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AKT2

  • AKT2
  • Protein found in humans

    AKT2, also known as RAC-beta serine/threonine-protein kinase, is an enzyme that in humans is encoded by the AKT2 gene. It influences metabolite storage

    AKT2

    AKT2

    AKT2

  • Protein kinase B
  • Set of three serine threonine-specific protein kinases

    isoforms of protein kinase B. These three genes are referred to as AKT1, AKT2, and AKT3 and encode the RAC alpha, beta, and gamma serine/threonine protein

    Protein kinase B

    Protein kinase B

    Protein_kinase_B

  • Arctic fox
  • Species of fox

    murine thymoma viral oncogene homolog 2 (AKT2). GLTPD1 is involved in the fatty acid metabolism, while AKT2 pertains to the glucose metabolism and insulin

    Arctic fox

    Arctic fox

    Arctic_fox

  • MTOR
  • Mammalian protein found in humans

    spontaneous apoptosis (AKT1), severe diabetes (AKT2), small brains (AKT3), and growth deficiency (AKT1/AKT2). Mice heterozygous for AKT1 have increased lifespan

    MTOR

    MTOR

    MTOR

  • PHLPP
  • Class of enzymes

    PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP may

    PHLPP

    PHLPP

  • Familial partial lipodystrophy
  • Medical condition

    associated with FPL have been reported in LMNA (lamin A/C), PPARG (PPARγ), AKT2 (AKT serine/threonine kinase 2), PLIN1 (perilipin-1), and CIDEC (cell-death-inducing

    Familial partial lipodystrophy

    Familial_partial_lipodystrophy

  • MK-2206
  • Chemical compound

    selective inhibitor of pan-Akt, namely, of all three Akt isoforms Akt1, Akt2, and Akt3. It is intended to be used with other cancer therapies that advanced

    MK-2206

    MK-2206

    MK-2206

  • AKT1
  • Protein-coding gene in humans

    serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid

    AKT1

    AKT1

    AKT1

  • Titin
  • Largest known protein in human muscles

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Titin

    Titin

    Titin

  • AKT (disambiguation)
  • Topics referred to by the same term

    Finnish music organization Karat (airline) (ICAO: AKT), in Russia AKT1, AKT2, or AKT3, enzymes Erich Akt (1898–?), German politician Akolet language (ISO

    AKT (disambiguation)

    AKT_(disambiguation)

  • Ovarian cancer
  • Cancer originating in or on the ovary

    subtypes Gene mutated Mutation type Subtype Prevalence AKT1 amplification 3% AKT2 amplification/mutation 6%, 20% ARID1A point mutation endometrioid and clear-cell

    Ovarian cancer

    Ovarian cancer

    Ovarian_cancer

  • AMP-activated protein kinase
  • Class of enzymes

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    AMP-activated protein kinase

    AMP-activated protein kinase

    AMP-activated_protein_kinase

  • GSK484
  • Pharmaceutical compound

    marrow neutrophils up-regulates macrophage osteoclastogenesis via cGAS-STING/AKT2 pathway to promote osteoporosis". Experimental Cell Research. 446 (2) 114477

    GSK484

    GSK484

    GSK484

  • P38 mitogen-activated protein kinases
  • Protein family

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    P38 mitogen-activated protein kinases

    P38_mitogen-activated_protein_kinases

  • TCL1 MTCP1 protein domain
  • Protein domain

    membrane potential. This protein exists as a homodimer. It interacts with AKT1, AKT2 and AKT3 via the PH protein domain. It interacts with PNPT1; the interaction

    TCL1 MTCP1 protein domain

    TCL1 MTCP1 protein domain

    TCL1_MTCP1_protein_domain

  • NLK
  • Mammalian protein found in Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    NLK

    NLK

    NLK

  • Akt/PKB signaling pathway
  • Series of biochemical reactions

    doi:10.1038/ncb839. PMID 12172553. S2CID 11880801. Chin YR, Toker A (2010). "Akt2 regulates expression of the actin-bundling protein palladin". FEBS Lett.

    Akt/PKB signaling pathway

    Akt/PKB_signaling_pathway

  • PI3K/AKT/mTOR pathway
  • Cell cycle regulation pathway

    integral signaling node of the PAM pathway. There are three Akt isozymes, Akt1, Akt2 and Akt3. Small-molecule inhibitors of Akt1 could be especially useful to

    PI3K/AKT/mTOR pathway

    PI3K/AKT/mTOR pathway

    PI3K/AKT/mTOR_pathway

  • Protein kinase domain
  • Protein domain

    ABL1 ; ABL2 ; ACVR1 ; ACVR1B ; ACVR1C ; ACVR2A ; ACVR2B ; ACVRL1 ; AKT1 ; AKT2 ; AKT3 ; ALK ; AMHR2 ; ANKK1 ; ARAF ; AURKA ; AURKB ; AURKC ; AXL ; BLK ;

    Protein kinase domain

    Protein kinase domain

    Protein_kinase_domain

  • Mitogen-activated protein kinase
  • P38 mitogen-activated protein kinases

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Mitogen-activated protein kinase

    Mitogen-activated_protein_kinase

  • Fox Chase Cancer Center
  • Cancer treatment and research institution in the US

    Philip Tsichlis, Alfonso Bellacosa, and Joseph Testa clone the AKT1 and AKT2 genes - the first viral oncogenes described that inhibit programmed cell

    Fox Chase Cancer Center

    Fox_Chase_Cancer_Center

  • Protein kinase N1
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Protein kinase N1

    Protein kinase N1

    Protein_kinase_N1

  • Cell division cycle 7-related protein kinase
  • Protein found in humans

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Cell division cycle 7-related protein kinase

    Cell division cycle 7-related protein kinase

    Cell_division_cycle_7-related_protein_kinase

  • TTK (gene)
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    TTK (gene)

    TTK (gene)

    TTK_(gene)

  • Anti-Müllerian hormone type-2 receptor
  • Protein receptor for anti-Müllerian hormone

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Anti-Müllerian hormone type-2 receptor

    Anti-Müllerian hormone type-2 receptor

    Anti-Müllerian_hormone_type-2_receptor

  • TBC1D4
  • Protein-coding gene in the species Homo sapiens

    discovered in a screen for novel substrates of the serine-threonine kinase Akt2, which phosphorylates AS160 at Thr-642 and Ser-588 after insulin stimulation

    TBC1D4

    TBC1D4

    TBC1D4

  • IRAK4
  • Protein-coding gene in humans

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    IRAK4

    IRAK4

    IRAK4

  • IDH3A
  • Protein-coding gene in humans

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    IDH3A

    IDH3A

    IDH3A

  • MAP2K3
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    MAP2K3

    MAP2K3

    MAP2K3

  • P70-S6 Kinase 1
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    P70-S6 Kinase 1

    P70-S6 Kinase 1

    P70-S6_Kinase_1

  • BMPR1B
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    BMPR1B

    BMPR1B

    BMPR1B

  • MAP3K3
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    MAP3K3

    MAP3K3

    MAP3K3

  • CHUK
  • Protein-coding gene in humans

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    CHUK

    CHUK

    CHUK

  • Pleckstrin homology domain
  • Clinical Significance

    ABR, ADAP2, ADRBK1, ADRBK2, AFAP, AFAP1, AFAP1L1, AFAP1L2, AKAP13, AKT1, AKT2, AKT3, ANLN, APBB1IP, APPL1, APPL2, ARHGAP10, ARHGAP12, ARHGAP15, ARHGAP21

    Pleckstrin homology domain

    Pleckstrin homology domain

    Pleckstrin_homology_domain

  • KSR1
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    KSR1

    KSR1

    KSR1

  • Fusion gene
  • Gene formed by the combination of two independent genes

    are found from hematological cancers, sarcomas, and prostate cancer. BCAM-AKT2 is a fusion gene that is specific and unique to high-grade serous ovarian

    Fusion gene

    Fusion gene

    Fusion_gene

  • SIK1
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    SIK1

    SIK1

    SIK1

  • GRK4
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    GRK4

    GRK4

    GRK4

  • PLK4
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    PLK4

    PLK4

    PLK4

  • MTORC1
  • Protein complex

    mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes". Molecular Endocrinology

    MTORC1

    MTORC1

    MTORC1

  • CUX1
  • Animal gene

    PI3K–AKT signaling pathway by insulin-like growth factor 1 (IGF1) or by AKT2 overexpression led to the upregulation of CUX1 and was associated with resistance

    CUX1

    CUX1

  • PANTHER
  • workflow using an example of a small gene list containing three genes AKT1, AKT2, AKT3. We first type these gene names within the box and separate them by

    PANTHER

    PANTHER

  • Low-density-lipoprotein receptor kinase
  • Kinase enzyme involved in cholesterol homeostasis

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Low-density-lipoprotein receptor kinase

    Low-density-lipoprotein_receptor_kinase

  • Primary testicular diffuse large B-cell lymphoma
  • Medical condition

    stimulation of cellular proliferation and survival. 3) the genes for AKT1, AKT2, and PIK3CB, any one of which can lead to overactivation of the PI3K/AKT/mTOR

    Primary testicular diffuse large B-cell lymphoma

    Primary_testicular_diffuse_large_B-cell_lymphoma

  • RPS6KB2
  • Enzyme

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    RPS6KB2

    RPS6KB2

    RPS6KB2

  • Wee1
  • Nuclear protein

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Wee1

    Wee1

    Wee1

  • Protein kinase A
  • Family of enzymes

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Protein kinase A

    Protein kinase A

    Protein_kinase_A

  • List of human protein-coding genes 1
  • HGNC:24056; Q8NHP1 532 AKT1 HGNC:391; P31749 533 AKT1S1 HGNC:28426; Q96B36 534 AKT2 HGNC:392; P31751 535 AKT3 HGNC:393; Q9Y243 536 AKTIP HGNC:16710; Q9H8T0 537

    List of human protein-coding genes 1

    List_of_human_protein-coding_genes_1

  • Gene duplication
  • Duplication of a gene sequence within a genome

    cancer CCND1 13% Neuroblastoma MYCN 20–25% Ovarian cancer MYC 20–30% ERBB2 15–30% AKT2 12% Sarcoma MDM2 10–30% CDK4 10% Small cell lung cancer MYC 15–20%

    Gene duplication

    Gene_duplication

  • Phosphatidylinositol 3-kinase-related kinase
  • Protein family

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Phosphatidylinositol 3-kinase-related kinase

    Phosphatidylinositol_3-kinase-related_kinase

  • Glucokinase
  • Enzyme participating to the regulation of carbohydrate metabolism

    6-bisphosphate (F2,6P 2) also stimulates GK transcription, it seems by way of Akt2 rather than SREBP1c. It is not known whether this effect is one of the downstream

    Glucokinase

    Glucokinase

    Glucokinase

  • Protein kinase C
  • Family of enzymes

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Protein kinase C

    Protein_kinase_C

  • BRAF (gene)
  • Protein-coding gene in humans

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    BRAF (gene)

    BRAF (gene)

    BRAF_(gene)

  • MTOR inhibitors
  • Class of pharmaceutical drugs

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    MTOR inhibitors

    MTOR inhibitors

    MTOR_inhibitors

  • MAP3K13
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    MAP3K13

    MAP3K13

    MAP3K13

  • SH3RF1
  • Protein-coding gene in the species Homo sapiens

    of a functional signaling module. SH3RF1 has been shown to interact with AKT2 and MAP3K11. GRCh38: Ensembl release 89: ENSG00000154447 – Ensembl, May 2017

    SH3RF1

    SH3RF1

    SH3RF1

  • ACVR1
  • Protein-coding gene

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    ACVR1

    ACVR1

    ACVR1

  • Aurora inhibitor
  • Putative drug class for treating cancer

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Aurora inhibitor

    Aurora inhibitor

    Aurora_inhibitor

  • Serine/threonine-specific protein kinase
  • Class of protein kinase enzymes

    human akt genes exist. All three Akt kinases regulate cell proliferation and Akt2 is particularly important for insulin actions in cells. A major target of

    Serine/threonine-specific protein kinase

    Serine/threonine-specific protein kinase

    Serine/threonine-specific_protein_kinase

  • Myosin light-chain kinase
  • Class of kinase enzymes

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Myosin light-chain kinase

    Myosin light-chain kinase

    Myosin_light-chain_kinase

  • Rho-associated protein kinase
  • Protein family

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Rho-associated protein kinase

    Rho-associated protein kinase

    Rho-associated_protein_kinase

  • C-Jun N-terminal kinases
  • Chemical compounds

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    C-Jun N-terminal kinases

    C-Jun N-terminal kinases

    C-Jun_N-terminal_kinases

  • Protein kinase C zeta type
  • Mammalian protein found in Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Protein kinase C zeta type

    Protein kinase C zeta type

    Protein_kinase_C_zeta_type

  • MAP3K12
  • Enzyme

    M006528200. PMID 10922377. Figueroa C, Tarras S, Taylor J, Vojtek AB (2004). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J.

    MAP3K12

    MAP3K12

    MAP3K12

  • IKBKG
  • Protein-coding gene in humans

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    IKBKG

    IKBKG

    IKBKG

  • Extracellular signal-regulated kinases
  • Class of enzymes

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Extracellular signal-regulated kinases

    Extracellular_signal-regulated_kinases

  • Marisa Bartolomei
  • American cell biologist

    and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)". Science. 292 (5522): 1728–1731. doi:10.1126/SCIENCE.292.5522

    Marisa Bartolomei

    Marisa_Bartolomei

  • MAP3K11
  • Protein-coding gene in humans

    PMID 10490659. Figueroa C, Tarras S, Taylor J, Vojtek AB (November 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J.

    MAP3K11

    MAP3K11

    MAP3K11

  • APPL1
  • Protein-coding gene in the species Homo sapiens

    endosomes. APPL1 has been shown to interact with Deleted in Colorectal Cancer, AKT2, but also Rab5, Rab21, OCRL and almost 30 other proteins. GRCh38: Ensembl

    APPL1

    APPL1

    APPL1

  • PKMYT1
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    PKMYT1

    PKMYT1

    PKMYT1

  • SMG1
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    SMG1

    SMG1

    SMG1

  • MTORC2
  • Protein complex

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    MTORC2

    MTORC2

  • CHEK2
  • Protein-coding gene in humans

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    CHEK2

    CHEK2

    CHEK2

  • Cyclin-dependent kinase
  • Class of enzymes

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Cyclin-dependent kinase

    Cyclin-dependent kinase

    Cyclin-dependent_kinase

  • Myotonin-protein kinase
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Myotonin-protein kinase

    Myotonin-protein kinase

    Myotonin-protein_kinase

  • Cyclin-dependent kinase 4
  • Human protein

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Cyclin-dependent kinase 4

    Cyclin-dependent kinase 4

    Cyclin-dependent_kinase_4

  • VRK2
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    VRK2

    VRK2

    VRK2

  • TCL1A
  • Protein-coding gene in the species Homo sapiens

    encoded by the TCL1A gene. TCL1A has been shown to interact with AKT1 and AKT2. GRCh38: Ensembl release 89: ENSG00000100721 – Ensembl, May 2017 GRCm38:

    TCL1A

    TCL1A

    TCL1A

  • Cyclin-dependent kinase 7
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Cyclin-dependent kinase 7

    Cyclin-dependent kinase 7

    Cyclin-dependent_kinase_7

  • MAP kinase kinase kinase
  • Class of enzymes

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    MAP kinase kinase kinase

    MAP_kinase_kinase_kinase

  • Fabiola Terzi
  • Italian-French scientist and physician

    fr. Retrieved 2021-05-15. Canaud, Guillaume; et al. (October 2013). "AKT2 is essential to maintain podocyte viability and function during chronic kidney

    Fabiola Terzi

    Fabiola_Terzi

  • DNA-PKcs
  • Protein found in humans

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    DNA-PKcs

    DNA-PKcs

    DNA-PKcs

  • SAFit2
  • Chemical compound

    Pöhlmann ML, et al. (November 2017). "Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function". Nature Communications. 8 (1) 1725

    SAFit2

    SAFit2

    SAFit2

  • MAPK1
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    MAPK1

    MAPK1

    MAPK1

  • LIN28B
  • Protein-coding gene in the species Homo sapiens

    "RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells". Signal Transduction and Targeted

    LIN28B

    LIN28B

    LIN28B

  • Protein kinase R
  • Human protein and coding gene

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Protein kinase R

    Protein kinase R

    Protein_kinase_R

  • Ataxia telangiectasia and Rad3 related
  • Protein kinase that detects DNA damage and halts cell division

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Ataxia telangiectasia and Rad3 related

    Ataxia telangiectasia and Rad3 related

    Ataxia_telangiectasia_and_Rad3_related

  • PIK3R4
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    PIK3R4

    PIK3R4

    PIK3R4

  • Mitogen-activated protein kinase kinase
  • Kinase enzyme

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Mitogen-activated protein kinase kinase

    Mitogen-activated_protein_kinase_kinase

  • IkappaB kinase
  • Class of enzymes

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    IkappaB kinase

    IkappaB_kinase

  • AKT3
  • Protein-coding gene in humans

    PK, Aoki M (2001). "Oncogenic transformation induced by membrane-targeted Akt2 and Akt3". Oncogene. 20 (32): 4419–23. doi:10.1038/sj.onc.1204486. PMID 11466625

    AKT3

    AKT3

    AKT3

  • Phosphoinositide-dependent kinase-1
  • Protein-coding gene in the species Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Phosphoinositide-dependent kinase-1

    Phosphoinositide-dependent kinase-1

    Phosphoinositide-dependent_kinase-1

  • RAF kinase
  • LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    RAF kinase

    RAF kinase

    RAF_kinase

  • (Pyruvate, phosphate dikinase) kinase
  • Class of enzymes

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    (Pyruvate, phosphate dikinase) kinase

    (Pyruvate,_phosphate_dikinase)_kinase

  • Ribosomal s6 kinase
  • Family of protein kinases

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Ribosomal s6 kinase

    Ribosomal s6 kinase

    Ribosomal_s6_kinase

  • Ca2+/calmodulin-dependent protein kinase II
  • Class of enzymes

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Ca2+/calmodulin-dependent protein kinase II

    Ca2+/calmodulin-dependent protein kinase II

    Ca2+/calmodulin-dependent_protein_kinase_II

  • MAP3K10
  • Protein-coding gene in the species Homo sapiens

    M204626200. PMID 12105200. Figueroa C, Tarras S, Taylor J, Vojtek AB (2004). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J.

    MAP3K10

    MAP3K10

    MAP3K10

  • GSK-3
  • Class of enzymes

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    GSK-3

    GSK-3

    GSK-3

  • CGMP-dependent protein kinase
  • Protein kinase

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    CGMP-dependent protein kinase

    CGMP-dependent protein kinase

    CGMP-dependent_protein_kinase

  • Cyclin-dependent kinase 1
  • Mammalian protein found in Homo sapiens

    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4

    Cyclin-dependent kinase 1

    Cyclin-dependent kinase 1

    Cyclin-dependent_kinase_1

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