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Protein-coding gene in humans
DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene. The protein encoded by this gene is one of the highly conserved
MCM2
Protein family
pre-replication complex (pre-RC), which includes Cdc6, Tah11 (a.k.a. Cdt1), and the Mcm2-Mcm7 complex. Pre-RC assembly during G1 is required for replication licensing
Origin_recognition_complex
Protein family
for genomic DNA replication. Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer. As a critical protein for cell division, MCM
Minichromosome_maintenance
DNA replication in eukaryotic organisms
Cdc6, and Cdt1 together are required for the stable association of the Mcm2-7 complex with replicative origins during the G1 phase of the cell cycle
Eukaryotic_DNA_replication
Protein complex formed during initiation of DNA replication
recruits the licensing factor Cdt1 and MCM2-7. Cdt1 binding and ATP hydrolysis by the ORC and Cdc6 load MCM2-7 onto DNA. There is a stoichiometric excess
Pre-replication_complex
Sequence in a genome
the minichromosome maintenance 2-7 (Mcm2-7) complex onto DNA. Like the archaeal replicative helicase core, Mcm2-7 is loaded as a head-to-head double
Origin_of_replication
Bus operator in Morris County, New Jersey
Ledgewood Mall Morristown station Route 10 Route 53 Route 202 Formerly parts of MCM2. 880 Rockaway Townsquare Mall Morristown station West Main Street Route 46
PABCO_Transit
genome replication. The MCM complex consisting of MCM6 (this protein) and MCM2, 4 and 7 possesses DNA helicase activity, and may act as a DNA unwinding
MCM6
Undesirable occurrence in eukaryotic cells
through the CDK-mediated phosphorylation of the pre-RC components Cdc6, MCM2-7, and the ORC subunits. The phosphorylation of these components is initiated
DNA_re-replication
Biological process
complex ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 Cdc6 Cdt1 Minichromosome maintenance MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 Licensing factor Autonomously replicating sequence
DNA_replication
Species of fungus
327205 Boletus hemichrysus Wikidata: Q107526116 AusFungi: 60090334 CoL: MCM2 GBIF: 5239730 IndexFungorum: 231328 MycoBank: 231328 SpeciesFungorum: 231328
Buchwaldoboletus_hemichrysus
Protein in eukaryotic cells
the origin recognition complex (ORC), Cdt1 and the MCM complex (containing MCM2-7p). CDC6 assembles after ORC in an ATP dependent manner and is required
Cdc6
Medical condition
Complex (ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6 genes), CDC6, CDT1, and MCM2-7 (MCM2, MCM3, MCM4, MCM5, MCM6, MCM7). This complex is loaded on so called origins
Meier-Gorlin_syndrome
Town in Morris County, New Jersey, US
and 880 bus routes, replacing service that had been offered on the MCM1, MCM2, MCM3, MCM4, MCM8 and MCM10 routes until 2010, when subsidies to the local
Morristown,_New_Jersey
Molecular complex
DNA and separates the strands ahead of DNA synthesis. In eukaryotes, the Mcm2-7 complex acts as a helicase, though which subunits are required for helicase
Replisome
Protein-coding gene in the species Homo sapiens
is encoded by the MCM10 gene. It is essential for activation of the Cdc45:Mcm2-7:GINS helicase, and thus required for proper DNA replication. The protein
MCM10
Chinese-American geneticist and biologist (born c. 1947)
PMID 1579162. S2CID 4346767. Yan, H.; Gibson, S.; Tye, B. K. (June 1991). "Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure
Bik_Kwoon_Tye
2000 video game
until June 19, 2006, multiplayer gameplay through the MSN Gaming Network. In MCM2, there are six types of racing: Stunts, Enduro, Baja, Supercross and Nationals
Motocross_Madness_2
Indian biologist (born 1968)
(February 2002). "Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45". Mol Cell. 9 (2): 233–40. doi:10
Suman_Kumar_Dhar
Class of enzymes
complex ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 Cdc6 Cdt1 Minichromosome maintenance MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 Licensing factor Autonomously replicating sequence
DNA_polymerase_epsilon
Township in Morris County, New Jersey, US
875 and 880 routes, which replaced service that had been offered on the MCM2 and MCM10 routes until June 2010, when NJ Transit pulled the subsidy. Denville
Denville_Township,_New_Jersey
Protein-coding gene in the species Homo sapiens
are complexed together. KAT7 has been shown to interact with: AR, CDT1, MCM2 ORC1L and VIM, GRCh38: Ensembl release 89: ENSG00000136504 – Ensembl, May
KAT7_(gene)
regulate the localization of Mcm2-7 is that inactivation of CDKs in nocodazole arrested cells induced accumulation of Mcm2-7 in the nucleus. Cdt1 is also
Control of chromosome duplication
Control_of_chromosome_duplication
Protein found in humans
Y, Arai K, Masai H (2001). "Biochemical activities associated with mouse Mcm2 protein". J. Biol. Chem. 276 (46): 42744–52. doi:10.1074/jbc.M106861200.
Cell division cycle 7-related protein kinase
Cell_division_cycle_7-related_protein_kinase
Genus of amphibians
EA, Su TV, Liu Y (October 2009). "MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication". The EMBO Journal. 28 (19): 3005–3014
Xenopus
Township in Morris County, New Jersey, US
875 route serves the township. NJ Transit offered local bus service on the MCM2 and MCM7 routes which were eliminated due to budget constraints. Randolph
Randolph,_New_Jersey
Protein-coding gene in humans
replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding
MCM4
Franco-Algerian physico-chemist (born 1964)
Official website of LCC Toulouse Official website of the EIMM http://www.gdr-mcm2.cnrs.fr/ "Azzedine Bousseksou – Académie des sciences". Académie des sciences
Azzedine_Bousseksou
Mall Route 10, Route 53, Route 202 Weekday service only Formerly parts of MCM2. 880 Morristown Station Rockaway Townsquare Mall West Main Street, Route
List of NJ Transit bus routes (800–880)
List_of_NJ_Transit_bus_routes_(800–880)
disease, affected neurons show signs of DNA replication such as phosphorylated Mcm2 and cell cycle regulators cyclin D, Cdk4, phosphorylated Rb, E2F1, and cyclin
Neuronal_cell_cycle
Borough in Morris County, New Jersey, US
872, 875 and 880 routes, replacing service that had been offered on the MCM2, MCM3 and MCM10 routes until 2010, when subsidies to the local provider were
Morris_Plains,_New_Jersey
Protein-coding gene in the species Homo sapiens
subunit of PKA. AKAP8 has been demonstrated to interact with: Cyclin D3 DDX5, MCM2, MYCBP, and PRKAR2A. GRCh38: Ensembl release 89: ENSG00000105127 – Ensembl
AKAP8
Protein-coding gene in humans
replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding
MCM7
Protein-coding gene in humans
complex ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 Cdc6 Cdt1 Minichromosome maintenance MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 Licensing factor Autonomously replicating sequence
POLE_(gene)
DNA region replicating from a single origin
complex ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 Cdc6 Cdt1 Minichromosome maintenance MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 Licensing factor Autonomously replicating sequence
Replicon_(genetics)
Town in Morris County, New Jersey, US
is served by NJ Transit bus routes 875 and 880, replacing service on the MCM2, MCM5, MCM7 and MCM10 routes until June 2010, when NJ Transit eliminated
Dover,_New_Jersey
Protein-coding gene in the species Homo sapiens
estradiol and progesterone in the endometrium by inhibiting the production of MCM2, a protein involved in DNA synthesis raising the possibility of preventing
KLF15
Protein-coding gene in humans
Kremmer E, Nasheuer HP, Grosse F (2007). "Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during
CDC45-related_protein
Township in Morris County, New Jersey, US
878 and 880 routes, replacing service that had been offered on the MCM1, MCM2, MCM3, MCM4, MCM8 and MCM10 routes until 2010, when subsidies to the local
Morris_Township,_New_Jersey
Protein found in humans
to the forming pre-RC, followed by minichromosome maintenance complexes (MCM2-7). The activity of CDT1 during the cell cycle is tightly regulated during
DNA_replication_factor_CDT1
Molecular biologist
by a cell-free extract of Xenopus eggs Dormant origins licensed by excess Mcm2–7 are required for human cells to survive replicative stress Regulatory phosphorylation
Julian_Blow
Protein-coding gene in the species Homo sapiens
complex ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 Cdc6 Cdt1 Minichromosome maintenance MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 Licensing factor Autonomously replicating sequence
POLE2
Protein-coding gene in the species Homo sapiens
distinct isoforms have been described. ORC5 has been shown to interact with: MCM2, MCM3, MCM4, MCM7, ORC1, ORC2, ORC3, and ORC4. GRCh38: Ensembl release 89:
ORC5
complex, which then allows a heterohexameric protein complex of proteins MCM2 to 7 to bind. This entire hexamer acts as a helicase unwinding the double
Licensing_factor
HGNC:20867; Q969V1 9353 MCIDAS HGNC:40050; D6RGH6 9354 MCL1 HGNC:6943; Q07820 9355 MCM2 HGNC:6944; P49736 9356 MCM3 HGNC:6945; P25205 9357 MCM3AP HGNC:6946; O60318
List of human protein-coding genes 5
List_of_human_protein-coding_genes_5
K19) Kit L-selectin (CD62L) Lamin A/C Lewis X antigen (Le(X)) LeX Lgr5 Lrp4 MCM2 MCSP Metallothionein (MT) crypt-restricted immunopositivity indices (MTCRII)
Stem_cell_marker
Protein-coding gene in humans
proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also
MCM3
Borough in Morris County, New Jersey, US
875 route. NJ Transit had previously offered service in the borough on the MCM2 and MCM7 routes. 2019 Census Gazetteer Files: New Jersey Places, United States
Victory_Gardens,_New_Jersey
Protein-coding gene in the species Homo sapiens
Cell division cycle 7-related protein kinase, Cyclin-dependent kinase 2, MCM2, MCM4, MCM6, MCM7, MYST2, ORC2, ORC4, ORC5, and SKP2. GRCh38: Ensembl release
ORC1
Protein-coding gene in the species Homo sapiens
complex ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 Cdc6 Cdt1 Minichromosome maintenance MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 Licensing factor Autonomously replicating sequence
POLE4
Rural district in South Khorasan province, Iran
Province, Iran" (Map). OpenStreetMap (in Persian). Retrieved 12 April 2026. "MCM2+82J Howz-e Zireh, یزد [Yazd]، Iran" (Map). Google Maps. Retrieved 12 April
Chah_Mosafer_Rural_District
Protein-coding gene in the species Homo sapiens
of replication. ORC2 has been shown to interact with: CDC6, DBF4, MCM10, MCM2 MCM4, MCM5, MCM6, MCM7, ORC1, ORC3, ORC4, ORC5, ORC6, and Replication protein
ORC2
Protein-coding gene in the species Homo sapiens
gene. Replication protein A1 has been shown to interact with: BRCA2, BLM, MCM2, MCM4, MCM6, MCM7, MUTYH, ORC2L, ORC6L, P53, RPA2, RPA3, TIPIN, TP53BP1,
Replication_protein_A1
Protein-coding gene in humans
been shown to interact with: Cell division cycle 7-related protein kinase, MCM2, MCM3, MCM7, ORC2L, ORC6L, and STAT1. GRCh38: Ensembl release 89: ENSG00000100297
MCM5
Protein-coding gene in the species Homo sapiens
the same protein have been reported. ORC4 has been shown to interact with: MCM2, MCM3, MCM4, MCM6, ORC1, ORC2, ORC3, ORC5, and ORC6. GRCh38: Ensembl release
ORC4
Protein-coding gene in the species Homo sapiens
complex ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 Cdc6 Cdt1 Minichromosome maintenance MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 Licensing factor Autonomously replicating sequence
POLD3
Protein-coding gene in the species Homo sapiens
T, Ficarro SB, Jiang W (Oct 2006). "Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells". Molecular
DBF4
MCM2
MCM2
MCM2
MCM2
Surname or Lastname
English
English : habitational name from Thornborough in North Yorkshire (Thornebergh in 12th-century records) or Thornbrough in Northumberland and North Yorkshire (T(h)orneburg in 13th-century records). The former is probably so named from Old English þorn ‘thorn bush’ + beorg ‘hill’; the latter from þorn + burh ‘fort’. Other possible though less likely sources are Thornbury in Devon, Gloucestershire, or Herefordshire, which are all named from Old English þorn + byrig, dative of burh ‘fortified place’.Possibly an Americanized spelling of Swedish Thornberg.
Girl/Female
Latin
Beautiful or loving.
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam
Name of a King
Boy/Male
German, Spanish
Bold; Valorous; Noteworthy
Girl/Female
Latin
Silver.
Boy/Male
Indian
Charm
Girl/Female
Hindu
To win, To conquer
Girl/Female
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sindhi, Telugu, Traditional
Honeybee
Male
English
Anglicized form of Hebrew Ashshuwr, ASSUR means "a step." In the bible, this is the name second son of Shem. It is also a name applied to the nation of Assyria and its people.
Boy/Male
Hindu
Loveliness
MCM2
MCM2
MCM2
MCM2
MCM2