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Protein-coding gene in humans
tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene. This gene is a member of the TYRO3/AXL/MER (TAM) receptor kinase family
MERTK
Topics referred to by the same term
an affix meaning "part", used in several words in chemistry and biology MERTK, MER, or proto-oncogene tyrosine-protein kinase MER, a human enzyme Membrane
Mer
Rat used for scientific research
many years, it was identified in the year 2000 as a mutation in the gene MERTK. This mutation results in defective retinal pigment epithelium phagocytosis
Laboratory_rat
Drug currently undergoing clinical studies
receptor tyrosine kinases, including VEGFR2, MET, and the TAM kinases AXL and MERTK. It could potentially be used to treat colorectal cancer and renal cell
Zanzalintinib
Protein-coding gene in the species Homo sapiens
tyrosine kinase, part of the TAM family of kinases including TYRO3 and MERTK. The Axl gene is evolutionarily conserved between vertebrate species. Human
AXL_receptor_tyrosine_kinase
Gradual retinal degeneration leading to progressive sight loss
PRCD Retinitis pigmentosa-36 611131 NR2E3 Retinitis pigmentosa-37 268000 MERTK Retinitis pigmentosa-38 268000 USH2A Retinitis pigmentosa-39 612095 PROM1
Retinitis_pigmentosa
Experimental cancer drug
MET and several other receptor tyrosine kinases such as MST1R, FLT3, AXL, MERTK, TEK, ROS1, NTRK1/2/3, and DDR1/2. Meristinib is part of a phase II clinical
Merestinib
Argentinian immunologist
that discovered the role of TAM receptor tyrosine kinases—Tyro3, Axl, and MerTk—in regulating inflammation. They found that these receptors inhibit Toll-like
Carla_V._Rothlin
CA4, HPRPF3, ABCA4, EYS, CERKL, FSCN2, TOPORS, SNRNP200, PRCD, NR2E3, MERTK, USH2A, PROM1, KLHL7, CNGB1, TTC8, ARL6, DHDDS, BEST1, LRAT, SPARA7, CRX
List_of_genetic_disorders
hyertonicity, starvation, and even space flight. Extracellular signaling receptor MERTK, expressed by cardiac-resident macrophages, is necessary for exopher clearance
Exopher
Retinitis pigmentosa-37; 611131; NR2E3 Retinitis pigmentosa-38; 268000; MERTK Retinitis pigmentosa-39; 268000; USH2A Retinitis pigmentosa-41; 612095;
List_of_OMIM_disorder_codes
Protein domain
LILRB5 LILRP2 LRIG1 LRIG2 LRIG3 LRIT1 LRRC4 LSAMP MAG MALT1 MCAM MDGA1 MDGA2 MERTK MFAP3 MIR MIR MXRA5 MYBPC3 MYOM1 MYOM3 NCA NCAM1 NCAM2 NEGR1 NEO1 NFASC
Immunoglobulin_domain
Protein domain
KALRN; L1CAM; LEPR; LIFR; LRFN2; LRFN3; LRFN4; LRFN5; LRIT1; LRRN1; LRRN3; MERTK; MID1; MID2; MPL; MYBPC1; MYBPC2; MYBPC3; MYBPH; MYBPHL; MYLK; MYOM1; MYOM2;
Fibronectin_type_III_domain
Enzyme
ITK; JAK1; JAK2; JAK3; KDR; KIT; KSR1; LCK; LMTK2; LMTK3; LTK; LYN; MATK; MERTK; MET; MLTK; MST1R; MUSK; NPR1; NTRK1; NTRK2; NTRK3; PDGFRA; PDGFRB; PKDCC;
Tyrosine_kinase
Protein-coding gene in the species Homo sapiens
Finnemann SC (2020). "Microglia Inhibition Delays Retinal Degeneration Due to MerTK Phagocytosis Receptor Deficiency". Frontiers in Immunology. 11: 1463. doi:10
Allograft inflammatory factor 1
Allograft_inflammatory_factor_1
Protein domain
MARK2 ; MARK3 ; MARK4 ; MAST1 ; MAST2 ; MAST3 ; MAST4 ; MASTL ; MATK ; MELK ; MERTK ; MET ; MINK1 ; MKNK1 ; MKNK2 ; MLKL ; MOK ; MOS ; MST1R ; MUSK ; MYLK ;
Protein_kinase_domain
Human gene coding for the GAS6 protein
proliferation. Gas6 has been shown to interact with AXL receptor tyrosine kinase, MerTK and TYRO3. The presence of Gla needs a vitamin K-dependent enzymatic reaction
GAS6
Skin macrophages used for wound repair and hair growth
macrophages is highlighted by the expression of cell markers such as CD64, MERTK and the downregulation of CCR2. Dermal macrophages can phagocytose and digest
Dermal_macrophage
Treatment for blindness
model shows that a recessive mutation in a receptor tyrosine kinase gene, mertk results in a premature stop codon and impaired phagocytosis function by
Gene therapy of the human retina
Gene_therapy_of_the_human_retina
Protein-coding gene in the species Homo sapiens
kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in
TNK2
efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway". Frontiers in Immunology. 15 1455771. doi:10.3389/fimmu
Ozone_and_biology
Protein-coding gene in humans
chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively". American Journal of Human Genetics. 70 (1): 224–229. doi:10
RPE65
Q16820 9465 MEPCE HGNC:20247; Q7L2J0 9466 MEPE HGNC:13361; Q9NQ76 9467 MERTK HGNC:7027; Q12866 9468 MESD HGNC:13520; Q14696 9469 MESP1 HGNC:29658; Q9BRJ9
List of human protein-coding genes 5
List_of_human_protein-coding_genes_5
RNA family
colonisation, through interaction with its target genes IGFBP2, PITPNC1, and MERTK. Increased expression of mir-126 inhibits cell proliferation of non-small
Mir-126
Protein that acts to slow or prevent metastases
primary tumor growth. miR-335 targets multiple pathways, including SOX4, MERTK, PTPRN2 and TNC, which contribute to metastasis-suppression. miR-335 expression
Metastasis_suppressor
MERTK
MERTK
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Girl/Female
Australian, French
Pear Tree
Boy/Male
Biblical
He.
Boy/Male
Muslim
Strong, Majesty, Dignity, Awe
Girl/Female
Hindu
Wise, A learned person, Knowledgeable person
Boy/Male
Indian
Unique, No one like him, Non duality
Boy/Male
Arabic, Assamese, Bengali, Celebrity, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Mythological, Punjabi, Sanskrit, Sikh, Tamil, Telugu, Traditional
Sun; Fit; Proper; Tawny; Green; Wind; Fire; The Moon; The One Belonging to God; Good Lover; Lord Siva; Lord Indra; God Narayanan; Lord Vishnu; Lord Krishna; Almighty; Pain Remover
Surname or Lastname
French
French : from a Germanic personal name, Warinhari, composed of the elements war(in) ‘guard’ + hari, heri ‘army’.English : variant of Garner 1.This name was also brought to America by the Huguenots.
Girl/Female
American, Arabic, Australian, Chinese, Christian, German, Greek, Latin
Nobility; Similar to Alice
Biblical
one who answers; afflicted
Boy/Male
Gaelic Irish
Rocky headland.
MERTK
MERTK
MERTK
MERTK
MERTK