Searches , social queries for MELANOCYTE
Search references for MELANOCYTE. Phrases containing MELANOCYTE
See searches and references containing MELANOCYTE!
Search references for MELANOCYTE. Phrases containing MELANOCYTE
See searches and references containing MELANOCYTE!MELANOCYTE
Melanin-producing cells of the skin
Melanocytes are melanin-producing neural crest-derived cells located in the bottom layer (the stratum basale) of the skin's epidermis, the middle layer
Melanocyte
Family of peptide hormones and neuropeptides
neuropeptides consisting of α-melanocyte-stimulating hormone (α-MSH), β-melanocyte-stimulating hormone (β-MSH), and γ-melanocyte-stimulating hormone (γ-MSH)
Melanocyte-stimulating hormone
Melanocyte-stimulating_hormone
Skin condition where patches lose pigment
The development of vitiligo is linked to aberrant attachments between melanocytes (which produce melanin) and laminins, an extracellular protein. The disorder
Vitiligo
Peptide hormone in mammals
α-Melanocyte-stimulating hormone (α-MSH) is an endogenous peptide hormone and neuropeptide of the melanocortin family, with a tridecapeptide structure
Α-Melanocyte-stimulating hormone
Α-Melanocyte-stimulating_hormone
Genetic pigmentation disorder of the skin and hair
melanin-forming cells (melanocytes) in certain areas of the skin and hair. It is a rare autosomal dominant disorder of melanocyte development. Common characteristics
Piebaldism
Natural process of hair turning grey or white with age
of hair follicles produce melanocytes, the cells that produce and store pigment in hair and skin. The death of the melanocyte stem cells causes the onset
Greying_of_hair
Chemical compound
β-Melanocyte-stimulating hormone (β-MSH) is an endogenous peptide hormone and neuropeptide. It is a melanocortin, specifically, one of the three types
Β-Melanocyte-stimulating hormone
Β-Melanocyte-stimulating_hormone
Chemical compound
Melanocyte-inhibiting factor (also known as Pro-Leu-Gly-NH2, melanostatin, MSH release–inhibiting hormone, or MIF-1) is an endogenous peptide fragment
Melanocyte-inhibiting_factor
Hair greying happening at a premature age
release in hair follicles. This overproduction causes depletion of the melanocyte stem cells which are required to produce melanin, the pigment responsible
Premature_greying_of_hair
Small pigment spots on skin
harmless (benign) hyperplasia of melanocytes which is linear in its spread. This means the hyperplasia of melanocytes is restricted to the cell layer directly
Lentigo
Melanin spots on skin
an increased number of the melanin-producing cells, or melanocytes, but instead have melanocytes that overproduce melanin granules (melanosomes) changing
Freckle
Dark vertical line that appears on the abdomen during pregnancy
emergence of linea nigra is attributed to an increased production of melanocyte-stimulating hormone by the placenta. This physiological phenomenon is
Linea_nigra
Chemical compound
γ-Melanocyte-stimulating hormone (γ-MSH) is an endogenous peptide hormone and neuropeptide. It is a melanocortin, specifically, one of the three types
Γ-Melanocyte-stimulating hormone
Γ-Melanocyte-stimulating_hormone
Protein controlling mammalian coloration
The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin
Melanocortin_1_receptor
Type of skin cancer
Melanoma is a group of serious skin cancers that arise from pigment cells (melanocytes); acral lentiginous melanoma is a kind of lentiginous skin melanoma.
Acral_lentiginous_melanoma
Benign skin tumor of pigment-producing cells
pigmented growth on the skin, formed mostly of a type of cell known as a melanocyte. The high concentration of the body's pigmenting agent, melanin, is responsible
Melanocytic_nevus
Practice of using chemical substances to lighten the skin
of which CREB is a transcription factor. Alpha-melanocyte stimulating hormone (α-MSH), beta-melanocyte stimulating hormone (β-MSH), and adrenocorticotropic
Skin_whitening
Drug that never made it to the market
Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis to facilitate tanning
Melanotan_II
Abnormal patches of white hair
poliosis is marked by the lack of melanin or melanocytes in the hair bulbs, though epidermal melanocytes typically remain unaffected unless associated
Poliosis
Cat having fur of two colors
is co-dominant to normal coat color as it prevents the migration of melanocytes into the developing hair follicles. The genetics of this pattern are
Bicolor_cat
Boundary between the anterior and posterior lobes of the pituitary
fetus, this area produces melanocyte stimulating hormone (MSH) which causes the release of melanin produced in melanocytes that can give a darker skin
Pars_intermedia
Endocrine gland of the brain
secreting prolactin). The intermediate lobe synthesizes and secretes melanocyte-stimulating hormone. The posterior pituitary (or neurohypophysis) is a
Pituitary_gland
Darkening of an area of skin or nails due to increased melanin
persistent in individuals with darker skin tones, who have more active melanocytes and are thus more prone to uneven pigmentation. Hyperpigmentation can
Hyperpigmentation
Type of melanocytic tumor
nevus (also known as an "acquired dermal melanocytosis", and "dermal melanocyte hamartoma") is a cutaneous condition characterized by a diffusely gray-blue
Blue_nevus
Pigmentation abnormality
cells called melanocytes, but may also be engulfed by other cells, which are then called melanophages. Hair acquires pigment from melanocytes in the root
Amelanism
Precursor cell of a melanocyte
A melanoblast is a precursor cell of a melanocyte. These cells migrate from the trunk neural crest cells (in terms of axial level from neck to posterior
Melanoblast
Organelle found in animal cells used for the synthesis, storage and transport of melanin
Melanosomes are synthesised in the skin in melanocyte cells, as well as the eye in choroidal melanocytes and retinal pigment epithelial (RPE) cells.
Melanosome
Basophilic cell in anterior pituitary that produces pro-opiomelanocortin
undergoes cleavage to adrenocorticotropin (ACTH), β-lipotropin (β-LPH), and melanocyte-stimulating hormone (MSH). These cells are stimulated by corticotropin
Corticotropic_cell
Type of birthmark caused by a collection of melanocytes
light-brown color. They are caused by a collection of pigment-producing melanocytes in the epidermis of the skin. These spots are typically permanent and
Café_au_lait_spot
Copper metalloprotein
oxidation. It is found inside melanosomes which are synthesized in the skin melanocytes. In humans, the tyrosinase enzyme is encoded by the TYR gene. Tyrosinase
Tyrosinase
Medical condition
nails from Terry's nails. The discoloration is thought to be due to β-melanocyte–stimulating hormone. Seventy percent of hemodialysis patients and 56%
Half_and_half_nail
Intermediate color between black and white
specialized cell, the melanocyte, which is found in each hair follicle, from which the hair grows. As hair grows, the melanocyte injects melanin into the
Grey
Tumors of melanin-producing skin cells
Melanocytic tumors are tumors developed from melanocytes. Melanocytic nevus Melanocytic tumors of uncertain malignant potential Melanoma DE, Elder; D
Melanocytic_tumor
Connective tissue composed of reticular collagen fibers
Cells Resident Fibroblast Fibrocyte Reticular cell Tendon cell Adipocyte Melanocyte Wandering cells Mast cell Macrophage Extracellular matrix Ground substance
Reticular_connective_tissue
Medical condition
Lentigo maligna is where melanocyte cells have become malignant and grow continuously along the stratum basale of the skin, but have not invaded below
Lentigo_maligna
Protein-coding gene in humans
P protein, also known as melanocyte-specific transporter protein or pink-eyed dilution protein homolog, is a protein that in humans is encoded by the oculocutaneous
P_protein
Human hair color
anterior pituitary gland. Melanocyte-stimulating hormones normally stimulates melanocytes to make black eumelanin, but if the melanocytes have a mutated receptor
Red_hair
Difference in coloration, usually of the iris but also of hair or skin
heterochromia. Piebaldism – similar to Waardenburg's syndrome, a rare disorder of melanocyte development characterized by a white forelock and multiple symmetrical
Heterochromia
Benign skin irregularity which appears near the time of birth
anywhere on the skin. They are caused by overgrowth of blood vessels, melanocytes, smooth muscle, fat, fibroblasts, or keratinocytes. Dermatologists divide
Birthmark
Chemical compound
Rhododendrol exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism. It has been shown to impair the normal proliferation of melanocytes through reactive
Rhododendrol
Mammalian protein found in humans
forms of obesity in humans. MC4R is a receptor that is activated by α-melanocyte-stimulating hormone (α-MSH), influencing energy homeostasis and feeding
Melanocortin_4_receptor
Condition characterized by absence of pigment
A mutation in the human TRP-1 gene may result in the deregulation of melanocyte tyrosinase enzymes, a change that is hypothesized to promote brown versus
Albinism_in_humans
G protein-coupled receptor
and activated by synthetic (i.e. afamelanotide) and endogenous agonist melanocyte-stimulating hormones. Several selective ligands for the melanocortin receptors
Melanocortin_receptor
Chemical compound
ABT-719, and ZP-1480) is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development by, at different
Modimelanotide
Type of pigment-producing skin cell
Nevus cells are a variant of melanocytes. They are larger than typical melanocytes, do not have dendrites, and have more abundant cytoplasm with coarse
Nevus_cell
Group of natural pigments found in most organisms
Melanin pigments are produced in a specialized group of cells known as melanocytes. There are five basic types of melanin: eumelanin, pheomelanin, neuromelanin
Melanin
Medical condition
surface, where they are expelled from the tissue surface. In this way the melanocytes and keratinocytes together protect the tissue, with melanin serving as
Smoker's_melanosis
Rose-like markings on fur and skin
differentiation of melanocytes, which are responsible for producing pigment in the skin and fur. The type of pigment produced by the melanocyte is mainly determined
Rosette_(zoology)
Pharmaceutical compound
Brzoska T, Luger TA, Maaser C, Abels C, Böhm M (August 2008). "Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory
KPV_tripeptide
Area of skin becoming lighter than the baseline skin color
pigment. It is caused by melanocyte or melanin depletion, or a decrease in the amino acid tyrosine, which is used by melanocytes to make melanin. Some common
Hypopigmentation
Medical intervention
Immunohistochemistry with SOX10 (staining the cell nuclei of melanocytes) of lentigo maligna, showing malignant melanocytes all the way to the resection margin (inked in
Radical_surgery
Partial loss of pigmentation in an animal
Albinism results in the reduction of melanin production only, though the melanocyte (or melanophore) is still present. Thus in species that have other pigment
Leucism
Chemical compound
in feces. Bremelanotide is a cyclic heptapeptide lactam analogue of α-melanocyte-stimulating hormone (α-MSH). It has the amino acid sequence
Bremelanotide
Horse coat color
phenotypes, and are all caused by areas of skin that lack pigment cells (melanocytes). Depigmentation phenotypes have various genetic causes, and those that
White_horse
Chemical compound
application of monobenzone in animals increases the excretion of melanin from melanocytes. The same action is thought to be responsible for the depigmenting effect
Monobenzone
Excess urea in the blood due to kidney dysfunction
and luteinizing hormone, decreased testosterone) Decreased sodium-potassium ATPase activity Increased serum gastrin and melanocyte-stimulating hormone
Uremia
Medical condition
a loss or reduction, which may be related to loss of melanocytes or the inability of melanocytes to produce melanin or transport melanosomes correctly
Pigmentation_disorder
Chemical compound
receptor (MC1 receptor) agonist and a synthetic peptide and analogue of α-melanocyte stimulating hormone. It is administered as subcutaneous implant. In the
Afamelanotide
Multi-colored fur in cats
are expressed in melanocytes that migrate to the skin surface later in development. In bicolored tortoiseshell cats, the melanocytes arrive relatively
Tortoiseshell_cat
Pituitary hormone
first 13 of which (counting from the N-terminus) may be cleaved to form α-melanocyte-stimulating hormones (α-MSH) (this common structure is responsible for
Adrenocorticotropic_hormone
Protein-coding gene in mammals
Agouti interacts with the melanocortin 1 receptor to determine whether the melanocyte (pigment cell) produces phaeomelanin (a red to yellow pigment), or eumelanin
Agouti-signaling_protein
Ultraviolet light therapy treatment
work by increasing the sensitivity of melanocytes, the cells that manufacture skin color, to UVA light. Melanocytes have sensors that detect UV light and
PUVA_therapy
melanin present. Melanin is produced within the skin in cells called melanocytes; it is the main determinant of the skin color of darker-skin humans.
Human_skin_color
Mole or birthmark; visible, circumscribed, chronic skin lesion
applied to a number of conditions caused by neoplasias and hyperplasias of melanocytes, as well as a number of pigmentation disorders, both hypermelanotic (containing
Nevus
Chemical compound
there is a report of Semax competitively antagonizing the action of α-melanocyte-stimulating hormone (α-MSH) at the MC4 and MC5 receptors in both in vitro
Semax
Hormone whose molecules are peptides
chorionic gonadotropin (hCG) Insulin Leptin Luteinizing hormone (LH) Melanocyte-stimulating hormone (MSH) Orexin/Hypocretin Oxytocin Parathyroid hormone
Peptide_hormone
Mammalian protein found in Homo sapiens
populations of neurons in the dorsomedial hypothalamus and brainstem Melanocytes in the skin. POMC is cut (cleaved) to give rise to multiple peptide hormones
Proopiomelanocortin
Protein-coding gene in humans
Melanocyte protein PMEL also known as premelanosome protein (PMEL), silver locus protein homolog (SILV) or Glycoprotein 100 (gp100), is a protein that
PMEL_(gene)
Type of eye cancer
pigment cells that reside within the uvea and give color to the eye. These melanocytes are distinct from the retinal pigment epithelium cells underlying the
Uveal_melanoma
Deepest layer of the five layers of the epidermis
superficially. Other types of cells found within the stratum basale are melanocytes (pigment-producing cells) and Merkel cells (touch receptors). Basal-cell
Stratum_basale
Horse coat color
receptor is part of a signalling pathway which when activated causes melanocytes to produce eumelanin, or black pigment, instead of pheomelanin, or red
Chestnut_(horse_color)
Monoclonal antibody for melanomas
antibody also reacts positively against junctional nevus cells and fetal melanocytes. Despite this relatively high sensitivity—HMB-45 does have its drawbacks
HMB-45
Medical condition
nevus. Histologically it is characterized by swollen, pale, polyhedral melanocytes, with pale cytoplasm and a central nucleus. It is different to balloon
Balloon_cell_nevus
Protein-coding gene in humans
pmel17 precursor, a melanocyte-specific protein. GPNMB has been reported to be expressed in various cell types, including: melanocytes, osteoclasts, osteoblasts
GPNMB
Colour between violet and cyan on the visible spectrum of light
(1998). "Characterization of melanins in human irides and cultured uveal melanocytes from eyes of different colors". Exp. Eye Res. 67 (3): 293–99. doi:10
Blue
Mammalian protein found in humans
lineage-specific pathway regulation of many types of cells including melanocytes, osteoclasts, and mast cells. The term "lineage-specific", since it relates
Microphthalmia-associated transcription factor
Microphthalmia-associated_transcription_factor
Enzyme
maintenance of melanosome structure and affects melanocyte proliferation and melanocyte cell death. Melanocytes are derived from the neural crest and migrate
TYRP1
Animal with white markings on a darker coat
appearance of symmetry can be obliterated if the proliferation of the melanocytes (pigment cells) within the developing spots is so great that the sizes
Piebald
Dark coloration of the eye
risk factor for uveal melanoma. The disease is caused by an increase of melanocytes in the iris, choroid, and surrounding structures. Overproduction of pigment
Ocular_melanosis
Biochemical process
Photoprotection is the biochemical process that helps organisms cope with molecular damage caused by sunlight. Plants and other oxygenic phototrophs have
Photoprotection
Alleged condition of hair suddenly turning white
I. et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature (2020). [1] How Stress Turns Hair White: Harvard Study
Canities_subita
Form of albinism
mutations in several genes that control the synthesis of melanin within the melanocytes. Seven types of oculocutaneous albinism have been described, all caused
Oculocutaneous_albinism
Black or brown pigmentation of nails
melanocyte proliferation are the two primary processes of melanonychia. Increased melanin production from a typical number of activated melanocytes in
Melanonychia
Skin cancer originating in melanocytes
typically skin cancer; it develops from the melanin-producing cells known as melanocytes. It typically occurs in the skin, but may rarely occur in the mouth,
Melanoma
Polygenic phenotypic characteristic
(1998). "Characterization of melanins in human irides and cultured uveal melanocytes from eyes of different colors". Exp. Eye Res. 67 (3): 293–9. doi:10.1006/exer
Eye_color
Medical condition
cause of melasma is unknown. Melasma is thought to be the stimulation of melanocytes (cells in the dermal layer, which transfer the pigment melanin to the
Melasma
Protein-coding gene in the species Homo sapiens
humans is encoded by the OSTM1 gene. It is required for osteoclast and melanocyte maturation and function. This gene encodes a protein that may be involved
OSTM1
Obesity caused by a mutation in a single gene
This activates POMC processing by proprotein convertase 1(PC1) into Α-Melanocyte-stimulating hormone (α-MSH). α-MSH is then released and acts on melanocortin
Monogenic_obesity
Mass of cells which cannot spread throughout the body
reasons. Malignant examples include melanoma (a skin cancer of pigmented melanocytes) and seminoma (a cancer of male reproductive cells). Not all benign growths
Benign_tumor
Pigmentation of human hair follicles
reddish-brown/reddish-yellow pheomelanin, synthesized by melanocytes. Inside the melanocytes, tyrosine is converted into L-DOPA and then L-dopaquinone
Human_hair_color
Skin color
pigments known as melanin is mainly responsible for variation in tone. Melanocytes insert granules of melanin called melanosomes into the other skin cells
Complexion
Primary type of cell found in the epidermis
containing the endogenous photoprotectant melanin, from epidermal melanocytes. Each melanocyte in the epidermis has several dendrites that stretch out to connect
Keratinocyte
Small growths on the iris of the eye
hamartoma, is a pigmented hamartomatous nodular aggregate of dendritic melanocytes affecting the iris, named after Austrian ophthalmologist Karl Lisch (1907–1999)
Lisch_nodule
Tanning without ultraviolet exposure
to stimulate melanogenesis in a mechanism that is independent from α-melanocyte-stimulating hormone (α-MSH) activation of the melanocortin 1 receptor
Sunless_tanning
Spreading of a disease inside a body
Melanoma spreads to the brain, presumably because neural tissue and melanocytes arise from the same cell line in the embryo. In 1928, James Ewing challenged
Metastasis
Protein-coding gene in humans
presumably an abbreviation for "melanocyte antigen". MART-1/melan-A is a protein antigen that is found on the surface of melanocytes. Antibodies against the antigen
MLANA
Darkening of skin in response to ultraviolet light
is a natural pigment produced by cells called melanocytes in a process called melanogenesis. Melanocytes produce two types of melanin: pheomelanin (red)
Sun_tanning
white bar has been attributed to a lack of pigment producing cells (melanocytes) in the feather follicle during feather growth. Initially it was proposed
Sex-linked_barring
Peptide consisting of three amino acids joined by peptide bonds
peptide hormone produced in the hypothalamus that inhibits the release of melanocyte-stimulating hormone (MSH) Ophthalmic acid (L-γ-glutamyl-L-α-aminobutyryl-glycine)
Tripeptide
Medical condition
are: Dome-shaped at low power Epidermis thin or normal Dermal nodule of melanocytes with a 'pushing' growth pattern No "radial growth phase" Therapies for
Nodular_melanoma
travel, tourism, insurance
MELANOCYTE
MELANOCYTE
MELANOCYTE
MELANOCYTE
MELANOCYTE
MELANOCYTE
MELANOCYTE
MELANOCYTE
MELANOCYTE
travel, tourism, insurance