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Gene that has the potential to cause cancer
An oncogene is a gene that has the potential to cause cancer. In tumor cells, these genes are often mutated, or expressed at high levels. Most normal cells
Oncogene
Dependence of tumor cells on a single oncogenic pathway or protein
Oncogene addiction is a process in which cancers with genetic, epigenetic, or chromosomal irregularities become dependent on one or several genes for maintenance
Oncogene_addiction
Academic journal
Oncogene is a peer-reviewed scientific journal published by the Nature Portfolio addressing cancer cell genetics and the structure and function of oncogenes
Oncogene_(journal)
Protein-coding gene in the species Homo sapiens
N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene
N-Myc
Protein created by joining other proteins into a single polypeptide
produce a functional fusion protein. Many important cancer-promoting oncogenes are fusion genes produced in this way. Examples include: Gag-onc fusion
Fusion_protein
Mammalian protein
The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular
RET_proto-oncogene
Spanish molecular biochemist (born 1949)
October 1949) is a Spanish molecular biochemist who discovered the first oncogene HRAS. Barbacid was born in Madrid, Spain on 4 October 1949. He completed
Mariano_Barbacid
Gene that inhibits tumorigenic phenotype
A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. When a tumor suppressor gene is
Tumor_suppressor_gene
Protein-coding gene in the species Homo sapiens
Transcription factor Maf, also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog, is a transcription factor that in
MAF_(gene)
Viruses that can cause cancer
into the host cell or to enhance already existing oncogenic genes (proto-oncogenes) in the genome. For example, it has been shown that vFLIP and vCyclin
Oncovirus
Protein-coding gene in humans
KRAS (Kirsten rat sarcoma virus oncogene homologue) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway
KRAS
Protein family
RAP1A, member of RAS oncogene family Identifiers Symbol RAP1A NCBI gene 5906 HGNC 9855 OMIM 179520 RefSeq NM_002884 UniProt P62834 Other data Locus Chr
Rap1
Set of three serine threonine-specific protein kinases
positive regulator of cell migration. Akt1 was originally identified as the oncogene in the transforming retrovirus, AKT8. Akt2 is an important signaling molecule
Protein_kinase_B
Tpr-Met fusion protein is an oncogene fusion protein consisting of TPR and MET. Tpr-Met was generated following a chromosomal rearrangement induced by
Tpr-met_fusion_protein
Protein
protein that in humans is encoded by the FBJ murine osteosarcoma viral oncogene homolog B (FOSB) gene. The FOS gene family consists of four members: FOS
FOSB
Mammalian protein and protein-coding gene
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation
KIT_gene
Uterine cancer that is located in tissues lining the uterus
associated with a good prognosis, particularly in obese women. The Her2/neu oncogene, which indicates a poor prognosis, is expressed in 20% of endometrioid
Endometrial_cancer
Electric current produced in living cells
(2013). "Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells". Oncogene. 32 (37): 4366–4376. doi:10.1038/onc.2012.471. PMC 3910169
Developmental_bioelectricity
Human protein-coding gene on chromosome 9
regions that enable binding to the actin cytoskeleton. The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been
Tyrosine-protein_kinase_ABL1
Protein-coding gene in the species Homo sapiens
Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene. This proto-oncogene, highly expressed in a variety
ROS1
Human protein and coding gene
known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene. FES was originally cloned as a retroviral oncogene from feline
Tyrosine-protein kinase Fes/Fps
Tyrosine-protein_kinase_Fes/Fps
GTP-binding proteins functioning on cell-cycle regulation
three Ras genes in humans (HRAS, KRAS, and NRAS) are the most common oncogenes in human cancer; mutations that permanently activate Ras are found in
Ras_GTPase
Family of regulator genes
Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc
Myc
Protein-coding gene in the species Homo sapiens
RAB44, member RAS oncogene family is a protein that in humans is encoded by the RAB44 gene. GRCh38: Ensembl release 89: ENSG00000255587 – Ensembl, May
RAB44
Mammalian protein found in Homo sapiens
Protein c-Fos is a proto-oncogene and transcription factor that plays an important role in cellular function and human disease including cancer. It is
Protein_c-Fos
Mammalian protein found in Homo sapiens
is a gene that functions as a regulator of cellular growth and a proto oncogene. Zbtb7 is a member of the POK (POZ and Krüppel) family of genes, and the
Zbtb7
Protein-coding gene in the species Homo sapiens
expression and alternative splicing of the human c-ets-1 proto-oncogene". Oncogene Research. 3 (3): 239–46. PMID 3060801. Lincoln DW, Bove K (Jan 2005)
ETS1
Mammalian protein found in Homo sapiens
RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded
C-Raf
German-American molecular biologist (1936–2026)
cause AIDS. Duesberg received acclaim early in his career for research on oncogenes and cancer. With Peter K. Vogt, he reported in 1970 that a cancer-causing
Peter_Duesberg
Protein-coding gene in the species Homo sapiens
The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors
REL
Protein-coding gene in humans
called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is more formally known
BRAF_(gene)
Protein found in humans
cause cancer. But simultaneous over-expression of Bcl-2 and the proto-oncogene myc may produce aggressive B-cell malignancies including lymphoma. In follicular
Bcl-2
Formation of cancer
events per tumor, of which 0.6 are point mutations in oncogenes, 1.5 are amplifications of oncogenes, 1.2 are point mutations in tumor suppressors, 2.1 are
Carcinogenesis
Protein-coding gene in the species Homo sapiens
humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia
Thrombopoietin_receptor
Transmembrane protein
myocardial fibrosis, chronic kidney disease). The identification of EGFR as an oncogene has led to the development of anticancer therapeutics directed against
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Mammalian protein found in humans
Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc", as it is short for sarcoma)
Proto-oncogene tyrosine-protein kinase Src
Proto-oncogene_tyrosine-protein_kinase_Src
Protein found in humans
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene. The CRK protein participates in the Reelin
Adapter_molecule_crk
Human protein and coding gene
Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene. The protein encoded by this proto-oncogene is a member of the Dbl family of
VAV1
Enzyme
This growth factor receptor is called c-kit and is produced by a proto-oncogene (c-kit). Mutation of c-kit causes the constitutive activity of tyrosine
Tyrosine_kinase
Protein-coding gene in the species Homo sapiens
MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA, MAS, MGRA), is a protein that in humans is encoded by the MAS1 gene. The
MAS1
Mammalian protein found in Homo sapiens
the MET gene are associated with papillary renal carcinoma. MET proto-oncogene (GeneID: 4233) has a total length of 125,982 bp, and it is located in the
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Protein-coding gene in the species Homo sapiens
MYB proto-oncogene like 1 is a protein that in humans is encoded by the MYBL1 gene. GRCh38: Ensembl release 89: ENSG00000185697 – Ensembl, May 2017 GRCm38:
MYB_proto-oncogene_like_1
Protein-coding gene in humans
GTPase HRas, also known as the "Harvey Rat sarcoma viral oncogene homolog" and transforming protein p21, is an enzyme that is encoded by the HRAS gene
HRAS
Protein-coding gene in humans
ERG (ETS-related gene) is an oncogene. ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. The ERG gene
ERG_(gene)
Protein-coding gene in the species Homo sapiens
found in animals, plants, and fungi. In humans, it includes Myb proto-oncogene like 1 and Myb-related protein B in addition to MYB proper. Members of
MYB_(gene)
Signaling glycoprotein regulating cell proliferation
to specificity of downstream signaling. It has been shown that the sis oncogene is derived from the PDGF B-chain gene. PDGF-BB is the highest-affinity
Platelet-derived growth factor
Platelet-derived_growth_factor
Protein-coding gene in the species Homo sapiens
"The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors". Oncogene. 5 (5): 663–668. PMID 1693183. Oikawa T,
SPI1
Protein-coding gene in the species Homo sapiens
Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene. Pim-1 is a proto-oncogene which encodes
PIM1
Protein-coding gene in humans
PMID 17986575. S2CID 44532648. "Entrez Gene: ETS2 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)". Chen Y, Ying Y, Wang M, Ma C, Jia M, Shi L, et al.
ETS2
Protein-coding gene in the species Homo sapiens
(Mar 1995). "Localization of the human HER4/erbB-4 gene to chromosome 2". Oncogene. 10 (6): 1235–7. PMID 7700649. Sardi SP, Murtie J, Koirala S, Patten BA
ERBB4
Protein-coding gene in humans
INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene. FGF-3 is a member of the fibroblast growth factor
FGF3
Class of enzymes
the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor gene PTEN, is implicated in the sensitivity
Phosphoinositide_3-kinase
Protein found in humans
part of the insulin signal transduction pathway. This gene is a putative oncogene encoding a protein belonging to the AKT subfamily of serine/threonine kinases
AKT2
Enzyme found in humans
proteins. It was named furin because it was in the upstream region of an oncogene known as FES. The gene was known as FUR (FES Upstream Region) and therefore
Furin
Protein-coding gene in humans
its initial identification in human neuroblastoma cells. The N-ras proto-oncogene is a member of the Ras gene family. It is mapped on chromosome 1, and it
Neuroblastoma RAS viral oncogene homolog
Neuroblastoma_RAS_viral_oncogene_homolog
Protein-coding gene in humans
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene. This gene is
FGR_(gene)
Chimeric cancer-related protein
antigen ('gag') gene and that of an oncogene ('onc'), a gene that plays a role in the development of a cancer. The oncogene can originate from the host or
Gag-onc_fusion_protein
Protein-coding gene in humans
Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene. This gene is a member of the TYRO3/AXL/MER (TAM) receptor
MERTK
Protein-coding gene in the species Homo sapiens
a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene. Fli-1 is a member of the ETS transcription factor family that was first
FLI1
Protein-coding gene in the species Homo sapiens
"Isolation and chromosomal localization of CRKL, a human crk-like gene". Oncogene. 8 (9): 2469–74. PMID 8361759. Senechal K, Halpern J, Sawyers CL (September
CRKL
Mammalian protein found in humans
is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein
HER2
American geneticist
for work on the regulation of gene expression in the Ras subfamily of oncogenes supervised by Robert Weinberg based in the MIT Department of Biology.
Clifford_Tabin
Birth defect in which the intestine lacks certain nerves
associated with Hirschsprung's disease[citation needed] The RET proto-oncogene accounts for the highest proportion of both familial and sporadic cases
Hirschsprung's_disease
Group of diseases involving cell growth
transformation can occur through the formation of novel oncogenes, the inappropriate over-expression of normal oncogenes, or by the under-expression or disabling of
Cancer
Protein-coding gene in the species Homo sapiens
RAB30, member RAS oncogene family is a protein that in humans is encoded by the RAB30 gene. GRCh38: Ensembl release 89: ENSG00000137502 – Ensembl, May
RAB30
Semen discharge from the male reproductive tract
ejaculatory response, researchers have studied the expression of c-Fos, a proto-oncogene expressed in neurons in response to stimulation by hormones and neurotransmitters
Ejaculation
Protein-coding gene in the species Homo sapiens
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene. MYCL1 is a bHLH (basic helix-loop-helix) transcription factor
MYCL
Protein-coding gene in the humans
Proto-oncogene DBL is a protein that in humans is encoded by the MCF2 gene. The commonly used name DBL is derived from “diffuse B-cell lymphoma”, the cancer
MCF2
Protein-coding gene in humans
Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from
GLI1
Biological process
hypermethylation is associated with promoters and can arise secondary to gene (oncogene suppressor) silencing, but might be a target for epigenetic therapy. In
DNA_methylation
Protein-coding gene in animals
WNT1 is a gene that encodes the WNT1 protein. It is a proto-oncogene involved in regulating embryonic development and is highly conserved among animals
WNT1
Protein-coding gene in the species Homo sapiens
BOC Identifiers Aliases BOC, CDON2, BOC cell adhesion associated, oncogene regulated, Boi External IDs OMIM: 608708; MGI: 2151153; HomoloGene: 32819; GeneCards:
BOC_(gene)
Central nervous system stimulant
that produce these alterations are Delta FBJ murine osteosarcoma viral oncogene homolog B (ΔFosB), cAMP response element binding protein (CREB), and nuclear
Amphetamine
Experimental cancer drug
inhibitor of the G12C mutant form of Kirsten rat sarcoma virus (KRAS), an oncogene commonly present in several forms of cancer. It is in early stage clinical
Divarasib
Private research university in Cambridge, Massachusetts, United States
Researchers". That number places MIT eighth among the world's universities. Oncogene – Robert Weinberg discovered genetic basis of human cancer. Reverse transcription –
Massachusetts Institute of Technology
Massachusetts_Institute_of_Technology
Protein domain
CBL proto-oncogene N-terminal domain 1 (four-helix bundle) structure of the n-terminal domain of cbl in complex with its binding site in zap-70 Identifiers
Cbl_TKB_domain
Chemical compound
c-Met is recognized as an oncogene. This is unsurprising since oncogenesis requires multiple mutations including both oncogene induction and tumor suppressor
Dihexa
Mammalian protein found in humans
ultraviolet or ionizing radiation), osmotic shock, ribonucleotide depletion, oncogene activation, and some viral infections. Activation involves stabilization
P53
Topics referred to by the same term
National Rental Affordability Scheme in Australia Neuroblastoma RAS viral oncogene homolog encoded by the NRAS gene NRA (disambiguation) This disambiguation
NRAS
Human protein
murine leukemia virus integration site 1). BMI1 is a polycomb ring finger oncogene. The BMI-1 gene is 10.04 kb with 10 exon and is highly conserved sequence
BMI1
oncogenes carried by retroviruses and oncogene cooperation in leukemia formation. In the late 70s Graf co-discovered several cell-derived oncogenes acquired
Thomas_Graf_(biologist)
Protein-coding gene in humans
Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded by the FYN gene. Fyn is a
FYN
Protein found in humans
gene. This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src
Tyrosine-protein_kinase_Yes
Protein family
RAB27A, member RAS oncogene family Identifiers Symbol RAB27A NCBI gene 5873 HGNC 9766 OMIM 603868 RefSeq NM_004580 UniProt P51159 Other data Locus Chr
RAB27
Protein found in humans
extensive homology to EGF receptor shares chromosomal location with neu oncogene". Science. 230 (4730): 1132–1139. Bibcode:1985Sci...230.1132C. doi:10.1126/science
ERBB3
uncontrolled growth in abnormal host cells. It was the first retroviral oncogene to be discovered. The src gene was taken up by RSV and incorporated into
V-Src
Protein-coding gene in the species Homo sapiens
proto-oncogene in that it can fuse with other genes to drive the development and/or progression of certain cancers. However, ETV6 is also an anti-oncogene or
ETV6
Protein-coding gene in the species Homo sapiens
REST corepressor 2 also known as CoREST2 is a protein that in humans is encoded by the RCOR2 gene. CoREST2 acts as a transcriptional corepressor protein
RCOR2
British biochemist
University College London for doctoral research, where she studied the oncogene. She then moved to the University of British Columbia, where she worked
Melanie_Welham
ALK inhibitor for treatment of non-small-cell lung cancer
neoplasms. It also acts as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor. Crizotinib is indicated for the treatment of metastatic non-small
Crizotinib
high-risk patients. Amplification occurs within a protein called the MYCN oncogene. This protein is amplified in approximately 20% of primary neuroblastoma
Targeted molecular therapy for neuroblastoma
Targeted_molecular_therapy_for_neuroblastoma
cancer-causing virus, the Kirsten Rat Sarcoma Virus, and consequently of the KRAS oncogene. Werner H. Kirsten was born in Leipzig in 1925. He attended the Universität
Werner_H._Kirsten
Cancer of the colon or rectum
into the nucleus, binds to DNA, and activates the transcription of proto-oncogenes. These genes are normally important for stem cell renewal and differentiation
Colorectal_cancer
Israeli-American cancer research scientist
his career he developed a sensitive PCR approach to detect mutant Ras oncogene in normal appearing tissues. Later on, his studies provided the foundation
Ze'ev_Ronai
Type of small GTPase
include: RAP1A, RAP1B RAP2A, RAP2B, RAP2C RAB5C "RAP1A RAP1A, member of RAS oncogene family". Entrez Gene. United States National Library of Medicine. Rousseau-Merck
Rap_GTP-binding_protein
Protein-coding gene in the species Homo sapiens
MYC proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the Myc family of transcription
MYC
are related to retroviral oncogenes. The mouse sarcoma virus 3611, a Gammaretrovirus, contains an RAF kinase-related oncogene that enhances fibrosarcoma
RAF_kinase
Protein-coding gene in the species Homo sapiens
of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45". Oncogene. 18 (18): 2892–900. doi:10.1038/sj.onc.1202667. PMID 10362260. S2CID 13112302
GADD45A
Negative regulation (or limiting) of body weight and cell proliferation
time of H19 replication. Evidence for the identification of H19 as an oncogene: Overexpression of H19 appears to be important in the development of esophageal
H19_(gene)
Cancer of plasma cells
of zeste homolog 2 (EZH 2) is an oncogene that influences myeloma cell growth and the mutant ras phenotype". Oncogene. 24 (41): 6269–6280. doi:10.1038/sj
Multiple_myeloma
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