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WEE1

  • Wee1

    • Nuclear protein

    Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular

    Wee1

    Wee1

    Wee1

  • Cell growth

    • Increase of the total mass of a cell

    balance of Wee1 and Cdc25 activity with changes in cell size is coordinated by the mitotic entry control system. It has been shown in Wee1 mutants, cells

    Cell growth

    Cell growth

    Cell_growth

  • G2 phase

    • Third subphase of interphase

    employ such a mechanism, via Cdr2-mediated spatial regulation of Wee1 activity. Though Wee1 is a fairly conserved negative regulator of mitotic entry, no

    G2 phase

    G2 phase

    G2_phase

  • Wee1-like protein kinase

    • Protein-coding gene in the species Homo sapiens

    WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene. This gene encodes a nuclear protein, which is a

    Wee1-like protein kinase

    Wee1-like protein kinase

    Wee1-like_protein_kinase

  • Cell cycle checkpoint

    • Control mechanism in the eukaryotic cell cycle

    and reaches the G2/M transition, the kinase Plk1 phosphorylates Wee1, which targets Wee1 for degradation via the SCF ubiquitin ligase complex. An additional

    Cell cycle checkpoint

    Cell cycle checkpoint

    Cell_cycle_checkpoint

  • Adavosertib

    • Chemical compound

    anti-cancer drug candidate. It is a small molecule inhibitor of the kinase enzyme WEE1. It is being developed by AstraZeneca. It is being investigated as a treatment

    Adavosertib

    Adavosertib

    Adavosertib

  • G2-M DNA damage checkpoint

    • Cell cycle checkpoint in eukaryotic organisms

    CyclinB-Cdc2 inhibitors, Wee1 and Myt1. Cdc25 activates the complex through the removal of phosphates from the active site while Wee1 inactivates the complex

    G2-M DNA damage checkpoint

    G2-M DNA damage checkpoint

    G2-M_DNA_damage_checkpoint

  • Maturation promoting factor

    • Biological factor

    phase, the CDK1 subunit of MPF is inactive due to an inhibitory enzyme, Wee1. Wee1 phosphorylates the Tyr-15 residue of CDK1, rendering MPF inactive. During

    Maturation promoting factor

    Maturation_promoting_factor

  • Hysteresis

    • Dependence of the state of a system on its history

    active CDK1 promotes the activation of more CDK1 molecules by inhibiting Wee1 (an inhibitor) and activating Cdc25 (a phosphatase that activates CDK1).

    Hysteresis

    Hysteresis

    Hysteresis

  • Tyrosine kinase inhibitor

    • Drug typically used in cancer treatment

    based on early studies on TKIs aiming at VEGF receptors. Adavosertib is a Wee1 kinase inhibitor that is undergoing numerous clinical trials in the treatment

    Tyrosine kinase inhibitor

    Tyrosine kinase inhibitor

    Tyrosine_kinase_inhibitor

  • Cyclin-dependent kinase

    • Class of enzymes

    phosphorylation state of CDKs is controlled by kinases and phosphatases such as WEE1 kinases, Myt1 kinases, and Cdc25c phosphatases for CDK1. Inhibitory phosphorylation

    Cyclin-dependent kinase

    Cyclin-dependent kinase

    Cyclin-dependent_kinase

  • PKMYT1

    • Protein-coding gene in the species Homo sapiens

    that in humans is encoded by the PKMYT1 gene. Myt 1 is an enzyme in the Wee1 family and found in vertebrates.  The Wee 1 family includes a variety of

    PKMYT1

    PKMYT1

    PKMYT1

  • Schizosaccharomyces pombe

    • Species of yeast

    Pom1 inhibits Cdr2, preventing Cdr2 and Cdr1 from inhibiting Wee1, and allowing Wee1 to phosphorylate Cdk1, thus inactivating cyclin-dependent kinase

    Schizosaccharomyces pombe

    Schizosaccharomyces pombe

    Schizosaccharomyces_pombe

  • Potrasertib

    • Pharmaceutical compound

    treatment of advanced solid tumors. It is an orally administered inhibitor of WEE1 kinase, a key regulator of cell cycle checkpoints. "IMP 7068". AdisInsight

    Potrasertib

    Potrasertib

    Potrasertib

  • Mitosis inducer protein kinase cdr2

    • non-essential. Cdr2 regulates mitotic entry through direct inhibition of Wee1, which is then unable to continue to Cdk1 and subsequently start mitosis

    Mitosis inducer protein kinase cdr2

    Mitosis_inducer_protein_kinase_cdr2

  • Meiosis

    • Cell division producing haploid gametes

    phosphorylation of CDK1 at amino acid residues Thr-14 and Tyr-15 by MYT1 and WEE1 as well as regulation of cyclin B levels facilitated by the anaphase-promoting

    Meiosis

    Meiosis

    Meiosis

  • Cyclin-dependent kinase 1

    • Mammalian protein found in Homo sapiens

    to stabilization of this phosphorylation, preventing mitotic progression. Wee1, conserved among all eukaryotes phosphorylates Tyr15, whereas members of

    Cyclin-dependent kinase 1

    Cyclin-dependent kinase 1

    Cyclin-dependent_kinase_1

  • PTGES3

    • Protein-coding gene in the species Homo sapiens

    (2000). "The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts". Genetics. 153 (4): 1561–72

    PTGES3

    PTGES3

    PTGES3

  • Titin

    • Largest known protein in human muscles

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Titin

    Titin

    Titin

  • Cell cycle

    • Events leading to cell division

    Retinoblastoma protein Synchronous culture – synchronization of cell cultures Wee1 Although in some cases Cdk inhibitor proteins or phosphorylation introduce

    Cell cycle

    Cell cycle

    Cell_cycle

  • Mitogen-activated protein kinase

    • P38 mitogen-activated protein kinases

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Mitogen-activated protein kinase

    Mitogen-activated_protein_kinase

  • Bistability

    • Quality of a system having two stable equilibrium states

    its activator Cdc25 while at the same time inactivating its inactivator, Wee1, thus allowing for progression of a cell into mitosis. Without this double

    Bistability

    Bistability

    Bistability

  • Serine/threonine-specific protein kinase

    • Class of protein kinase enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Serine/threonine-specific protein kinase

    Serine/threonine-specific protein kinase

    Serine/threonine-specific_protein_kinase

  • C-Jun N-terminal kinases

    • Chemical compounds

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    C-Jun N-terminal kinases

    C-Jun N-terminal kinases

    C-Jun_N-terminal_kinases

  • MAP kinase kinase kinase kinase

    • Family of proteins

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    MAP kinase kinase kinase kinase

    MAP_kinase_kinase_kinase_kinase

  • CHEK1

    • Protein-coding gene in humans

    through phosphorylating Nek11. WEE1 kinase and PLK1 are also targeted by Chk1 to induce cell cycle arrest. Phosphorylation of WEE1 kinase inhibits cdk1 which

    CHEK1

    CHEK1

    CHEK1

  • Protein kinase A

    • Family of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Protein kinase A

    Protein kinase A

    Protein_kinase_A

  • MTORC2

    • Protein complex

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    MTORC2

    MTORC2

  • Rho-associated protein kinase

    • Protein family

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Rho-associated protein kinase

    Rho-associated protein kinase

    Rho-associated_protein_kinase

  • Ca2+/calmodulin-dependent protein kinase II

    • Class of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Ca2+/calmodulin-dependent protein kinase II

    Ca2+/calmodulin-dependent protein kinase II

    Ca2+/calmodulin-dependent_protein_kinase_II

  • ACVR1

    • Protein-coding gene

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    ACVR1

    ACVR1

    ACVR1

  • Let-7 microRNA family

    • RNA family

    of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts". The Journal of Biological Chemistry. 284

    Let-7 microRNA family

    Let-7_microRNA_family

  • Myosin light-chain kinase

    • Class of kinase enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Myosin light-chain kinase

    Myosin light-chain kinase

    Myosin_light-chain_kinase

  • HSP90AB1

    • Protein-coding gene in the species Homo sapiens

    kinase 14), ERK5 (extracellular regulated kinase 5), or the checkpoint kinase Wee1. Cystic fibrosis (CF, mucoviscidosis) is a genetic disease with increased

    HSP90AB1

    HSP90AB1

    HSP90AB1

  • Extracellular signal-regulated kinases

    • Class of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Extracellular signal-regulated kinases

    Extracellular_signal-regulated_kinases

  • MTOR

    • Mammalian protein found in humans

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    MTOR

    MTOR

    MTOR

  • Phosphatidylinositol 3-kinase-related kinase

    • Protein family

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Phosphatidylinositol 3-kinase-related kinase

    Phosphatidylinositol_3-kinase-related_kinase

  • AMP-activated protein kinase

    • Class of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    AMP-activated protein kinase

    AMP-activated protein kinase

    AMP-activated_protein_kinase

  • Aurora inhibitor

    • Putative drug class for treating cancer

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Aurora inhibitor

    Aurora inhibitor

    Aurora_inhibitor

  • G protein-coupled receptor kinase

    • Family of protein kinases

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    G protein-coupled receptor kinase

    G protein-coupled receptor kinase

    G_protein-coupled_receptor_kinase

  • Protein kinase B

    • Set of three serine threonine-specific protein kinases

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Protein kinase B

    Protein kinase B

    Protein_kinase_B

  • Mitogen-activated protein kinase kinase

    • Kinase enzyme

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Mitogen-activated protein kinase kinase

    Mitogen-activated_protein_kinase_kinase

  • John M. Maris

    • American pediatric oncologist

    January 2013, Maris co-authored Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma which was a combination

    John M. Maris

    John_M._Maris

  • Casein kinase 2

    • Protein

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Casein kinase 2

    Casein_kinase_2

  • Pom1

    • then phosphorylates and inhibits Wee1, also recruited to the medial node by the presence of Cdr2. The phosphorylated Wee1 allows Cdc25 to dephosphorylate

    Pom1

    Pom1

  • MTORC1

    • Protein complex

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    MTORC1

    MTORC1

    MTORC1

  • Novak–Tyson model

    • loops through Cdc25 and Wee1, and delayed activation by MPF of the APC, but includes additional reactions such as that of Wee1 and Cdc25. The result is

    Novak–Tyson model

    Novak–Tyson_model

  • Pyruvate dehydrogenase kinase

    • Class of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Pyruvate dehydrogenase kinase

    Pyruvate dehydrogenase kinase

    Pyruvate_dehydrogenase_kinase

  • GSK-3

    • Class of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    GSK-3

    GSK-3

    GSK-3

  • GAK (protein)

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    GAK (protein)

    GAK (protein)

    GAK_(protein)

  • Dephospho-(reductase kinase) kinase

    • Class of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Dephospho-(reductase kinase) kinase

    Dephospho-(reductase_kinase)_kinase

  • FBXW11

    • Protein-coding gene in the species Homo sapiens

    whereas in G2, βTrCP contributes to CDK1 activation by targeting the kinase WEE1 for degradation. In early mitosis, βTrCP mediates the degradation of EMI1

    FBXW11

    FBXW11

    FBXW11

  • Protein kinase C

    • Family of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Protein kinase C

    Protein_kinase_C

  • ATM serine/threonine kinase

    • Mammalian protein found in Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    ATM serine/threonine kinase

    ATM serine/threonine kinase

    ATM_serine/threonine_kinase

  • MTOR inhibitors

    • Class of pharmaceutical drugs

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    MTOR inhibitors

    MTOR inhibitors

    MTOR_inhibitors

  • Biochemical switches in the cell cycle

    • Wee1 has an ultrasensitive response to Cdk1, and this likely arises because of substrate competition among the various phosphorylation sites on Wee1.

    Biochemical switches in the cell cycle

    Biochemical_switches_in_the_cell_cycle

  • BRSK2

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    BRSK2

    BRSK2

    BRSK2

  • MAP kinase kinase kinase

    • Class of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    MAP kinase kinase kinase

    MAP_kinase_kinase_kinase

  • Ataxia telangiectasia and Rad3 related

    • Protein kinase that detects DNA damage and halts cell division

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Ataxia telangiectasia and Rad3 related

    Ataxia telangiectasia and Rad3 related

    Ataxia_telangiectasia_and_Rad3_related

  • IkappaB kinase

    • Class of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    IkappaB kinase

    IkappaB_kinase

  • PPP2R1A

    • Enzyme

    pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–370. doi:10.1006/viro.2001.1007. PMID 11531413

    PPP2R1A

    PPP2R1A

    PPP2R1A

  • SMG1

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    SMG1

    SMG1

    SMG1

  • AP-1 transcription factor

    • Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)

    v t e Regulome Activates cAMP, IL-2, CREB, WEE1, OPN, RD, MMP, calpain-2, G1-Cyclin–dependent Kinases, BMP-4, H1 receptor, cyclin D1, GC-A, TGF-b, NOTCH4

    AP-1 transcription factor

    AP-1 transcription factor

    AP-1_transcription_factor

  • Cyclin-dependent kinase 4

    • Human protein

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Cyclin-dependent kinase 4

    Cyclin-dependent kinase 4

    Cyclin-dependent_kinase_4

  • Myotonin-protein kinase

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Myotonin-protein kinase

    Myotonin-protein kinase

    Myotonin-protein_kinase

  • CAMK

    • Enzyme type

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    CAMK

    CAMK

  • VRK2

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    VRK2

    VRK2

    VRK2

  • PRKD3

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    PRKD3

    PRKD3

    PRKD3

  • Rhodopsin kinase

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Rhodopsin kinase

    Rhodopsin_kinase

  • Tau-protein kinase

    • Class of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Tau-protein kinase

    Tau-protein kinase

    Tau-protein_kinase

  • Ubiquitin ligase

    • Protein

    Sarott, Roman C.; Fischer, Eric S. (2024-11-20). "Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library". Journal

    Ubiquitin ligase

    Ubiquitin ligase

    Ubiquitin_ligase

  • MAP2K7

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    MAP2K7

    MAP2K7

    MAP2K7

  • Acetate kinase

    • Class of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Acetate kinase

    Acetate kinase

    Acetate_kinase

  • Phosphorylase kinase

    • Enzyme involved in glycogenolysis

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Phosphorylase kinase

    Phosphorylase kinase

    Phosphorylase_kinase

  • SCF complex

    • Type of protein

    Myc, E2f1, p130 cyclin-dependent kinase inhibitors (CKIs): p27Kip1, p21, Wee1 centriole proteins: Cep250, Ninein There are approximately seventy human

    SCF complex

    SCF complex

    SCF_complex

  • Cyclin-dependent kinase 6

    • Protein found in humans

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Cyclin-dependent kinase 6

    Cyclin-dependent kinase 6

    Cyclin-dependent_kinase_6

  • EIF2AK4

    • Protein-coding gene in humans

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    EIF2AK4

    EIF2AK4

    EIF2AK4

  • MAP2K2

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    MAP2K2

    MAP2K2

    MAP2K2

  • Phototropin

    • Class of photoreceptor proteins in plants

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Phototropin

    Phototropin

  • Casein kinase 1, alpha 1

    • Enzyme found in humans

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    Casein kinase 1, alpha 1

    Casein kinase 1, alpha 1

    Casein_kinase_1,_alpha_1

  • BCKDHA

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    BCKDHA

    BCKDHA

    BCKDHA

  • PRKAG3

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    PRKAG3

    PRKAG3

    PRKAG3

  • FBXL7

    • Protein-coding gene in humans

    (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419–24. Bibcode:2004PNAS

    FBXL7

    FBXL7

    FBXL7

  • P38 mitogen-activated protein kinases

    • Protein family

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    P38 mitogen-activated protein kinases

    P38_mitogen-activated_protein_kinases

  • MAP3K12

    • Enzyme

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    MAP3K12

    MAP3K12

    MAP3K12

  • SGK

    • Protein family

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    SGK

    SGK

  • DAPK3

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    DAPK3

    DAPK3

    DAPK3

  • TRIO (gene)

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    TRIO (gene)

    TRIO (gene)

    TRIO_(gene)

  • Cln3

    • Protein

    was inspired by a similar study in Schizosaccharomyces pombe, in which the Wee1 gene was identified as an inhibitor of cell cycle progression that maintained

    Cln3

    Cln3

  • FBXW2

    • Protein-coding gene in the species Homo sapiens

    (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419–24. Bibcode:2004PNAS

    FBXW2

    FBXW2

    FBXW2

  • 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase

    • Class of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase

    3-methyl-2-oxobutanoate_dehydrogenase_(acetyl-transferring)_kinase

  • PRKAB2

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    PRKAB2

    PRKAB2

    PRKAB2

  • VRK1

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    VRK1

    VRK1

    VRK1

  • CDK12

    • Protein kinase gene

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    CDK12

    CDK12

    CDK12

  • TRIB1

    • Protein-coding gene in the species Homo sapiens

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    TRIB1

    TRIB1

    TRIB1

  • Cyclin B1

    • Protein-coding gene in the species Homo sapiens

    present in the cell, but it is inactive due to phosphorylation of Cdk1 by the Wee1 kinase. The complex is activated by dephosphorylation by the phosphatase

    Cyclin B1

    Cyclin B1

    Cyclin_B1

  • RAF kinase

    • Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    RAF kinase

    RAF kinase

    RAF_kinase

  • Ultrasensitivity

    • positive feedback can induce bistability in Cyclin B1- by the two regulators Wee1 and Cdc25C, leading to the cell's decision to commit to mitosis. The system

    Ultrasensitivity

    Ultrasensitivity

    Ultrasensitivity

  • TGF beta receptor

    • Protein family

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    TGF beta receptor

    TGF_beta_receptor

  • (tyrosine 3-monooxygenase) kinase

    • Class of enzymes

    Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase

    (tyrosine 3-monooxygenase) kinase

    (tyrosine_3-monooxygenase)_kinase

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Online names & meanings

  • Ebenezer

    • Boy/Male

    Christian & English(British/American/Australian)

    Ebenezer

    Rock of Help

  • Haasini | ஹாஸீநீ

    • Girl/Female

    Tamil

    Haasini | ஹாஸீநீ

    Pleasant, Wonderful, Happy or full of laughter

  • Deavon

    • Boy/Male

    British, English

    Deavon

    Bard; Poet; Variant of the English County Name Devon

  • Froille

    • Boy/Male

    Arthurian Legend

    Froille

    Killed by Arthur.

  • Darshvi

    • Girl/Female

    Gujarati, Hindu, Indian

    Darshvi

    Vision; Moonlight; See; Seen

  • ROLLAND

    • Male

    English

    ROLLAND

    English variant spelling of Norman French Roland, ROLLAND means "famous land."

  • Dibiksha

    • Girl/Female

    Indian

    Dibiksha

    Life for Light

  • Rabiya |

    • Girl/Female

    Muslim

    Rabiya |

    Spring, Springtime, Garden

  • Nadi

    • Girl/Female

    Arabic, Gujarati, Indian, Muslim, Telugu

    Nadi

    River; Flow

  • Maithra

    • Girl/Female

    Hindu, Indian, Tamil

    Maithra

    Friendly

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WEE1

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