AI & ChatGPT searches , social queries for TRK RECEPTOR
Search references for TRK RECEPTOR. Phrases containing TRK RECEPTOR
See searches and references containing TRK RECEPTOR!
Search references for TRK RECEPTOR. Phrases containing TRK RECEPTOR
See searches and references containing TRK RECEPTOR!TRK RECEPTOR
InterPro Family
Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system. Trk receptors affect neuronal
Trk_receptor
Protein found in humans
Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming
Tropomyosin_receptor_kinase_A
Protein found in humans
Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase
Tropomyosin_receptor_kinase_C
Protein and coding gene in humans
Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type
Tropomyosin_receptor_kinase_B
Topics referred to by the same term
Indonesia Potassium transport proteins (Trk), a constituent of the protein family bacterial potassium transporter Trk receptor, a family of tyrosine kinases that
Trk
Mammalian protein found in humans
TrkA receptor facilitates receptor dimerization and tyrosine residue phosphorylation of the cytoplasmic tail by adjacent Trk receptors. Trk receptor phosphorylation
Nerve_growth_factor
Protein found in humans
activates the TrkB tyrosine kinase receptor. BDNF acts on certain neurons of the central nervous system and the peripheral nervous system expressing TrkB, helping
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
TrkA and TrkB positive modulator
ACD856, or ACD-856, is a tropomyosin receptor kinase TrkA, TrkB, and TrkC positive allosteric modulator which is under development for the treatment of
ACD856
Class of kinase enzymes
Signaling by many receptors is dependent on nRTKs including T-cell receptors (TCR), B-cell receptors (BCR), IL-2 receptors (IL-2R), Ig receptors, erythropoietin
Non-receptor_tyrosine_kinase
Enzyme
factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), stem cell factor receptor, and colony-stimulating factor-1 receptor (Burstein
Tyrosine_kinase
Group of protein families
neurotrophic factor receptors are the p75 and the "Trk" families of tyrosine kinase receptors. p75 is a low affinity neurotrophin receptor, to which all neurotrophins
Neurotrophic_factor_receptor
Kinase that plays a role in B cell development
development as it is required for transmitting signals from the pre-B cell receptor that forms after successful immunoglobulin heavy chain rearrangement. It
Bruton's_tyrosine_kinase
Protein found in humans
stimulate, given its ability to activate two of the receptor tyrosine kinase neurotrophin receptors (TrkC and TrkB). Mice born without the ability to make NT-3
Neurotrophin-3
Human protein-coding gene
TrkA. p75NTR activation of NF-kB, which promotes survival, is unaffected by NGF binding to TrkA. p75NTR functions in a complex with Nogo-66 receptor (NgR1)
Low-affinity nerve growth factor receptor
Low-affinity_nerve_growth_factor_receptor
Family of intracellular tyrosine kinases
Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They
Janus_kinase
Protein-coding gene in the species Homo sapiens
most prominently known to be recruited upon antigen binding to the T cell receptor (TCR), and it plays a critical role in T cell signaling. ZAP-70 was initially
ZAP70
Human protein-coding gene on chromosome 9
(March 2000). "Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop". FEBS
Tyrosine-protein_kinase_ABL1
Class of enzymes
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90
Receptor_tyrosine_kinase
Protein-coding gene in the species Homo sapiens
Discoidin domain-containing receptor 2, also known as CD167b (cluster of differentiation 167b), is a protein that in humans is encoded by the DDR2 gene
Discoidin domain-containing receptor 2
Discoidin_domain-containing_receptor_2
Transmembrane protein
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Family of proteins
stimulate, given its ability to activate two of the receptor tyrosine kinase neurotrophin receptors (TrkC and TrkB). Mice born without the ability to make NT-3
Neurotrophin
Non-receptor tyrosine kinase and coding gene in humans
interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g
Janus_kinase_2
Protein found in humans
Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation
Colony stimulating factor 1 receptor
Colony_stimulating_factor_1_receptor
Protein with antiangiogenic properties
antiangiogenic properties. A non-membrane associated splice variant of VEGF receptor 1 (Flt-1), sFlt-1 binds the angiogenic factors VEGF (vascular endothelial
Soluble fms-like tyrosine kinase-1
Soluble_fms-like_tyrosine_kinase-1
Mammalian protein found in humans
Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated
HER2
Family of proteins that bind to fibroblast growth factors
The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of
Fibroblast growth factor receptor
Fibroblast_growth_factor_receptor
Protein found in humans
concentrations, for all of three Trk proteins (encoded by the three NTRK genes, respectively) as well as the ROS1, and ALK receptor tyrosine kinases. An open
Anaplastic_lymphoma_kinase
Mammalian protein found in Homo sapiens
Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Cell receptor protein found in humans
insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone
Insulin-like growth factor 1 receptor
Insulin-like_growth_factor_1_receptor
Cell surface receptors
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF)
Platelet-derived growth factor receptor
Platelet-derived_growth_factor_receptor
Mammalian protein and protein-coding gene
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation
KIT_gene
Human protein-coding gene
Platelet-derived growth factor receptor A, also termed CD140a, is a receptor located on the surface of a wide range of cell types. The protein is encoded
Platelet-derived growth factor receptor A
Platelet-derived_growth_factor_receptor_A
Gene involved in the most common form of dwarfism
Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster
Fibroblast growth factor receptor 3
Fibroblast_growth_factor_receptor_3
Group of peptide hormones in mammals
I to angiotensin II, and of angiotensin II receptor antagonists which block angiotensin II AT1 receptors. Angiotensin II results in increased inotropy
Angiotensin
Cell receptor found in humans
The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase
Insulin_receptor
Protein-coding gene in the species Homo sapiens
De Luca M (Nov 1993). "Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and
DDR1
Protein-coding gene in the species Homo sapiens
concentrations, for all of three Trk proteins (encoded by the three NTRK genes, respectively) as well as the ROS1, and ALK receptor tyrosine kinases. An open
ROS1
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene
Fibroblast growth factor receptor 2
Fibroblast_growth_factor_receptor_2
Protein found in humans
Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome
Fibroblast growth factor receptor 1
Fibroblast_growth_factor_receptor_1
Protein family
VEGF receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending
VEGF_receptor
Chemical compound
Trk receptor phosphorylation through a mechanism that requires the adenosine A2A receptor. Adenosine in the brain acts through three major receptor subtypes—A1
Adenosine
Mammalian protein found in humans
(cellular Src; pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. It belongs
Proto-oncogene tyrosine-protein kinase Src
Proto-oncogene_tyrosine-protein_kinase_Src
Mammalian protein
The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular
RET_proto-oncogene
Type of membrane receptor that acts through a second messenger
A metabotropic receptor, also referred to by the broader term G-protein-coupled receptor, is a type of membrane receptor that initiates a number of metabolic
Metabotropic_receptor
Protein-coding gene in the species Homo sapiens
Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental
EPH_receptor_B1
Family of proteins
family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member
ErbB
Protein-coding gene in humans
Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with
PDGFRB
Protein-coding gene in humans
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing
PTPN11
Enzyme
receptor and T-cell receptor. Syk plays a similar role in transmitting signals from a variety of cell surface receptors including CD74, Fc receptor,
Tyrosine-protein_kinase_SYK
Protein-tyrosine kinase family of enzymes
Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck
Src_family_kinase
Chemical compound
acting as a melatonin receptor agonist, an agonist of the TrkB, and having antioxidant effects. NAS binds to the melatonin receptors MT1, MT2, and MT3, and
N-Acetylserotonin
Enzyme and coding gene in humans
Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. TYK2 was the first member of the JAK family that was
Tyrosine_kinase_2
Protein-coding gene in the species Homo sapiens
domain receptor (KDR, a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR
Kinase_insert_domain_receptor
Protein-coding gene in humans
PDGFRA PDGFRB FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptor family VEGFR1 VEGFR2 VEGFR3 HGF receptor family MET RON Trk receptor family NTRK1 NTRK2
FGR_(gene)
Protein found in humans
Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is
ERBB3
American biomedical scientist (born 1959)
growth factor family. His group also cloned receptors for neurotrophic factors, such as TrkB, the receptor for BDNF, and showed that they were sufficient
George_Yancopoulos
Antipruritic drug
Nalfurafine (INN, USAN; brand name Remitch; former developmental code names TRK-820, AC-820, MT-9938) is an antipruritic (anti-itch drug) that is marketed
Nalfurafine
Protein-coding gene in the species Homo sapiens
1998). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. doi:10.1016/s0896-6273(00)80620-0
GRB2
Mammalian protein found in Homo sapiens
tyrosine kinases that are specifically associated with cytokine receptors. Since cytokine receptor proteins lack enzymatic activity, they are dependent upon
Janus_kinase_3
Human protein and coding gene
PDGFRA PDGFRB FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptor family VEGFR1 VEGFR2 VEGFR3 HGF receptor family MET RON Trk receptor family NTRK1 NTRK2
Tyrosine-protein kinase Fes/Fps
Tyrosine-protein_kinase_Fes/Fps
Investigational drug
Jiangsu Vcare Pharmatech for the treatment of solid tumors. It is a Trk receptor antagonist targeting specifically TRKA, TRKB and TRKC. It has been approved
Eratrectinib
Protein-coding gene in the species Homo sapiens
EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene. This gene belongs to the ephrin receptor subfamily
EPH_receptor_A1
Protein-coding gene in the species Homo sapiens
EPH receptor A4 (ephrin type-A receptor 4) is a protein that in humans is encoded by the EPHA4 gene. This gene belongs to the ephrin receptor subfamily
EPH_receptor_A4
Human gene
kinase is the name-giving member of the Tec kinase family, a family of non-receptor protein-tyrosine kinases. Tec kinase contains five protein interaction
TEC_(gene)
Protein-coding gene in humans
PTK2, PTPRT UNC119, RICS, SH2D1A, SKAP1, Syk, TNK2, TRPC6, Tau protein, TrkB, TYK2, TUBA3C, WAS, and ZAP-70, The Src family of kinases is commonly associated
FYN
Mammalian protein found in Homo sapiens
type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R
Janus_kinase_1
Protein-coding gene in the species Homo sapiens
phosphorylation negative regulation of glycolytic process neurotrophin TRK receptor signaling pathway negative regulation of intracellular signal transduction
DDIT4
Protein-coding gene in the species Homo sapiens
Angiopoietin-1 receptor is an angiopoietin receptor protein that in humans is encoded by the TEK gene. TEK is also known as TEK tyrosine kinase, TIE2 and
Angiopoietin-1_receptor
Protein-coding gene in the species Homo sapiens
product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor". The Biochemical Journal. 330 ( Pt 2) (Pt 2): 923–932. doi:10.1042/bj3300923
ABL2
Protein-coding gene in humans
has a role in motility and cell survival. FAK is a highly conserved, non-receptor tyrosine kinase originally identified as a substrate for the oncogene protein
PTK2
Protein-coding gene in the species Homo sapiens
EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5 gene. This gene belongs to the ephrin receptor subfamily
EPH_receptor_A5
Mammalian protein found in Homo sapiens
MuSK (for Muscle-Specific Kinase) is a receptor tyrosine kinase required for the formation and maintenance of the neuromuscular junction. It is activated
MuSK_protein
Medication
tyrosine-protein kinase ROS1 (ROS1) and of the tropomyosin receptor tyrosine kinases (TRKs) TRKA, TRKB, and TRKC. The most common adverse reactions include
Repotrectinib
Protein-coding gene in humans
encoded by the MERTK gene. This gene is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin
MERTK
Protein family
Eph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding
Ephrin_receptor
Protein-coding gene in the species Homo sapiens
in the vacuolar protein sorting 10 protein (Vps10p) family of sorting receptors. While it is ubiquitously expressed in many tissues, sortilin is most
Sortilin
Protein-coding gene in humans
Angiotensin II receptor type 2, also known as the AT2 receptor is a protein that in humans is encoded by the AGTR2 gene. Angiotensin II is a potent pressor
Angiotensin II receptor type 2
Angiotensin_II_receptor_type_2
Long projection on a neuron that conducts signals to other neurons
bind to Trk receptors. The ganglioside-converting enzyme plasma membrane ganglioside sialidase (PMGS), which is involved in the activation of TrkA at the
Axon
Protein-coding gene in the species Homo sapiens
Tyrosine-protein kinase receptor UFO is a protein that in human is encoded by the AXL gene. The gene was initially designated as UFO, in allusion to the
AXL_receptor_tyrosine_kinase
Protein-coding gene in the species Homo sapiens
Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental
EPH_receptor_B2
Protein-coding gene in humans
ADAM15 BCR gene, Cbl gene, ELMO1, Granulocyte colony-stimulating factor receptor, RAPGEF1, RAS p21 protein activator 1, and RASA3. GRCh38: Ensembl release
HCK
(1989). "Preliminary biochemical characterization of two angiotensin II receptor subtypes". Biochem. Biophys. Res. Commun. 163 (1): 284–91. doi:10
WASF1
Protein-coding gene in the species Homo sapiens
(Jan 2000). "Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade". Journal of Biological Chemistry. 275 (3):
ITK_(gene)
Protein-coding gene in humans
EPH receptor A2 (ephrin type-A receptor 2) is a protein that in humans is encoded by the EPHA2 gene. This gene belongs to the ephrin receptor subfamily
EPH_receptor_A2
Protein-coding gene in the species Homo sapiens
factor receptor 1 is a protein that in humans is encoded by the FLT1 gene. FLT1 is a member of VEGF receptor gene family. It encodes a receptor tyrosine
VEGFR1
Protein-coding gene in the species Homo sapiens
carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated
SPRY2
Protein found in humans
L, Corset V, Shin H, Bredesen DE, et al. (March 2001). "The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for
Caspase_3
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster
Fibroblast growth factor receptor 4
Fibroblast_growth_factor_receptor_4
Protein family
field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in regulating
Receptor tyrosine kinase-like orphan receptor
Receptor_tyrosine_kinase-like_orphan_receptor
Protein-coding gene in the species Homo sapiens
Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental
EPH_receptor_B4
Protein-coding gene in humans
increases in the intracellular calcium concentration , nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. In
PTK2B
Chemical compound
small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of the neurotrophin brain-derived neurotrophic
Tropoflavin
Class of proteins produced by muscle
their effects on neurons primarily through Trk receptor tyrosine kinases. Of these, BDNF and its receptor TrkB are most widely and abundantly expressed
Myokine
Lymphocyte protein
Src kinase family (SKF) and is important for the activation of T-cell receptor (TCR) signaling in both naive T cells and effector T cells. The role of
Tyrosin-protein_kinase_Lck
Protein-coding gene in the species Homo sapiens
It is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. NT-4 was first discovered and isolated from xenopus
Neurotrophin-4
Protein found in humans
FLT3 gene. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. CD135 is the receptor for the cytokine Flt3 ligand (FLT3L)
CD135
Protein-coding gene in the species Homo sapiens
colon carcinoma kinase 4 (CCK4) is a receptor tyrosine kinase that in humans is encoded by the PTK7 gene. Receptor protein tyrosine kinases transduce extracellular
PTK7
Protein-coding gene in the species Homo sapiens
EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the EPHA3 gene. This gene belongs to the ephrin receptor subfamily
EPH_receptor_A3
Spanish molecular biochemist (born 1949)
"Ras genes." (1987). "The TRK proto-oncogene encodes a receptor for nerve growth-factor." (1991). "trkC, a new member of the trk family of tyrosine protein-kinases
Mariano_Barbacid
Kinase enzyme that phosphorylates Src-family kinases
Src-family kinases (SFKs) including SRC, HCK, FYN, LCK, LYN and YES1. This Non-receptor tyrosine-protein kinase plays an important role in the regulation of cell
Tyrosine-protein_kinase_CSK
TRK RECEPTOR
TRK RECEPTOR
TRK RECEPTOR
TRK RECEPTOR
TRK RECEPTOR
TRK RECEPTOR
TRK RECEPTOR
TRK RECEPTOR
TRK RECEPTOR