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Molecular complex
The replisome is a complex molecular machine that carries out replication of DNA. The replisome first unwinds double stranded DNA into two single strands
Replisome
Biological process
molecular machine called the replisome. The following is a list of major DNA replication enzymes that participate in the replisome: In vitro single-molecule
DNA_replication
DNA replication in eukaryotic organisms
coordinating many proteins at the site of replication, forming the replisome. The replisome is responsible for copying the entirety of genomic DNA in each
Eukaryotic_DNA_replication
Molecule that carries genetic information
most organisms, DNA polymerases function in a large complex called the replisome that contains multiple accessory subunits, such as the DNA clamp or helicases
DNA
Primary enzyme complex involved in prokaryotic DNA replication
5'→3'. DNA Pol III is a component of the replisome, which is located at the replication fork. The replisome is composed of the following: 2 DNA Pol III
DNA_polymerase_III_holoenzyme
Repeat sequences Repetitive DNA Replica plating Replication fork Replicon Replisome Reporter gene Repression Repressor Reproductive cells Reproductive success
Index_of_genetics_articles
Explanation of the flow of genetic information within a biological system
step in information transfer. A complex group of proteins called the replisome performs the replication of the information from the parent strand to
Central dogma of molecular biology
Central_dogma_of_molecular_biology
Chinese-American geneticist and biologist (born c. 1947)
(MCM) genes in 1984, which encode the catalytic core of the eukaryotic replisome. Tye also determined the first high-resolution structures of both the
Bik_Kwoon_Tye
DNA located in mitochondria
gene and two 55 kDa accessory subunits encoded by the POLG2 gene. The replisome machinery is formed by DNA polymerase, TWINKLE and mitochondrial SSB proteins
Mitochondrial_DNA
Sequence in a genome
different stages. During initiation, the replication machineries – termed replisomes – are assembled on DNA in a bidirectional fashion. These assembly loci
Origin_of_replication
Enzymes that catalyze DNA formation
revealed the synergies between DNA polymerases and other molecules of the replisome (helicases and SSBs) and with the DNA replication fork. These results
DNA_polymerase
Type of chromosome
involved in DNA replication on each arm is called a replisome. At the forefront of the replisome is a DNA helicase that unwinds the two strands of DNA
Circular_chromosome
DNA replication in prokaryotes
E coli replisome with a loop in lagging strand DNA
Prokaryotic_DNA_replication
Enzyme
replication systems. In addition to T7 DNA polymerase (also known as gp5), T7 replisome requires only four accessory proteins for proper function: host thioredoxin
T7_DNA_polymerase
American chemist
the replication of DNA—the T4 replisome Of particular importance is how multiple protein systems such as the replisomes responsible for DNA replication
Stephen_J._Benkovic
Family of viruses
own enzymes to aid replication, instead likely using the host cell's replisomes. ACV has no known relation to any other archaea-infecting viruses, but
Spiraviridae
High frequency of mutations within the genome of a cellular lineage
the cell cycle, DNA is usually most vulnerable during replication. The replisome must be able to navigate obstacles such as tightly wound chromatin with
Genome_instability
Russian-American molecular biologist (born 1956)
Alexander A.; Krasilnikova, Maria M.; Mirkin, Sergei M. (February 2009). "Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal
Sergei_Mirkin
2011 studio album by Björk
starting from the blood tissue descending into showing the DNA and the replisome. The "Hollow" instrument let the user tap different enzymes depicted in
Biophilia_(album)
Class of enzymes
holoenzyme dnaC dnaE dnaH dnaN dnaQ dnaT dnaX holA holB holC holD holE Replisome DNA ligase DNA clamp Topoisomerase DNA gyrase Prokaryotic DNA polymerase:
DNA_polymerase_epsilon
Protein family
core of the Cdc45-MCM-GINS helicase - the DNA unwinding engine of the replisome. Site selection for replication origins is carried out by the Origin Recognition
Minichromosome_maintenance
Species of virus
increases the rate of synthesis. Phage T7 has the simplest known DNA replisome, consisting of a helicase and primase that reside in a single polypeptide
T7_phage
damage. Mechanisms that process damaged DNA in coordination with the replisome in order to maintain replication fork progression are considered to be
DNA_replication_stress
Protein family around which DNA winds to form nucleosomes
histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity". The Journal of Biological Chemistry. 282 (39): 28587–96. doi:10
Histone
System for fixing base errors of DNA replication
PMID 20478261. S2CID 26969788. Heller RC, Marians KJ (December 2006). "Replisome assembly and the direct restart of stalled replication forks". Nature
DNA_mismatch_repair
American biochemist
of Technology, where he specializes in researching DNA replication and replisomes. He was named a Howard Hughes Medical Investigator in 2000. In 2009, Bell
Stephen_P._Bell
DNA region replicating from a single origin
holoenzyme dnaC dnaE dnaH dnaN dnaQ dnaT dnaX holA holB holC holD holE Replisome DNA ligase DNA clamp Topoisomerase DNA gyrase Prokaryotic DNA polymerase:
Replicon_(genetics)
Protein complex formed during initiation of DNA replication
replication. After the pre-RC is formed it must be activated and the replisome assembled in order for DNA replication to occur. In prokaryotes, DnaA
Pre-replication_complex
Chemical compound
Karadeema, Rebekah J.; Romesberg, Floyd E. (2018-01-17). "Reprograming the Replisome of a Semisynthetic Organism for the Expansion of the Genetic Alphabet"
DNaM
"Structure and function of the GINS complex, a key component of the eukaryotic replisome". Biochemical Journal. 425 (3): 489–500. doi:10.1042/BJ20091531. Labib
GINS
Mammalian protein found in Homo sapiens
Otterlei M (2012). "Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA"
Proliferating cell nuclear antigen
Proliferating_cell_nuclear_antigen
Damage in DNA which occurs naturally
reactive oxygen increase by transmembrane transporters, chromosome loss by replisome binding, replication stalling by transcription factors. The DDP human
DNA damage (naturally occurring)
DNA_damage_(naturally_occurring)
proteins associated with the replisome. There is some debate within the literature as to whether Rrm3p is part of the replisome or if it is a protein that
RRM3
DNA. Histones are removed during DNA replication; following behind the replisome, histones start to assemble as immature pre-nucleosomes on nascent DNA
Chromodomain helicase DNA-binding (CHD) subfamily
Chromodomain_helicase_DNA-binding_(CHD)_subfamily
Mechanism of nuclear organization
interact with cohesin subunits. DNA replication: Replication forks and replisomes have been shown to restrict loop extrusion activity. Additionally, the
Loop_extrusion
Protein-coding gene in humans
domain. GINS3 is essential for the initiation of DNA replication and replisome progression in eukaryotes. NDRG4 a member of the N-myc downregulated gene
CCDC113
region of DNA or RNA that replicates from a single origin of replication. replisome The entire complex of molecular machinery that carries out the process
Glossary of cellular and molecular biology (M–Z)
Glossary_of_cellular_and_molecular_biology_(M–Z)
Protein synthesis process in bacteria
at a rate of only 18 amino acid residues per second, whereas bacterial replisomes synthesize DNA at a rate of 1000 nucleotides per second. This difference
Bacterial_translation
Protein family
3511. PMID 10698628. Shamoo Y, Steitz TA (October 1999). "Building a replisome from interacting pieces: sliding clamp complexed to a peptide from DNA
DNA_clamp
Initiation site for the opening of the DNA double helix
PMID 27241926. Bell SD (2012). "Archaeal Orc1/Cdc6 Proteins". The Eukaryotic Replisome: A Guide to Protein Structure and Function. Subcellular Biochemistry.
DNA_unwinding_element
Human mitochondrial protein
Pellegrini M, Falkenberg M (June 2004). "Reconstitution of a minimal mtDNA replisome in vitro". The EMBO Journal. 23 (12): 2423–9. doi:10.1038/sj.emboj.7600257
Twinkle_(protein)
Protein-coding gene in humans
holoenzyme dnaC dnaE dnaH dnaN dnaQ dnaT dnaX holA holB holC holD holE Replisome DNA ligase DNA clamp Topoisomerase DNA gyrase Prokaryotic DNA polymerase:
POLE_(gene)
American biochemist
Richardson developed a single-molecule assay to measure the activity of the replisome with fluorescently-labeled DNA polymerases. Richardson then used this
Charles_C._Richardson
American bioinorganic chemist
topics of enzyme kinetics, metallo-beta-lactamase, and the mechanics of replisome and primase in DNA replication. In 2001, Valentine joined the chemistry
Ann_M._Valentine
Damage to the structure of a biological molecule
reactive oxygen by transmembrane transporters, losing chromosomes by replisome binding, and stalling replication by transcription factors. For RNA lesions
Molecular_lesion
Protein-coding gene in the species Homo sapiens
holoenzyme dnaC dnaE dnaH dnaN dnaQ dnaT dnaX holA holB holC holD holE Replisome DNA ligase DNA clamp Topoisomerase DNA gyrase Prokaryotic DNA polymerase:
POLE2
Protein-coding gene in the species Homo sapiens
of that gene can take longer than one round of replication. When the replisome and transcription machinery collide, R loops can form and double stranded
SETX
Sexually transmitted virus of corn earworm moths
ISSN 1674-0769. S2CID 42113307. Shamoo Y, Steitz TA (October 1999). "Building a replisome from interacting pieces: sliding clamp complexed to a peptide from DNA
Helicoverpa_zea_nudivirus_2
Protein-coding gene in the species Homo sapiens
holoenzyme dnaC dnaE dnaH dnaN dnaQ dnaT dnaX holA holB holC holD holE Replisome DNA ligase DNA clamp Topoisomerase DNA gyrase Prokaryotic DNA polymerase:
POLE4
Indian biological physicist
Padinhateeri, Ranjith; Das, Dibyendu; Bameta, Tripti (1 June 2018). "Coupling of replisome movement with nucleosome dynamics can contribute to the parent–daughter
Ranjith_Padinhateeri
Realm of viruses
appear to encode replication proteins, so they rely entirely on host DNA replisomes for replication. Floreovirians have a relatively high rate of substitution
Floreoviria
Protein-coding gene in the species Homo sapiens
component perinuclear region of cytoplasm membrane nucleus cytoplasm replisome Biological process DNA replication DNA synthesis involved in DNA repair
WRNIP1
Protein-coding gene in the species Homo sapiens
holoenzyme dnaC dnaE dnaH dnaN dnaQ dnaT dnaX holA holB holC holD holE Replisome DNA ligase DNA clamp Topoisomerase DNA gyrase Prokaryotic DNA polymerase:
POLD3
REPLISOME
REPLISOME
REPLISOME
REPLISOME
Boy/Male
Indian
Bold, Courageous, An able minister, Forgiveness
Boy/Male
Afghan, Arabic, Muslim
Star
Girl/Female
Tamil
Dhanishta | தநிஷà¯à®Ÿà®¾
A star
Boy/Male
British, English, Irish
Fire
Boy/Male
Hindu, Indian, Malayalam, Marathi
Seeker of God
Boy/Male
Arabic
Winner
Girl/Female
Indian, Pakistani, Swedish
Protection
Girl/Female
Hebrew
Burning fire.
Surname or Lastname
Irish (Munster)
Irish (Munster) : Anglicized form of Gaelic Ó hÃceadh ‘descendant of Ãcidhe’, a byname meaning ‘doctor’, ‘healer’.English : from a pet form of Hick.
Boy/Male
Arabic, Muslim
Praise of Allah
REPLISOME
REPLISOME
REPLISOME
REPLISOME
REPLISOME