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Catecholamine hormone and neurotransmitter
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and
Norepinephrine
Class of antidepressant medication
Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant medications used to treat major depressive disorder (MDD), anxiety disorders
Serotonin–norepinephrine reuptake inhibitor
Serotonin–norepinephrine_reuptake_inhibitor
Drug that inhibits the reuptake of norepinephrine and dopamine
A norepinephrine–dopamine reuptake inhibitor (NDRI) is a type of drug that inhibits the reuptake of the monoamine neurotransmitters norepinephrine and
Norepinephrine–dopamine reuptake inhibitor
Norepinephrine–dopamine_reuptake_inhibitor
Medications that increase norepinephrine
A norepinephrine reuptake inhibitor (NRI), also known as a noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor, is a type of drug that acts
Norepinephrine reuptake inhibitor
Norepinephrine_reuptake_inhibitor
Protein-coding gene in the species Homo sapiens
The norepinephrine transporter, or more precisely sodium-dependent norepinephrine transporter (NET), also known as noradrenaline transporter, or more
Norepinephrine_transporter
Therapeutic use of norepinephrine
Norepinephrine, also known as noradrenaline and sold under the brand name Levophed among others, is a medication used to treat people with very low blood
Norepinephrine_(medication)
Class of drugs
A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI or TUI), is a type of drug that acts as
Serotonin–norepinephrine–dopamine reuptake inhibitor
Serotonin–norepinephrine–dopamine_reuptake_inhibitor
Chemical substance that enables neurotransmission
neurotransmitters include glutamate, GABA, acetylcholine, glycine, dopamine and norepinephrine. Neurotransmitters are generally synthesized in neurons and are made
Neurotransmitter
Class of chemical compounds
epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine. Release of the hormones epinephrine and norepinephrine from the adrenal medulla
Catecholamine
Catecholaminergic type of drug
A norepinephrine releasing agent (NRA), also known as an adrenergic releasing agent, is a catecholaminergic type of drug that induces the release of norepinephrine
Norepinephrine releasing agent
Norepinephrine_releasing_agent
Drug class
A norepinephrine–dopamine releasing agent (NDRA) is a type of drug which induces the release of norepinephrine (and epinephrine) and dopamine in the body
Norepinephrine–dopamine releasing agent
Norepinephrine–dopamine_releasing_agent
Lustral) Indalpine (Upstene) Zimelidine (Normud, Zelmid) Serotonin–norepinephrine reuptake inhibitors include: Desvenlafaxine (Pristiq) Duloxetine (Cymbalta)
List_of_antidepressants
Drug class
Selective norepinephrine reuptake inhibitors (sNRIs) are a class of drugs that have been marketed as antidepressants and are used for various mental disorders
Selective norepinephrine reuptake inhibitor
Selective_norepinephrine_reuptake_inhibitor
Type of drug
A serotonin–norepinephrine–dopamine releasing agent (SNDRA), also known as a triple releasing agent (TRA), is a type of drug which induces the release
Serotonin–norepinephrine–dopamine releasing agent
Serotonin–norepinephrine–dopamine_releasing_agent
[controlled release] (CTX-1301) – norepinephrine–dopamine reuptake inhibitor Edivoxetine (LY-2216684) – norepinephrine reuptake inhibitor Molindone [extended-release]
List of investigational attention deficit hyperactivity disorder drugs
List_of_investigational_attention_deficit_hyperactivity_disorder_drugs
Antidepressant
A norepinephrine and dopamine disinhibitor (NDDI or NDD) is a drug that acts at specific sites to disinhibit downstream norepinephrine and dopamine release
Norepinephrine–dopamine disinhibitor
Norepinephrine–dopamine_disinhibitor
Antihypertensive drug
such as norepinephrine. Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET
Guanethidine
Medication mainly used for depression and smoking cessation
seasonal affective disorder and to support smoking cessation. It is a norepinephrine–dopamine reuptake inhibitor (NDRI). Some evidence-based guidelines support
Bupropion
Stress and panic response centre
for brain synthesis of norepinephrine (noradrenaline). The locus coeruleus and the areas of the body affected by the norepinephrine it produces are described
Locus_coeruleus
Neurotransmitter metabolite and neurotoxin
4-dihydroxymandelaldehyde, DHMAL, norepinephrine aldehyde, or epinephrine aldehyde) is a metabolite of the monoamine neurotransmitters norepinephrine and epinephrine.
3,4-Dihydroxyphenylglycolaldehyde
3,4-Dihydroxyphenylglycolaldehyde
Synthetic amino acid/norepinephrine prodrug
neurotransmitter norepinephrine (noradrenaline). Hence, it acts as a non-selective agonist of the α- and β-adrenergic receptors. Unlike norepinephrine, but similarly
Droxidopa
Class of medications
serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake inhibitors (SNRIs) and norepinephrine reuptake inhibitors (NRIs). The TCAs are used
Tricyclic_antidepressant
Central nervous system stimulant
Methylphenidate is believed to work by blocking the reuptake of dopamine and norepinephrine by neurons. It is a CNS stimulant of the phenethylamine and piperidine
Methylphenidate
Central part of the adrenal gland
cells that secrete catecholamines, including epinephrine (adrenaline), norepinephrine (noradrenaline), and a small amount of dopamine, in response to stimulation
Adrenal_medulla
Central nervous system stimulant
neurotransmission in the brain, with its most pronounced effects targeting the norepinephrine and dopamine neurotransmitter systems. At therapeutic doses, amphetamine
Amphetamine
Type of drug
non-selective DRAs, including norepinephrine–dopamine releasing agents (NDRAs) like amphetamine and methamphetamine, serotonin–norepinephrine–dopamine releasing
Dopamine_releasing_agent
Serotonin-norepinephrine-dopamine reuptake inhibitor
addiction. The drug is a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), with preference for norepinephrine and then dopamine over serotonin
Centanafadine
Psychoactive stimulant and norepinephrine releasing agent
is a psychostimulant and selective norepinephrine releasing agent (NRA) or norepinephrine-preferring norepinephrine–dopamine releasing agent (NDRA). The
Phenylalaninol
Drug class
one or more of the three major monoamine neurotransmitters serotonin, norepinephrine, and dopamine by blocking the action of one or more of the respective
Monoamine_reuptake_inhibitor
Pertaining to adrenaline or noradrenaline, or their receptors
Adrenergic means "working on adrenaline (epinephrine) or noradrenaline (norepinephrine)" (or on their receptors). When not further qualified, it is usually
Adrenergic
Protein family
express a fourth α2D-adrenergic receptor as well. Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α2-adrenergic
Alpha-2_adrenergic_receptor
Psychoactive drug, often called ecstasy
increasing the release of the neurotransmitters serotonin, dopamine, and norepinephrine in parts of the brain. It belongs to the substituted amphetamine classes
MDMA
Drug class
A serotonin–norepinephrine releasing agent (SNRA) is a type of drug which induces the release of serotonin and norepinephrine (and epinephrine) in the
Serotonin–norepinephrine releasing agent
Serotonin–norepinephrine_releasing_agent
Chemical compound
early 1970s, is a potent and selective inhibitor for the reuptake of norepinephrine (noradrenaline) into synapses. It currently has no clinical applications
Nisoxetine
Medical condition
and the absence of norepinephrine (NE) and epinephrine. Dopamine is released, as a false neurotransmitter, in place of norepinephrine (a.k.a. noradrenaline
Dopamine beta hydroxylase deficiency
Dopamine_beta_hydroxylase_deficiency
Designer drug
a monoamine releasing agent, including of serotonin, dopamine, and norepinephrine. However, in contrast to cathinones and amphetamines, 3-MeOMC appears
3-Methoxymethcathinone
Medical condition
sertraline), serotonin–norepinephrine reuptake inhibitors (SNRIs) (e.g., venlafaxine, milnacipran, duloxetine), norepinephrine reuptake inhibitors (NRIs)
Spontaneous_orgasm
Class of compounds in the nervous system
release in the striatum, substantia nigra, and olfactory tubercle; norepinephrine release from the locus coeruleus; and/or serotonin release from the
Monoaminergic activity enhancer
Monoaminergic_activity_enhancer
Medication used to treat ADHD
Atomoxetine, sold under the brand name Strattera, is a selective norepinephrine reuptake inhibitor medication used to treat attention deficit hyperactivity
Atomoxetine
SNRI medication
types of chronic pain. It is taken by mouth. Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI). The precise mechanism for its antidepressant
Duloxetine
Compounds metabolized into monoamines
(levodopa) are precursors of dopamine, epinephrine (adrenaline), and norepinephrine (noradrenaline). Administration of monoamine precursors can increase
Monoamine_precursor
Chemical class of organic compounds
Catecholamine neurotransmitter/Fight or Flight hormone Norepinephrine (Noradrenaline) OH OH OH β,3,4-trihydroxyphenethylamine Catecholamine
Substituted_phenethylamine
Central nervous system stimulant prodrug
dopamine neurotransmission in the mesocorticolimbic projection and norepinephrine neurotransmission in the noradrenergic projections from the locus coeruleus
Lisdexamfetamine
Chemical compound
Methylenedioxypyrovalerone (MDPV) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). MDPV acts as a stimulant and has
Methylenedioxypyrovalerone
Class of medication used to treat depression and other conditions
(SSRIs) or norepinephrine reuptake inhibitors, while a person suffering from loss of energy and enjoyment of life would take a norepinephrine–dopamine reuptake
Antidepressant
Neurodevelopmental disorder
systems, particularly those involving dopamine and norepinephrine. The dopamine and norepinephrine pathways that originate in the ventral tegmental area
Attention deficit hyperactivity disorder
Attention_deficit_hyperactivity_disorder
Chemical compound
is an end-stage metabolite of the catecholamines (epinephrine, and norepinephrine). It is produced via intermediary metabolites. VMA synthesis is the
Vanillylmandelic_acid
Connection of the sympathetic nervous system and adrenal medulla
activate the adrenal medulla through acetylcholine. Once activated, norepinephrine and epinephrine are released directly into the blood by adrenomedullary
Sympathoadrenal_system
Tricyclic antidepressant
serotonin transporter (SERT) and norepinephrine transporter (NET). It is metabolized to nortriptyline, a stronger norepinephrine reuptake inhibitor, further
Amitriptyline
Chemical compound
(MHPG, MOPEG) is a metabolite of norepinephrine degradation. In the brain, it is the principal norepinephrine metabolite. It is released into the blood
3-Methoxy-4-hydroxyphenylglycol
3-Methoxy-4-hydroxyphenylglycol
Drug mixture used mainly to treat ADHD and narcolepsy
and narcolepsy by increasing the activity of the neurotransmitters norepinephrine and dopamine in the brain, which results in part from their interactions
Adderall
Muscle relaxant medication
works is unclear. In any case, it is known to inhibit serotonin and norepinephrine reuptake and to block serotonin, adrenergic, histamine, and muscarinic
Cyclobenzaprine
Class of drug
Relative to serotonin–norepinephrine–dopamine reuptake inhibitors (SNDRIs), which also inhibit the reuptake of norepinephrine in addition to serotonin
Serotonin–dopamine reuptake inhibitor
Serotonin–dopamine_reuptake_inhibitor
Alpha-adrenergic agonist
instances of dexmedetomidine withdrawal. The reduction in circulating norepinephrine by clonidine was used in the past as an investigatory test for phaeochromocytoma
Clonidine
Organic chemical that functions both as a hormone and a neurotransmitter
the synthesis of the neurotransmitters norepinephrine and epinephrine. Dopamine is converted into norepinephrine by the enzyme dopamine β-hydroxylase,
Dopamine
Drug that releases serotonin and dopamine in the brain
rare, as it has proven extremely difficult to dissociate dopamine and norepinephrine release. However, in 2014, the first selective SDRAs, a series of substituted
Serotonin–dopamine releasing agent
Serotonin–dopamine_releasing_agent
SNRI antidepressant
Effexor among others, is an antidepressant medication of the serotonin–norepinephrine reuptake inhibitor (SNRI) class. It is used to treat major depressive
Venlafaxine
Abnormally high heart rate after a postural change
acting sympathomimetics, like the norepinephrine releasing agents ephedrine and pseudoephedrine and the norepinephrine–dopamine reuptake inhibitors methylphenidate
Postural orthostatic tachycardia syndrome
Postural_orthostatic_tachycardia_syndrome
Investigational narcolepsy and hypersomnia drugs
2025. It is likely to become outdated with time. Reboxetine (AXS-12) – norepinephrine reuptake inhibitor (NRI) – narcolepsy [1] Sodium oxybate (Xyrem) controlled
List of investigational narcolepsy and hypersomnia drugs
List_of_investigational_narcolepsy_and_hypersomnia_drugs
Pharmaceutical compound
relationships (SAR) of phenethylamine and amphetamine MRAs. It acts as a norepinephrine–dopamine releasing agent (NDRA). However, phenylpropylamine is dramatically
Phenylpropylamine
Drug class
more of the monoamine neurotransmitters – serotonin, dopamine, and norepinephrine. One mechanism by which these agents act is by inhibiting reuptake by
Monoamine-depleting_agent
Chemical compound
MIBG, is an aralkylguanidine analog of the adrenergic neurotransmitter norepinephrine (noradrenaline), typically used as a radiopharmaceutical. It acts as
Iobenguane
CNS stimulant and isomer of amphetamine
proteins for the monoamine neurotransmitters (namely the serotonin, norepinephrine and dopamine transporters) either via trace amine-associated receptor
Dextroamphetamine
Compounds that damage or destroy monoaminergic neurons
stimulation by monoamine neurotransmitters including serotonin, dopamine, and norepinephrine. Examples of monoamine neurotoxins include the serotonergic neurotoxins
Monoamine_neurotoxin
Designer stimulant
and designer drug of the cathinone family. It acts as a dopamine and norepinephrine releasing agent (NDRA). The drug has an EC50Tooltip half-maximal effective
2-Fluoromethcathinone
Pharmaceutical compound
N-desalkylquetiapine, is a 5-HT2B serotonin receptor modulator, and norepinephrine reuptake inhibitor. It is the principal metabolite of quetiapine. "CAS
Norquetiapine
SNRI antidepressant
major depressive disorder. It is an antidepressant of the serotonin–norepinephrine reuptake inhibitor (SNRI) class and is taken by mouth. It is recommended
Desvenlafaxine
Pharmaceutical compound
releasing agent of the phenylpiperazine family. It acts as a serotonin–norepinephrine–dopamine releasing agent (SNDRA), with EC50Tooltip half-maximal effective
Ortho-Bromophenylpiperazine
Class of medications used to alleviate anxiety
level of norepinephrine and serotonin by inhibiting their reuptake transport proteins. The majority of TCAs exert greater effect on norepinephrine, which
Anxiolytic
Phenethylamine derivative
(EC50 > 10,000 nM) and the EC50 for norepinephrine was not assessed but the drug induced 96% release of norepinephrine at a concentration of 10,000 nM. Hence
2-Aminoacetophenone
Withdrawn anti-obesity drug combination
Fenfluramine acts as a serotonin releasing agent, phentermine as primarily a norepinephrine releasing agent. Phentermine also induces the release of serotonin and
Fenfluramine/phentermine
Speed of the heartbeat, measured in beats per minute
accelerans nerve provides sympathetic input to the heart by releasing norepinephrine onto the cells of the sinoatrial node (SA node), and the vagus nerve
Heart_rate
Class of antidepressant medication
Serotonin releasing agent (SRA) Serotonin–norepinephrine reuptake inhibitor (SNRI) Serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) Barlow
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Class of G protein-coupled receptors
protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but
Adrenergic_receptor
Behavioral measure in animals
effects of norepinephrine elevation change in the brains of DAT knockout mice. Whereas dextromethamphetamine is a well-balanced norepinephrine–dopamine
Locomotor_activity
Opioid analgesic of benzenoid class
as a highly selective full agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI). Tapentadol is used medically for the treatment
Tapentadol
Type of medication
monoamine neurotransmitters and related amines, including serotonin, norepinephrine, dopamine, epinephrine, tyramine, and several trace amines. MAOIs include
Monoamine_oxidase_inhibitor
List of pharmaceutical drugs under clinical development for treatment of depression
(BMS-820836; DB-104) – serotonin, norepinephrine, and dopamine reuptake inhibitor Lisdexamfetamine (Vyvanse) – norepinephrine and dopamine releasing agent
List of investigational antidepressants
List_of_investigational_antidepressants
Part of the autonomic nervous system that stimulates fight-or-flight responses
proportion of norepinephrine, and more substantially, epinephrine. The synthesis and release of epinephrine as opposed to norepinephrine is another distinguishing
Sympathetic_nervous_system
Class of drug
biosynthesis of norepinephrine and epinephrine. It was not until dopamine was found in the brain in similar levels as norepinephrine that the possibility
Dopamine_reuptake_inhibitor
SNRI antidepressant
milnacipran, and has similar effects and pharmacology, acting as a serotonin–norepinephrine reuptake inhibitor. Levomilnacipran was approved for medical use in
Levomilnacipran
Medication, stimulant and decongestant
breastfeeding is not recommended. Ephedrine works by inducing the release of norepinephrine and hence indirectly activating the α- and β-adrenergic receptors. Chemically
Ephedrine
Chemical compound
amoxapine's pharmacology. It is a serotonin-norepinephrine reuptake inhibitor (SNRI) with similar norepinephrine, but more serotonin, reuptake inhibition
8-Hydroxyamoxapine
Dissociative anesthetic and anti-depressant
modulate the in vitro inhibitory effects of propofol and ketamine on norepinephrine and serotonin transporter function". J Clin Neurosci. 15 (11): 1264–9
Ketamine
Synthetic opioid pain medication
name Tramal among others, is an opioid pain medication and a serotonin–norepinephrine reuptake inhibitor (SNRI) used to treat moderate to severe pain. When
Tramadol
(SMSs) (e.g., vilazodone, vortioxetine) Norepinephrine reuptake inhibitors (NRIs) (e.g., reboxetine) Norepinephrine–dopamine reuptake inhibitors (NDRIs)
List of psychiatric drugs by type
List_of_psychiatric_drugs_by_type
Class of chemical compound
(via activation of β1-adrenergic receptors) Norepinephrine prodrugs like droxidopa (L-DOPS) Norepinephrine reuptake inhibitors like atomoxetine, reboxetine
Cardiac_stimulant
Pharmaceutical compound
3′-chloro-2-(tert-butylamino)pentanophenone or as α-desmethyl-α-propylbupropion, is a norepinephrine–dopamine reuptake inhibitor (NDRI) and stimulant of the cathinone family
RTI-6037-13
Hormone used as a medicine
phenethylamine and catecholamine. It is the N-methylated analogue of norepinephrine (noradrenaline; 3,4,β-trihydroxyphenethylamine) and the N-methylated
Epinephrine_(medication)
Investigational fibromyalgia drugs
outdated with time. Esreboxetine ((S,S)-Reboxetine; AXS-14; PNU-165442G) – norepinephrine reuptake inhibitor (NRI) [1] Pregabalin controlled release (GRO-12;
List of investigational fibromyalgia drugs
List_of_investigational_fibromyalgia_drugs
SNDRI antidepressant drug
for use in other countries like the United States. It is a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) and was developed by Luye Pharma
Toludesvenlafaxine
Proteins that function as integral plasma-membrane transporters
are serotonin transporters (SERTs), dopamine transporters (DATs), and norepinephrine transporters (NETs) and are responsible for the reuptake of their associated
Monoamine_transporter
Class of drugs
action of epinephrine and norepinephrine signaling in the heart, smooth muscle and central nervous system, with norepinephrine being the highest affinity
Alpha-adrenergic_agonist
Pharmaceutical compound
drug of the phenylpiperazine family. It acts as a partial serotonin–norepinephrine releasing agent (SNRA), with EC50Tooltip half-maximal effective concentration
2,3-Dimethylphenylpiperazine
Drug that increases alertness
synaptic concentrations of excitatory neurotransmitters, particularly norepinephrine and dopamine. Other stimulants work by binding to the receptors of excitatory
Stimulant
Pharmaceutical compound
replaced with a 1-naphthalene ring. The drug acts as a potent serotonin–norepinephrine–dopamine releasing agent (SNDRA). Its EC50Tooltip half-maximal effective
1-Naphthylmethcathinone
Medication used to treat high blood pressure
alpha-methyldopamine, a false precursor to norepinephrine, which in turn reduces synthesis of norepinephrine in the vesicles. Dopamine beta hydroxylase
Methyldopa
G protein-coupled receptor
confusion, naming was continued with the letter D. Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α1-adrenergic
Alpha-1_adrenergic_receptor
Class of enzymes
catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catechol estrogens, and various drugs and substances having a catechol
Catechol-O-methyltransferase
Pharmaceutical compound
families. It acts specifically as a fairly well-balanced serotonin–norepinephrine–dopamine releasing agent (SNDRA), with EC50Tooltip half-maximal effective
4-APBT
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