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Human protein
p14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus). p14ARF
P14arf
Protein-coding gene in humans
for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. Both act as tumor suppressors by regulating the cell cycle. p16 inhibits
CDKN2A
Mammalian protein found in humans
phosphorylate p53 at Ser15. Oncogene-induced activation of p53 can also occur via p14ARF (ARF), which inhibits the p53 antagonist MDM2 and thereby stabilizes p53
P53
Medical condition
of the p14ARF tumor suppressor to block cell growth so it is commonly mutated or inhibited in cancer cells. The AML1-ETO is incapable of p14ARF transcription
Acute myeloblastic leukemia with maturation
Acute_myeloblastic_leukemia_with_maturation
Mammalian protein found in humans
Gupta SD, Ralhan R (April 2007). "Promoter hypermethylation of p16INK4A, p14ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients"
P16
Phenomenon
cellular pathways, such as DNA repair (hMLH1, for example), cell cycle (p14ARF), apoptosis (DAPK), and cell adherence (CDH1, CDH13), are inactivated by
CpG_island_hypermethylation
Protein-coding gene in humans
p53-stabilizing signals. This loop can be interfered with by kinases and genes like p14arf when p53 activation signals, including DNA damage, are high. The full-length
Mdm2
Cancer associated with asbestos
suppressor genes:[citation needed] Neurofibromatosis type 2 at 22q12 P16INK4A P14ARF Asbestos has also been shown to mediate the entry of foreign DNA into target
Mesothelioma
Mammalian protein found in Homo sapiens
tumor suppressor. More specifically, P14ARF is a protein in which in humans is modulated by the PANO1 gene. P14ARF is known to function as a tumor suppressor
PANO1
Biological process
8 9 10 11A 11B 12 13 14 CDK-activating kinase CDK inhibitor INK4a/ARF (p14arf/p16, p15, p18, p19) cip/kip (p21, p27, p57) P53 p63 p73 family p53 p63 p73
Cell_division
Events leading to cell division
p16INK4a, which binds to CDK4 and arrests the cell cycle in G1 phase, and p14ARF which prevents p53 degradation. Synthetic inhibitors of Cdc25 could also
Cell_cycle
Topics referred to by the same term
Resonance Filter or atomic line filter Auxin Response Factors in plants p14arf or ARF tumor suppressor Arf (Nanoha), character in Magical Girl Lyrical
ARF
Phenomenon characterized by the cessation of cell division
are two primary tumor suppressor pathways known to mediate senescence: p14arf/p53 and INK4A/RB. More specifically p16INK4a-pRb tumor suppressor and p53
Cellular_senescence
Protein-coding gene in the species Homo sapiens
Woodruff S, Becker TM, Rooney RJ, Kefford RF (February 2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition"
E4F1
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List_of_MeSH_codes_(D12.776)
Protein-coding gene in humans
Hackenbroch M, Boström J, et al. (December 2001). "Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progression"
CDKN2B
Cancer originating in lymph nodes
that is involved in activating T-cells), CDKN2A (encoding p16INK4a and p14arf tumor suppressor proteins) or CDKN2B (encoding cyclin dependent kinase inhibitor
Follicular_lymphoma
Protein-coding gene in the species Homo sapiens
Digiovanna JJ, et al. (September 2013). "Chimeric negative regulation of p14ARF and TBX1 by a t(9;22) translocation associated with melanoma, deafness,
TBX1
Protein-coding gene in the species Homo sapiens
using the knockout model of Tbx2 for study of tumorigenesis is limited. p14ARF/MDM2/p35/p21CIP1 Pathway. When up-regulated, Tbx2 inhibits p21CIP1. p21CIP1
TBX2
Field of study
this includes the promoters of the genes CDKN2/p16, RB, PTEN, TP53 and p14ARF. Importantly, glioblastomas are known to have high frequency of methylation
Neuroepigenetics
Medical condition
melanoma may also be caused by germline mutations in the MC1R, MITF, and P14arf genes in addition to increased copy number gains in 8q24. Research findings
Amelanotic_melanoma
Protein-coding gene in the species Homo sapiens
cancer context, TBX3 directly represses the cell cycle regulators p19ARF/p14ARF, p21WAF1 and TBX2 as well as E-cadherin which encodes a cell adhesion molecule
TBX3
Protein-coding gene in the species Homo sapiens
cancer cell line growth and is involved in down-regulating the expression of p14ARF and p53". FEBS Lett. 586 (9): 1356–62. Bibcode:2012FEBSL.586.1356S. doi:10
Piwi like rna-mediated gene silencing 4
Piwi_like_rna-mediated_gene_silencing_4
Protein-coding gene in humans
protein should not be confused with p19-ARF (mouse) or the human equivalent p14ARF, which are alternative products of the CDKN2A gene. GRCh38: Ensembl release
CDKN2D
Protein-coding gene in humans
PMID 16354571. S2CID 24253878. Gjerset RA (September 2006). "DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer". Journal of Molecular Histology. 37
NPM1
Protein-coding gene in humans
Korshunov A, Golanov A (2002). "Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade
CDKN2C
Mammalian protein found in humans
PMID 18254724. S2CID 13038944. Ivanchuk SM, Mondal S, Rutka JT (June 2008). "p14ARF interacts with DAXX: effects on HDM2 and p53". Cell Cycle. 7 (12): 1836–50
Ubiquitin_C
Protein-coding gene in the species Homo sapiens
(2002). "CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53". J. Biol. Chem. 277 (40): 37765–70. doi:10.1074/jbc
ALS2CR8
Protein-coding gene in the species Homo sapiens
et al. (April 2013). "Modulation of p53 C-terminal acetylation by mdm2, p14ARF, and cytoplasmic SirT2". Molecular Cancer Therapeutics. 12 (4): 471–480
Sirtuin_2
Protein-coding gene in the species Homo sapiens
polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas". Clinical Cancer
PCGF2
Substance or process that is indicative of the presence of cancer in the body
cancer; abnormal methylation of tumor suppressor genes p16, CDKN2B, and p14ARF for brain cancer; hypermethylation of MYOD1, CDH1, and CDH13 for cervical
Cancer_biomarker
up-regulation of p73 (TP73), a homolog of p53, and deletion of the p53 pathway gene p14arf/p16/INK4A (CDKN2A) have also been found in pediatric ependymomas. Over-expression
Pediatric_ependymoma
Precursor microRNA family
of c-myc, cyclins D3 and E2, and cyclin-dependent kinases CDK4 and CDK6. p14ARF and p21CIPI CDK inhibitor expression are conversely enhanced, mediated chiefly
Mir-26 microRNA precursor family
Mir-26_microRNA_precursor_family
P14ARF
P14ARF
P14ARF
P14ARF
Female
German
Variant spelling of German Anneliese, ANNALIESA means "favor; grace" and "God is my oath."
Female
English
Elaborated form of English Donalda, DONALDINA means "world ruler."
Boy/Male
Tamil
Winter
Girl/Female
Indian
Elevated, Exalted, The empowered, The honored, The strengthener
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Tamil
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Male
German
Low German form of Latin Stephanus, STEFFEN means "crown."
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Greek American Latin English Italian Shakespearean
Priceless.
Female
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Vietnamese name THI means "poem."
Girl/Female
Tamil
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Beloved daughter
Boy/Male
Hindu
God of Sathi, Lord Shiva, Kind
P14ARF
P14ARF
P14ARF
P14ARF
P14ARF