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Pharmacological phenomenon
Reverse tolerance or drug sensitization is a pharmacological phenomenon describing subjects' increased reaction (positive or negative) to a drug following
Reverse_tolerance
Reduced reaction to a drug following repeated use
not incompatible and tolerance may sometimes lead to reverse tolerance. For example, heavy drinkers initially develop tolerance to alcohol (requiring
Drug_tolerance
Bodily responses to the functional effects of ethanol within alcoholic beverages
dependence. Heavy alcohol consumption over a period of years can lead to "reverse tolerance". A liver can be damaged by chronic alcohol use, leading to a buildup
Alcohol_tolerance
Medical condition caused by drug dependence
exposure to a stimulus (e.g., drug intake) drug sensitization or reverse tolerance – the escalating effect of a drug resulting from repeated administration
Drug_withdrawal
Process of extracting design information from anything artificial
the reverse engineering of a cylinder head, which includes freeform cast features, such as water jackets and high-tolerance machined areas. Reverse engineering
Reverse_engineering
Non-associative learning process
procedures than those who were given anesthesia. Drug sensitization (or reverse tolerance) occurs in substance use disorder, and is defined as an increased
Sensitization
Harmful repetitive gambling
exposure to a stimulus (e.g., drug intake) drug sensitization or reverse tolerance – the escalating effect of a drug resulting from repeated administration
Problem_gambling
Form of behavioral dependence involving emotional symptoms
feedback mechanism that involves neuronal-counter adaptation, leading to tolerance to the desirable effects of certain drugs or stimuli and a subsequent
Psychological_dependence
Physical condition caused by chronic use of a tolerance-forming drug
Physical dependence is a physical condition caused by chronic use of a tolerance-forming drug, in which abrupt or gradual drug withdrawal causes unpleasant
Physical_dependence
Continual use of drugs despite negative consequences
taking opiates as prescribed, they may experience physiologic effects of tolerance and withdrawal, but this would not cause an individual to meet criteria
Substance_use_disorder
Punishment policy with no discretion for leniency
A zero-tolerance policy is one which imposes a punishment for every infraction of a stated rule. Zero-tolerance policies forbid people in positions of
Zero_tolerance
State of unresponsiveness of the immune system
Immune tolerance, also known as immunological tolerance or immunotolerance, is the immune system's state of unresponsiveness to substances or tissues that
Immune_tolerance
Resilience of systems to component failures or errors
Fault tolerance is the ability of a system to contain the propagation of faults (e.g. failed transistor, shorted connector, intermittent data bus). Faults
Fault_tolerance
Medical condition
defines a situation in which one has developed one or more of either tolerance, withdrawal symptoms, drug seeking behaviors, such as continued use despite
Benzodiazepine_dependence
Cognitive process
amplified, the user may want the drug more and more while liking it less as tolerance develops to the drug's pleasurable effects. Amphetamine improves task
Motivational_salience
Need for a drug, whose discontinuation results in withdrawal symptoms
single diagnosis of substance use disorders. This was done because "the tolerance and withdrawal that previously defined dependence are actually very normal
Substance_dependence
Drugs used to achieve relief from pain
origin. Dextromethorphan has been noted to slow the development of and reverse tolerance to opioids, as well as to exert additional analgesia by acting upon
Analgesic
Discomfort following alcohol consumption
Association between Alcohol Hangover Frequency and Severity: Evidence for Reverse Tolerance?". Journal of Clinical Medicine. 8 (10): 1520. doi:10.3390/jcm8101520
Hangover
Proposed compulsive sexual disorder
effects, reward deficiency syndrome, withdrawal syndrome with cessation, tolerance, or enhanced late positive potentials." Аs well as evidence of a key neurobiological
Sexual_addiction
Medical condition
of the following criteria must be manifest during a 12-month period: Tolerance Withdrawal symptoms or clinically defined alcohol withdrawal syndrome
Alcohol_dependence
Compulsive engagement of excessive physical exercise despite negative consequences
harmful. A desire to experience euphoria; exercise may be increased as tolerance of the euphoric state increases. Not participating in physical activity
Exercise_addiction
Topics referred to by the same term
within the microstructure of an alloy Drug sensitization, also called Reverse tolerance "Sensitized", a song by Kylie Minogue from X Sensitivity (disambiguation)
Sensitization (disambiguation)
Sensitization_(disambiguation)
Benzodiazepine analog drug
benzodiazepine binding sites (tolerance/dependence), while etizolam caused an increase in alpha-2 benzodiazepine binding sites (reverse tolerance to anti-anxiety effects)
Etizolam
Consequence affecting an organism's future behavior
down-regulation due to continual drug stimulation, producing 'liking' tolerance. Incentive-sensitization would produce addiction, by selectively magnifying
Reinforcement
Chemical substance that alters brain function
to dependence or long-term neural adaptations such as sensitization or tolerance. Addiction and dependence involve psychological and physical reliance
Psychoactive_drug
Generalized alphabetical order
trailing "0" digit. When negative numbers are also considered, one has to reverse the order for comparing negative numbers. This is not usually a problem
Lexicographic_order
Continued use of cannabis despite clinically significant impairment
emotion and addiction severity. Cannabis users can develop tolerance to the effects of THC. Tolerance to the behavioral and psychological effects of THC has
Cannabis_use_disorder
Atypical opioid drug
less analgesic tolerance. Moreover, substitution of conventional opioids like morphine with SR-17018 can reverse analgesic tolerance and suppress withdrawal
SR-17018
Predisease state of hyperglycemia
be diagnosed by measuring hemoglobin A1c, fasting glucose, or glucose tolerance test. Many people may be diagnosed through routine screening tests. The
Prediabetes
Rewarding and reinforcing behaviours
exposure to a stimulus (e.g., drug intake) drug sensitization or reverse tolerance – the escalating effect of a drug resulting from repeated administration
Addictive_behavior
2024 Indian film by Shankar
Indian 2: Zero Tolerance is a 2024 Indian Tamil-language vigilante action film directed by Shankar, who co-wrote the script with B. Jeyamohan, Kabilan
Indian_2
Addiction to playing video games
attempting to cut down or stop gaming, or when you are unable to play? Tolerance. Do you feel the need to play for increasing amounts of time, play more
Video_game_addiction
Protein
cocaine continues to increase ΔFosB levels with no apparent ceiling of tolerance.[citation needed] Elevated levels of ΔFosB leads to increases in brain-derived
FOSB
Dormant, persistent state of a bacterial population
dormancy or quiescence. Persister cells in their dormancy do not divide. The tolerance shown in persister cells differs from antimicrobial resistance in that
Persister_cells
Range of genetic and environmental risk factors for developing an addiction
Cannabinoid Type 1 Receptors in Dopamine D2 Receptor Knockout Mice Is Reversed by Chronic Forced Ethanol Consumption". Alcoholism: Clinical and Experimental
Addiction_vulnerability
Medical condition
stimulates the up-regulation and reverses the uncoupling of benzodiazepine receptors to the GABAA receptor, thereby reversing tolerance and reducing withdrawal
Benzodiazepine withdrawal syndrome
Benzodiazepine_withdrawal_syndrome
Discrimination against members of a dominant or majority group
Reverse discrimination based on race or ethnicity is also called reverse racism. Philosopher Richard Arneson argues that while a program of reverse discrimination
Reverse_discrimination
Integral of drug concentration in blood plasma over time
Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves" purports to have independently discovered
Area under the curve (pharmacokinetics)
Area_under_the_curve_(pharmacokinetics)
Restrictions on the psychoactive plant
kappa Opioid receptors and is noted for its reverse tolerance. As such, using Salvia divinorum decreases tolerance to salvinorin A and makes dysphoria more
Legal status of Salvia divinorum in the United States
Legal_status_of_Salvia_divinorum_in_the_United_States
2017–2018 U.S. border policy
parents or guardians. The policy was presented to the public as a "zero tolerance" approach, intended to encourage tougher legislation and discourage unauthorized
Trump administration family separation policy
Trump_administration_family_separation_policy
Laboratory technique to multiply an RNA sample for study
Reverse transcription polymerase chain reaction (RT-PCR) is a laboratory technique combining reverse transcription of RNA into DNA (in this context called
Reverse transcription polymerase chain reaction
Reverse_transcription_polymerase_chain_reaction
Inability to perform physical exercise at normal levels
elevated blood levels of creatine kinase. Exercise tolerance is significantly compromised. Exercise tolerance reflects the combined capacity of components in
Exercise_intolerance
Drug discovery by identifying protein targets
In the field of drug discovery, reverse pharmacology also known as target-based drug discovery (TDD), a hypothesis is first made that modulation of the
Reverse_pharmacology
Half maximal inhibitory concentration
and examining the effect of different concentrations of antagonist on reversing agonist activity. IC50 values can be calculated for a given antagonist
IC50
School policy
A zero-tolerance policy in schools is a policy of strict enforcement of school rules against behaviors or the possession of items deemed undesirable.
Zero-tolerance policies in schools
Zero-tolerance_policies_in_schools
Microbiological method for identification
radiating from the test organism near the S. aureus indicates positivity The reverse CAMP test is a method to identify Clostridium perfringens using β-hemolytic
CAMP_test
Season of television series
finale, which includes elements from the crossover event "Operation: Zero Tolerance" (1997). The final episodes see the X-Men split into two teams, Blue and
X-Men_'97_season_1
Theoretical drug measure in pharmacology
Chemotherapy Lists of drugs WHO list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple
Volume_of_distribution
Removing the protective cover of an integrated circuit
epoxy packages. Delidding may also be done to test the chip for radiation-tolerance with a heavy-ion beam or in an effort to reduce the operating temperatures
Decapping
Ability to digest milk after infancy
Lactase persistence or lactose tolerance is the continued activity of the lactase enzyme in adulthood, allowing the digestion of lactose in milk. In most
Lactase_persistence
Breakdown of red blood cells
and Listeria monocytogenes. A modified version of this test called the reverse CAMP test, utilizing S. agalactiae instead of S. aureus, can also be used
Hemolysis_(microbiology)
Font style with cursive typeface and slanted design
10 February 2017. Truss, Lynne (2004), Eats, Shoots & Leaves: The Zero Tolerance Approach to Punctuation, New York: Gotham Books, p. 146, ISBN 978-1-59240-087-4
Italic_type
Autotomated microbiology analyzer
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
VITEK
Class of CNS depressant drugs
and effective drugs in the short term for a wide range of conditions. Tolerance can develop to their effects and there is also a risk of dependence, and
Benzodiazepine
Stain used for diagnosis of malaria
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Giemsa_stain
Backward recording technique
records, reversed". In the movie Gold Diggers of 1935, the end of the dancing-pianos musical number, "The Words Are in My Heart," is filmed in reverse motion
Backmasking
Biochemical analysis procedure
Chemotherapy Lists of drugs WHO list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple
Ligand_binding_assay
Typographic character indicating a question (?)
chapter), pp. 3–7. Truss, Lynne (2003). Eats, Shoots & Leaves: The Zero Tolerance Approach to Punctuation. London: Profile Books. ISBN 1861976127. Wikimedia
Question_mark
System for classifying streptococci bacteria
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Lancefield_grouping
Method of vehicle parking
distance, then followed by reversing into that space. Subsequent position adjustment may require the use of forward and reverse gears. Parallel parking is
Parallel_parking
Political party
Research Institute, agrees. All these findings about Republican voters' tolerance for violence and conspiracy theories, he says, present "a chilling portrait
Republican Party (United States)
Republican_Party_(United_States)
Concentration of chemical that stops bacterial growth
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Minimum inhibitory concentration
Minimum_inhibitory_concentration
Absence of disease-causing microorganisms
strict isolation vs. reverse isolation. Strict isolation quarantines patients to prevent them from infecting others, while reverse isolation prevents vulnerable
Asepsis
Bacteriological technique
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Ziehl–Neelsen_stain
Drug discovery by phenotypic screening
animals to see if they have the desired effect. This approach is known as "reverse pharmacology" or "target based drug discovery" (TDD). However, recent statistical
Classical_pharmacology
Test for syphilis
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Rapid_plasma_reagin
Deuterium-substituted isotopologue of caffeine
as caffeine. d9-Caffeine was non-genotoxic in both the Ames’s bacterial reverse mutation assay and mammalian cell micronucleus assay. In a human clinical
D9-Caffeine
Scale for turbidity measurement
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
McFarland_standards
Contract bridge bidding convention
the bid major and 4 in an as yet undisclosed minor suit. If he has a tolerance for the major suit, the advancer passes. Otherwise, he bids 2NT, inviting
Cappelletti_convention
Free online crowdsourced encyclopedia
harboring a battleground culture of sexism and harassment. The perceived tolerance of abusive language was a reason put forth in 2013 for the gender gap
Wikipedia
Parker November 13, 2002 (2002-11-13) 613 2.80 93 14 "The Death Camp of Tolerance" Trey Parker Trey Parker November 20, 2002 (2002-11-20) 614 2.23 94 15
List_of_South_Park_episodes
Passive electronic component providing electrical resistance
magnitude. The nominal value of the resistance falls within the manufacturing tolerance, indicated on the component. Two typical schematic diagram symbols are
Resistor
Smallest value Indian banknote
Standard weight and remedy allowed.—The standard paper weight and remedy (tolerance) allowed in printing of One Rupee Currency Notes shall be as specified
Indian_1-rupee_note
Type of white blood cell
distinct population of T cells that provide the critical mechanism of tolerance, whereby immune cells are able to distinguish invading cells from "self
T_cell
Computer-aided tomographic process
generation of CAD data. The CAD data can be used for reverse engineering, geometric dimensioning and tolerance analysis, and production part approval. One of
Industrial computed tomography
Industrial_computed_tomography
American boxer and activist (1942–2016)
lack of explicit racism, the lack of crime on the streets, and Soviet tolerance of religion, especially Islam. In early 1980, Ali was recruited by President
Muhammad_Ali
Examination of microbial colonies
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Colonial_morphology
Gynecologic test
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Vaginal_wet_mount
Criminological theory
"zero-tolerance" policing style, including in some academic studies. Bratton and Kelling have said that broken windows policing and zero tolerance are different
Broken_windows_theory
World's first 8-speed automatic from 2006
previous unit. With new micro-laser technology gear tooth production tolerances have been reduced by 50%. Aluminum has also replaced steel on gear tooth
Aisin–Toyota 8-speed automatic transmission
Aisin–Toyota_8-speed_automatic_transmission
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Sulphide Indole Motility medium
Sulphide_Indole_Motility_medium
Chemical compound
Wiesenfeld-Hallin Z (December 1994). "The CCK-B receptor antagonist Cl 988 reverses tolerance to morphine in rats". NeuroReport. 5 (18): 2565–8. doi:10
CI-988
CAD software
rendering, data Interoperability, routed systems design, simulation, tolerance analysis, numerical control (NC) and tooling design. Creo Parametric can
Creo_Parametric
Benzodiazepine used for anesthesia and procedural sedation
a decrease in efforts to breathe, low blood pressure, and sleepiness. Tolerance to its effects and withdrawal syndrome may occur following long-term use
Midazolam
President of the United States (2017–2021; since 2025)
Richard (June 19, 2018). "What We Know: Family Separation And 'Zero Tolerance' At The Border". NPR News. Retrieved May 30, 2020. Epstein, Jennifer (June
Donald_Trump
Color space
Larson, "Performance testing of color difference metrics using a color-tolerance dataset". Color Research and Application, 21:174–188 (1989). Schanda,
CIELUV
Cereal grain and staple food
backcrossed to IR56 with the aim of preserving the genes responsible for salt tolerance that were inherited from O. coarctata. Rice is sensitive to temperatures
Rice
Type of capacitor
each tolerance is specified in IEC 60062. rated capacitance, series E3, tolerance ±20%, letter code "M" rated capacitance, series E6, tolerance ±20%,
Electrolytic_capacitor
Investigative procedure in microbiology
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Gram_stain
Laboratory technique to identify viruses
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Viral_culture
of North Island electorates were outside the permitted ±5% population tolerance, necessitating extensive boundary changes across Auckland, Wellington
2026 New Zealand general election
2026_New_Zealand_general_election
Russian Old Ritualist religious dissenters
century, under Catherine the Great, Old Believers gained nearly complete tolerance, and large urban centers emerged, the members of which had a leading role
Old_Believers
Proposed tax reform
In economics, a negative income tax (NIT) is a system which reverses the direction in which tax is paid for incomes below a certain level; in other words
Negative_income_tax
Graph representation in quantum mechanics
widely used for quantum circuit verification, optimization and fault-tolerance constructions. The same graphical rules apply to many network topologies;
Tensor_network
Notion that species can revert to primitive forms
possible for small changes (such as in the frequency of a single gene) to be reversed by chance or selection, but this is no different from the normal course
Devolution_(biology)
Persuasion technique
and in the 1960s, when US President John F. Kennedy caused U.S. Steel to reverse its decision to increase prices by sharply criticizing the company. Moral
Moral_suasion
Test for strep throat
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Rapid_strep_test
White supremacist ideology
social collapse is inevitable, typically because of perceived flaws of tolerance, secularity and multiculturalism in liberal democracies, and, in its violent
Militant_accelerationism
Medical test of heart capacity
an exercise stress test may provide more information about exercise tolerance than a pharmacologic stress test. Commonly used agents include: Vasodilators
Cardiac_stress_test
Class of bacterial proteins
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Coagulase
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REVERSE TOLERANCE
REVERSE TOLERANCE
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REVERSE TOLERANCE
REVERSE TOLERANCE
REVERSE TOLERANCE
REVERSE TOLERANCE
REVERSE TOLERANCE
REVERSE TOLERANCE
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