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Extension to the MIPS architecture
The MDMX (MIPS Digital Media eXtension), also known as MaDMaX, is an extension to the MIPS architecture released in October 1996 at the Microprocessor
MDMX
Instruction set architecture
set of floating-point SIMD instructions dedicated to 3D computer graphics; MDMX (MaDMaX), a more extensive integer SIMD instruction set using 64-bit floating-point
MIPS_architecture
Chemical compound
domain of p53, a tumor suppressor protein. As such, it binds to MDM2 and MDMX, leading to tumor cell apoptosis. Sulanemadlin is notable as the first stapled
Sulanemadlin
Type of parallel processing
in its UltraSPARC I microprocessor. MIPS followed suit with their similar MDMX system. The first widely deployed desktop SIMD was with Intel's MMX extensions
Single instruction, multiple data
Single_instruction,_multiple_data
Protein-coding gene in the species Homo sapiens
MDMX protein". J. Biol. Chem. 274 (53): 38189–96. doi:10.1074/jbc.274.53.38189. PMID 10608892. Jackson MW, Lindstrom MS, Berberich SJ (2001). "MdmX binding
MDM4
American rapper (born 1988)
with his solo career is Ferg". His first single under the new moniker, "MDMX," was released in May 2024. Ferg released his sixth album Darold, on November
ASAP_Ferg
American chemical biologist
the Verdine Lab, sulanemadlin (ALRN-6924), is a first-in-class dual MDM2/MDMX inhibitor currently in Phase II clinical development by Aileron Therapeutics
Gregory_L._Verdine
Chemical compound
increased solubility, irreversible MDM2 inhibitors, improved binding to MDMX, the PROTAC methodology, dual-action molecules, and fluorescent probes. Vassilev
Nutlin
RISC processor architecture
Fixed Branching Condition register Endianness Bi-endian Extensions None, but MDMX & MIPS-3D could be used Open Yes Registers General-purpose 32 (R0=0) Floating-point
DLX
Instructions for the x86 microprocessors
v t e Instruction set extensions SIMD (RISC) Alpha MVI ARM NEON SVE MIPS MDMX MIPS-3D MXU MIPS SIMD PA-RISC MAX Power ISA VMX SPARC VIS SIMD (x86) MMX
Advanced_Vector_Extensions
Instruction set extensions accelerating AES operations
v t e Instruction set extensions SIMD (RISC) Alpha MVI ARM NEON SVE MIPS MDMX MIPS-3D MXU MIPS SIMD PA-RISC MAX Power ISA VMX SPARC VIS SIMD (x86) MMX
AES_instruction_set
partenariat avec MDMX, Mazagan Beach & Golf Resort a accueilli les 28 et 29 avril un Enduro Amical de Motocross" [In partnership with MDMX, Mazagan Beach
Sand_racing_in_Mazagan
Parallel processing technique
MVI, Hewlett-Packard's PA-RISC MAX, Silicon Graphics Incorporated's MIPS MDMX, and Sun's SPARC V9 VIS. Like MMX, many of the SWAR instruction sets are
SWAR
Extensions to the x86 instruction set architecture
v t e Instruction set extensions SIMD (RISC) Alpha MVI ARM NEON SVE MIPS MDMX MIPS-3D MXU MIPS SIMD PA-RISC MAX Power ISA VMX SPARC VIS SIMD (x86) MMX
Advanced_Matrix_Extensions
Extension to the x86 instruction set
v t e Instruction set extensions SIMD (RISC) Alpha MVI ARM NEON SVE MIPS MDMX MIPS-3D MXU MIPS SIMD PA-RISC MAX Power ISA VMX SPARC VIS SIMD (x86) MMX
CLMUL_instruction_set
Protein-coding gene in humans
well as breast tumors. An additional Mdm2 family member, Mdm4 (also called MdmX), has been discovered and is also an important negative regulator of p53
Mdm2
Mammalian protein found in humans
1016/S0092-8674(00)81401-4. PMID 9529249. Badciong JC, Haas AL (December 2002). "MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2
P53
Computer instruction for returning hardware-generated random numbers
v t e Instruction set extensions SIMD (RISC) Alpha MVI ARM NEON SVE MIPS MDMX MIPS-3D MXU MIPS SIMD PA-RISC MAX Power ISA VMX SPARC VIS SIMD (x86) MMX
RDRAND
American DJ and producer
includes a new collaboration with drum and bass producer Gridlok called "MDMX," and three tracks by Faces of Def, a new collaborative project between Dieselboy
Dieselboy
64-bit RISC instruction set architecture
Unlike most other SIMD instruction sets of the same period, such as MIPS' MDMX or SPARC's Visual Instruction Set, but like PA-RISC's Multimedia Acceleration
DEC_Alpha
Architectural instruction
v t e Instruction set extensions SIMD (RISC) Alpha MVI ARM NEON SVE MIPS MDMX MIPS-3D MXU MIPS SIMD PA-RISC MAX Power ISA VMX SPARC VIS SIMD (x86) MMX
F16C
Species of amphibian
Bolitoglossa_alvaradoi AmphibiaWeb: 3952 ASW: Bolitoglossa-alvaradoi CoL: MDMX EoL: 329702 GBIF: 2431254 iNaturalist: 26993 IRMNG: 10594430 ITIS: 208374
Alvarado's_salamander
Proposed extension to x86-64 instruction set architecture
v t e Instruction set extensions SIMD (RISC) Alpha MVI ARM NEON SVE MIPS MDMX MIPS-3D MXU MIPS SIMD PA-RISC MAX Power ISA VMX SPARC VIS SIMD (x86) MMX
Advanced Synchronization Facility
Advanced_Synchronization_Facility
Register–Register RISC 4–32 (including "zero") Fixed (32-bit) Condition register Bi MDMX, MIPS-3D No No MMIX 64 ? 1999 3 Register–Register RISC 256 Fixed (32-bit)
Comparison of instruction set architectures
Comparison_of_instruction_set_architectures
Extension to the x86 instruction set
v t e Instruction set extensions SIMD (RISC) Alpha MVI ARM NEON SVE MIPS MDMX MIPS-3D MXU MIPS SIMD PA-RISC MAX Power ISA VMX SPARC VIS SIMD (x86) MMX
VIA_PadLock
American professor at Hunter College
the Bargonetti laboratory. The work focuses on the mutant p53, MDM2, and MDMX molecular signal transduction pathways. The Bargonetti team works to activate
Jill_Bargonetti
Extension to the x86 instruction set
v t e Instruction set extensions SIMD (RISC) Alpha MVI ARM NEON SVE MIPS MDMX MIPS-3D MXU MIPS SIMD PA-RISC MAX Power ISA VMX SPARC VIS SIMD (x86) MMX
FMA_instruction_set
Chemical compound
(December 2021). "Sulfonamide derivatives of cis-imidazolines as potent p53-MDM2/MDMX protein-protein interaction inhibitors". Medicinal Chemistry Research. 30
2-Imidazoline
v t e Instruction set extensions SIMD (RISC) Alpha MVI ARM NEON SVE MIPS MDMX MIPS-3D MXU MIPS SIMD PA-RISC MAX Power ISA VMX SPARC VIS SIMD (x86) MMX
SSE5
Protein-coding gene in humans
some of the known cellular binding partners of USP7/HAUSP: p53 Mdm2 Mdm4/MdmX FOXO4 Daxx PTEN March7 UVSSA USP7 has been shown to interact with Ataxin
USP7
α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy". Proceedings of the National Academy of
Stapled_peptide
Protein-coding gene in the species Homo sapiens
S2CID 34118663. Bergamaschi D, Samuels Y, Zhong S, Lu X (2005). "Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation"
PPP1R13B
Hip hop recording artist discography
(featuring Pharrell and The Neptunes) 2021 — — — — — — — Non-album singles "MDMX" 2024 — — — — — — — Darold "Allure" (featuring Future and Mike Will Made
ASAP_Ferg_discography
Protein-coding gene in the species Homo sapiens
doi:10.1074/jbc.M201252200. PMID 11927591. Badciong JC, Haas AL (2003). "MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2
UBE2D1
Computer instruction set introduced by AMD in 2009
v t e Instruction set extensions SIMD (RISC) Alpha MVI ARM NEON SVE MIPS MDMX MIPS-3D MXU MIPS SIMD PA-RISC MAX Power ISA VMX SPARC VIS SIMD (x86) MMX
XOP_instruction_set
Protein-coding gene in the species Homo sapiens
transcription factor is negatively regulated by its interaction with the MDMX protein". J. Cell. Biochem. 88 (3): 557–68. doi:10.1002/jcb.10318. PMID 12532331
E2F1
Mammalian protein found in Homo sapiens
Y, Jochemsen AG (September 2005). "ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation". Cell Cycle. 4 (9):
ATM_serine/threonine_kinase
British biologist
P.; Brown Swigart, L.; Passegue, E.; Evan, G. I. (2011). "Validation of MdmX as a therapeutic target for reactivating p53 in tumors". Genes & Development
Gerard_Evan
Massoud (2016-01-15). "Discovery of novel dual inhibitors against Mdm2 and Mdmx proteins by in silico approaches and binding assay". Life Sciences. 145:
Inte:Ligand
MDMX
MDMX
MDMX
MDMX
Girl/Female
Hindu, Indian, Traditional
Durga Devi
Boy/Male
Australian, French, German, Polish
A Pole
Boy/Male
Arabic, Bengali, Indian, Polish
Gentle in Nature; High Ability
Boy/Male
Hindu
Clear
Girl/Female
Muslim
Sharp
Boy/Male
Irish American Gaelic English
Fair.
Boy/Male
Indian, Telugu
Lot of Wealth
Female
Polish
 Feminine form of Polish Klaudiusz, KLAUDIA means "lame." Compare with another form of Klaudia.
Girl/Female
Australian, Biblical, Christian, Danish, Hebrew
Benevolent; Complaisant; Pleasing; Pleasantness
Boy/Male
Tamil
Supreme Lord
MDMX
MDMX
MDMX
MDMX
MDMX