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MDM4

MDM4

Protein-coding gene in the species Homo sapiens

Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein

MDM4

Guillermina Lozano

American geneticist

drive tumor development and progression. She also found out how the Mdm2 and Mdm4 proteins work in the body, especially in stopping cancer and controlling

Guillermina Lozano

Guillermina_Lozano

CDKN2A

Protein-coding gene in humans

binding RNA binding DNA binding p53 binding transcription factor binding MDM2/MDM4 family protein binding ubiquitin-protein transferase inhibitor activity SUMO

CDKN2A

Triple-negative breast cancer

Type of breast cancer lacking certain gene expressions

identified as high risk for triple-negative. Changes or mutations in 19p13.1 and MDM4 loci have also been associated with triple-negative breast cancer, but not

Triple-negative breast cancer

Triple-negative_breast_cancer

Mammalian protein found in humans

HIPK2, HMGB1, HSPA9, Huntingtin, ING1, ING4, ING5, IκBα, KPNB1, LMO3, Mdm2, MDM4, MED1, MAPK9, MNAT1, NDN, NCL, NUMB, NF-κB, P16, PARC, PARP1, PIAS1, CDC14B

P53

Mdm2

Protein-coding gene in humans

osteosarcomas as well as breast tumors. An additional Mdm2 family member, Mdm4 (also called MdmX), has been discovered and is also an important negative

Mdm2

Mammalian protein found in humans

binding RNA binding DNA binding p53 binding transcription factor binding MDM2/MDM4 family protein binding ubiquitin-protein transferase inhibitor activity SUMO

P16

Fibroblast growth factor receptor 1

Protein found in humans

Gerken M, Rohrmeier C, et al. (August 2016). "Genomic aberrations of MDM2, MDM4, FGFR1 and FGFR3 are associated with poor outcome in patients with salivary

Fibroblast growth factor receptor 1

Fibroblast_growth_factor_receptor_1

Peroxisome proliferator-activated receptor alpha

Nuclear receptor protein found in humans

transcription coactivator binding phosphatase binding NFAT protein binding MDM2/MDM4 family protein binding transcription cis-regulatory region binding RNA polymerase

Peroxisome proliferator-activated receptor alpha

Peroxisome_proliferator-activated_receptor_alpha

Two-hybrid screening

Molecular biology technique

inhibitors in live cells: targeting the interaction of p53 with Mdm2 and Mdm4". Journal of Biomolecular Screening. 19 (4): 516–25. doi:10.1177/1087057113518067

Two-hybrid screening

Two-hybrid_screening

Serum response factor

Mammalian protein found in Homo sapiens

"Serum Response Factor (SRF) Drives the Transcriptional Upregulation of the MDM4 Oncogene in HCC". Cancers. 13 (2): 199. doi:10.3390/cancers13020199. PMC 7829828

Serum response factor

Serum_response_factor

USP7

Protein-coding gene in humans

list of some of the known cellular binding partners of USP7/HAUSP: p53 Mdm2 Mdm4/MdmX FOXO4 Daxx PTEN March7 UVSSA USP7 has been shown to interact with Ataxin

USP7

Protein-coding gene in the species Homo sapiens

kinase binding p53 binding DNA-binding transcription factor activity MDM2/MDM4 family protein binding DNA-binding transcription factor activity, RNA polymerase

P73

TP63

Protein-coding gene in the species Homo sapiens

chromatin binding p53 binding DNA-binding transcription factor activity MDM2/MDM4 family protein binding DNA-binding transcription factor activity, RNA polymerase

TP63

CDK5RAP3

Protein-coding gene in humans

BioGPS More reference expression data Gene ontology Molecular function MDM2/MDM4 family protein binding NF-kappaB binding mitogen-activated protein kinase

CDK5RAP3

E2F1

Protein-coding gene in the species Homo sapiens

been shown to interact with: ARID3A, CUL1, Cyclin A1, Cyclin A2, GTF2H1, MDM4, NCOA6, NDN, NPDC1, PURA, PHB, RB1, UDG, RBL1, SKP2, SP1, SP2, SP3, SP4,

E2F1

MARCH7

Protein-coding gene in the species Homo sapiens

enzyme binding ubiquitin conjugating enzyme binding ubiquitin binding MDM2/MDM4 family protein binding protein binding Cellular component nucleus cytosol

MARCH7

List of human protein-coding genes 5

HGNC:6972; P21741 9391 MDM1 HGNC:29917; Q8TC05 9392 MDM2 HGNC:6973; Q00987 9393 MDM4 HGNC:6974; O15151 9394 MDN1 HGNC:18302; Q9NU22 9395 MDP1 HGNC:28781; Q86V88

List of human protein-coding genes 5

List_of_human_protein-coding_genes_5

PSME3

Protein found in humans

reference expression data Gene ontology Molecular function p53 binding MDM2/MDM4 family protein binding endopeptidase activator activity protein binding identical

PSME3