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Drugs that modify immune system response
Biological response modifiers (BRMs) are substances that modify immune responses. They can be endogenous (produced naturally within the body) or exogenous
Biological_response_modifier
Activation or suppression of the immune system to treat disease
the mutualistic and symbiotic approach being much more likely. Biological response modifier Sepsivac Checkpoint inhibitor Interleukin-2 immunotherapy Immunostimulant
Immunotherapy
Drug class
include the following: disease-modifying antirheumatic drugs, biologic response modifiers, analgesics, non-steroidal anti-inflammatory drugs, and corticosteroids
Antiarthritics
countries for use as an anti-tumor drug. It appears to work as a biological response modifier (BRM), enhancing the body's own use of macrophages and T-lymphocytes
Polysaccharide_peptide
Type of therapy
immunology. Thus, as immunomodulators, they are one type of biological response modifiers. The most successful targeted therapies are chemical entities
Targeted_therapy
Proteins present in many animal tissues
In relation to diseases, thymosins have been categorized as biological response modifiers. Thymosins are important for proper T-cell development and differentiation
Thymosin
Chemical compound
glucose polymers commonly called beta-glucans demonstrating biological response modifier properties. These immunomodulating properties render the host
Pleuran
Long-term inflammatory arthritis
HAQ ≤0.5. Biologics (also called biological response modifiers) are a class of therapeutics developed using recombinant DNA technology. Biologic medications
Psoriatic_arthritis
Species of edible kelp
T.; et al. (1993). "Eisenin (L-pyroGlu-L-Gln-L-Ala), a new biological response modifier". Journal of Immunotherapy. 13 (1): 36–42. doi:10.1097/00002371-199301000-00005
Arame
Bioavailable – Biochanin A – Biochemical reactions – Biological response modifier – Biological therapy – Biomarker – Biomed 101 – Biopsy – Biopsy specimen
Index_of_oncology_articles
Tripeptide with immunological activity
T. (January 1993). "Eisenin (L-pyroGlu-L-Gln-L-Ala), a new biological response modifier". Journal of Immunotherapy with Emphasis on Tumor Immunology
Eisenin
Medical treatment
interactions Staren ED, Essner R, Economou JS (1989). "Overview of biological response modifiers". Seminars in Surgical Oncology. 5 (6): 379–84. doi:10.1002/ssu
Biological therapy for inflammatory bowel disease
Biological_therapy_for_inflammatory_bowel_disease
American biochemist (born 1937)
neuropathy. Dr. Goldstein's research has helped define the role of biological response modifiers in health and disease, and has led to the discovery of important
Allan_L._Goldstein
Italian allergist and pulmonologist
to treatment strategies for allergic diseases which includes biological response modifier in form of targeted immunotherapy with primary emphasis on sublingual
Giorgio_Walter_Canonica
System of procedure codes within ICD-9 Clinical Modification
tranquilizer (99.27) Iontophoresis (99.28) Injection or infusion of biological response modifier (BRM) as an antineoplastic agent (99.29) Injection or infusion
ICD-9-CM_Volume_3
Collection of human autoimmune diseases
(2017-07-01). "Additional Improvements in Clinical Response From Adjuvant Biologic Response Modifiers in Adults With Moderate to Severe Systemic Lupus Erythematosus
Lupus_erythematosus
Topics referred to by the same term
Organization for Standardization (ISO) procedure Biological response modifiers, substances that alter immune response British Railway Modelling, a British hobby
BRM_(disambiguation)
Non-profit organization
cell biology, molecular biology, biochemistry, and the use of biological response modifiers clinically. As the premier organization in the field of cytokine
International Cytokine & Interferon Society
International_Cytokine_&_Interferon_Society
Polyoxyethylene-polyoxypropylene block co-polymer
evolution of drug delivery concept from inert nanocarriers to biological response modifiers". Journal of Controlled Release. 130 (2): 98–106. doi:10.1016/j
Poloxamer
Special form of in vitro fertilisation
In 2002, the US Food and Drug Administration (FDA) asked a Biological Response Modifiers Advisory Committee Meeting to advise on the technique of cytoplasmic
Mitochondrial replacement therapy
Mitochondrial_replacement_therapy
Monoclonal antibody
Substances (INN), World Health Organization. Khardori NM (2011). Biologic Response Modifiers in Infectious Diseases, An Issue of Infectious Disease Clinics
Foravirumab
Medical condition
In the remaining 20% of TRALI cases, non–antibody factors or biological response modifiers are suggested to contribute the second hit, and these may possibly
Transfusion-related acute lung injury
Transfusion-related_acute_lung_injury
Exopolysaccharide
; BeMiller, James N. (January 1995). "(1→3)-β-d-Glucans as biological response modifiers: a review of structure-functional activity relationships". Carbohydrate
Botryosphaeran
Type of modifier gene
A human disease modifier gene is a modifier gene that alters expression of a human gene at another locus that in turn causes a genetic disease. Whereas
Human_disease_modifier_gene
Physiological and psychological changes in preparation for sexual intercourse
interbreeding populations. The effect of sexual response is thought to be a plastic positive reinforcement behavior modifier associated with the Baldwin effect. The
Sexual_arousal
evolution of drug delivery concept from inert nanocarriers to biological response modifiers". Journal of Controlled Release. 130 (2): 98–106. doi:10.1016/j
Alexander_Kabanov_(chemist)
Medical treatment in addition to a primary treatment to maximise effectiveness
Systemic therapy consists of chemotherapy, immunotherapy or biological response modifiers or hormone therapy. Oncologists use statistical evidence to
Adjuvant_therapy
Proteins that control apoptosis
which prevents the activation of BAX and BAK. crmA, or cytokine response modifier A, is a cowpox serpin that inhibits caspases 1, 6 and 8, forming complexes
Inhibitor_of_apoptosis
Mammalian protein found in Homo sapiens
2004.05.032. PMID 15261142. Reang P, Gupta M, Kohli K (2006). "Biological response modifiers in cancer". MedGenMed. 8 (4): 33. PMC 1868326. PMID 17415315
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
American oncologist and researcher
lymphoblastoid interferon in patients with multiple myeloma". Journal of Biological Response Modifiers. 7 (3): 318–325. ISSN 0732-6580 PMID 3392554 Laszlo, John (1995)
John_Laszlo
American physician, immunologist, oncologist, and professor (1940–2013)
Institute in 1984. In 1988, he was appointed chairman of the Biological Response Modifiers Committee of the National Institute of Allergy and Infectious
Ronald_B._Herberman
British surgeon
Cytofluorometry to predict effects of biological response modifiers in Poulik D. et al. eds. 'Protides of the biological fluids' 1989; 36: 3–17 Hobbs, J. R
John_Raymond_Hobbs
Protein-coding gene in the species Homo sapiens
Journal of Biological Response Modifiers. 8 (5): 501–10. PMID 2552026. Cohen S, Velan B, Grosfeld H, et al. (1985). "Cloning, expression and biological activity
IFNA7
enhancement therapy Autophagy Beta-2 microglobulin Binding antibody Biological response modifiers Blocking antibody Blotto (biology) BNAber Body odor Bone marrow-derived
Index_of_immunology_articles
Protein found in humans
Journal of Biological Chemistry. 261 (19): 8811–6. doi:10.1016/S0021-9258(19)84453-8. PMID 3087979. "Entrez Gene: ISG15 ISG15 ubiquitin-like modifier". Subedi
ISG15
American physician (born 1960)
antioxidant selenium and the anti-inflammatory drug class called biological response modifiers on male fertility. He has also tried to better delineate the
Paul_J._Turek
beta-2 microglobulin (β2M) – bilirubin – bioavailability – biological response modifiers (BRMs) – biopsy – biotechnology – blinded study – blips – blood–brain
Index of HIV/AIDS-related articles
Index_of_HIV/AIDS-related_articles
Family of proteins which attach to other proteins to modify them
In molecular biology, SUMO (Small Ubiquitin-like MOdifier) proteins are a family of small proteins that are covalently attached to and detached from other
SUMO_protein
Enzyme in glutathione biosynthesis
ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response". The Journal of Biological Chemistry
Glutamate–cysteine_ligase
Type of cancer
immune response. They can be administered alone or be linked (conjugated) to anticancer drugs, radioisotopes, or other biologic response modifiers. There
Germinal center B-cell like diffuse large B-cell lymphoma
Germinal_center_B-cell_like_diffuse_large_B-cell_lymphoma
Physical effects resulting from activation of the immune system
Latin: inflammatio) is part of the biological defence response of body tissues. Inflammatory immunovascular responses can be triggered by a broad range
Inflammation
American patent attorney and government official
Administration inventions in the areas of cancer, gene therapy and biological response modifiers. While working at the NIH, Bahar first served as the regional
Mojdeh_Bahar
Field of sexual orientation research
biological level. Researchers have suggested that this possibility could be further explored by studying young subjects to see if similar responses in
Biology and sexual orientation
Biology_and_sexual_orientation
Protein-coding gene in the species Homo sapiens
Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene. The modification of proteins with ubiquitin is an
UBA7
Overreaction of the immune system to an antigen
Hypersensitivity (also called hypersensitivity reaction) is an immune response characterized by mechanisms that cause significant tissue damage or physiological
Hypersensitivity
Low-calorie sweetener and flavor modifier
Thaumatin (also known as talin) is a low-calorie sweetener and taste modifier. The protein is often used primarily for its flavor-modifying properties
Thaumatin
Protein-coding gene in the species Homo sapiens
Small ubiquitin-related modifier 2 is a protein that in humans is encoded by the SUMO2 gene. This gene encodes a protein that is a member of the SUMO (small
SUMO2
Protein-coding gene in the species Homo sapiens
Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene. UBA1 participates in ubiquitination and the
UBA1
Protein-coding gene in the species Homo sapiens
Small ubiquitin-related modifier 1 is a protein that in humans is encoded by the SUMO1 gene. This gene encodes a protein that is a member of the SUMO (small
SUMO1
American biomedical scientist (1945-2018)
cells and T cell subsets as the head of a laboratory in the Biological Response Modifiers Program at the NCI-Frederick. Mathieson served as a program
Bonnie_Mathieson
Protein-coding gene in the species Homo sapiens
Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene. This gene encodes a member of the E1-like activating
UBA5
Human protein and coding gene
Freshwater S, Harrer JM, He L, et al. (May 2002). "Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause
NFE2L2
Concept in genetic epidemiology
contrasting cystic fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis disease severity and CFTR mediated residual chloride
Endophenotype
696.477.136.377 – hemagglutinins MeSH D27.505.696.477.274 – biological response modifiers MeSH D27.505.696.477.274.050 – adjuvants, immunologic MeSH D27
List_of_MeSH_codes_(D27)
Process of regulating a functional proteome
proteome. The proteostasis network includes competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking
Proteostasis
Protein-coding gene in the species Homo sapiens
Ueno T, Kominami E (June 2006). "Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3".
ATG7
Surfactant and antiseptic agent
while more concentrated solutions require incorporation of rheology modifiers (alcohols, polyethylene glycols, etc.) to prevent increases in viscosity
Benzalkonium_chloride
Anthology television series
Harry's stern agent Ursula Khan (Leslie Grossman), tattooist and body modifier Lark Feldman (Billie Lourd), an eccentric homeless woman called Tuberculosis
American_Horror_Story
Immunotherapeutic company founded by Jonas Salk and Kevin Kimberlin
The Immune Response Corporation (IRC) was a pharmaceutical company that worked in the development of immunotherapeutic products. The firm was founded by
The Immune Response Corporation
The_Immune_Response_Corporation
Type of enzymes
binding to SIN3A. SUMOylation refers to the addition of Small Ubiquitin-like Modifier (SUMO) proteins onto histones. SUMOylation involves covalent attachments
Histone-modifying_enzymes
2025 video game
Cursed is an advanced version of Zombies, featuring additional difficulty modifiers called "Relics" and legacy elements from older Call of Duty games. In
Call_of_Duty:_Black_Ops_7
Enzyme
enzyme (AtSCE1) is an enzyme that is a member of the small ubiquitin-like modifier (SUMO) post-translational modification pathway. This process, and the SCE1
AtSCE1
Family of proteins
proteins produced by cells in response to exposure to a stressor. They were first described in relation to the heat shock response, but are now known to also
Heat_shock_protein
Therapeutic cancer vaccine in development
using GM-CSF to grow more cells. The NIH calls this topic "Biological response modifiers (BRMs) occur naturally in the body and can be produced in the
Neuvenge
Protein found in humans
Ubiquitin-like modifier-activating enzyme 6 is an enzyme that in humans is encoded by the UBA6 gene (previously UBE1L2). This enzyme functions to activate
UBA6
Underground animal home dug in soft dirt
animals can be divided into three categories: primary excavators, secondary modifiers and simple occupants. Primary excavators are the animals that originally
Burrow
Statistics concept
is referred to as the moderator variable (or effect modifier) or simply the moderator (or modifier). The effect of a moderating variable is characterized
Moderation_(statistics)
Attraction between people of the opposite sex or gender
support, scientists favor biologically based theories. There is considerably more evidence supporting nonsocial, biological causes of sexual orientation
Heterosexuality
Chemical compound
first compound found in the hypobranchial gland mucus to produce a biological response. BrMT is a brominated tryptamine. It has a thiol group, allowing
BrMT
Protein found in humans
that occurs in some neurons. On the left hand side are some of the known modifiers of this process. Electrical activity in neurons changes the association
Alpha-synuclein
Species of ant (Anoplolepis gracilipes)
world's tropics. The yellow crazy ant has colloquially been given the modifier "crazy" on account of the ant's erratic movements when disturbed. Its long
Yellow_crazy_ant
Class of enzymes capable of forming isopeptide bonds in certain regions of proteins
L, Hitomi K, Kojima S (2015). Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery. Springer Japan. ISBN 978-4-431-55823-1
Transglutaminase
Family of small proteins
turning point in the field, with the discovery of SUMO (small ubiquitin-like modifier, also known as Sentrin or SENP1) reported around the same time by a variety
Ubiquitin-like_protein
Mitochondrion Mitosis Mitotic apparatus Mitotic crossover Model organisms Modifier gene Molecular biology Molecular chaperone Molecular farming Molecular
Index_of_genetics_articles
Protein-coding gene in humans
1995.1083. PMID 7826375. "Entrez Gene: GCLM glutamate-cysteine ligase, modifier subunit". Dickinson DA, Levonen AL, Moellering DR, et al. (2005). "Human
GCLM
Species of protozoan parasite
development in T. gondii. Farhat and colleagues showed that chromatin modifiers MORC and HDAC3 play critical roles in silencing sexual development-specific
Toxoplasma_gondii
Protein-coding gene in humans
substrates. SAE2 has been shown to interact with SAE1, Small ubiquitin-related modifier 1, and UBE2I. GRCh38: Ensembl release 89: ENSG00000126261 – Ensembl, May
UBA2
Corticosteroid precursor and metabolite of cortisol
prohormone of cortisol (hydrocortisone), which is responsible for its biological activity. It is metabolized into cortisol via the actions of 11β-hydroxysteroid
Cortisone
Biological mechanism that controls circadian rhythm
hours. In response to light stimulus, the body corresponds with a system and network of pathways that work together to determine the biological day and
Circadian_clock
Surface reactive glass-ceramic biomaterial
glass is immersed in a physiological environment: Ion exchange in which modifier cations (mostly Na+) in the glass exchange with hydronium ions in the external
Bioactive_glass
Protein-coding gene in the species Homo sapiens
phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16". J. Biol. Chem. 281 (6): 3017–24. doi:10.1074/jbc
MAP1LC3A
Mammalian protein found in Homo sapiens
template switch pathway. Furthermore, sumoylation (by small ubiquitin-like modifier, SUMO) of PCNA lysine-164 (and to a lesser extent, lysine-127) inhibits
Proliferating cell nuclear antigen
Proliferating_cell_nuclear_antigen
Regulatory protein found in most eukaryotic tissues
ubiquitin-like modifier (SUMO), ubiquitin cross-reactive protein (UCRP, also known as interferon-stimulated gene-15 ISG15), ubiquitin-related modifier-1 (URM1)
Ubiquitin
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
expression increases during the immune response include the 11S regulatory particle, whose main known biological role is regulating the production of MHC
Proteasome
Protein-coding gene in the species Homo sapiens
(July 1998). "Identification and mapping of human histone acetylation modifier gene homologues". Genomics. 51 (2): 262–269. doi:10.1006/geno.1998.5370
Histone_deacetylase_2
2016 video game
early-game, mid-game, and end-game segments dictating certain events and modifiers. The economy of a player's empire throughout the game is primarily based
Stellaris_(video_game)
Protein-coding gene in the species Homo sapiens
Ludolph AC, Patsch W, Weydt P (2013). "PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis". Human Molecular
PGC-1α
Basic taste
processing in modern society has changed consumption patterns, but the biological preference for sweetness has remained. In the natural settings that human
Sweetness
Protein-coding gene in the species Homo sapiens
Feinberg AP (1998). "Identification and mapping of human histone acetylation modifier gene homologues". Genomics. 51 (2): 262–269. doi:10.1006/geno.1998.5370
KAT2A
Protein-coding gene in the species Homo sapiens
Ubiquitin-fold modifier 1, also known as UFM1, is a protein which in humans is encoded by the UFM1 gene. UFM1 is a ubiquitin-like protein that is conjugated
UFM1
Sex hormone
unidentified. Detailed characterization of the events occurring in sperm in response to progesterone has explained certain events including intracellular calcium
Progesterone
Protein-coding gene in the species Homo sapiens
Ubiquitin-fold modifier conjugating enzyme 1 is a protein that in humans is encoded by the UFC1 gene. UFC1 is an E2-like conjugating enzyme for ubiquitin-fold
Ubiquitin-fold modifier conjugating enzyme 1
Ubiquitin-fold_modifier_conjugating_enzyme_1
Species of bacterium
from Streptococcus pyogenes - a potent modifier of immunologically important host and bacterial proteins". Biological Chemistry. 392 (12): 1077–1088. doi:10
Streptococcus_pyogenes
Central nervous system stimulant
methylphenidate may act as a "DAT inverse agonist" or "negative allosteric modifier of the DAT" by reversing the direction of the dopamine flux through the
Methylphenidate
Field of sexual orientation research
influences from hormonal influences, while other researchers include biological influences such as prenatal hormones as part of environmental influences
Environment and sexual orientation
Environment_and_sexual_orientation
Analysis of material by examining response to heat
computer-aided cooling curve thermal analysis to optimise eutectic refiner and modifier in Al–Si alloys". Journal of Thermal Analysis and Calorimetry. 109 (1):
Thermal_analysis
Class of steroid hormones
in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein
Corticosteroid
Single nucleotide polymorphism in human BDNF gene
den Buuse, M. (2015-08-01). "The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy". Molecular
Rs6265
Protein and coding gene in humans
present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1
NAIP_(gene)
Protein found in humans
receptor alpha, SIN3A, SKI protein, STAT3, Serum response factor and Small ubiquitin-related modifier 1, Sp1 transcription factor, TOPBP1, Thymine-DNA
Promyelocytic leukemia protein
Promyelocytic_leukemia_protein
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BIOLOGICAL RESPONSE-MODIFIER
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BIOLOGICAL RESPONSE-MODIFIER
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