List of minor planets: 755001–756000
List_of_minor_planets:_755001–756000
Primary immune deficiency disorder
type 3 is a form of hyper IgM syndrome characterized by mutations of the CD40 gene. In this type, Immature B cells cannot receive signal 2 from helper
Hyper-IgM_syndrome_type_3
Monoclonal antibody
Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target CD40 ligand Clinical data ATC code none Identifiers CAS Number 252662-47-8 N ChemSpider
Toralizumab
Human blood group classification
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
Kell_antigen_system
Mammalian protein found in Homo sapiens
TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)
IL2RA
2000 CX39 — January 11, 2000 Socorro LINEAR · 1.4 km MPC · JPL 483421 2000 CD40 — February 3, 2000 Socorro LINEAR · 2.1 km MPC · JPL 483422 2000 CE59 —
List of minor planets: 483001–484000
List_of_minor_planets:_483001–484000
Mammalian protein found in Homo sapiens
surface receptor proteins, including the B cell antigen receptor (BCR), CD40, or CD19. The abbreviation Lyn is derived from Lck/Yes novel tyrosine kinase
LYN
Family of regulator genes
anti-apoptotic pathways, this also includes tuning of BCR signaling and CD40 signaling in regulation of microRNAs (miR-29, miR-150, miR-17-92). c-Myc
Myc
Protein-coding gene in the species Homo sapiens
can also interact with other proteins (CLEC7A, CD137, CD40). For example, an interaction with CD40 on T-cells inhibits their proliferation and induces cell
Galectin-9
Protein family
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
Mannose_receptor
Autoimmune disease
Ohlsson M, Szodoray P, Loro LL, Johannessen AC, Jonsson R (December 2002). "CD40, CD154, Bax and Bcl-2 expression in Sjögren's syndrome salivary glands: a
Sjögren's_disease
Protein-coding gene in the species Homo sapiens
different isoforms. AKNA is known to upregulate expression of the receptor CD40 and its ligand CD40L/CD154. AKNA is an essential part in the construction
AKNA
Mammalian protein found in humans
physically coupled to major histocompatibility complex class II (MHCII), CD40 and B-cell receptor (BCR). The biological function of CD20 as well as its
CD20
— October 20, 2003 Kitt Peak Spacewatch · 3.1 km MPC · JPL 580594 2015 CD40 — November 3, 2004 Kitt Peak Spacewatch GEF 1.5 km MPC · JPL 580595 2015
List of minor planets: 580001–581000
List_of_minor_planets:_580001–581000
Protein family
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
CD79
Protein in humans
TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)
Interleukin-31_receptor
Human protein-coding gene
receptors, including tumor necrosis factor 1 (TNFR1) and TNFR2, Fas, RANK, and CD40. All members of the TNFR superfamily contain structurally related cysteine-rich
Low-affinity nerve growth factor receptor
Low-affinity_nerve_growth_factor_receptor
Mammalian protein found in humans
Sagurachi group that Treg cells were able to downregulate CD80 and CD86, but not CD40 or MHC class II on DC in a way that was adhesion dependent. Downregulation
CD86
Medical condition
syndrome: X-linked disorder that causes a deficiency in the production of CD40 ligand on activated T cells. This increases the production and release of
Immune_disorder
Primary immune deficiency disorder
group of primary immune deficiency disorders characterized by defective CD40 signaling; via B cells affecting class switch recombination (CSR) and somatic
Hyper-IgM_syndrome_type_2
Protein-coding gene found in humans
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
CD52
Protein-coding gene in the species Homo sapiens
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
T-cell surface glycoprotein CD3 zeta chain
T-cell_surface_glycoprotein_CD3_zeta_chain
Protein-coding gene in the species Homo sapiens
TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)
IL2RB
Skin cancer originating in melanocytes
antibodies (ipilimumab and tremelimumab), toll-like receptor (TLR) agonists, CD40 agonists, anti-PD-1 (pembrolizumab, pidilizumab, and nivolumab) and PD-L1
Melanoma
Protein-coding gene in the species Homo sapiens
Zoog SJ, Dang TT, Kehry MR, Crute JJ (2001). "Molecular characterization of CD40 signaling intermediates". The Journal of Biological Chemistry. 276 (46):
Baculoviral IAP repeat-containing protein 2
Baculoviral_IAP_repeat-containing_protein_2
Mammalian protein found in Homo sapiens
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
Integrin_alpha_2b
Type of immune cell important for T-cell-dependent antibody responses to proteins
than B1 B and MZ B cell compartments. More importantly, FO B cells require CD40-CD40L dependent TFH cell help to promote effective primary immune responses
Follicular_B_cell
Lack of or compromised immune system
The key genes associated with immunodeficiency diseases include CD40L, CD40, RAG1, RAG2, IL2RG, and ADA. Here is a summary of some methods utilized to
Immunodeficiency
Transmembrane protein on the surface of a B cell
lymphoid neoplasms. It has been shown that BCR signaling is synchronised with CD40 pathway activation provided by B-T cell interactions, and this seems to be
B-cell_receptor
Species of oncocytic human adenovirus
contains two transgenes expressing the heavy and light chains for a secreted CD40 agonist monoclonal antibody. NG-641: This vector contains four transgenes
Enadenotucirev
Type of immunotherapy
antigen-specific immune responses. Professional APCs express MHC class II and CD40 molecules as surface receptors, and can be activated through direct interactions
APC_Activator
Protein involved in multiple prion diseases
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
Major_prion_protein
Vaccine against SARS-CoV-2
Retrieved 30 August 2024. "Safety and Immunogenicity of a Sub-unit Protein CD40.RBDv Bivalent COVID-19 Vaccine, Adjuvanted or Not, as a Booster in Volunteers"
COVID-19_vaccine
Protein-coding gene in humans
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
CD1A
Protein-coding gene in humans
Baculoviral IAP repeat-containing protein 3, CASP8AP2, CD134, CD137, CD27, CD40, CFLAR, CHUK, Caveolin 1, EDARADD, HIVEP3, IKK2, Low affinity nerve growth
TRAF2
Type of immune cell
blood Bregs were mostly CD24 and CD27 positive after cultivation with anti-CD40 antibody and CpG bacterial DNA. They were also positive for CD25, CD71 and
Regulatory_B_cell
Membrane receptor protein found in humans
of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b". Journal of Immunology. 168 (7): 3318–3322. doi:10.4049/jimmunol
Tumor necrosis factor receptor 2
Tumor_necrosis_factor_receptor_2
Protein-coding gene in the species Homo sapiens
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
ALCAM
Mammalian protein found in Homo sapiens
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
Integrin_beta_3
Cytokine
phase), and repressing other key regulatory genes such as c-myc and ATM. CD40, a key surface molecule in the activation of the innate immune response,
Transforming growth factor beta
Transforming_growth_factor_beta
CD33 Causing serious injury by careless or inconsiderate driving 3 - 9 4 CD40 Causing death through careless driving when unfit through drink 3 - 11 11
List of UK driving licence endorsements
List_of_UK_driving_licence_endorsements
with other signaling components such as the transmembrane TNF receptors and CD40. TRAF1 is abundant in lymphoid and myeloid cells to promote survival signaling
TNF receptor associated factor
TNF_receptor_associated_factor
Protein-coding gene in the species Homo sapiens
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
Decoy_receptor_2
Protein-coding gene in the species Homo sapiens
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
Signal-regulatory protein alpha
Signal-regulatory_protein_alpha
Protein found in humans
CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100
CD163
Dutch physician, molecular biologist and professor
particular, the signalling axis between the protein CD40 and its ligand, CD40L. Lutgens identified that the CD40 ligand was expressed in atherosclerotic plaque
Esther_Lutgens
Protein-coding gene in the species Homo sapiens
J, Izawa K, Kambe N, Yasumi T, Nakahata T, Heike T (January 2012). "The CD40-CD40L axis and IFN-γ play critical roles in Langhans giant cell formation"
Dendrocyte expressed seven transmembrane protein
Dendrocyte_expressed_seven_transmembrane_protein
CD40
CD40
CD40
CD40
Boy/Male
American, Anglo, Australian, British, English
Valley Ford; From the Hall by the Ford
Boy/Male
Australian, Gaelic, Irish, Japanese
Red Haired; Red-head
Male
Egyptian
, a mystical title of the deity Amen Ra.
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi
Fog
Boy/Male
Irish American
Fair hero.
Boy/Male
Indian, Punjabi, Sikh
Bright Love
Boy/Male
Hindu
Goon ka adhikari
Boy/Male
Hindu, Indian
No Limit
Girl/Female
Hawaiian
Wildflower.
Girl/Female
Indian
Goddess Durga
CD40
CD40
CD40
CD40
CD40