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Protein found in humans
Alpha-synuclein (aSyn) is a protein that in humans is encoded by the SNCA gene. It is a neuronal protein involved in the regulation of synaptic vesicle
Alpha-synuclein
Progressive neurodegenerative disease
related cell groups in the brainstem. Misfolded proteins, such as alpha-synuclein, aggregate to form clumps called Lewy bodies, if not cleared from cells
Parkinson's_disease
Spherical inclusion commonly found in damaged neurons
atrophy. The defining proteinaceous component of Lewy bodies is alpha-synuclein (α-synuclein), which aggregates to form Lewy bodies within neuronal cell bodies
Lewy_body
Pathogenic type of misfolded protein
diseases were thought to be caused by PrP until 2015 when a prion form of alpha-synuclein was linked to multiple system atrophy (MSA). Misfolded proteins are
Prion
Neurodegenerative disorder
sometimes initial clinical manifestation of the disorder. A prion of the alpha-synuclein protein within affected neurons may cause MSA. About 55% of MSA cases
Multiple_system_atrophy
Type of progressive dementia
synucleinopathy, meaning that it is characterized by abnormal deposits of alpha-synuclein protein in the brain. The synucleinopathies include Parkinson's disease
Dementia_with_Lewy_bodies
Cognitive disorder
Early onset dementia or young onset dementia refers to dementia with symptom onset prior to age 65 years. Early onset dementia is a general term that describes
Early_onset_dementia
Protein family
electric ray. The synuclein family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. Interest in the synuclein family began
Synuclein
Medical condition
diseases characterised by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells. The synucleinopathies
Synucleinopathy
Models used in Parkinson's disease research
lungs and kidney, resulting high toxicity; as well, as death. Alpha-synuclein (α-synuclein) is an endogenous protein that is encoded by the SNCA gene and
Animal models of Parkinson's disease
Animal_models_of_Parkinson's_disease
Central nervous system disease
Parkinson's disease-associated mutant alpha-synucleins through axons of cultured neurons. Membrane damage by alpha-synuclein could be another Parkinson's disease
Neurodegenerative_disease
Form of dementia associated with Parkinson's disease
mechanistic basis in neuroinflammation and alpha-synuclein aggregation involving the spreading of misfolded alpha-synuclein aggregates. After initiation of neuroinflammation
Parkinson's_disease_dementia
Classification of disease severity
One mechanism consists of an abnormal accumulation of the protein alpha-synuclein bound to ubiquitin in the damaged cells. This protein accumulation
Braak_staging
Structure in the basal ganglia of the brain
oxidative stress can be repaired by processes modulated by alpha-synuclein. Alpha synuclein is expressed in the substantia nigra, but its DNA repair function
Substantia_nigra
Umbrella term covering two types of dementia
neurites have been found to develop from the aggregation of misfolded alpha-synuclein, a protein thought to assist in neurotransmitter release and vesicle
Lewy_body_dementia
Medical condition
misfolded proteins such as alpha-synuclein. Alpha-synuclein is normally found in the presynaptic terminals of neurons. If alpha-synuclein is mis-folded and not
Pathophysiology of Parkinson's disease
Pathophysiology_of_Parkinson's_disease
Neurodegenerative disorder
Neuronal Alpha-Synuclein Disease (NSD) is a proposed new combined definition of Parkinson's disease and Dementia with Lewy bodies based on biology instead
Neuronal Alpha-Synuclein Disease
Neuronal_Alpha-Synuclein_Disease
Factors causing Parkinson's disease
misfolded proteins such as alpha-synuclein. Alpha-synuclein is normally found in the presynaptic terminals of neurons. If alpha-synuclein is mis-folded and not
Causes_of_Parkinson's_disease
Drugs that inhibit α-synuclein
An anti-α-synuclein drug, or an α-synuclein inhibitor, is a drug which blocks or inhibits α-synuclein. α-Synuclein is a protein which is thought to be
Anti-α-synuclein_drug
Greek-American physician, scientist, (b 1960)
in the Human Genome Project and the discovery of mutations in the alpha synuclein gene as the first genetic cause of Parkinson's disease while at the
Mihael_Polymeropoulos
Comune in Campania, Italy
led by Maria Grazia Spillantini reported on alpha-synuclein deposits in Lewy bodies as well as alpha-synuclein inclusions in other neurodegenerative disorders
Contursi_Terme
Chemical compound
Cuminaldehyde has been investigated for inhibition of the fibrillation of alpha-synuclein, Cuminaldehyde can be prepared synthetically by the reduction of 4-isopropylbenzoyl
Cuminaldehyde
Group of six protein isoforms produced from the MAPT gene
H1H1 in iPSC-derived cortical neurons revealed a higher expression of alpha-synuclein compared to H2H2, which may explain the association of haplotype with
Tau_protein
Protein-coding gene in the species Homo sapiens
Beta-synuclein is a protein that in humans is encoded by the SNCB gene. The protein encoded by this gene is highly homologous to alpha-synuclein. These
Beta-synuclein
Mammalian protein found in humans
regarded a late-onset neurodegenerative condition characterised by alpha-synuclein-enriched Lewy bodies, autosomal recessive PD due to parkin mutations
Parkin_(protein)
HIV entry inhibitor discovered in 1986
blocking the synaptotoxic actions of oligomeric forms of amyloid beta and alpha-synuclein., as well as HIV gp120, via a PrPc dependent pathway. Synapse loss
Peptide_T
Gastrointestinal dysfunction and Parkinson's disease
in figure) and the presence of aggregated alpha-synuclein. Under physiological conditions, alpha-synuclein, a protein encoded by the SNCA gene, is found
Parkinson's disease and gut-brain axis
Parkinson's_disease_and_gut-brain_axis
mutation (PARK1) in the brain protein, alpha-synuclein. Within days of the publication of the PARK1 findings, alpha-synuclein was discovered to be the major component
History of Parkinson's disease
History_of_Parkinson's_disease
Family of heat shock proteins
human neuroglioma cells transfected with mutant alpha-synuclein led to 50% less oligomeric alpha-synuclein species, pointing towards the possibility that
Hsp70
Chemical compound
including amyloid precursor proteins (APP) and amyloid beta, tau, alpha-synuclein (αSYN), huntingtin, and TDP-43. Buntanetap performs in a noncholinergic
Buntanetap
; Low, Phillip A.; Soto, Claudio (5 February 2020). "Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy". Nature. 578
Protein misfolding cyclic amplification
Protein_misfolding_cyclic_amplification
PARP-1 dependent cell death
accumulation and aggregation of alpha-synuclein. In the neurons of individuals with Parkinson's disease, alpha-synuclein is deposited as fibrils in intracytoplasmic
Parthanatos
Italian neuroscientist
University of Cambridge. She is most noted for identifying the protein alpha-synuclein as the major component of Lewy bodies, the characteristic protein deposit
Maria_Grazia_Spillantini
Virus of the herpes family
The Epstein–Barr virus has been implicated in disorders related to alpha-synuclein aggregation (e.g., Parkinson's disease, dementia with Lewy bodies,
Epstein–Barr_virus
British physician and neuroscientist
Trust intermediate clinical fellowship to study the misfolding of alpha-synuclein in Parkinson's disease, and how this misfolding causes neurotoxicity
Sonia_Gandhi_(scientist)
Protein-coding gene in the species Homo sapiens
Gamma-synuclein is a protein that in humans is encoded by the SNCG gene. Synuclein-gamma is a member of the synuclein family of proteins, which are believed
Gamma-synuclein
Swedish neuroscientist
of alpha-synuclein aggregates between neurons and developed corresponding animal models. This work contributed to the recognition of alpha-synuclein as
Patrik_Brundin
US-based Parkinson's disease charity
Parkinson's can be detected by the presence of a biomarker protein, abnormal alpha-synuclein. The biomarker can be detected before the onset of symptoms. The organization
The_Michael_J._Fox_Foundation
Diseases caused by abnormal protein structure
formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein". Proceedings of the National Academy of Sciences of the United States
Proteinopathy
Repeated DNA variation between individuals
Johnson J, Singleton A, Hague S, Kachergus J, et al. (October 2003). "alpha-Synuclein locus triplication causes Parkinson's disease". Science. 302 (5646):
Copy_number_variation
for "synuclein, alpha interacting protein". Synphilin-1 is a cytosolic protein first identified in 1999 as a novel binding partner of α-synuclein, localized
SNCAIP
Science fraudster
Alzheimer's and Parkinson's disease, particularly surrounding the alpha-synuclein protein. The dossier was sent to the HHS Office of Research Integrity
Eliezer_Masliah
American-Yemeni neuroscientist
of several proteins linked to neurodegenerative diseases, including alpha-synuclein, Tau and several N-terminal fragments of the Huntingtin protein. In
Hilal_Lashuel
glutamate uptake and diminished lactate dehydrogenase (LDH) leakage. Alpha synuclein Asphalt (disambiguation) Concrete Joss paper Parkinsonism Particulates
Manganese_poisoning
Field of study
neuroprotective effect by preventing translocation of alpha-synuclein into cell nuclei. Vorinostat In an alpha-synuclein overexpressing Drosophila model of PD, vorinostat
Epigenetics of neurodegenerative diseases
Epigenetics_of_neurodegenerative_diseases
Protein-coding gene in the species Homo sapiens
PMID 26708217. Yeast SUB1 has structural and functional similarities to human alpha-synuclein, a protein that has an important role in Parkinson's disease.Schaser
SUB1
Chemical compound
displace alpha-synuclein from neuronal membranes both in vitro, in isolated cells, and in a C. elegans Parkinson disease model. Since alpha synuclein accumulates
Squalamine
American neuroscientist and biochemist
caused by alpha-synuclein built-up, and that similar to the tau protein and Alzheimer's, healthy neurons may take up extracellular alpha-synuclein and become
Virginia_Man-Yee_Lee
Mammalian protein found in Homo sapiens
substances. Dopamine transporter has been shown to interact with: Alpha-synuclein, PICK1, Synaptogyrin-3, and TGFB1I1, Apart from these innate protein-protein
Dopamine_transporter
Extracellular deposits of the amyloid beta protein
Checler F (September 2002). "Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's
Amyloid_plaques
Intelligence of machines
to identify compounds that block the clumping, or aggregation, of alpha-synuclein (the protein that characterises Parkinson's disease). They were able
Artificial_intelligence
Protein-coding gene in the species Homo sapiens
of UCH-L1. Ubiquitin carboxyl-terminal esterase L3—the gene UCHL3 Alpha synuclein Parkinson disease Proteasome GRCh38: Ensembl release 89: ENSG00000154277
Ubiquitin carboxy-terminal hydrolase L1
Ubiquitin_carboxy-terminal_hydrolase_L1
Type of brain cell
Ingelsson M, et al. (December 2017). "Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes". The Journal of Neuroscience. 37 (49): 11835–53
Astrocyte
Type of cytotoxic lymphocyte
disease, levels of Natural killer cells are elevated as they degrade alpha-synuclein aggregates, destroy senescent neurons, and attenuate the neuroinflammation
Natural_killer_cell
Family of sleep disorders involving sleep disruptions
neurological disorders is frequently related to abnormal accumulation of alpha-synuclein, and more than 80% of patients with idiopathic RBD might develop Lewy
Parasomnia
Chemical compound
abnormality and electron transport chain impairment in mice lacking alpha-synuclein". Molecular and Cellular Biology. 25 (22): 10190–10201. doi:10.1128/MCB
Cardiolipin
Award for breakthroughs in the life sciences
amyotrophic lateral sclerosis, and revealing that different forms of alpha-synuclein, in different cell types, underlie Parkinson's disease and Multiple
Breakthrough Prize in Life Sciences
Breakthrough_Prize_in_Life_Sciences
Cellular structure
sites. Mutations in the genes that encode the proteins Parkin, PINK1, alpha-Synuclein (α-Syn) or the protein deglycase DJ-1 have been linked to this disease
Mitochondria associated membranes
Mitochondria_associated_membranes
German anatomist
PMID 1759558. Braak, E.; Sandmann-Keil, D.; Rüb, U.; Gai WP, R.A.I (2001). "Alpha-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower
Heiko_Braak
Topics referred to by the same term
Sistema Nacional de Creadores de Arte, Mexican culture organization Alpha-synuclein, a protein found in neural tissue, encoded by the SNCA gene Society
SNCA
Membrane-bound extracellular vesicles
neurodegenerative disorders, exosomes appear to play a role in the spread of alpha-synuclein, and are being actively investigated as a tool to both monitor disease
Exosome_(vesicle)
Process of introducing a phosphate group on to a protein
MG; Crowther, RA; Jakes, R; Hasegawa, M; Goedert, M (26 May 1998). "alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and
Protein_phosphorylation
Chemical compound
Martin; Biere, Anja-Leona (17 July 2023). "In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson's
Minzasolmin
Proteins which help tardigrades survive in extreme environments
(October 2003). "A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders". Journal
Tardigrade_specific_proteins
Cognitive decline
in the brain. (A Lewy body is an inclusion body as an aggregate of alpha-synuclein a presynaptic protein in neurons). Parkinson's disease dementia, and
Dementia
Medical disorder of a person's sleep patterns
disorders, particularly when characterized by the abnormal accumulation of alpha-synuclein, as seen in multiple system atrophy (MSA), Parkinson's disease (PD)
Sleep_disorder
Inflammation of nervous tissue
inflammatory response in the gut may play a role[citation needed] in alpha-synuclein (α-Syn) aggregation and misfolding, a characteristic of Parkinson's
Neuroinflammation
Disease caused by accumulation of crystals
following: Paraproteins Amyloid beta peptides Amylin Transthyretin Alpha-synuclein Prions Uromodulin ASC speck complex Myoglobin Heme Misfolded proteins
Crystallopathy
Protein without a fixed 3D structure
clear that IDPs are common among disease-related proteins, such as alpha-synuclein and tau. Proteins exist as an ensemble of similar structures with some
Intrinsically disordered proteins
Intrinsically_disordered_proteins
Experimental monoclonal antibody
aggregated forms of alpha-synuclein while sparing the physiological monomeric form. The antibody recognizes the C-terminus of α-synuclein and preferentially
Prasinezumab
American physician–scientist and immunologist
administered derivative of squalamine designed to displace aggregated alpha-synuclein in enteric neurons. Clinical trials have shown improvements in bowel
Michael_Zasloff
Physiological nature of sleep
diseases, mainly when they are characterized by abnormal accumulation of alpha-synuclein, such as multiple system atrophy (MSA), Parkinson's disease (PD) and
Neuroscience_of_sleep
American medical researcher (1946–2022)
proteins in neurodegenerative diseases: tau in Alzheimer's disease, alpha-synuclein in Parkinson's disease, and TDP-43 in Amyotrophic Lateral Sclerosis
John_Q._Trojanowski
Autophagic process in which mitochondria are delivered to the vacuole and degraded
Oliveira, CR; Cardoso, SM (2011). "Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD". Parkinson's Disease. 2011 693761. doi:10.4061/2011/693761
Mitophagy
Human disease-causing mutation
Another potential consequence is abnormal levels of tau proteins and alpha-synuclein, which play a role in conditions like Alzheimer's, Lewy body dementia
HFE_H63D_gene_mutation
Investigational Parkinson's disease drugs
[96] Alpha-synuclein aggregation inhibitor (ACI-5755; morphomer α-synuclein) – α-synuclein inhibitor [97] BEBT-758 – RNA interference and α-synuclein expression
List of investigational Parkinson's disease drugs
List_of_investigational_Parkinson's_disease_drugs
Protein-coding gene found in humans
2004). "DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation". PLoS Biology. 2 (11) e362. doi:10.1371/journal
DJ-1
Chemical compound
and lifespan in mouse models of Alzheimer's disease; reduction in alpha-synuclein aggregation and increase in healthspan and lifespan in a C.elegans
Trodusquemine
Protein found in humans
TDP43—is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FTLD-TDP, previously referred to
TAR_DNA-binding_protein_43
Protein-coding gene in the species Homo sapiens
Clayton DF, George JM (November 2001). "Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells". Brain Research. Molecular
Tubulin_alpha-1A_chain
ebolavirus glycoprotein Ebola virus disease Prasinezumab mab humanized Alpha-synuclein Parkinson's disease Prezalizumab mab humanized inducible T-cell co-stimulatory
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Danish healthcare company
tiered") Ordesekimab IL-15 Sanofi Gluten-free diet non-responsive Celiac disease II - Lu AF82422 Alpha-Synuclein Lundbeck Multiple system atrophy (MSA) II -
Genmab
Protein-coding gene in the species Homo sapiens
purified kallikrein were also performed on alpha-synuclein, and it was effective in degrading alpha-synuclein. Both the inhibition and successful in vitro
KLK6
Relative preservation of neurons
(help) Li W, Lee MK (June 2005). "Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3
Neuroprotection
Specialized technique for electron diffraction
GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56". doi:10.2210/pdb4znn/pdb. {{cite journal}}: Cite journal
Microcrystal electron diffraction
Microcrystal_electron_diffraction
Aggregation of misfolded proteins in cells
autophagic clearance from the cell. Some pathological proteins, such as alpha-synuclein, cannot be degraded and cause the aggresomes to form inclusion bodies
Aggresome
Protein kinase found in humans
GlobeNewswire. Retrieved 2026-05-22. Singleton AB (August 2005). "Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin"
LRRK2
Computational models of intrinsically-disordered proteins
M (December 2009). "Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements". Journal
Conformational_ensembles
US nonprofit organization
Parkinson's Foundation found evidence that Parkinson's requires the alpha-synuclein protein, a now well-known hallmark of the disease. In 2011, the Parkinson's
Parkinson's_Foundation
Tauopathies, as well as filaments of Amyloid beta from Alzheimer's disease, Alpha-synuclein from Multiple system atrophy and TMEM106B. Scheres has been a member
Sjors_Scheres
Endocrine disease of horses
Donaldson MT, Miller L, Cribb AE (February 2005). "Nitration and increased alpha-synuclein expression associated with dopaminergic neurodegeneration in equine
Pituitary pars intermedia dysfunction
Pituitary_pars_intermedia_dysfunction
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
Herrera SK, Johnson BE, Vaidya T, Shrestha R, Debburman SK (2006). "alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative
Proteasome
American neuroscientist
effects of the alpha-synuclein molecule on reward and punishment learning, and has shown parallels with those who have alpha-synuclein with unmedicated
Mark_A._Gluck
Protein-coding gene in the species Homo sapiens
impairing insulin. Phospholipase D1 has been shown to interact with: Alpha-synuclein, Amphiphysin, BIN1, CDC42, PEA15, Protein kinase N1 RALA, and RHOA
Phospholipase_D1
Subtype of Dopamine Receptor
as pramipexole and rotigotine show neuroprotective effects, reduce alpha-synuclein aggregation, and improve motor and non-motor symptoms. Neuropsychiatric
Dopamine_receptor_D3
Scientist, author and researcher
first Parkinson disease-causing mutation (PARK1) in the brain protein, alpha-synuclein. Lazzarini worked with the Italian Instituto de Scienze Neurologiche
Alice_Lazzarini
the brain by Lewy bodies—abnormal clumps inside neurons made up of alpha-synuclein (αSyn) protein fibrils. These Lewy bodies are believed to cause the
Mural_cell
Luxembourgish-British neuroscientist
that the intracellular filaments of these diseases are made of either alpha-synuclein or tau protein. Goedert's team identified mutations in MAPT, the tau
Michel_Goedert
Precursor microRNA family
PMID 20230785. Doxakis E (April 2010). "Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153". The Journal of Biological Chemistry
Mir-7_microRNA_precursor
Experimental NLRP3 inflammasome inhibitor for neurological conditions
models of Parkinson's disease, including neurotoxin-based, genetic, and alpha-synuclein aggregate models. Treatment with MCC950 improved motor function, reduced
Selnoflast
ALPHA SYNUCLEIN
ALPHA SYNUCLEIN
Girl/Female
English American
Healer.
Girl/Female
Indian
Loving
Boy/Male
Hindu
First letter of the greek alphabet
Girl/Female
Greek American
Firstbom.' The first letter of the Greek alphabet.
Girl/Female
Indian
Little
Male
African
(ox); the first letter of the Greek alphabet.
Boy/Male
African, Australian, Chinese, French, Latin, Swedish
First Letter of the Greek Alphabet; Leader
Girl/Female
Gujarati, Hindu, Indian, Jain, Kannada, Malayalam, Marathi, Oriya, Sanskrit, Tamil, Telugu
Little; Collection of Many Small Things
Girl/Female
Arabic
Respectable
Girl/Female
American, British, English, Greek
Healer; With Healing Power
Boy/Male
Tamil
First letter of the greek alphabet
Girl/Female
Tamil
Little
ALPHA SYNUCLEIN
ALPHA SYNUCLEIN
Girl/Female
Australian, British, English, Irish
Security; One who Guards
Boy/Male
Armenian
Farmer.
Girl/Female
Muslim
Oasis in northwest arabia
Boy/Male
Hindu, Indian
Brightness
Girl/Female
German
Famed; bright; shining.
Boy/Male
American, Australian, British, English, French, Greek, Irish, Latin
Son of Pierce; A Rock; Form of Piers from Peter
Male
English
Anglicized form of Hebrew Gemaryah, GEMARIAH means "God has accomplished." In the bible, this is the name of the son of Hilkiah who bore Jeremiah's letter to the captive Jews.Â
Girl/Female
English
Dearly loved.
Girl/Female
Greek
Wisdom.
Girl/Female
Indian
ALPHA SYNUCLEIN
ALPHA SYNUCLEIN
ALPHA SYNUCLEIN
ALPHA SYNUCLEIN
ALPHA SYNUCLEIN
n.
The last letter of the Greek alphabet. See Alpha.
a.
Implying privation or negation; giving a negative force to a word; as, alpha privative; privative particles; -- applied to such prefixes and suffixes as a- (Gr. /), un-, non-, -less.
n.
Alt. of Alpia
n.
A five-pointed star, resembling five alphas joined at their bases; -- used as a symbol.
n.
The first letter in the Greek alphabet, answering to A, and hence used to denote the beginning.
n.
A northern constellation, the Harp, containing a white star of the first magnitude, called Alpha Lyrae, or Vega.
n.
The seed of canary grass (Phalaris Canariensis), used for feeding cage birds.