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Family of proteins which attach to other proteins to modify them
biology, SUMO (Small Ubiquitin-like MOdifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells
SUMO_protein
Protein inhibitor of activated STAT (PIAS), also known as E3 SUMO-protein ligase PIAS, is a protein that regulates transcription in mammals. PIAS proteins
Protein inhibitor of activated STAT
Protein_inhibitor_of_activated_STAT
Change of a linear protein chain to a 3D structure
Protein folding is the physical process by which a protein, after synthesis by a ribosome as a linear chain of amino acids, changes from an unstable random
Protein_folding
Family of small proteins
other proteins: SUMO, NEDD8, ATG8, ATG12, URM1, UFM1, FAT10, and ISG15. One additional protein, known as FUBI, is encoded as a fusion protein in the
Ubiquitin-like_protein
SUMO enzymatic cascade catalyzes the dynamic posttranslational modification process of sumoylation (i.e. transfer of SUMO protein to other proteins).
SUMO_enzymes
Topics referred to by the same term
Look up sumo, Sumo, or SUMO in Wiktionary, the free dictionary. Sumo is a form of wrestling. Sumo may also refer to: Sumo (people), a people of Central
Sumo_(disambiguation)
Japanese form of full-contact wrestling
Sumo (Japanese: 相撲, Hepburn: sumō; pronounced [ˈsɯmoː], lit. 'striking one another') is a form of competitive full-contact wrestling where a rikishi (wrestler)
Sumo
Japanese hot pot dish
dish in its own right, chankonabe is very protein-rich and usually served in massive quantities. Modern sumo wrestlers typically accompany the stew with
Chankonabe
Chemical changes in proteins following their translation from mRNA
of protein pharmaceuticals. ubiquitination, the covalent linkage to the protein ubiquitin. SUMOylation, the covalent linkage to the SUMO protein (small
Post-translational modification
Post-translational_modification
Class of enzymes
molecular chaperones are proteins that assist the conformational folding or unfolding of proteins or macromolecular protein complexes. There are a number
Chaperone_(protein)
Family of proteins
Heat shock proteins (HSPs) are a family of proteins produced by cells in response to exposure to a stressor. They were first described in relation to the
Heat_shock_protein
Family of heat shock proteins
kilodalton heat shock proteins (Hsp70s or DnaK) are a family of conserved ubiquitously expressed heat shock proteins. Proteins with similar structure
Hsp70
Protein-coding gene in the species Homo sapiens
E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene. Protein inhibitor of activated STAT2 has been shown to interact
Protein inhibitor of activated STAT2
Protein_inhibitor_of_activated_STAT2
Heat shock proteins with a molecular mass around 90kDa
shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation
Hsp90
Protein-coding gene in the species Homo sapiens
E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as a protein inhibitor of activated
PIAS4
Short peptide present at N-terminal of newly synthesized proteins
translocate the protein, usually to the cellular membrane. In prokaryotes, signal peptides direct the newly synthesized protein to the SecYEG protein-conducting
Signal_peptide
Biological mechanism for routing proteins
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside
Protein_targeting
Protein
ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists
Ubiquitin_ligase
The following words are terms used in sumo wrestling in Japan. Contents: A B C D E F G H I J K L M N O P Q R S T U V W Y Z References External links Agari-zashiki
Glossary_of_sumo_terms
Protein in animal cells
Survival of motor neuron or survival motor neuron (SMN) is a protein that in humans is encoded by the SMN1 and SMN2 genes. SMN is found in the cytoplasm
Survival_of_motor_neuron
Protein-coding gene in the species Homo sapiens
protein that in humans is encoded by the SUMO1 gene. This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein
SUMO1
Protein found in humans
attachment of SUMO proteins to the RING domain by UBC9 SUMO-conjugating enzyme, which occurs in a cell cycle dependent way. PML contains a SUMO-binding domain
Promyelocytic leukemia protein
Promyelocytic_leukemia_protein
Family of heat shock proteins
a family of heat shock proteins that assist in the folding of newly synthesized proteins and refolding of misfolded proteins during stressful conditions
Chaperonin
Protein-coding gene in humans
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1), or sumoylation, regulates protein structure and intracellular
UBA2
Protein-coding gene in the species Homo sapiens
E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene. This gene encodes a member of the mammalian PIAS [protein inhibitor
PIAS1
Protein-coding gene in the species Homo sapiens
immunoglobulin protein (BiPS) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a protein that in humans
Binding immunoglobulin protein
Binding_immunoglobulin_protein
Protein-coding gene in the species Homo sapiens
interact with other proteins or DNA. UBC9 performs the third step in the sumoylation life cycle: the conjugation step. When SUMO protein precursors are first
UBE2I
Class of enzymes
ubiquitin protein. The E1 enzyme then passes the ubiquitin protein to a second protein, called ubiquitin carrier or conjugation protein (E2). The E2 protein complexes
Ubiquitin-activating_enzyme
Protein-coding gene in humans
E3 SUMO-protein ligase PIAS3 is an enzyme that in humans is encoded by the PIAS3 gene. IAS proteins were originally identified in studies that were aimed
PIAS3
American biologist
ubiquitin-proteasome system and the small ubiquitin-like modifier (SUMO) protein. He was elected a Member of the National Academy of Sciences in 2025
Mark_Hochstrasser
Regulatory protein found in most eukaryotic tissues
Autophagin Endoplasmic-reticulum-associated protein degradation JUNQ and IPOD Prokaryotic ubiquitin-like protein SUMO enzymes Goldstein G, Scheid M, Hammerling
Ubiquitin
Pharmaceutical compound
SUMOylation inhibitor. By preventing cellular proteins from being stabilised by conjugation with SUMO proteins, it makes it more difficult for cancer cells
Subasumstat
Protein family
that targets a protein for degradation via the proteasome. The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids
Ubiquitin-conjugating_enzyme
Protein-coding gene in the species Homo sapiens
of many proteins. To function properly, GroEL requires the lid-like cochaperonin protein complex GroES. In eukaryotes the organellar proteins Hsp60 and
GroEL
Protein family
Ubiquitin SUMO protein Neddylation Pearce, M. J.; Mintseris, J.; Ferreyra, J.; Gygi, S. P.; Darwin, K. H. (2008). "Ubiquitin-Like Protein Involved in
Prokaryotic ubiquitin-like protein
Prokaryotic_ubiquitin-like_protein
Type of peptide chain
target peptides are cleaved from the protein by signal peptidases after the proteins are transported. Almost all proteins that are destined to the secretory
Target_peptide
Protein found in humans
serine. MOD_SUMO_rev_2 is an inverted version of SUMOylation motif recognized for modification by SUMO-1. SUMOylation occurs when SUMO proteins covalently
Zinc_finger_protein_730
Protein-coding gene in the species Homo sapiens
Heat shock protein 47, also known as SERPINH1, is a serpin which serves as a human chaperone protein for collagen. HSP47 contains 3 beta sheets and 9
Heat_shock_protein_47
Protein-coding gene in humans
encodes the SMN protein in humans.The chemical formula is:C1394H2154N384O438S13 SMN1 is the telomeric copy of the gene encoding the SMN protein; the centromeric
SMN1
Protein-coding gene in the species Homo sapiens
protein that in humans is encoded by the SUMO2 gene. This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein
SUMO2
Protein-coding gene in the species Homo sapiens
Small ubiquitin-related modifier 3 is a protein that in humans is encoded by the SUMO3 gene. SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339)
SUMO3
Mammalian protein found in humans
The Von Hippel–Lindau tumor suppressor also known as pVHL is a protein that, in humans, is encoded by the VHL gene. Mutations of the VHL gene are associated
Von Hippel–Lindau tumor suppressor
Von_Hippel–Lindau_tumor_suppressor
Type of enzymes
Small Ubiquitin-like Modifier (SUMO) proteins onto histones. SUMOylation involves covalent attachments between SUMO proteins and lysine (K) residues on histones
Histone-modifying_enzymes
Hydrophobic scaffold protein
scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING
Cullin
Protein-coding gene in the species Homo sapiens
"Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1". J. Biol. Chem. 274 (15): 10618–24. doi:10.1074/jbc.274.15.10618.
UBE2E3
Protein-coding gene in the species Homo sapiens
Ataxin-3 is a protein that in humans is encoded by the ATXN3 gene. Machado–Joseph disease, also known as spinocerebellar ataxia type 3, is an autosomal
Ataxin_3
Enzyme
E2 SUMO-SCE1 complex with a target protein, however it often needs direction from an E3 ligase. SUMO chains can also be created on a target protein through
AtSCE1
Protein-coding gene in the species Homo sapiens
ubiquitin (Ub) is a 110–120 kDa monomeric protein, and the UBA1 for the ubiquitin-like protein (Ubls) NEDD8 and SUMO are heterodimeric complexes with similar
UBA1
Protein-coding gene in humans
Heat shock 70 kDa protein 6 is a protein that in humans is encoded by the HSPA6 gene. GRCh38: Ensembl release 89: ENSG00000173110 – Ensembl, May 2017 "Human
HSPA6
Protein-coding gene in the species Homo sapiens
there are multiple other phosphorylation, glycation, 0-beta-GlcNAc, and SUMO protein attachment sites. TEX9's two coiled-coil regions make up its tertiary
TEX9
Protein-coding gene in humans
SENP1 catalyzes maturation of SUMO protein (small ubiquitin-related modifier). SENP1 causes hydrolysis of a peptide bond of SUMO in the conserved sequence
SENP1
Protein found in humans
Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. ISG15 is induced by type I interferon
ISG15
Protein-coding gene in humans
double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important
Mdm2
Amino acid
acetyllysine or reverting to lysine, up to three methyl (−CH3), ubiquitin or a sumo protein group. The various modifications have downstream effects on gene regulation
Lysine
Protein-coding gene in the species Homo sapiens
Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene. The modification of proteins with ubiquitin is an important cellular
UBE2C
Protein-coding gene in the species Homo sapiens
Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene. UBE2O functions during terminal erythroid differentiation
UBE2O
Protein-coding gene in the species Homo sapiens
Ubiquitin-conjugating enzyme E2 A is a protein that in humans is encoded by the UBE2A gene. The modification of proteins with ubiquitin is an important cellular
UBE2A
Gene
regulates a lot of proteins. The GPS CUCKOO workgroup database predicted SUMO protein sites at 347, 348 and 349. These residues were conserved in even the
FAM98C
Protein-coding gene in Homo sapiens
Ubiquitin-Protein Ligase E3B (UBE3B) is an enzyme encoded by UBE3B gene in humans. UBE3B has an N-terminal IQ motif, which mediates calcium-independent
Ubiquitin-protein_ligase_E3B
Global biotechnology company based in San Diego, California
of proteins. SUMO-modified proteins contain the tetrapeptide motif B-K-x-D/E where B is a hydrophobic residue, K is the lysine conjugated to SUMO, x is
Abgent
Post-translational modification
(−CO−CH2−CH2−CO2H) is added to a lysine residue of a protein molecule. This modification is found in many proteins, including histones. The potential role of succinylation
Succinylation
Mammalian protein found in Homo sapiens
The human gene UBR1 encodes the enzyme ubiquitin-protein ligase E3 component n-recognin 1. The N-end rule pathway is one proteolytic pathway of the ubiquitin
UBR1
Protein-coding gene in the species Homo sapiens
Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene. TRAP1 has been shown to interact with EXT2, EXT1 and
TRAP1
Protein family
reversing the fate of the proteins. In addition, a less understood role of DUBs is the cleavage of ubiquitin-like proteins such as SUMO and NEDD8. Some DUBs
Deubiquitinating_enzyme
Protein-coding gene in the species Homo sapiens
Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene. The modification of proteins with ubiquitin is an important cellular
UBE2L6
InterPro Family
Hsp33 protein is a molecular chaperone, distinguished from all other known chaperones by its mode of functional regulation. Its activity is redox regulated
Hsp33
Protein-coding gene in the species Homo sapiens
Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene. The modification of proteins with ubiquitin is an important cellular
UBE2G1
Protein-coding gene in the species Homo sapiens
Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene. The gene, HSP90AA1, encodes the human stress-inducible 90-kDa
Heat shock protein 90kDa alpha (cytosolic), member A1
Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1
Protein found in humans
vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification
Centromere_protein_C
Transmembrane protein 251, also known as C14orf109 or UPF0694, is a protein that in humans is encoded by the TMEM251 gene. One notable feature of this protein is
Transmembrane_protein_251
Protein-coding gene in humans
Survival of motor neuron 2 (SMN2) is a gene that encodes the SMN protein (full and truncated) in humans. The SMN2 gene is part of a 500 kb inverted duplication
SMN2
Post-translational modification
Lysine malonylation (Kmal, maK), protein malonylation or malonylation, is a reversible post-translational modification (PTM) in eukaryotic and prokaryotic
Lysine_malonylation
Protein-coding gene in the species Homo sapiens
NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene. The modification of proteins with ubiquitin is an important cellular
UBE2M
Protein-coding gene in the species Homo sapiens
Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene. The modification of proteins with ubiquitin is an important cellular
UBE2H
Protein-coding gene in the species Homo sapiens
Autophagy related 12 is a protein that in humans is encoded by the ATG12 gene. Autophagy is a process of bulk protein degradation in which cytoplasmic
ATG12
Protein in budding yeast
Autophagy-related protein 8 (Atg8) is a ubiquitin-like protein required for the formation of autophagosomal membranes. The transient conjugation of Atg8
ATG8
Mammalian protein found in Homo sapiens
36, 42, 59, and 97. Additionally, this protein is predicted to be SUMOylated at aa71 with the SUMO protein binding from aa189 through aa193. Cholesin
Cholesin
Protein created by joining other proteins into a single polypeptide
maltose binding protein (MBP) or small ubiquitin-like molecule (SUMO), serve to enhance enzyme expression and secretion of the target protein. Immobilization:
Fusion_protein
Protein-coding gene in the species Homo sapiens
as UFM1, is a protein which in humans is encoded by the UFM1 gene. UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating
UFM1
Gene of the species Homo sapiens
residues that SUMO (small ubiquitin-like modifier) proteins can bind to modify the protein's function. SUMO proteins may modify proteins to perform many
C8orf34
Protein-coding gene in the species Homo sapiens
BRISC complex subunit Abraxas 2 is a protein that in humans is encoded by the gene ABRAXAS2 (previously FAM175B or KIAA0157). Abraxas 2 is involved in
ABRAXAS2
Protein-coding gene in the species Homo sapiens
Heat shock protein 27 (Hsp27) also known as heat shock protein beta-1 (HSPB1) is a protein that in humans is encoded by the HSPB1 gene. Hsp27 is a chaperone
Hsp27
Protein-coding gene in the species Homo sapiens
DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene. DNAJA1 has been shown to interact with PTTG1. GRCh38: Ensembl
DNAJA1
Protein-coding gene in the species Homo sapiens
Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene. This gene encodes a protein with a BIR (baculoviral inhibition
BIRC6
Protein-coding gene in the species Homo sapiens
Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene. The modification of proteins with ubiquitin is an important cellular
UBE2J1
Protein-coding gene in the species Homo sapiens
Heat shock 70 kDa protein 4 is a protein that in humans is encoded by the HSPA4 gene. The protein encoded by this gene was originally suggested to be
HSPA4
Protein-coding gene in the species Homo sapiens
Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene. The modification of proteins with ubiquitin is an important cellular
UBE2E1
Protein-coding gene in the species Homo sapiens
Mitochondrial 70kDa heat shock protein (mtHsp70), also known as mortalin, is a protein that in humans is encoded by the HSPA9 gene. The product encoded
HSPA9
Protein-coding gene in humans
UBCH7, is a protein that in humans is encoded by the UBE2L3 gene. As an E2 enzyme, UBE2L3 participates in ubiquitination to target proteins for degradation
UBE2L3
Protein-coding gene in humans
Chromosome 18 open reading frame 12, also known as C18orf12, is a protein encoded in humans by the C18orf12 gene. The exact biological function of C18orf12
Chromosome 18 open reading frame 12
Chromosome_18_open_reading_frame_12
Protein-coding gene in the species Homo sapiens
Heat shock protein 90kDa beta member 1 (HSP90B1), known also as endoplasmin, gp96, grp94, or ERp99, is a chaperone protein that in humans is encoded by
HSP90B1
Post-translational modification
Protein neddylation refers to the post-translational modification in which ubiquitin-like protein NEDD8 is covalently attached to the lysine residue of
Neddylation
Protein-coding gene in the species Homo sapiens
E3 ubiquitin-protein ligase FANCL is an enzyme that in humans is encoded by the FANCL gene. The Fanconi Anemia (FA) DNA repair pathway is essential for
FANCL
Protein-coding gene in the species Homo sapiens
DnaJ homolog subfamily B member 2 is a protein that in humans is encoded by the DNAJB2 gene. GRCh38: Ensembl release 89: ENSG00000135924 – Ensembl, May
DNAJB2
Mammalian gene
founding member the Cbl family. The protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to
CBL_(gene)
Protein family
Ubiquitin-related modifier-1 (URM1) is a ubiquitin-like protein that modifies proteins in the yeast ubiquitin-like urmylation pathway. Structural comparisons
URM1
Protein-coding gene in the species Homo sapiens
SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene. SAE1 has been shown to interact with SAE2, the protein product
SAE1
Protein-coding gene in the species Homo sapiens
Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene. The modification of proteins with ubiquitin is an important cellular
UBE2D1
Protein-coding gene in the species Homo sapiens
enzyme E2 variant 2 is a protein that in humans is encoded by the UBE2V2 gene. Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily
UBE2V2
Protein found in humans
a protein that in humans is encoded by the CLU gene on chromosome 8. CLU is an extracellular molecular chaperone which binds to misfolded proteins in
Clusterin
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SUMO PROTEIN
SUMO PROTEIN
SUMO PROTEIN
SUMO PROTEIN
SUMO PROTEIN
SUMO PROTEIN
SUMO PROTEIN
SUMO PROTEIN
SUMO PROTEIN
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